Celiac disease (CD) may often be associated with various motor disorders 
affecting the different segments of the digestive tract, including the 
esophagus. Although it has not been universally reported, some available 
evidences indicate that pediatric and adult celiac patients could manifest a 
higher frequency of esophagitis and gastroesophageal reflux disease-related 
symptoms compared to nonceliac patients. In addition, several published studies 
have consistently shown the efficacy of a gluten-free diet in rapidly 
controlling esophageal symptoms and in preventing their recurrence. Since the 
participation of gluten in the esophageal symptoms of CD seems clear, its 
intimate mechanisms have yet to be elucidated, and several hypothesis have been 
proposed, including the specific immune alterations characterizing CD, the 
reduction in nutrient absorption determining the arrival of intact gluten to 
distal gastrointestinal segments, and various dysregulations in the function of 
gastrointestinal hormones and peptides. Recent studies have suggested the 
existence of a possible relationship between CD and eosinophilic esophagitis, 
which should be more deeply investigated.