Super-enhancers (SEs) are regions of the genome consisting of clusters of 
regulatory elements bound with very high amounts of transcription factors, and 
this architecture appears to be the hallmark of genes and noncoding RNAs linked 
with cell identity. Recent studies have identified SEs in CD4(+) T cells and 
have further linked these regions to single nucleotide polymorphisms (SNPs) 
associated with immune-mediated disorders, pointing to an important role for 
these structures in the T cell differentiation and function. Here we review the 
features that define SEs, and discuss their function within the broader 
understanding of the mechanisms that define immune cell identity and function. 
We propose that SEs present crucial regulatory hubs, coordinating intrinsic and 
extrinsic differentiation signals, and argue that delineating these regions will 
provide important insight into the factors and mechanisms that define immune 
cell identity.