The hypoglycemic effects of the fruit extract of C. metuliferus was investigated 
in normoglycemic and alloxan-induced hyperglycemic rats. The results showed that 
there was an insignificant (P > 0.05) decrease in the blood glucose 
concentration of normoglycemic rats treated with oral doses of 1000 and 1500 
mg/kg of the extract. On the other hand, 500 mg/kg of the fruit extract produced 
an insignificant (P > 0.05) decrease in blood glucose levels of alloxan-treated 
rats, while 1000 and 1500 mg/kg oral dose points produced a significant (P < 
0.05) decrease in the blood glucose concentration of hyperglycemic rats 
comparable to that produced by tolbutamide. From this study, the data suggested 
that the fruit extract did not alter the BGC level in normoglycemic rats, but 
had a potential hypoglycemic property in alloxan-induced hyperglycemic rats.