Community-associated methicillin resistant Staphylococcus aureus (CA-MRSA) has 
become a severe health concern because of its treatment difficulties. Herein, we 
report the synthesis and biological evaluation of two phenazine natural products 
and a series of phenazines that show promising activities against MRSA with MIC 
values in the low micromolar range. Basic studies revealed that these compounds 
are bacteriostatic agents. The most active compound also displayed promising 
IC50 values against HaCat cells. Finally, a QSAR model was developed to 
understand the key structural features of the molecules.