P73 is a member of the p53 transcription factors family with a prominent role in 
neurobiology, affecting brain development as well as controlling neuronal 
survival. Accordingly, p73 has been identified as key player in many age-related 
neurodegenerative diseases, such as Alzheimer's disease, neuroAIDS and 
Niemann-Pick type C disease. Here we investigate possible correlations of p73 
with Parkinson disease. Tyrosine hydroxylase is a crucial player in Parkinson 
disease being the enzyme necessary for dopamine synthesis. In this work we show 
that levels of tyrosine hydroxylase can be influenced by p73. We also 
demonstrate that p73 can protect against tyrosine hydroxylase depletion in an in 
vitro model of Parkinson disease.