We report the first case of McLeod syndrome (MLS) in a 47-year-old Chinese man 
who presented with progressive limb weakness, chorea of feet, red blood cell 
acanthocytosis, absence of Kx red blood cell antigen and weak expression of Kell 
antigens. The diagnosis of MLS was confirmed by genetic testing showing a 
hemizygous mutation of XK gene. We review literature on neuroacanthocytosis in 
the Chinese population.