The Melkersson-Rosenthal syndrome consists of a triad of recurrent lip and/or 
face swelling, fissured tongue, and intermittent facial palsy. Onset of the 
symptoms may occur during childhood, and treatment of the condition is 
difficult. We describe two children with Melkersson-Rosenthal syndrome in whom 
combination treatment with prednisone and minocycline proved effective and well 
tolerated.