PURPOSE: The authors describe the clinical feature of ten patients with a new 
syndrome characterized by the presence of retinal vasculitis, multiple 
macroaneurysms, neuro-retinitis, and peripheral capillary nonperfusion.
METHODS: The authors evaluated ten patients identified to have clinical features 
compatible with the syndrome of idiopathic retinal vasculitis, aneurysms and 
neuroretinits (IRVAN). Clinical examination findings, sequential funds 
photographs (when available), fluorescein angiograms, systemic investigations, 
response to therapy, and visual outcomes were reviewed.
RESULTS: Seven eyes of four patients sustained a marked decrease in visual 
acuity of 20/200 or worse. Visual loss was due to a combination of an exudative 
maculopathy and sequelae of retinal ischemia. Capillary nonperfusion was seen in 
all ten patients and was severe enough to warrant panretinal laser 
photocoagulation in six patients. Systemic investigations were uniformly 
noncontributory. Oral prednisone appears to have little beneficial effects on 
patients with this disorder.
CONCLUSIONS: Patients with IRVAN have characteristic retinal features that 
readily identify this syndrome. An increased awareness of this rare syndrome may 
help to identify sight-threatening complications at an earlier stage. The 
authors caution against extensive medical investigations.