The Evaluation of Xience Prime or Xience V versus Coronary Artery Bypass Surgery 
for Effectiveness of Left Main Revascularization (EXCEL) trial is a multicenter, 
ongoing trial conducted in patients with left main disease and SYNTAX score ≤ 32 
to establish the presumptive advantage of percutaneous coronary intervention 
(PCI) versus bypass surgery in patients with less complex coronary artery 
disease than those enrolled in the Synergy between PCI with Taxus and Cardiac 
Surgery (SYNTAX) trial. In this article, we aimed at critically discussing key 
features and issues relevant to design and clinical interpretation of this new 
contemporary trial of left main PCI.