Pseudotumor is an uncommon but severe complication in patients with hemophilia. 
To our knowledge, although China has large population of persons with 
hemophilia, there is rare information on the incidence, clinical feature, image 
finding, and management of pseudotumor among Chinese patients. This study aimed 
at improving our knowledge on clinical diagnosis and management of hemophiliac 
pseudotumor. In this retrospective study, the medical records of 1248 patients 
with hemophilia diagnosed between January 1983 and October 2004 at our hospital 
were reviewed. The clinical feature, imaging finding, management, and outcome of 
14 patients with pseudotumor among these patients with hemophilia were analyzed. 
All patients have hemophilia A (8 severe cases and 6 moderate cases). Eight 
patients sustained an injury prior to the development of pseudotumor. Main image 
findings included osteolysis lesion, soft tissue swelling, or lump. Surgical 
therapy was carried out in 7 patients and 6 achieved remission, with fistula 
formation remaining in 1. One patient underwent radiotherapy together with 
replacement therapy achieved remission. Three patients accepted replacement 
therapy as only management and only 1 patient achieved improvement of swelling. 
Our study showed that the incidence of pseudotumor in our enrolled patients with 
hemophilia is 1.12%. Hemophilic history of patients can contribute to the right 
diagnosis of pseudotumor. Surgical therapy together with sufficient replacement 
therapy is safe and effective.