Molluscum contagiosum is a benign contagious disease caused by a poxvirus. The 
virus proliferates within keratinocytes and forms intracytoplasmic Molluscum 
bodies. Though it is a common clinical condition, histologically is not yet 
reported from this region of Mymensingh. We received a skin biopsy specimen in a 
pathology laboratory for histological examination. The Haematoxylin and Eosin 
stained sections revealed typical intracytoplasmic Molluscum bodies in 
keratinocytes. The lesions were in the trunk, which is a common site for 
Molluscum Contagiosum (MC). As the diagnosis of Molluscum contagiosum is easy by 
histological examination, every patient suspected to be this disease is 
recommended to be examined histologically to exclude other similar types of 
lesions.