BACKGROUND: Bartter syndrome is a rare autosomal recessive disorder 
characterized by hypokalemia, salt loss, and metabolic alkalosis. Short stature 
is one of the clinical manifestations in these children. Although polyuria, 
polydipsia, hypokalemia, and salt loss may be responsible for growth 
retardation, the exact pathogenesis of short stature in Bartter syndrome is not 
known.
CASE DIAGNOSIS AND TREATMENT: In this study, we present three children diagnosed 
as having Bartter syndrome with short stature and growth hormone (GH) 
deficiency. After recombinant human growth hormone therapy (rhGH), their growth 
velocities were improved.
CONCLUSIONS: These results indicate that GH deficiency may contribute to short 
stature in children with Bartter syndrome, and rhGH therapy would be an 
excellent adjunctive treatment for short children with this syndrome whose 
condition is resistant to conventional therapies in terms of growth.