STUDY OBJECTIVE: Adult women with endometriosis are often diagnosed with 
comorbid pain, mood, and autoimmune conditions. This study aims to describe the 
occurrence of pain syndromes, mood conditions, and asthma in adolescents and 
young women with endometriosis evaluated at our medical center.
DESIGN: Retrospective review of medical records.
SETTING: Department of Obstetrics and Gynecology at a tertiary referral center.
PARTICIPANTS: 138 adolescents/young women who were less than age 24 years at the 
time of their initial visit at our medical center, and whose surgical diagnosis 
of endometriosis was made at our institution or by outside institutions by the 
age of 21.
INTERVENTIONS: None.
MAIN OUTCOME MEASURES: Prevalence of comorbid pain syndromes (defined as 
interstitial cystitis, irritable bowel syndrome, chronic headaches, chronic low 
back pain, vulvodynia, fibromyalgia, temporomandibular joint disease, and 
chronic fatigue syndrome), mood conditions (defined as depression and anxiety), 
and asthma.
RESULTS: Comorbid pain syndromes were found in 77 (56%) women, mood conditions 
in 66 (48%) women, and asthma in 31 (26%) women. Comparing endometriosis 
patients with and without comorbid pain syndromes, no differences were found in 
age at time of diagnosis, endometriosis symptoms, and endometriosis stage. 
Patients with comorbid pain syndromes were more likely to report mood conditions 
(62% vs 30% respectively, P < .001) and smoking (31% vs 10% respectively, P = 
.003), underwent more surgeries for endometriosis (median of 2 [range, 1-7] vs 1 
[range, 1-5], P < .005), and were more likely to undergo appendectomy or 
cholecystectomy (30% vs 13%, P = .02).
CONCLUSIONS: Comorbid pain syndromes, mood conditions and asthma are common in 
adolescents and young women with endometriosis.