Macromolecules gain access to the cytoplasm of eukaryotic cells using one of 
several ways of which clathrin-dependent endocytosis is the most researched. 
Although the mechanism of clathrin-mediated endocytosis is well understood in 
general, novel adaptor proteins that play various roles in ensuring specific 
regulation of the mentioned process are being discovered all the time. This 
review provides a detailed account of the mechanism of clathrin-mediated 
internalization of activated G protein-coupled receptors, as well as a 
description of the major proteins involved in this process.