INTRODUCTION: Research has shown that a disrupted stratum corneum permeability 
barrier coupled with chronic inflammation induce signs of extrinsic aging 
(photoaging). An novel herbal-based three product cosmeceutical regimen used to 
reverse these two anomalies that does not contain retinol, soy, niacinamide, 
tea, L-ascorbic acid or esters, hydroxy acids, tocopherol, or growth factors was 
tested in six human clinical trials to determine effectiveness and safety in 
reversing photoaging.
MATERIALS AND METHODS: Six randomized split face, double blind, prospective, 
controlled clinical trials involving a total of 110 subjects compared a 
cosmeceutical blend of novel herbs in regimens consisting of one to three 
products to several common antiaging topical treatments. These comparative 
products include prescription tretinoin, physician strength idebenone, kinetin, 
polyhydroxy, lactic and glycolic acids in reversing signs of photoaging.
RESULTS: The novel cosmeceutical blend regimen showed superior efficacy and 
safety in all six trials.
DISCUSSION: These trials substantiate that herbs not used in common antiaging 
products effectively and safely mitigate and reverse photoaging signs and 
symptoms. The novel concept of treating photoaging and preventing its 
progression by repairing and optimizing the stratum corneum barrier, while 
reversing and inhibiting chronic cutaneous inflammation, has now been proven.