Slitrks are a family of structurally related transmembrane proteins belonging to 
the leucine-rich repeat (LRR) superfamily. Six family members exist (Slitrk1-6) 
and all are highly expressed in the central nervous system (CNS). Slitrks have 
been implicated in mediating basic neuronal processes, ranging from neurite 
outgrowth and dendritic elaboration to neuronal survival. Recent studies in 
humans and genetic mouse models have led to the identification of Slitrks as 
candidate genes that might be involved in the development of neuropsychiatric 
conditions, such as obsessive compulsive spectrum disorders and schizophrenia. 
Although these system-level approaches have suggested that Slitrks play 
prominent roles in CNS development, key questions remain regarding the molecular 
mechanisms through which they mediate neuronal signaling and connectivity.