Epilepsy is the most common serious neurological condition and sudden unexpected 
death in epilepsy (SUDEP) is the most important direct epilepsy-related cause of 
death. Information concerning risk factors for SUDEP is conflicting, but high 
seizure frequency is a potential risk factor. Additionally, potential 
pathomechanisms for SUDEP are unknown, but it is very probable that cardiac 
arrhythmias during and between seizures or transmission of epileptic activity to 
the heart via the autonomic nervous system potentially play a role. In parallel, 
studies have shown a link between vitamin D dysfunction and epilepsy. Moreover, 
several evidences in the literature suggest an association between low vitamin D 
and seizures, indicating the possibility of anticonvulsant properties of this 
hormone. Quite interesting, a growing body of data suggests that low vitamin D 
levels may adversely affect cardiovascular health, directly associated with 
death from heart failure and sudden cardiac death. In view of the above 
findings, our research group focused in this review article that SUDEP, at least 
in some cases, could be related with low vitamin D levels.