It has been shown in experiments on mice that sodium diclofenac and indomethacin 
inhibited antibody titers and the number of rosette-forming cells (RFC) in mice 
immunized with sheep red blood cells. Sodium salicylate in all test doses did 
not produce any shifts in rosette-formation but lowered the number of RFC. As 
regards the immunodepressant activity, sodium diclofenac compares very 
favourably with indomethacin and sodium salicylate. Enhancement of the 
immunoreactivity inhibition caused by the drugs was not proportional to the 
increase in their antiphlogistic effects determined by the Selye model of 
inflammation.