Resveratrol (3,4',5-trihydroxystilbene; RSV), a natural polyphenol found in a 
variety of daily food including grapes and red wine, has long been suspected to 
have multifaceted health beneficial properties, including anti-inflammation, 
anti-oxidant, and anticancer activities. Over the past few years, numerous 
studies have suggested that suppressing the activity of mammalian target of 
rapamycin (mTOR), a critical regulator of cell metabolism, growth, and 
proliferation, may provide a key mechanism underlying the anticarcinogenic 
properties of resveratrol. It has been found that resveratrol targets multiple 
components of the phosphatidylinositol 3- kinase(PI3K)/Akt and mTOR signaling 
pathways, including PI3K, Akt, PTEN, and DEPTOR, suggesting that this natural 
compound and its derivatives may offer a promising new cancer treatment. In the 
current review, we discuss recent findings on the molecular mechanisms 
regulating mTOR signaling and the therapeutic potential of resveratrol for 
cancer treatment by targeting mTOR.