The tumor-suppressor protein p53 is activated in response to numerous cellular 
stresses including DNA damage. p53 functions primarily as a sequence-specific 
transcription factor that controls the expression of hundreds of protein-coding 
genes and noncoding RNAs, including microRNAs (miRNAs) and long noncoding RNAs 
(lncRNAs). While the role of protein-coding genes and miRNAs in mediating the 
effects of p53 has been extensively studied, the physiological function and 
molecular mechanisms by which p53-regulated lncRNAs act is beginning to be 
understood. In this review, we discuss recent studies on lncRNAs that are 
directly or indirectly regulated by p53 and how they contribute to the 
biological outcomes of p53 activation. WIREs RNA 2017, 8:e1410. doi: 
10.1002/wrna.1410 For further resources related to this article, please visit 
the WIREs website.