Zinc cluster proteins are a large family of transcriptional regulators with a 
wide range of biological functions. The zinc cluster proteins Ecm22, Upc2, Sut1 
and Sut2 have initially been identified as regulators of sterol import in the 
budding yeast Saccharomyces cerevisiae. These proteins also control adaptations 
to anaerobic growth, sterol biosynthesis as well as filamentation and mating. 
Orthologs of these zinc cluster proteins have been identified in several species 
of Candida. Upc2 plays a critical role in antifungal resistance in these 
important human fungal pathogens. Upc2 is therefore an interesting potential 
target for novel antifungals. In this review we discuss the functions, mode of 
actions and regulation of Ecm22, Upc2, Sut1 and Sut2 in budding yeast and 
Candida.