Melkersson-Rosenthal syndrome (MRS) is a rare granulomatous inflammatory disease 
characterised by the triad of orofacial oedema, facial nerve palsy and furrowed 
tongue. We describe the case of a 29-year-old patient suffering from an 
oligosymptomatic form of the disease with orofacial oedema, cobblestone pattern 
on the buccal mucosa and swelling of the tongue, accompanied by intermittent 
fatigue, influenza-like symptoms, intermittent tinnitus and acute hearing loss. 
An increase of several autoimmune-associated antibodies was also detected. 
Treatment with prednisolone, azathioprine or methotrexate failed to adequately 
control all symptoms in the long term. In the absence of a specific and 
well-established therapy for MRS, treatment with adalimumab was administered. 
Under adalimumab, total remission of all symptoms was achieved, indicating that 
tumour necrosis factor-α blockers are a promising therapeutic option for 
patients with Melkersson-Rosenthal syndrome.