The coexistence of essential hypertension (EH) in type 2 diabetic (T2D) patients 
greatly enhances chronic kidney disease.
OBJECTIVES: To assess the acute renal dysfunction in two cohorts of 
diabetic-hypertensive subjects. The inaugural pathology for each group is either 
T2D or EH.
PATIENTS AND METHODS: The study was undertaken on 506 subjects who were divided 
in 5 groups according to age and sex: diabetic, hypertensive, diabetic- 
hypertensive (DH and HD) and healthy groups. Patients were phenotyped regarding 
their cardiometabolic syndrome (CMS) profile using the NCEP/ATPIII criteria and 
cardiorenal syndrome (CRS) according to the International kidney foundation. 
Hypertension was defined as systolic (SBP) and diastolic (DBP) blood pressure ≥ 
140/90 mmHg, respectively. Insulin resistance (IR) was assessed by Homa-IR 
model. Glomerular filtration rate (GFR) by creatinine clearance. CMS and CRS 
parameters were determined on Cobas®. The SBP and DBP measurements by electronic 
blood pressure using Omron 705 CP® type.
RESULTS: IR was found in all diabetics and hypertensive patients. Dyslipidemia 
are correlated to % body fat mass accretion in all groups. In DH group, the 
renal disorder is confirmed by decreased GFR (30%) and increased 
microalbuminuria (> 30 mg/24h); associated with increased NT-pro BNP and plasma 
aldosterone depletion.
CONCLUSION: Several biomarkers are necessary to detection kidney disease and 
renal failure prevention in diabetic patients to hypertensive state. The renal 
dysfunction was significantly related to T2D-EH disease.