Sex-linked dystonia parkinsonism (XDP, DYT3, "Lubag") is an adult-onset, 
progressive, debilitating movement disorder first described in Filipino males 
from Panay Islands in 1975. XDP manifests predominantly as torsion dystonia, 
later combined with or sometimes replaced with parkinsonism. Within the Island 
of Panay, the prevalence rate is highest in the province of Capiz, where 1:4000 
men suffer from the disorder. There is a high degree of penetrance and 
generalization. While women often serve as carriers, XDP is not limited to men. 
An updated XDP Philippine registry (as of January 2010) has identified 505 
cases, with 500 males and 5 females. While some report that females may carry a 
milder form of the disorder, in our experience, both sexes generally follow a 
similar progressive clinical course.