Hepatic mesenchymal hamartoma is a rare benign tumor in children, and infantile 
hepatic hemangioendothelioma is also a rare liver neoplasm. We report a female 
newborn with an abdominal mass noted by the regular maternal ultrasound at 32 
weeks of gestation. After birth, a liver mass was detected by computed 
tomography and magnetic resonance cholangiopancreatography. Frequent 
postprandial vomiting and progressive abdominal distension occurred 4 months 
later. Three tumor masses were detected this time, and the serum 
alpha-fetoprotein (AFP) was 6700 ng/mL. Segmental resection was performed 
initially and complete resection of these tumors and left lobectomy were 
performed 21 days later. Pathologic examination of these liver masses revealed 
mesenchymal hamartoma combined with infantile hepatic hemangioendothelioma. 
After half a year of regular follow-up, the AFP level decreased gradually to 
79.5 ng/mL, without evidence of tumor recurrence.