INTRODUCTION: We describe the feasibility of using minimally invasive robotic 
laser interstitial thermotherapy (LITT) for achieving an anterior two-thirds as 
well as a complete corpus callosotomy.
METHODS: Ten probe trajectories were plotted on normal magentic resonance 
imaging (MRI) scans using the Brainlab Stereotactic Planning Software (Brainlab, 
Munich, Germany). The NeuroBlate® System (Monteris Medical, MN, USA) was used to 
conform the thermal burn to the corpus callosum along the trajectory of the 
probe. The distance of the ideal entry site from either the coronal suture and 
the torcula or nasion and the midline was calculated. The distance of the probe 
tip from the dorsal and ventral limits of the callosotomy in the sagittal plane 
were also calculated.
RESULTS: Anterior two-thirds callosotomy was possible in all patients using a 
posterior parieto-occipital paramedian trajectory through the non-dominant 
lobe. The average entry point was 3.64 cm from the midline, 10.6 cm behind the 
coronal suture, and 9.2 cm above the torcula. The probe tip was an average of 
1.4 cm from the anterior commissure. For a total callosotomy, an additional 
contralaterally placed frontal probe was used to target the posterior 
one-third of the corpus callosum. The average entry site was 3.3 cm from the 
midline and 9.1 cm above the nasion. The average distance of the probe tip from 
the base of the splenium was 0.94 cm.
CONCLUSION: The directional thermoablation capability of the NeuroBlate® 
system allows for targeted lesioning of the corpus callosum, to achieve a 
two-thirds or complete corpus callosotomy. A laser distance of < 2 cm is 
sufficient to reach the entire corpus callosum through one trajectory for an 
anterior two-thirds callosotomy and two trajectories for a complete callosotomy.