Clonidine is experiencing increasing use in the pediatric population as a 
sedative and analgesic because of its central alpha2-adrenergic agonism. We 
report three cases of preoperative use of intranasal clonidine in pediatric 
patients, all for different indications. One patient was treated for 
preoperative agitation and hallucinations associated with oral midazolam. One 
patient was given clonidine as a premedicant. The third patient was treated for 
preoperative agitation and hypertension. All three patients had subjective 
resolution of indicated symptoms and none experienced adverse outcomes.