BACKGROUND/AIMS: This study aimed to determine the performance of the AIMS65 
score (AIMS65), Glasgow-Blatchford score (GBS), and Rockall score (RS) in 
predicting outcomes in patients with upper gastrointestinal bleeding (UGIB), and 
to compare the results between patients with nonvariceal UGIB (NVUGIB) and those 
with variceal UGIB (VUGIB).
METHODS: We conducted a prospective observational study between March 2016 and 
December 2017. Receiver operating characteristic curve analysis was performed 
for all outcomes for comparison. The associations of all three scores with 
mortality were evaluated using multivariate logistic regression analysis.
RESULTS: Of the total of 337 patients with UGIB, 267 patients (79.2%) had 
NVUGIB. AIMS65 was significantly associated (odds ratio [OR], 1.735; 95% 
confidence interval [CI], 1.148-2.620), RS was marginally associated (OR, 1.225; 
95% CI, 0.973-1.543), but GBS was not associated (OR, 1.017; 95% CI, 
0.890-1.163) with mortality risk in patients with UGIB. However, all three 
scores accurately predicted all other outcomes (all p<0.05) except rebleeding 
(p>0.05). Only AIMS65 precisely predicted mortality, the need for blood 
transfusion and the composite endpoint (all p<0.05) in patients with VUGIB.
CONCLUSION: AIMS65 is superior to GBS and RS in predicting mortality in patients 
with UGIB, and also precisely predicts the need for blood transfusion and the 
composite endpoint in patients with VUGIB. No scoring system could 
satisfactorily predict rebleeding in all patients with UGIB.