OBJECTIVE: This is a retrospective study for risk assessment of acute kidney 
injury after allogeneic hematopoietic stem cell transplantation (allo HSCT) 
based on the Acute Kidney Injury Network (AKIN) criteria.
METHODS: Two hundred and eighty-nine consecutive patients who received allo HSCT 
were studied retrospectively to identify the risk factors for AKI according to 
the AKIN criteria. The incidence of AKI based on AKIN staging and overall 
survival (OS) was evaluated using Cox proportional hazard regression models 
treating each AKIN stage as a time-dependent covariate.
PATIENTS: We identified a total of 180 patients who developed AKI within 100 
days after allo HSCT; AKI was classified as stage 1 in 88 patients (30.5%), 
stage 2 in 46 patients (15.9%) and stage 3 in 46 patients (15.9%).
RESULTS: Patients who developed stage 3 AKI had a significantly worse survival 
compared to those who developed no AKI or lower stage AKI (HR: 7.6, 95%CI: 
4.8-12.1; p<0.001). Multivariate analysis for risks for developing AKI revealed 
an episode of sepsis or sinusoidal obstruction syndrome (SOS) and the use of 
liposomal amphotericin as a major cause of the severe stage of AKI.
CONCLUSION: On the basis of our analysis, sepsis, hemorrhagic cystitis, and 
acute GVHD were associated with severe AKI, and SOS was associated any stage of 
AKI.