In the present study, monoclonal gammapathy was identified in a total of 245 
patients of plasma cell dyscrasias during period of 1987 to 2000. The monoclonal 
band was identified in serum by agar gel electrophoresis in all the cases and in 
urine in a few cases. Characterization of paraprotein (monoclonal immunoglobulin 
class and light chain type) was carried out by employing immunoelectrophoresis 
and/or immunofixation electrophoresis using heavy chain specific gamma, alpha, 
mu, delta and epsilon and light chain specific kappa (K), lambda (λ) antisera. 
Serum immunoglobulins Ig G, Ig A, and Ig M were estimated by immunoturbidometry. 
Serum urea, creatinine, uric acid, alkaline phosphatase, total proteins, 
albumin, calcium and phosphorus were estimated by using routine biochemical 
methods. Among the 245 cases, 73.1% monoclonal gammapathies were of secretory 
type and 7.3% were non-secretory. Monoclonal gammapathies were associated with 
80.4% of multiple myeloma, 8.9% of solitary plasmacytoma, 4.1% of 
extra-medullary plasmacytoma, 3.3% of lymphoma and 2.9% of plasma cell leukemia. 
Classification of secretory monoclonal immunoglobulin revealed monoclonal 
immunoglobulin Ig G in 74%, Ig A 15% and Ig M in 2.9% cases.