The Library of Integrated Network-based Cellular Signatures (LINCS) program is a 
national consortium funded by the NIH to generate a diverse and extensive 
reference library of cell-based perturbation-response signatures, along with 
novel data analytics tools to improve our understanding of human diseases at the 
systems level. In contrast to other large-scale data generation efforts, LINCS 
Data and Signature Generation Centers (DSGCs) employ a wide range of assay 
technologies cataloging diverse cellular responses. Integration of, and unified 
access to LINCS data has therefore been particularly challenging. The Big Data 
to Knowledge (BD2K) LINCS Data Coordination and Integration Center (DCIC) has 
developed data standards specifications, data processing pipelines, and a suite 
of end-user software tools to integrate and annotate LINCS-generated data, to 
make LINCS signatures searchable and usable for different types of users. Here, 
we describe the LINCS Data Portal (LDP) (http://lincsportal.ccs.miami.edu/), a 
unified web interface to access datasets generated by the LINCS DSGCs, and its 
underlying database, LINCS Data Registry (LDR). LINCS data served on the LDP 
contains extensive metadata and curated annotations. We highlight the features 
of the LDP user interface that is designed to enable search, browsing, 
exploration, download and analysis of LINCS data and related curated content.