Pannexins (Panxs) are a multifaceted family of ion and metabolite channels that 
play key roles in a number of physiological and pathophysiological settings. 
These single membrane large-pore channels exhibit a variety of tissue, cell 
type, and subcellular distributions. The lifecycles of Panxs are complex, yet 
must be understood to accurately target these proteins for future therapeutic 
use. Here we review the basics of Panx function and localization, and then 
analyze the recent advances in knowledge regarding Panx trafficking. We examine 
several intrinsic features of Panxs including specific post-translational 
modifications, the divergent C-termini, and oligomerization, all of which 
contribute to Panx anterograde transport pathways. Further, we examine the 
potential influence of extrinsic factors, such as protein-protein interactions, 
on Panx trafficking. Finally, we highlight what is currently known with respect 
to Panx internalization and retrograde transport, and present new data 
illustrating Panx1 internalization following an activating stimulus.