Oculocutaneous albinism (OCA) in man may be caused by mutations within the 
tyrosinase gene (TYR) resulting in OCA1. Analysing patients with recessively 
inherited albinism we found DNA variations in 82 unrelated individuals. 53 out 
of 78 mutations and polymorphisms revealed by this study are not published 
previously. The changes include 68 nucleotide substitutions resulting in amino 
acid changes, stop mutations and polymorphisms as well as four nucleotide 
insertions and six deletions. Furthermore, we found an accumulation of three to 
five mutations in 17 patients with OCA1.