Acrokeratosis paraneoplastica (Bazex's syndrome) is a rare obligate 
paraneoplastic dermatosis characterized by erythematosquamous lesions localized 
symmetrically at the acral sites. The condition almost exclusively affects 
Caucasian men older than 40 years. It is usually associated with primary 
malignant neoplasms of the upper aerodigestive tract. In most cases, the skin 
changes precede the clinical manifestation of the underlying neoplasm. The 
dermatosis can be cured only by removal of the underlying carcinoma. We describe 
a case of acrokeratosis paraneoplastica associated with a retroperitoneal 
liposarcoma in a 71-year-old Caucasian man. The liposarcoma was surgically 
removed but recurred several times, with acrokeratosis paraneoplastica showing a 
parallel development. We, therefore, add liposarcoma to the growing list of 
malignant neoplasms associated with acrokeratosis paraneoplastica.