Fanconi anemia is a rare disorder resulting from defects in genes responsible 
for DNA damage responses. It is characterized by congenital anomalies, aplastic 
anemia, and a predisposition to cancer. Currently, hematopoietic stem cell 
transplant (HSCT) is the only curative treatment available for bone marrow 
failure; however, HSCT increases oral squamous cell carcinoma (OSCC) risk. Here 
we report the case of a patient diagnosed with Fanconi anemia in childhood who 
was treated with HSCT and later diagnosed with multiple OSCCs during a 12-year 
follow-up. Despite multiple surgical interventions and radiotherapy regimens, 
the patient`s health deteriorated. Management of individuals with Fanconi anemia 
is challenging and must be provided by a multidisciplinary healthcare team to 
ensure better staging, treatment planning, and coordination.