Heyde syndrome is a triad of aortic stenosis, an acquired coagulopathy and 
anaemia due to bleeding from intestinal angiodysplasia. The evidence that aortic 
stenosis is the root cause of this coagulopathy is compelling. Resolution of 
anaemia usually follows aortic valve replacement. This article discusses studies 
linking aortic stenosis with other conditions in the triad as well as diagnosis 
and management of this complex pathology.