A systematic review was conducted to identify the available data for the term 
Krokodil, which is a jargon expression for an allegedly new drug. Krokodil seems 
to be a mixture of several substances and was first used in Russia in 2003, with 
a tremendous increase in the number of addicted individuals since then. The 
psychoactive core agent of Krokodil is desomorphine, an opioid-analogon that can 
be manufactured by boiling tablets containing codeine and other ingredients. The 
procedure results in a suspension that is used intravenously and regularly 
causes complications such as abscess, thrombophlebitis, and gangrene.