Ehlers-Danlos syndrome (EDS), a heterogeneous group of inheritable connective 
tissue disorders, is attributed to mutations in connective tissue genes. These 
mutations cause defects in collagen. Collagen, a connective tissue protein that 
acts like glue, gives strength to the body and provides support and elasticity 
for movement. Thus, the altered gene affects the mechanical properties of skin, 
joints, ligaments, and blood vessels. Ehlers-Danlos syndrome is transmitted 
through autosomal dominant, autosomal recessive, or x-linked patterns of 
inheritance. The life expectancy of an affected infant varies with the type of 
EDS. This article provides an overview of the 6 major classifications of EDS, 
their unique clinical presentations, a focused physical assessment guide, 
considerations for nursing care, and resources for parents. Ehlers-Danlos 
syndrome can be a potentially debilitating syndrome. It requires preventative 
and protective measures starting at birth to preserve joint function to improve 
infant outcomes. Caring for patients with EDS requires an understanding of the 
potential associated complications to help minimize the physical and emotional 
impact of the syndrome and improve the quality of life for affected individuals.