High-throughput techniques have considerably increased the potential of 
comparative genomics whilst simultaneously posing many new challenges. One of 
those challenges involves efficiently mining the large amount of data produced 
and exploring the landscape of both conserved and idiosyncratic genomic regions 
across multiple genomes. Domains of application of these analyses are diverse: 
identification of evolutionary events, inference of gene functions, detection of 
niche-specific genes or phylogenetic profiling. Insyght is a comparative genomic 
visualization tool that combines three complementary displays: (i) a table for 
thoroughly browsing amongst homologues, (ii) a comparator of orthologue 
functional annotations and (iii) a genomic organization view designed to improve 
the legibility of rearrangements and distinctive loci. The latter display 
combines symbolic and proportional graphical paradigms. Synchronized navigation 
across multiple species and interoperability between the views are core features 
of Insyght. A gene filter mechanism is provided that helps the user to build a 
biologically relevant gene set according to multiple criteria such as 
presence/absence of homologues and/or various annotations. We illustrate the use 
of Insyght with scenarios. Currently, only Bacteria and Archaea are supported. A 
public instance is available at http://genome.jouy.inra.fr/Insyght. The tool is 
freely downloadable for private data set analysis.