INTRODUCTION: Preeclampsia has the highest rate of obstetric morbidity and 
mortality.
METHODS: We recruited 21 women with preeclampsia and 27 women with uncomplicated 
pregnancies. We used a quantitative protein macroarray that allowed for analysis 
of 40 proteins.
RESULTS: We found a statistically significant increase in the concentration of 
DR3, LIF and a significant decrease of VEGF, PlGF, syndecan-4 and galectin-2, in 
the plasma of women with preeclampsia.
CONCLUSIONS: There are no previous studies assessing syndecan 4, galectin 2, and 
DR3 concentrations in women with preeclampsia; Our results indicate these 
proteins are new factors that play important roles in the immunological 
pathomechanism of preeclampsia.