Chronic myelogenous leukemia (CML) is genetically characterized by the 
reciprocal translocation of chromosome 9 and 22, t(9;22)(q34;q11) which results 
in the fusion of BCR/ABL gene observed on the derivative chromosome 22 called 
Philadelphia (Ph') chromosome. About 5-8% of Philadelphia positive patients with 
CML show various complex translocations involving one or more other chromosomes, 
in addition to chromosome 9 and 22. In our report we discuss one case with CML, 
his cytogenetic study revealed a complex translocation t(5;9;22)(p15.1; q34; 
q11.2), del 5p15.1-->pter, translocation BCR(22q11.2-->qter) to der(5), positive 
Ph-chromosome and positive t(BCR\ABL). Further confirmation of complex 
translocation was done by FISH study using the LSI BCR/ABL dual color dual 
fusion (DF) translocation probe, chromosome 5 and 22 whole paint probes.