There is extensive transcription throughout the eukaryotic genome resulting in 
both antisense transcripts from coding regions and cryptic unstable transcripts 
(CUTs) from intergenic regions. In this issue, Camblong et al. (2007) 
demonstrate in the budding yeast that antisense transcripts, if stabilized by 
exosome impairment, are able to mediate gene silencing via the recruitment of 
histone deacetylases.