Nemaline myopathy (NM) is a genetically and clinically heterogenous muscle 
disorder, which is myopathologically characterized by nemaline bodies. Mutations 
in six genes have been reported to cause NM: Nebulin (NEB Pelin 1999), 
alpha-skeletal muscle actin (ACTA1 Nowak 1999), alpha-slow tropomyosin (TPM3 
Laing 1995), beta-tropomyosin (TPM2 Donner 2002), slow troponin T (TNNT1 
Johnston 2000) and cofilin 2 (CFL2 Agrawal 2007). The majority of cases are due 
to mutation in NEB and ACTA1. We report on the clinical, myopathological and 
muscle MRI findings in a German family with autosomal dominant NM due to a novel 
pathogenic TPM3 mutation (p.Ala156Thr).