Over the past 10 years, it has emerged that pervasive transcription in mammalian 
genomes has a tremendous impact on several biological functions. Most of 
transcribed RNAs are lncRNAs and repetitive elements. In this review, we will 
detail the discovery of a new functional class of natural and synthetic 
antisense lncRNAs that stimulate translation of sense mRNAs. These molecules 
have been named SINEUPs since their function requires the activity of an 
embedded inverted SINEB2 sequence to UP-regulate translation. Natural SINEUPs 
suggest that embedded Transposable Elements may represent functional domains in 
long non-coding RNAs. Synthetic SINEUPs may be designed by targeting the 
antisense sequence to the mRNA of choice representing the first scalable tool to 
increase protein synthesis of potentially any gene of interest. We will discuss 
potential applications of SINEUP technology in the field of molecular biology 
experiments, in protein manufacturing as well as in therapy of 
haploinsufficiencies.