Benefiting from the fast development of sequencing technique and bioinformatics 
methods, more and more new long non-coding RNAs (lncRNAs) are discovered and 
identified. lncRNAs were firstly thought to be transcription noise that from 
genome desert without biological function; however, as the discovery of lncRNA 
XIST and HOTAIR uncovers the emerging roles of lncRNAs in development and 
tumorigenesis. In the past decades, accumulating evidence have indicated that 
lncRNAs involve in a wide range of biological functions, such as X-chromosome 
inactivation, reprogramming stem cell pluripotency, regulation of the immune 
response and carcinogenesis. Although lots of studies have demonstrated that 
dysregulation of lncRNAs involve in diverse diseases including cancers, the 
underlying molecular mechanisms of lncRNAs are not well documented. 
Interestingly, our previous studies and others' have shown that numerous of 
lncRNAs expression was misregulated in gastric cancer. In this review, we will 
focus on the dysregulated lncRNAs and their biological function and underlying 
pathways or mechanisms in GC. Finally, we will discuss the potential roles of 
lncRNAs acting as biomarkers or therapeutic targets in GC patients.