The 50th annual Interscience Conference on Antimicrobial Agents and Chemotherapy 
(ICAAC), held in Boston, included topics covering new therapeutic developments 
in the field of infectious disease. This conference report highlights selected 
presentations on research with novel antimicrobial agents. Investigational drugs 
discussed include the chitin synthase inhibitor nikkomycin Z (Valley Fever 
Solutions/University of Arizona), the glycosylphosphatidylinositol biosynthesis 
inhibitor E-1210 (Eisai), the β-1,3-d-glucan synthesis inhibitor MK-3118 (Merck 
& Co/SCYNEXIS), the metalloenzyme inhibitors VT-1129 and VT-1161 (both Viamet 
Pharmaceuticals), and the anti-inflammatory nanoemulsion NB-003 (NanoBio).