We report a case of a 6-week-old infant with diabetes mellitus based on a 
genetic defect in the sulfonylurea receptor 1 (SUR1), an ATP-sensitive potassium 
(KATP) channel protein. A spectacular improvement in glucose regulation was 
shown by real-time continuous glucose monitoring when switching her from insulin 
to oral glibenclamide. Children with neonatal onset of diabetes deserve genetic 
testing in order to replace insulin with oral medication.