PURPOSE: To describe a patient with metastasis of Ewing sarcoma to the choroid 
and the molecular genetics of the tumor.
METHODS: A 26-year-old woman with metastatic Ewing sarcoma developed large 
choroidal masses in the left eye and died 2 months later. Autopsy of the eyes 
was performed. Dual-color fluorescent in situ hybridization was used to detect 
genetic alteration in the ocular tumor with EWS and FLI-1 probes.
RESULTS: Histopathology confirmed choroidal metastatic Ewing sarcoma. Molecular 
analysis showed chromosomal translocation t(11;22)(q24;q12) or EWS/FLI-1 
rearrangement in the malignant cells of the eye.
CONCLUSIONS: Ewing sarcoma can rarely metastasize to the uvea. Molecular 
detection of the t(11;22)(q24;q12) translocation in Ewing sarcoma is valuable in 
the differential diagnosis of small round cell tumors.