A double-blind controlled trial of thyrotropin releasing hormone (TRH) 150 mg IM 
daily in 30 patients with amyotrophic lateral sclerosis is reported. The 
drug/placebo was administered for 2 months, followed by a 2-month "wash-out". 
Evaluation of strength, functional ability, and respiratory functions was 
performed. A temporary increase in the strength of some muscles was detected 
following the administration of TRH, but no change in functional performance was 
noted. Neither the patients nor the investigators believed the effects were of 
any marked clinical significance. The course of the illness was not altered.