Multisystem inflammatory syndrome in children (MIS-C) is a rare and critical 
condition that affects children following exposure to severe acute respiratory 
syndrome Coronavirus 2 (SARS-CoV-2) infection, leading to multiorgan dysfunction 
and shock. MIS-C has been reported from different parts of the world but rarely 
from Arab countries. In this report, we describe a 15-year-old Arab boy who was 
admitted to the ICU during the surge of Coronavirus transmission in Syria with a 
clinical picture consistent with MIS-C, including high-grade fever, 
gastrointestinal symptoms, rash, multiorgan dysfunction, and shock. Laboratory 
profile showed significant elevation of inflammatory markers, negative 
SARS-CoV-2 RT-PCR testing but positive serologic testing for SARS-CoV-2. The 
patient received intravenous immunoglobulins (IVIG) and glucocorticoids with 
remarkable cardiac improvement and significant alleviation in inflammatory 
markers. To our knowledge, this is the first reported case of MIS-C from Syria, 
which adds to the epidemiological data about this new syndrome.