Brugada syndrome is an inherited arrhythmia syndrome predisposing to sudden 
cardiac death. Six years after its initial description as a clinical entity, the 
first mutations in SCN5A encoding the cardiac sodium channel Nav1.5 were 
reported. Over 300 mutations in SCN5A have since been described in addition to 
mutations in genes encoding Nav1.5 auxiliary units, potassium and calcium 
channels. This review summarizes the current knowledge on the genetics of 
Brugada syndrome, focusing on SCN5A, and discusses its use as a biomarker for 
diagnosis, prognosis and treatment.