Emergency granulopoiesis is a very important strategy to supply efficient 
neutrophil number in response to infection. However, molecular mechanism 
involved in this process remains unclear. Here, we found that administration of 
WKYMVm, an immune modulating peptide, to septic mice strongly increased 
neutrophil number through augmented emergency granulopoiesis. WKYMVm-induced 
emergency granulopoiesis was blocked not only by a formyl peptide receptor 2 
(FPR2) antagonist (WRW4), but also by FPR2 deficiency. As progenitors of 
neutrophils, Lin-c-kit＋Sca-1- cells expressed FPR2. WKYMVm-induced emergency 
granulopoiesis was also blocked by a phospholipase C inhibitor (U-73122). These 
results suggest that WKYMVm can stimulate emergency granulopoiesis via FPR2 and 
phospholipase C enzymatic activity. [BMB Reports 2018; 51(8): 418-423].