Nephrotic syndrome is basically a set of signs or symptoms that may point to 
kidney problems, a condition when large amounts of protein leak out into the 
urine. In children protein excretion greater than 40 mg/m2.hr(-1) indicate 
presence of nephrotic syndrome. Edema is the prominent feature of nephrotic 
syndrome and initially develops around the eyes and legs. The 1st line treatment 
given is steroid therapy. The prospective study was conducted to determine the 
rational use of steroidal therapy, steroid sensitive nephrotic syndrome and 
causes of remission. 10 children were selected randomly presenting with the 
complaint of steroid sensitive nephrotic syndrome. The result of this study 
provide some evidence that steroidal therapy is effective in treating childhood 
nephrotic syndrome and they recover more rapidly if the steroidal regimen is 
carefully followed. It is concluded that rational use of steroid (prednisolone) 
has a very effective role in the prevention and control of nephrotic syndrome 
either at initial stage or in complicated cases. Corticosteroids have decreased 
the mortality rate upto 3%. Some very interesting findings have been observed 
and thus recorded and reported in this paper.