Collagen is mostly found in fibrous tissues such as tendons, ligaments and skin. 
Collagen makes up approximately 30% of the proteins within the body. These are 
tough and strong structures found all over the body: in bones, tendons and 
ligaments. Collagen being the most abundant protein provides tensile strength 
via cell matrix interactions to tissue architecture. Biomimetic materials of 
collagen origin gained wide spread acceptance in clinical applications. Vitamin 
C deficiency causes scurvy a serious and painful disease in which defective 
collagen prevents the formation of strong connective tissue, gums deteriorate 
and bleed, with loss of teeth; skin discolors, and wounds do not heal. Effective 
collagens prevent the manifestation of such disorders. Polyurethanes on the 
other hand are frequently used for various applications as they offered in 
wide-ranging of compositions, properties and complex structures. Collagen/PU 
bio-composites have potential array for biomedical applications. Considering 
versatile properties of the elongated fibrils and wide industrial and biomedical 
applications including biocompatibility of polyurethane, this review shed a 
light on collagen based polyurethane materials with their potential applications 
especially focusing the bio-medical field.