Vortioxetine is a novel antidepressant with effects on multiple 5-HT receptors 
and on the serotonin transporter. This paper reviews preclinical and clinical 
evidence regarding its mechanism of action, its tolerability, and its efficacy 
in treating major depression. Clinical studies indicate that vortioxetine is 
effective in the treatment of major depression, though there is no suggestion of 
superiority over active comparators. There may be a clinically meaningful 
advantage in terms of tolerability.