POEMS (polyneuropathy, organomegaly, endocrinopathy, monoclonal protein and skin 
signs) and AESOP (adenopathy and extensive skin patch overlying a plasmacytoma) 
syndromes are rare paraneoplastic conditions due to an underlying plasma cell 
dyscrasia. We report a 70-year-old patient with the rare coexistence of POEMS 
and AESOP syndromes and in whom skin signs, that differ both clinically and 
histologically, were the clues to the diagnosis of a plasma cell disorder. 
Vascular endothelial growth factor-A overexpression seems to be the common 
pathogenetic link of the different clinicopathological presentations of the skin 
lesions.