Resveratrol (RSV, trans-3,4,5-Trihydroxystilbene), a type of polyphenol 
originally found in red wines, shows a great promise for the treatment of 
cancer, aging, type 2 diabetes and cardiovascular diseases. Recent studies 
suggest that suppressing the signaling pathway mediated by mTOR, a well-known 
energy sensor that integrates various hormonal, nutrient and environmental 
signals to regulate cell growth, metabolism and survival, could play an 
important role in mediating the beneficial effect of RSV. The underlying 
mechanisms by which RSV inhibits mTOR signaling remain elusive, but our recent 
studies show that RSV inhibits amino acid-stimulated mTOR signaling in C2C12 
fibroblasts via a Sirt1- and AMPK-independent mechanism. RSV treatment has no 
effect on the expression levels of mTOR, raptor and DEPTOR, but greatly promotes 
the interaction between mTOR and its inhibitor DEPTOR. Our results reveal a 
novel mechanism by which RSV inhibits mTOR signaling and its function.