Cloned DNA fragments form the human beta-like globin genomic region can be 
transcribed in vitro by RNA polymerase III. We have investigated the structure 
of two templates and their transcripts by DNA sequencing, size fractionation of 
ribonuclease T1 generated oligonucleotides, and ribonuclease H digestion of RNA 
: DNA duplexes. The data indicate the repetitive DNA sequences, members of the 
Alu family of interpersed 300 bp reiterated DNA, are imbedded in both templates. 
The RNAs transcribed from them are composed of an entire Alu family sequence at 
their 5' ends linked to 3' ends of non-repetitive sequence.