Focal, small-to-moderate and transient improvement occurred in the muscle 
strength and function of patients with ALS who received TRH in dose-response and 
screening studies. In a small pilot study of 12 patients, 3 months 
administration of TRH at 10 mg per kg on alternate days resulted in localized 
increased strength of jaw muscles as well as significant improvement in lower 
extremity function. Aerobic exercise capacity was particularly improved in 
patients with ALS following administration of TRH. Autonomic effects of TRH on 
heart rate, respiration, and blood pressure were not serious and attenuated 
slightly over the course of the study.