Charcot-Marie-Tooth (CMT) disease is a common neurogenetic disorder and its 
heterogeneity is a challenge for genetic diagnostics. The genetic diagnostic 
procedures for a CMT patient can be explored according to the 
electrophysiological criteria: very slow motor nerve conduction velocity (MNCV) 
(<15 m/s), slow MNCV (15-25 m/s), intermediate MNCV (25-45 m/s), and normal MNCV 
(>45 m/s). Based on the inheritance pattern, intermediate CMT can be divided 
into dominant (DI-CMT) and recessive types (RI-CMT). GJB1 is currently 
considered to be associated with X-linked DI-CMT, and MPZ, INF2, DNM2, YARS, 
GNB4, NEFL, and MFN2 are associated with autosomal DI-CMT. Moreover, GDAP1, 
KARS, and PLEKHG5 are associated with RI-CMT. Identification of these genes is 
not only important for patients and families but also provides new information 
about pathogenesis. It is hoped that this review will lead to a better 
understanding of intermediate CMT and provide a detailed diagnostic procedure 
for intermediate CMT.