One of the challenges faced by Mycobacterium tuberculosis (M. tuberculosis) in 
dormancy is hypoxia. DosR/DevR of M. tuberculosis is a two component dormancy 
survival response regulator which induces the expression of 48 genes. In this 
study, we have used DosR regulon proteins of M. tuberculosis H37Rv as the query 
set and performed a comprehensive homology search against the non-redundant 
database. Homologs were found in environmental mycobacteria, environmental 
bacteria and archaebacteria. Analysis of genomic context of DosR regulon 
revealed that they are distributed as nine blocks in the genome of M. 
tuberculosis with many transposases and integrases in their vicinity. Further, 
we classified DosR regulon proteins into eight functional categories. One of the 
hypothetical proteins Rv1998c could probably be a methylisocitrate lyase or a 
phosphonomutase. Another hypothetical protein, Rv0572 was found only in 
mycobacteria. Insights gained in this study can potentially aid in the 
development of novel therapeutic interventions.