The molecular events occurring after cerebral ischemia in hypertension may 
include de novo expression of numerous genes. Receptor genes are predominantly 
involved in the process of cell death, neuroprotection and reconstruction after 
ischemic injury. Ischemic stroke was observed in the non-genetic, non-surgical 
model of hypertension, the cold-induced hypertensive rat. In hypertensive rats 
suppression subtractive hybridization analysis was used to identify 
differentially expressed receptor genes in stroke-tissue compared to normal rat 
brain. We found 76 genes predominantly expressed in hypertensive rat 
stroke-tissue. These predominantly expressed genes included genes involved in 
energy metabolism, signal transduction/cell regulation, and 
replication/transcription/translation. For example, the T3 receptor alpha was 
predominantly expressed in stroke-tissue, indicating that regeneration of nerves 
in stroke tissue may be facilitated by increased T3 receptor alpha expression.