Long non-coding RNAs (ncRNAs) have been shown to regulate important biological 
processes that support normal cellular functions. Aberrant regulation of these 
essential functions can promote tumor development. In this review, we underscore 
the importance of the regulatory role played by this distinct class of ncRNAs in 
cancer-associated pathways that govern mechanisms such as cell growth, invasion, 
and metastasis. We also highlight the possibility of using these unique RNAs as 
diagnostic and prognostic biomarkers in malignancies.