The histone chaperones play an important role in chromatin assembly and 
disassembly during replication and transcription. We have assessed the global 
roles of histone chaperones in Saccharomyces cerevisiae. Microarray 
transcriptional analyzes indicate that histone chaperones have their own 
specific target genes, and various histone chaperones have partially overlapping 
functions during transcriptional regulation. The histone deacetylase inhibitor 
TSA and histone chaperones Asf1, Vps75 and Rtt106 can function in parallel 
pathways to regulate transcription. Moreover, TSA can specifically antagonize 
histone chaperone Chz1-mediated telomere anti-silencing. This study demonstrates 
that a mutual cross-talk mechanism exists between histone chaperones and histone 
deacetylation in transcriptional regulation.