The PSIPRED Workbench is a web server offering a range of predictive methods to 
the bioscience community for 20 years. Here, we present the work we have 
completed to update the PSIPRED Protein Analysis Workbench and make it ready for 
the next 20 years. The main focus of our recent website upgrade work has been 
the acceleration of analyses in the face of increasing protein sequence database 
size. We additionally discuss any new software, the new hardware infrastructure, 
our webservices and web site. Lastly we survey updates to some of the key 
predictive algorithms available through our website.