BACKGROUND: Morton's neuromas are abnormalities of the common digital nerve 
branch located between the lesser metatarsal heads. Historically, interdigital 
(Morton's) neuromas have been characterized as being most common in the third 
interspace and predominantly identified in females. The principal investigator 
observed Morton's neuromas commonly in both the 2nd and 3rd interspaces in both 
genders. To the best of our knowledge, no literature exists to evaluate Morton's 
neuroma location with a focus on each gender independently. The present study 
evaluates Morton's neuroma interspace location and if there is a variation 
between males and females.
METHODS: In this retrospective study, 582 de-identified ProScan magnetic 
resonance imaging reports, with a diagnosis code for Morton's neuroma (ICD Code 
355.6), were obtained from their centralized database. These reports were 
evaluated for patients scanned from January 2015-April 2016. Incomplete records 
and those where the radiologist findings were not consistent with Morton's 
neuroma were eliminated. For the remaining 379 patients, data was collected on 
several factors such as gender, laterality, history of trauma, plantar plate 
tear, age and interspace location. Special focus was given to second and third 
interspace Morton's neuromas. Data was then evaluated statistically utilizing 
the Pearson Chi-Square and Independent Samples Mann-Whitney U Test with 
statistical significance deemed p&lt;0.05.
RESULTS: No statistically significant distribution between gender and second and 
third interspace Morton's neuromas were noted. Additionally, right vs left foot, 
age and history of trauma did not vary between genders in a significant way. 
Lastly, there was a statistically significant difference between the presence of 
plantar plate tears between genders. Male patients with Morton's neuromas were 
found to have a higher rate of plantar plate tears (34/92, p=0.01).
CONCLUSION: Our study found that there was not a statistically significant 
difference between female and male and Morton's neuromas location, laterality or 
age.