Prostate cancer (PCA) still represents a leading cause of death. An increasing 
number of studies have documented that microRNAs (miRNAs), a subgroup of 
non-coding RNAs with gene regulatory functions, are differentially expressed in 
PCA respect to the normal tissue counterpart, suggesting their involvement in 
prostate carcinogenesis and dissemination. Interestingly, it has been shown that 
miRNAs undergo the same regulatory mechanisms than any other protein coding 
gene, including epigenetic regulation. In turn, miRNAs can also affect the 
expression of oncogenes and tumor suppressor genes by targeting effectors of the 
epigenetic machinery, therefore indirectly affecting the epigenetic controls on 
these genes. Among the genes that undergo this complex regulation, there is the 
androgen receptor (AR), a key therapeutic target for PCA. This review will focus 
on the role of epigenetically regulated and epigenetically regulating miRNAs in 
PCA and on the fine regulation of AR expression, as mediated by this 
miRNA-epigenetics interaction.