The 2014 outbreak of Ebola virus disease (EVD) in West Africa, caused by Ebola 
virus (Zaire Ebola virus species), is the largest outbreak of EVD in history. It 
cause hemorrhagic fever in human and nonhuman primates with high mortality rate 
up to 90% and can be transmitted by direct contact with blood, body fluids, skin 
of EVD patients or persons who have died of EVD. As of December 17, 2014, 450 
healthcare personnel are known to have been infected with Ebola, of whom 244 
died. For development of Ebola vaccine and treatment are highly difficult due to 
its dangerous and accessibility that requires biosafety level 4 (BSL-4) to 
conduct experiment. Also there is no specific vaccine and treatment for Ebola 
virus; however, many candidate vaccines and antiviral-drugs such as ZMapp and 
TKM-Ebola are being developed for Ebola virus disease. In this review, we focus 
on the epidemiology of 2014 outbreak of Ebola virus and candidate agent for 
preventing and curing from Ebola virus.