The RNA-binding protein HuR, while known to stabilize cytoplasmic mRNAs, is 
largely nuclear. In this issue of Molecular Cell, Mukherjee et al. (2011) and 
Lebedeva et al. (2011) identify transcriptome-wide HuR-RNA interactions using 
PAR-CLIP, unveiling HuR's nuclear role in pre-mRNA processing.