Ghrelin, a gastrointestinal peptide with a major role in regulating feeding and 
metabolism, has recently been investigated for its neuroprotective effects. In 
this review we discuss pre-clinical evidence suggesting ghrelin may be a useful 
therapeutic in protecting the brain against injury after ischemic stroke. 
Specifically, we will discuss evidence showing ghrelin administration can 
improve neuronal cell survival in animal models of focal cerebral ischemia, as 
well as rescue memory deficits. We will also discuss its proposed mechanisms of 
action, including anti-apoptotic and anti-inflammatory effects, and suggest 
ghrelin treatment may be a useful intervention after stroke in the clinic.