Metastatic cancer cells produce invasive membrane protrusions called invadopodia 
and pseudopodia, which play a central role in driving cancer cell dissemination 
in the body. Malignant cells use these structures to attach to and degrade 
extracellular matrix proteins, generate force for cell locomotion, and to 
penetrate the vasculature. Recent work using unique subcellular fractionation 
methodologies combined with spatial genomic, proteomic, and phosphoproteomic 
profiling has provided insight into the invadopodiome and pseudopodiome 
signaling networks that control the protrusion of invasive membranes. Here I 
highlight how these powerful spatial 'omics' approaches reveal important 
signatures of metastatic cancer cells and possible new therapeutic targets aimed 
at treating metastatic disease.