A fourteen years old girl showed the classic signs of acrocephalosyndactyly I: 
dysostosis craniofacialis with hypertelorism, exophthalmus, strabism, amblyopia 
and cleft palate as well as syndactyly of the fingers and toes. The feet showed 
on both side a 6 cm long horny band. Since the twelfth year of life, she had 
suffered from papulo-pustular acne with many comedomes. Her menstruation started 
one year later. Intellectual development was normal. At time of her birth, her 
father was 54 years old, and her mother 36 years old. Two elder siblings are 
healthy. The inheritance of acrocephalosyndactyly I is usually autosomal 
dominant, but sporadic cases are frequent.