Recent genome-wide studies have revealed a remarkable correspondence between 
nucleosome positions and exon-intron boundaries, and several studies have 
implicated specific histone modifications in regulating alternative splicing. In 
addition, recent progress in cracking the 'splicing code' shows that sequence 
motifs carried on the nascent RNA molecule itself are sufficient to accurately 
predict tissue-specific alternative splicing patterns. Together, these studies 
shed light on the complex interplay between RNA sequence, DNA sequence, and 
chromatin properties in regulating splicing.