Protein degradation in normal living cells is precisely regulated to match the 
cells' physiological requirements. The selectivity of protein degradation is 
determined by an elaborate degron-tagging system. Degron refers to an amino acid 
sequence that encodes a protein degradation signal, which is oftentimes a 
poly-ubiquitin chain that can be transferred to other proteins. Current 
understanding of ubiquitination dependent and independent protein degradation 
processes has expanded the application of degrons for targeted protein 
degradation and novel cell engineering strategies. Recent findings suggest that 
small molecules inducing protein association can be exploited to create degrons 
that target proteins for degradation. Here, recent applications of degron-based 
targeted protein degradation in eukaryotic organisms are reviewed. The degron 
mediated protein degradation represents a rapidly tunable methodology to control 
protein abundance, which has broad application in therapeutics and cellular 
function control and monitoring.