Melanocytes are pigment-producing cells that reside in the skin, eyes, ears, 
heart, and central nervous system meninges of mammals. Schwann cells are glial 
cells, which closely associate with peripheral nerves, myelinating, and 
sheathing them. Melanocytes and Schwann cells both arise from the neural crest 
during development, and some melanocytes arise directly from Schwann cell 
precursors lining developing spinal nerves. In this review, we explore the 
connections between melanocytes and Schwann cells in development and 
transformation.