Thrombotic thrombocytopenic purpura (TTP) is a severe disease, potentially 
fatal, if not diagnosed and treated promptly. TTP is clinically characterized by 
the pentad of thrombocytopenia, Coombs-negative hemolytic anemia, fever, renal 
abnormalities and neurological disturbances. Advances in recent years have 
delineated the molecular mechanisms of acquired and hereditary TTP.Many 
infectious organisms have been reported to be associated with TTP, especially 
mycoplasma, but few cases of Brucella infection associated with thrombotic 
microangiopathy have been reported.We describe a young woman who presented with 
TTP after acute infection with both Brucella melitensis and Brucella abortus. 
The patient completely recovered following aggressive therapy with 
plasmapharesis, high-dose corticosteroids and appropriate antimicrobial 
therapy.Since measurement of ADAMTS13 activity and neutralizing antibodies is 
now available, and none of the reported cases of brucellosis with thrombotic 
microangiopathy (including the present report) were tested, for better 
understanding of this rare association, we recommend this work-up in future 
cases.