Circular RNAs are new players in regulation of post transcriptional gene 
expression. Animal genomes express many circular RNAs from diverse genomic 
locations. A recent study has validated a fairly large number of circular RNAs 
in human, mouse, and nematode. Circular RNAs play a crucial role in fine tuning 
the level of miRNA mediated regulation of gene expression by sequestering the 
miRNAs. Their interaction with disease associated miRNAs indicates that circular 
RNAs are important for disease regulation. In this paper we studied the 
potential association of circular RNAs (circRNA) with human diseases in two 
different ways. Firstly, the interactions of circRNAs with disease associated 
miRNAs were identified, following which the likelihood of a circRNA being 
associated with a disease was calculated. For the miRNAs associated with 
individual diseases, we constructed a network of predicted interactions between 
the miRNAs and protein coding, long non-coding and circular RNA genes. We 
carried out gene ontology (GO) enrichment analysis on the set of protein coding 
genes in the miRNA- circRNA interactome of individual diseases to check the 
enrichment of genes associated with particular biological processes. Secondly, 
disease associated SNPs were mapped on circRNA loci, and Argonaute (Ago) 
interaction sites on circular RNAs were identified. We compiled a database of 
disease-circRNA association in Circ2Traits (http://gyanxet-beta.com/circdb/), 
the first comprehensive knowledgebase of potential association of circular RNAs 
with diseases in human.