Aim: To determine the effectiveness of Centro Nacional de Investigaciones 
Cardiovasculares (CNIC)-polypill (acetylsalicylic acid 100 mg, ramipril 5/10 mg, 
simvastatin 40 mg) in achieving blood pressure (BP) goals. Patients & methods: A 
multicenter, observational, one cohort, prospective study. BP targets were 
analyzed in patients with cardiovascular disease after 12-months treatment with 
the CNIC polypill. Results: A total of 572 patients (59.4 ± 13.9 years, 57.3% 
men) were analyzed. At baseline, BP was 147.1 ± 18.1/88.3 ± 10.6 mmHg, 97.1% of 
patients were taken renin-angiotensin system inhibitors, 5.4% calcium 
antagonists, 1.9% diuretics and 13.1% β-blockers. The proportion of patients who 
achieved BP targets increased from 20.1 to 55.4% (p < 0.001). Conclusion: In 
routine practice, switching from usual care to the CNIC-polypill in patients 
with cardiovascular disease could facilitate achieving BP goals.