OBJECTIVE: Comparison of gamma glutamyltransferase in normal and type 2 
diabetics.
METHODS: In a cross-sectional study, 100 apparently normal healthy subjects and, 
47 type 2 diabetic subjects were selected from either sex with ages between 
18-65 years. Subjects were measured for waist/hip ratio, BMI and serum levels of 
ALT, AST, Alk phosphatase and glutamyl transferase (GGT). The study excluded by 
screening for AntiHCV, HBsAg and patients with aspartate amino transferase 
(SGOT), alanine amino transferase (SGPT), GGT levels more than three times the 
normal and subject with a total leukocyte count more than 10,000/microl.
RESULTS: The levels of GGT levels were found to be most significant among all 
the liver enzymes (P = 0.001). The levels of GGT compared with type 2 diabetics 
was found to be significantly increased when compared with BMI, 
waist/circumference, cholesterol, triglycerides (TG), high density lipoprotein 
(HDL), low density lipoprotein (LDL), fasting blood sugar level and blood 
pressure (P = 0.001). The pearson regression analysis showed a positive relation 
with systolic, diastolic blood pressure and fasting blood sugar.
CONCLUSION: These results indicate that levels of GGT were raised with increased 
waist girth, BMI, blood pressure TG and low HDL, all of these are the features 
of metabolic syndrome according to ATP III criteria. Hence, serum GGT may be an 
important investigation for diabetes and metabolic syndrome.