We previously reported that prostate derived Ets transcription factor (PDEF) is 
a breast tumor-associated molecule. To obtain further insights into PDEF 
expression in other human tumor types, a cDNA library database from human adult 
normal and tumor tissues was compiled and searched for PDEF distribution. The 
results showed that PDEF is present at relative higher frequencies in the cDNA 
libraries from brain, breast, lung and ovarian tumors in comparison to those 
from the corresponding normal tissues. RT/PCR analysis of PDEF expression in 
ovarian tumors confirmed that PDEF is expressed in 36 out of 51 (71%) ovarian 
tumors. Further comparison of the distribution of PDEF with other widely 
recognized cancer-associated molecules showed that PDEF has more restricted 
distributions than Her-2/neu, Bcl-2, survivin or telomerase in cDNA libraries 
from normal human tissues and more increased distribution than Her-2/neu, 
CA-125, Bcl-2, survivin and telomerase in cDNA libraries from brain (except 
survivin), breast, lung and ovarian tumors. These data together show a better 
tumor-association for PDEF and suggest that PDEF is a more suitable target for 
developing specific cancer therapies.