The focus of this article is acrokeratosis paraneoplastica, one of two disorders 
that have acquired the eponym Bazex syndrome. To date, all of the patients 
reported in the literature have had an underlying neoplasm, most commonly 
squamous cell carcinoma of the upper aerodigestive tract. In this review of 113 
cases of acrokeratosis paraneoplastica (mean age, 61 years; 105 males, 8 
females), the psoriasiform lesions preceded the diagnosis of the associated 
malignancy in 73 (67%) of 109 patients, whereas the cutaneous manifestations 
followed the diagnosis of the neoplasm in only 16 (15%) of 109; in the 
remainder, the onset of the skin lesions and the diagnosis of the tumor occurred 
simultaneously. Therefore, awareness of the cutaneous signs of Bazex syndrome is 
of obvious importance to dermatologists. Evidence in favor of the paraneoplastic 
nature of this disease is as follows: in 81 (93%) of 87 patients with adequate 
clinical descriptions, the skin lesions either improved significantly (or 
resolved) when the underlying neoplasm was treated or they remained unchanged in 
the setting of persistent disease. Occasionally, the reappearance of skin 
lesions has signaled a recurrence of the tumor.