Although it has long been known that fasting or the consumption of certain foods 
can trigger headaches, abdominal and total body obesity have only recently been 
linked to migraine. Several adipocytokines appear to play an integral role in 
feeding and obesity--and have also been linked to pain. Among these proteins are 
adiponectin and leptin. The author reviews the regulation of adipose tissue and 
feeding and provides an in-depth examination of adiponectin and leptin and their 
association with migraine.