Calciphylaxis is a rare condition characterized by medial calcification of 
small- and medium-sized vessels that subsequently leads to ischemic necrosis. 
Calciphylaxis most often occurs in patients with end-stage renal disease and 
secondary hyperparathyroidism. We present a unique case of calciphylaxis in 
which the patient did not have end-stage renal disease. Instead, primary 
hyperparathyroidism and/or alcoholic cirrhosis were the more likely causes of 
her calciphylaxis. In addition, our case demonstrated not only calciphylaxis but 
also fragmentation and calcification of elastic fibers within the dermis, 
changes that are most often seen in pseudoxanthoma elasticum. This is the first 
reported case of calciphylaxis, to our knowledge, with histopathologic changes 
of pseudoxanthoma elasticum in a patient who is nonuremic.