Here we demonstrated that, at cytostatic, near-toxic concentrations, resveratrol 
inhibited S6 phosphorylation and prevented the senescence morphology in human 
cells. Using a sensitive functional assay, we found that resveratrol partially 
prevented loss of the proliferative potential associated with cellular 
senescence. Resveratrol was less effective than rapamycin, because 
aging-suppression by resveratrol was limited by its toxicity at high 
concentrations. We discuss whether concentrations of resveratrol that inhibit 
mTOR (target of rapamycin) and suppress cellular senescence are clinically 
achievable and whether partial inhibition of mTOR by resveratrol might be 
sufficient to affect organismal aging.