Catecholamine-induced polymorphic ventricular tachycardia (CPVT), a rare disease 
that occurs in subjects without obvious organic heart disease, is characterized 
by episodes of syncope, seizures, or sudden death in response to physiologic or 
emotional stress. This report reviews evidence that a missense mutation in the 
CASQ2 gene is associated with autosomal-recessive CPVT.