In neurofibromatosis type-1 (NF1), cerebrovascular disorders are rarely 
encountered although vasculopathy is a well-known complication. Several 
mutations seen in methylenetetrahydrofolate reductase (MTHFR) give rise to the 
formation of hyperhomocysteinemia and homocystinuria, a considerable risk factor 
for cardiovascular and cerebrovascular disorders, by leading to enzymatic 
inactivation. In the paper, a 31-year-old young stroke female patient with the 
coexistence of neurofibromatosis and MTHFR C677T gene mutation was presented.