Calciphylaxis is a small vessel vasculopathy, characterized by medial wall 
calcification that develops in a few patients with chronic renal failure. The 
prognosis of skin calciphylaxis has improved considerably since the introduction 
of sodium thiosulfate (STS), but it remains unclear whether this therapy is 
effective against organ lesions related to calciphylaxis. Pulmonary 
calciphylaxis is a usually fatal medical condition that may occur in association 
with skin involvement in patients with end-stage renal disease.We report here 
the case of a 49-year-old woman homozygous sickle cell disease patient on 
chronic hemodialysis with biopsy-proven systemic calciphylaxis involving the 
lungs and skin. On admission, ulcerative skin lesions on the lower limbs and 
bilateral pulmonary infiltrates on chest computerized tomography scan were the 
main clinical and radiological findings. Skin and bronchial biopsies 
demonstrated calciphylaxis lesions. The intravenous administration of STS in 
association with cinacalcet for 8 consecutive months led to a clear improvement 
in skin lesions and thoracic lesions on chest computerized tomography scan.This 
case suggests for the first time that organ lesions related to calciphylaxis, 
and particularly lung injury, are potentially reversible. This improvement 
probably resulted from the combination of 3 interventions (more frequent 
dialysis, cinacalcet, and STS), rather than the administration of STS alone.