Nine patients (7 with amyotrophic lateral sclerosis, 1 with progressive spinal 
amyotrophy and 1 with chronic anterior poliomyelitis) were treated by sequential 
intravenous administration of 240 mg of TRH over one hour every two weeks. 
Results were assessed by an analytical evaluation of muscle strength before and 
24 h after each infusion and by objective and subjective evaluation of 
spasticity. Significant improvement, as shown by statistical analysis, was noted 
in muscle strength in the 9 patients by 5 infusions over a 4-week period and a 
sub-group of 5 patients treated by 8 infusions over 10 weeks. Continued use of 
this therapy is justified by the need to determine its long-term effects and the 
psychological improvement noted in some patients after an even transient 
improvement in motor performance. However this treatment is obviously not 
curative.