Dopamine causes in anesthetized rats expressed diuretic response that is 
accompanied by an increase in GRF and a significant enhance of sodium and 
potassium excretion. Pretreatment the animals in diclofenac sodium or contrical 
in doses, that inhibit respectively activity of renal PG-system and 
kallikrein-kinin system, don't prevent of renal effects of dopamine. Preliminary 
assignment a direct renin inhibitor aliskiren enhances the diuretic, natriuretic 
and kaliyuretic effects of the drug. It is concluded that renal PG-system and 
kallikrein-kinin system are not involved in the formation of renal effects of 
dopamine. Renal tissue RAS directly included in the mechanism of action of 
dopamine in the kidney, acting as a modulator, preventing excessive loss of 
water and electrolytes with urine.