Abstract BACKGROUND:Morton's neuroma is a frequently painful condition of the 
forefoot, causing sufferers to seek medical care to alleviate symptoms. A 
plethora of therapeutic options are available, some of which include injection 
therapies. Researchers have investigated injection therapy for Morton's neuroma, 
and latterly the evidence base has been augmented with methodologies which 
utilise diagnostic ultrasound (US) as a vehicle to deliver the injectate under 
image guidance for additional accuracy. There appears to date to be no consensus 
that US-guided injections provide better therapeutic outcomes than non US-guided 
(blind) injections for treatment of Morton's neuroma. METHODS:A systematic 
review was chosen, as this methodology can undertake such a process. The review 
process identified 13 key papers using pre-determined inclusion and exclusion 
criteria, which then underwent methodological quality assessment using a 
pre-tested Quality Index. A narrative synthesis of the review findings was 
presented in light of the heterogeneity of the data from the extraction process. 
RESULTS:This systematic review provides an argument that ultrasound-guidance can 
produce better short- and long-term pain relief for corticosteroid injections, 
can reduce the need for additional procedures in a series of sclerosing alcohol 
injections, can reduce the surgical referral rate, and adds efficacy to a single 
injection.
CONCLUSIONS: Ultrasound guidance should be considered for injection therapy in 
the management of Morton's neuroma.