There is no effective treatment for recurrent glioblastoma (GBM) after 
bevacizumab failure. Putative mechanisms of resistance to bevacizumab include 
increased pericyte coverage, mediated partly by platelet-derived growth factor 
receptor (PDGFR) signaling, and an infiltrative tumor growth pattern potentially 
dependent on SRC. We explored the efficacy of dasatinib, a SRC, BCR-ABL, c-KIT, 
EPHA2, and PDGFRβ inhibitor, in patients with recurrent GBM after bevacizumab 
failure. Adult patients with histologically confirmed GBM who failed bevacizumab 
therapy were treated with dasatinib 70-100 mg twice daily in combination with 
bevacizumab (n = 14), until tumor progression or unacceptable toxicity. Fourteen 
patients were treated. Median age was 55 years (range 32-66) and median KPS was 
80 (range 50-90). All patients (100%) had glioblastomas. The median number of 
prior regimens was 4 (range from 2 to 6). Of the thirteen evaluable patients, 
none had a complete or partial response. Only one patient had stable disease 
after an 8 week interval. Median progression-free survival (PFS) was 28 days 
(95% confidence interval [CI] 26-35 days). Six month progression-free survival 
(PFS6) was 0%. Median overall survival (OS) was 78 days (95% CI 41-137 days). 
Treatment was moderately well-tolerated, although one patient sustained a grade 
4 intracerebral hemorrhage. Dasatinib in conjunction with bevacizumab does not 
appear to have activity in patients with recurrent, heavily pretreated GBM.