The objective of this study is to describe the initial use of propranolol as the 
sole treatment for focal infantile airway hemangiomas, and to report on 
available literature describing the use of propranolol for airway lesions. This 
retrospective case series was carried out at a tertiary pediatric medical 
center. We obtained the following results: two children demonstrated significant 
response to oral propranolol therapy and avoided not only invasive surgical 
procedures, but also long-term administration of oral corticosteroids. This is 
the first report of treating infantile airway hemangiomas with only propranolol 
without additional surgical intervention or corticosteroid use. Review of 
literature reveals initial case series with similar, successful results using 
propranolol as an adjuvant treatment along with other medications and surgical 
interventions. We conclude that the initial use of propranolol as the sole 
treatment for infantile airway hemangioma is promising. Literature review 
reveals that propranolol as the sole treatment for most head and neck 
hemangiomas shows significant promise based on early case reports. Further 
studies are needed to determine the long-term effectiveness, dosing strategies, 
and side effect profile of propranolol treatment for hemangiomas.