Ferroptosis is a newly defined iron-dependent, non-apoptotic mode of cell death 
with necrotic morphology. Distinctive from other death mechanisms, ferroptosis 
requires cellular iron and lipid peroxides, and is dictated by specific cellular 
metabolic processes. Importantly, ferroptosis has been implicated in a plethora 
of human diseases. This paper reviews the recent advances and outstanding 
questions of the field by focusing on the role of cellular metabolism in 
ferroptosis. The relevance of ferroptosis to disease and therapy is also 
discussed.