Women during perimenopausal period experience a range of symptoms, which 
interfere with physical, sexual, and social life. About 65-75% of symptoms 
connected with postmenopausal period are vasomotor symptoms (VMS), such as hot 
flushes and night sweats. Hot flushes are subjective sensation of heat 
associated with cutaneous vasodilatation and drop in core temperature. It is 
suspected that VMS are strongly correlated with pulsatile oversecretion of 
gonadotropin-releasing hormone (GnRH) and subsequently luteinizing hormone (LH). 
Evidence has accumulated in parallel showing that lack of negative feedback of 
steroid hormones synthesized in ovary causes overactivation of hypertrophied 
kisspeptin/neurokinin B/dynorphin (KNDy) neurons, located in infundibular 
nucleus. Oversecretion of both kisspeptin (KISS1) and neurokinin B (NKB), as 
well as downregulation of dynorphin, plays dominant role in creation of GnRH 
pulses. This in turn causes VMS. Administration of senktide, highly potent and 
selective NK3R agonist, resulted in increase of serum LH concentration, 
induction of VMS, increase in heart rate, and skin temperature in postmenopausal 
women. These finding suggest that modulation of KNDy neurons may become new 
therapeutic approach in the treatment of VMS.