The purpose of this study was to evaluate the antipyretic action of tolfenamic 
acid, as well as its possible adverse reactions, especially in children with 
severe or partial form of glucose-6-phosphate dehydrogenase (G6PD) deficiency. 
In the study 55 febrile children were included, whose mean age was +/- SD 3.5 
+/- 3.3 years, range 0.5-15. Ten of them had severe or partial form of G6PD 
deficiency. Fifty-three of the patients responded with a decrease of temperature 
which lasted at least 6 hours, though in 2 of them the temperature decrease 
lasted less than 6 hours. The tolerance of the drug was good and no side-effects 
were noted. None of the patients with or without G6PD deficiency showed 
symptoms, signs, or laboratory findings indicating hemolysis before 
administration of the drug and 4 days thereafter. In conclusion, tolfenamic acid 
is a strong antipyretic agent with excellent tolerance and high safety in 
children.