Author information:
(1)Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, 
University of Oxford, Oxford, UK.
(2)Wellcome Centre for Human Genetics, University of Oxford, Oxford, UK.
(3)Center for Molecular Medicine & Clinical Epidemiology Unit, Department of 
Medicine Solna, Karolinska Institutet, Stockholm, Sweden.
(4)School of Biological Sciences, Monash University, Clayton, Victoria, 
Australia.
(5)IBD Pharmacogenetics, College of Medicine and Health, University of Exeter, 
Exeter, UK.
(6)Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
(7)William Harvey Research Institute, Barts & The London School of Medicine & 
Dentistry, Queen Mary University of London, London, UK.
(8)Nuffield Department of Population Health, University of Oxford, Oxford, UK.
(9)23andMe, Inc., Sunnyvale, CA, USA.
(10)Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK.
(11)Saint Edmund Hall, University of Oxford, Oxford, UK.
(12)Enteric NeuroScience Program, Division of Gastroenterology and Hepatology, 
Department of Medicine, Mayo Clinic, Rochester, MN, USA.
(13)Institute of Clinical Molecular Biology, Christian-Albrechts-University of 
Kiel, Kiel, Germany.
(14)Department of Dermatology, Quincke Research Center, University Hospital 
Schleswig-Holstein, Kiel, Germany.
(15)Department of Biostatistics, University of Michigan, School of Public 
Health, Ann Arbor, MI, USA.
(16)Department of Laboratory Medicine, Children's and Women's Health, Norwegian 
University of Science and Technology, Trondheim, Norway.
(17)Department of Public Health and Nursing, Norwegian University of Science and 
Technology, Trondheim, Norway.
(18)Department of Medicine, Levanger Hospital, Nord-Trøndelag Hospital Trust, 
Levanger, Norway.
(19)Department of Molecular Medicine and Surgery, Karolinska Institutet, 
Karolinska University Hospital, Stockholm, Sweden.
(20)Estonian Genome Center, Institute of Genomics, University of Tartu, Tartu, 
Estonia.
(21)Department of Genetics, University Medical Center Groningen, Groningen, the 
Netherlands.
(22)Clinical Enteric Neuroscience Translational and Epidemiological Research and 
Division of Gastroenterology and Hepatology, Department of Medicine, Mayo 
Clinic, Rochester, MN, USA.
(23)David Geffen School of Medicine, University of California, Los Angeles, Los 
Angeles, CA, USA.
(24)Neurogastroenterology Unit, Wythenshawe Hospital, Centre for 
Gastrointestinal Sciences, University of Manchester, Manchester, UK.
(25)Nottingham Digestive Diseases Centre, National Institute for Health Research 
Nottingham Biomedical Research Centre, Nottingham University Hospitals NHS Trust 
and the University of Nottingham, Nottingham, UK.
(26)Center for Molecular Medicine & Clinical Epidemiology Unit, Department of 
Medicine Solna, Karolinska Institutet, Stockholm, Sweden. mdamato@cicbiogune.es.
(27)School of Biological Sciences, Monash University, Clayton, Victoria, 
Australia. mdamato@cicbiogune.es.
(28)Institute of Clinical Molecular Biology, Christian-Albrechts-University of 
Kiel, Kiel, Germany. mdamato@cicbiogune.es.
(29)Biodonostia Health Research Institute, San Sebastian, Spain. 
mdamato@cicbiogune.es.
(30)Gastrointestinal Genetics Lab, CIC bioGUNE - Basque Research and Technology 
Alliance, Derio, Spain. mdamato@cicbiogune.es.
(31)IKERBASQUE, The Basque Science Foundation, Bilbao, Spain. 
mdamato@cicbiogune.es.
(32)Big Data Institute, Li Ka Shing Centre for Health Information and Discovery, 
University of Oxford, Oxford, UK. luke.jostins@kennedy.ox.ac.uk.
(33)Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK. 
luke.jostins@kennedy.ox.ac.uk.
(34)Christ Church, University of Oxford, Oxford, UK. 
luke.jostins@kennedy.ox.ac.uk.
(35)Division of Gastroenterology and Hepatology, Department of Medicine, 
University of Cambridge, Cambridge, UK. miles.parkes@addenbrookes.nhs.uk.
(36)Department of Gastroenterology, Cambridge University Hospital, Cambridge, 
UK. miles.parkes@addenbrookes.nhs.uk.
(#)Contributed equally