PURPOSE: To report a case of corneal endothelial deposits associated with 
rifabutin therapy for Crohn's disease.
METHOD: Case report, anterior segment photography, and current literature 
search.
RESULTS: Persistence of corneal endothelial deposits was found to occur in a 
55-year-old gentleman 6 years after cessation of a 3-year course of rifabutin. 
The corneal deposits were not associated with lenticular findings or retinal 
dysfunction, the latter side effect being published in a recent research 
article.
CONCLUSIONS: This is only the second published case of corneal deposits in 
conjunction with rifabutin therapy for Crohn's disease. This case uniquely 
confirms the persistence of the corneal deposits longer than previously 
documented.