BACKGROUND: Magnetic resonance-guided laser-interstitial thermotherapy (MR-LITT) 
is a minimally invasive technique that shows promise in neuro-oncology because 
of its superiority in delivering precise minimally invasive thermal energy with 
minimal collateral damage.
OBJECTIVE: In this analysis, we investigate initial data on the use of MR-LITT 
in the treatment of newly diagnosed high-grade gliomas.
METHODS: With the use of the PubMed, OVID, and Google-scholar database systems, 
a comprehensive search of the English literature was performed. Eighty-five 
articles were identified plus 1 that is pending publication. Four articles were 
accounted for in this review, including 25 patients with newly diagnosed 
high-grade gliomas who underwent MR-LITT treatment. We evaluated safety, 
progression-free survival, and overall survival.
RESULTS: Twenty-five patients with a mean age of 53.8 years underwent LITT 
treatments. On average, 82.9% of the pretreatment lesion volume was ablated. The 
average tumor volume treated was 16.5 cm. The mean follow-up time was 7.6 
months. Median overall survival was found to be 14.2 months (range 0.1-23 
months). The median progression-free survival was 5.1 months (range 2.4-23 
months); however, these data are limited by the relatively short follow-up of 
the patients reviewed and small sample size of only 25 patients. There was 1 
(3.4%) major perioperative complication, which was a central nervous system 
infection.
CONCLUSION: MR-LITT is a promising technology for the treatment of small, yet 
difficult-to-treat newly diagnosed high-grade gliomas. This study demonstrates 
that MR-LITT is safe, and future randomized studies are needed to evaluate its 
role as a treatment adjunct for newly diagnosed high-grade gliomas.
ABBREVIATIONS: BBB, blood-brain barrierHGG, high-grade gliomaLITT, 
laser-interstitial thermal therapyWHO, World Health Organization.