Henoch-Schönlein purpura (HSP) is the most common form of childhood vasculitis. 
Various viral and bacterial infections, drugs, vaccines, food allergy and even 
insect bites have been considered as triggering factors in pathogenesis of HSP. 
Epstein-Barr virus (EBV) infection, which is associated with HSP, have been 
rarely reported. Herein we present HSP patient possibly caused by EBV infection. 
A 8-year old boy was admitted to our department with fever, rashes on legs and 
arms and intermittent mild abdominal pain. Multiple purpuric rashes were on his 
extremities, abdomen and buttock. Laboratory investigations revealed that 
monospot test was positive, EBV serology tests; Anti-EA-D Ig G: 3+, Anti-VCA 
gp125 Ig G: 3+, Anti-VCA p19 Ig M: 2+, Anti EBNA-1 Ig M: negative, Anti EBNA-1 
Ig M: negative, Anti EBNA-1 Ig G: negative. The patient was interpreted as the 
primary active acute EBV infection. A skin biopsy showed leucocytoclastic 
vasculitis. The other viral and bacterial investigations were negative. The 
patient was diagnosed as HSP vasculitis according to EULAR criteria and treated 
with intravenous hydration and ibuprofen. He was discharged after 15 days with 
normal laboratory findings and physical examination. We think that EBV infection 
may be stimulant factor for autoimmune reactions and may cause HSP vasculitis. 
Hence, it may be useful to investigate the EBV infection in etiology of HSP 
cases.