lncRNA H19 is essential for human tumor growth. However, little is known about 
whether H19 regulates bladder cancer metastasis. Here we found that H19 levels 
are remarkably increased in bladder cancer tissues, and upregulated H19 promotes 
bladder cancer cell migration in vitro and in vivo. H19 is associated with 
enhancer of zeste homolog 2 (EZH2), and that this association results in 
Wnt/β-catenin activation and subsequent downregulation of E-cadherin. A 
significant negative correlation is also observed between H19 levels and E-cad 
levels in vivo. These data suggest that upregulated H19 enhances bladder cancer 
metastasis by associating with EZH2 and inhibiting E-cad expression.