Calciphylaxis is a metastatic calcification-induced vasculopathy that results in 
the occlusion of small blood vessels. Although calciphylaxis is normally 
associated with end-stage renal disease, calciphylaxis from non-uremic origin 
occurs as well. While the number of reports continues to increase, a standard 
treatment for non-uremic calciphylaxis has yet to be established. Sodium 
thiosulfate (STS), which has been proven to be effective in the treatment of 
uremic calciphylaxis, shows promise; however, reports of its use in non-uremic 
cases are limited. We describe a case of non-uremic calciphylaxis in a patient 
with normal renal and parathyroid function who had complete resolution of 
disease after treatment with STS, and we review similar cases in the published 
work. Based on the successful outcomes detailed in this case series, STS appears 
to be an effective therapy for non-uremic calciphylaxis.