Tuberculosis and sarcoidosis represent the granulomatous diseases. The aim of 
the study was to compare the markers of oxidative stress: in exhaled breath 
condensate (EBC) and in serum of patients with tuberculosis and sarcoidosis.
MATERIAL AND METHODS: 19 patients with active lung tuberculosis and 15 patients 
with sarcoidosis were enrolled into the study. As a control served 15 healthy 
subjects. Hydrogen peroxide (H2O2) was measured in EBC and the ends products of 
lipid peroxidation (TBARs) were assessed in serum.
RESULTS: The concentrations of H202 and TBARs (1022.96+/-186.02 nM and 4.22+/-0. 
80 microM, respectively) were significantly higher in patients with tuberculosis 
as compared with the controls (398.15+/-37.10 nM and 0.48+/-0.17 microM, 
respectively). The patients with sarcoidosis revealed only the significantly 
elevated levels of hydrogen peroxide (963.30+/-105.77 nM) in breath condensate.
CONCLUSIONS: It was found that local and systemic oxidative stress were present 
in patients with tuberculosis, while in those with sarcoidosis existed only the 
local reaction.