We report a case of severe digital ulcerations associated with systemic 
sclerosis, successfully treated with treprostinil (Remodulin). There was 
improvement within days of the treatment initiation; complete healing was 
accomplished after 16 weeks of therapy. Patients with systemic sclerosis and 
peripheral small vessel disease have limited therapeutic options. Treprostinil 
is a prostacyclin analogue that can be delivered by subcutaneous infusion and is 
approved in the USA only for treatment of primary pulmonary hypertension. This 
report provides an impressive example of an alternative, complementary 
indication for the use of treprostinil.