Medulloblastoma is the most common brain tumor of childhood. Multiple signaling 
pathways have been associated with medulloblastoma formation and growth. These 
include the developmental pathways Hedgehog, (Hh) Notch, and Wnt as well as the 
receptor tyrosine kinases (RTK) c-Met, erbB2, IGF-R and TrkC, and the 
oncoprotein Myc. Here we review the involvement of these pathways in 
medulloblastoma malignancy with a focus on their mode of deregulation, 
prognostic value, functional effects, cellular and molecular mechanisms of 
action, and implications for therapy.