OBJECTIVE AND IMPORTANCE: Hemophilic pseudotumor is a rare complication of 
hemophilia, occurring in 1 to 2% of patients with severe hemophilia. Its 
principal sites of occurrence are the long bones and the pelvis. Only one case 
of this tumor occurring in the cranium has been previously reported.
CLINICAL PRESENTATION: We report a case of cranial hemophilic pseudotumor 
involving the diploe of the right parietal vault. A 29-year-old man with severe 
hemophilia (Factor VIII, 0.8% of normal activity) presented with an unsightly 
scalp protrusion measuring 5 x 5 x 2 cm and tingling discomfort in the left arm. 
About 5 years before admission, he noted a walnut-sized, nontender mass in the 
right parietal area that had enlarged slightly after minor head trauma. Tingling 
discomfort developed as the manifestation of the compression of the parietal 
lobe in the 2 to 3 months after the head trauma.
INTERVENTION: Under proper factor replacement therapy, surgery was undertaken 
for excision and tissue diagnosis. Histological examination of the content in 
the diploe revealed old blood coagulum.
CONCLUSION: Postoperatively, the tingling discomfort in the arm resolved 
completely. To our knowledge, this is the second case of the cranial hemophilic 
pseudotumor in the English literature. Diagnosis and management of cranial 
hemophilic pseudotumor are presented with a review of the literature.