Many bacterial genomes are under asymmetric mutational pressure which introduces 
compositional asymmetry into DNA molecule resulting in many biases in coding 
structure of chromosomes. One of the processes affected by the asymmetry is 
translocation changing the position of the coding sequence on chromosome in 
respect to the orientation on the leading and lagging DNA strand. When analysing 
sets of paralogs in 50 genomes, we found that the number of observed genes which 
switched their positions on DNA strand is lowest for genomes with the highest 
DNA asymmetry. However, the number of orthologs which changed DNA strand 
increases with the phylogenetic distance between the compared genomes. 
Nevertheless, there is a fraction of coding sequences that stay on the leading 
strand in all analysed genomes, whereas there are no sequences that stay always 
on the lagging strand. Since sequences diverge very fast after switching the DNA 
strand, this bias in mobility of sequences is responsible, in part, for higher 
divergence rates among some of coding sequences located on the lagging DNA 
strand.