Chronic myeloid leukemia (CML) is a hematologic malignancy associated with 
increased circulating myeloid cells and platelets in the peripheral blood, with 
accompanying bone marrow hyperplasia. The Philadelphia chromosome, 
t(9;22)(q34;q11), is present in 95% of CML patients, resulting in constitutive 
tyrosine kinase activity; however, ~5% of CML patients possess a Philadelphia 
variant. A novel three-way Philadelphia translocation variant, 
t(9;22;17)(q34;q11.2;q11.2), was identified in a 54-year old man who presented 
with leukocytosis, anemia and thrombocytosis that was diagnosed with chronic 
myeloid leukemia, chronic phase. Cytogenetic analysis by G-banding revealed the 
presence of a three-way translocation involving the long arms of chromosomes 9, 
22 and 17. Fluorescence is situ hybridization utilizing a dual-color fusion 
probe confirmed the presence of the Bcr-Abl fusion gene.