This report summarizes what we believe to be the first verifiable case of a 
significant and progressive motor neuron disease (MND) consistent with 
amyotrophic lateral sclerosis that resolved during treatment with i.v. 
ceftriaxone plus oral atovaquone and mefloquine. The rationale for use of these 
antibiotics was (i) positive testing for Borrelia burgdorferi and (ii) red blood 
cell ring forms consistent with Babesia species infection. The patient has 
continued to be free of MND signs and symptoms for 15 months, although some 
symptoms consistent with disseminated Borreliosis remain.