Despite our growing knowledge about the COVID pandemic, not much concern has 
been focused upon the effective pain management in pediatric patients suffering 
from this SARS CoV2 virus. Symptoms with pain like myalgia (10%-40%), sore 
throat (5%-30%), headache (14%-40%) and abdominal pain (10%) are common in 
children suffering from COVID. (3-5) We conducted a systematic review regarding 
analgesia for COVID positive pediatric patients. Cochrane, PubMed, and Google 
scholar databases were searched for relevant literature. Owing to the novel 
status of COVID-19 with limited literature, we included randomized controlled 
trials (RCTs), observational studies, case series and case reports in the 
descending order of consideration. Articles in languages other than English, 
abstract only articles and non-scientific commentaries were excluded. The 
Primary outcome was evaluation of pain related symptoms and best strategies for 
their management. Our review revealed that a multidisciplinary approach starting 
from non-pharmacological techniques like drinking plenty of water, removing 
triggers like inadequate sleep, specific foods and psychotherapy including 
distraction, comfort and cognitive behavioural strategies should be used. 
Pharmacological approaches like acetaminophen, NSAIDS, spasmolytics etc. can be 
used if non-pharmacological therapy is inadequate. As per the current strength 
of evidence, acetaminophen and ibuprofen can be safely administered for pain 
management in children with COVID-19. Undertreated pain is a significant 
contributor to increased morbidity and poor prognosis. Integration of evidence 
based non-pharmacotherapies in the multidisciplinary pain management will 
contribute towards improved functioning, early recovery and better quality care 
for pediatric patients suffering from COVID.