Collapsin response mediator protein 2 (CRMP2) plays a key role in axon guidance, 
dendritic morphogenesis and cell polarization. CRMP2 is implicated in various 
neurological and psychiatric disorders. However, in vivo functions of CRMP2 
remain unknown. We generated CRMP2 gene-deficient (crmp2-/- ) mice and examined 
their behavioral phenotypes. During 24-h home cage monitoring, the activity 
level during the dark phase of crmp2-/- mice was significantly higher than that 
of wild-type (WT) mice. Moreover, the time during the open arm of an elevated 
plus maze was longer for crmp2-/- mice than for WT mice. The duration of social 
interaction was shorter for crmp2-/- mice than for WT mice. Crmp2-/- mice also 
showed mild impaired contextual learning. We then examined the 
methamphetamine-induced behavioral change of crmp2-/- mice. Crmp2-/- mice showed 
increased methamphetamine-induced ambulatory activity and serotonin release. 
Crmp2-/- mice also showed altered expression of proteins involved in GABAergic 
synapse, glutamatergic synapse and neurotrophin signaling pathways. In addition, 
SNAP25, RAB18, FABP5, ARF5 and LDHA, which are related genes to schizophrenia 
and methamphetamine sensitization, are also decreased in crmp2-/- mice. Our 
study implies that dysregulation of CRMP2 may be involved in pathophysiology of 
neuropsychiatric disorders.