Multiple familial meningiomas occur in rare genetic syndromes, particularly 
neurofibromatosis type 2. The association of meningiomas and cerebral cavernous 
malformations (CCMs) has been reported in few patients in the medical 
literature. The purpose of our study is to corroborate a preferential 
association of CCMs and multiple meningiomas in subjects harbouring mutations in 
the PDCD10 gene (also known as CCM3). Three members of an Italian family 
affected by seizures underwent conventional brain Magnetic Resonance Imaging 
(MRI) with gadolinium contrast agent including gradient echo (GRE) imaging. The 
three CCM-causative genes were sequenced by Sanger method. Literature data 
reporting patients with coexistence of CCMs and meningiomas were reviewed. MRI 
demonstrated dural-based meningioma-like lesions associated to multiple 
parenchymal CCMs in all affected individuals. A disease-causative mutation in 
the PDCD10 gene (p.Gln112PhefsX13) was identified. Based on neuroradiological 
and molecular data as well as on literature review, we outline a consistent 
association between PDCD10 mutations and a syndrome of CCMs with multiple 
meningiomas. This condition should be considered in the differential diagnosis 
of multiple/familial meningioma syndromes. In case of multiple/familial 
meningioma the use of appropriate MRI technique may include GRE and/or 
susceptibility-weighted imaging (SWI) to rule out CCM. By contrast, proper 
post-gadolinium scans may aid defining dural lesions in CCM patients and are 
indicated in PDCD10-mutated individuals.