Thyroid hormone (TH), apart from its "classical" actions on cardiac 
contractility and heart rhythm, appears to regulate various intracellular 
signalling pathways related to response to stress and cardiac remodelling. There 
is now accumulating experimental and clinical evidence showing a beneficial 
effect of TH on limiting myocardial ischaemic injury, preventing/reversing post 
infarction cardiac remodelling and improving cardiac hemodynamics. Thyroid 
analogs have already been developed and may allow TH use in clinical practice. 
However, the efficacy of TH in the treatment of cardiac diseases is now awaiting 
to be tested in large clinical trials.