The synthesis of the recently characterized depsipeptide szentiamide (1), which 
is produced by the entomopathogenic bacterium Xenorhabdus szentirmaii, is 
described. Whereas no biological activity was previously identified for 1, the 
material derived from the efficient synthesis enabled additional bioactivity 
tests leading to the identification of a notable activity against insect cells 
and Plasmodium falciparum, the causative agent of malaria.