Dravet syndrome, a severe infantile epilepsy syndrome, is typically resistant to 
anti-epileptic drugs (AED). Lamotrigine (LTG), an AED that is effective for both 
focal and generalized seizures, has been reported to aggravate seizures in 
Dravet syndrome. Therefore, LTG is usually avoided in Dravet syndrome. We 
describe two adults and a child with Dravet syndrome in whom LTG resulted in 
decreased seizure duration and frequency. This benefit was highlighted in each 
patient when LTG was withdrawn after 6 to 15 years, and resulted in an increased 
frequency of convulsive seizures together with longer seizure duration. A 
25-year-old male required hospital admission for frequent seizures for the first 
time in 7 years, 6 weeks after ceasing LTG. Reintroduction of LTG improved 
seizure control, suggesting that in some patients with Dravet syndrome, LTG may 
be beneficial.