Author information:
(1)RIKEN Center for Integrative Medical Sciences, Yokohama, Kanagawa 230-0045, 
Japan.
(2)RIKEN Center for Life Science Technologies, Yokohama, Kanagawa 230-0045, 
Japan.
(3)Laboratorio Nazionale Consorzio Interuniversitario Biotecnologie (CIB), 
Trieste 34127, Italy.
(4)Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 
Moscow 119991, Russia.
(5)Institute of Protein Research, Russian Academy of Sciences, Pushchino 142290, 
Russia.
(6)Department of Computer Science, University of Toronto, Toronto, Ontario M5S 
1A1, Canada.
(7)Program in Cardiovascular and Metabolic Disorders, Duke-National University 
of Singapore Medical School, Singapore 169857, Singapore.
(8)Roslin Institute, University of Edinburgh, Edinburgh EH25 9RG, United 
Kingdom.
(9)Center for RNA Medicine, Department of Clinical Medicine, Aalborg University, 
Copenhagen 9220, Denmark.
(10)Institute of Clinical Sciences, Faculty of Medicine, Imperial College 
London, London W12 0NN, United Kingdom.
(11)Computational Regulatory Genomics, MRC London Institute of Medical Sciences, 
London W12 0NN, United Kingdom.
(12)Berlin Institute for Medical Systems Biology, Max Delbrük Center for 
Molecular Medicine in the Helmholtz Association, Berlin 13125, Germany.
(13)Institute of Bioengineering, Research Center of Biotechnology, Russian 
Academy of Sciences, Moscow 117312, Russia.
(14)Graduate School of Integrated Sciences for Life, Hiroshima University, 
Higashi-Hiroshima City 739-0046, Japan.
(15)Centre for Genomic Regulation (CRG), The Barcelona Institute of Science and 
Technology, Barcelona, Catalonia 08003, Spain.
(16)International Centre for Genetic Engineering and Biotechnology (ICGEB), 
University of Cape Town, Cape Town 7925, South Africa.
(17)Institute of Infectious Diseases and Molecular Medicine (IDM), Department of 
Pathology, Division of Immunology and South African Medical Research Council 
(SAMRC) Immunology of Infectious Diseases, Faculty of Health Sciences, 
University of Cape Town, Cape Town 7925, South Africa.
(18)School of Computer Science, McGill University, Montréal, Québec H3G 1Y6, 
Canada.
(19)Department of Biochemistry, Rosalind and Morris Goodman Cancer Research 
Center, McGill University, Montréal, Québec H3G 1Y6, Canada.
(20)Department of Molecular Biophysics and Biochemistry, Yale University, New 
Haven, Connecticut 06510, USA
(21)Biomedical Cybernetics Group, Biotechnology Center (BIOTEC), Center for 
Molecular and Cellular Bioengineering (CMCB), Center for Systems Biology Dresden 
(CSBD), Cluster of Excellence Physics of Life (PoL), Department of Physics, 
Technische Universität Dresden, Dresden 01062, Germany.
(22)Center for Complex Network Intelligence (CCNI) at the Tsinghua Laboratory of 
Brain and Intelligence (THBI), Department of Bioengineering, Tsinghua 
University, Beijing 100084, China.
(23)Institute of Cancer and Genomic Sciences, College of Medical and Dental 
Sciences, University of Birmingham, Birmingham B15 2TT, United Kingdom.
(24)Center for Personal Dynamic Regulome, Stanford University, Stanford, 
California 94305, USA.
(25)Institute of Pharmaceutical Sciences, Swiss Federal Institute of Technology, 
Zurich 8093, Switzerland.
(26)Department of Computational Systems Biology, Vavilov Institute of General 
Genetics, Russian Academy of Sciences, Moscow 119991, Russia.
(27)Department of Oncology, Johns Hopkins University, Baltimore, Maryland 21287, 
USA.
(28)Department of Biological Regulation, Weizmann Institute of Science, Rehovot 
76100, Israel.
(29)Epigenetics and Genome Reprogramming Laboratory, IRCCS Fondazione Santa 
Lucia, Rome 00179, Italy.
(30)Genome Biology of Neurodegenerative Diseases, German Center for 
Neurodegenerative Diseases (DZNE), Tübingen 72076, Germany.
(31)Graduate School of Frontier Biosciences, Osaka University, Suita 565-0871, 
Japan.
(32)RIKEN Preventive Medicine and Diagnosis Innovation Program (PMI), Saitama 
351-0198, Japan.
(33)Institute of Infection, Immunity, and Inflammation, University of Glasgow, 
Glasgow, Scotland G12 8QQ, United Kingdom.
(34)Department of Biosciences and Nutrition, Karolinska Institutet, Huddinge 
14157, Sweden.
(35)Moscow Institute of Physics and Technology, Dolgoprudny 141701, Russia.
(36)Biological and Environmental Sciences and Engineering Division, King 
Abdullah University of Science and Technology, Thuwal 23955-6900, Kingdom of 
Saudi Arabia.
(37)Department of Biology and BRIC, University of Copenhagen, Denmark, 
Copenhagen N DK2200, Denmark.
(38)MRC Human Genetics Unit, University of Edinburgh, Edinburgh EH4 2XU, United 
Kingdom.
(39)National Centre for Cell Science, Pune, Maharashtra 411007, India.
(40)Centre for Global Health Research, Usher Institute, University of Edinburgh, 
Edinburgh EH8 9AG, United Kingdom.
(41)Harry Perkins Institute of Medical Research, QEII Medical Centre and Centre 
for Medical Research, The University of Western Australia, Nedlands, Perth, 
Western Australia 6009, Australia.
(42)Universitat Pompeu Fabra (UPF), Barcelona, Catalonia 08002, Spain.
(43)Princess Margaret Cancer Centre, Toronto, Ontario M5G 1L7, Canada.
(44)Stem Cells and Metabolism Research Program, University of Helsinki and 
Folkhälsan Research Center, 00290 Helsinki, Finland.
(45)Sars International Centre for Marine Molecular Biology, University of 
Bergen, Bergen N-5008, Norway.
(46)Department of Medicine and Consorzio Interuniversitario Biotecnologie p.zle 
Kolbe 1 University of Udine, Udine 33100, Italy.
(#)Contributed equally