Wolf-Hirschhorn syndrome (WHS) and Patau syndrome are two of the most severe 
conditions resulting from chromosome abnormalities. WHS is caused by a deletion 
of 4p16, while Patau syndrome is caused by trisomy for some or all regions of 
chromosome 13. Though the etiologies of these syndromes differ, they share 
several features including pre- and postnatal growth retardation, microcephaly, 
cleft lip and palate, and cardiac anomalies. We present here a female fetus with 
deletion of 4p16 --> pter and duplication of 13q32 --> qter due to unbalanced 
segregation of t(4;13)(p16;q32) in the father. She displayed overlapping 
features of both of these syndromes on ultrasound. To the best of our knowledge, 
this is the first report of a fetus with both partial trisomy 13 and deletion of 
4p16, the critical region for WHS.