Psoriasis treatments range from topical treatments and phototherapy to oral 
systemic medications and injections. Despite good control of the disease when 
applying appropriate treatments (according to disease severity, insurance 
parameters, patient preference, and patients' ability to adhere), continued 
advancements will allow even better symptomatic control, reduced adverse 
effects, and patient satisfaction. This review aims to assess traditional and 
new psoriasis treatments and how to apply them in clinical practice. A 
literature review on psoriasis treatments and clinical applications was 
performed using PubMed. Mild-to-moderate psoriasis treatments include topicals, 
localized phototherapy, and newer therapies combining two types of topicals, 
phototherapy with topicals, and easy-to-use foam and spray vehicles. 
Moderate-to-severe psoriasis therapies include monotherapy or various 
combinations of generalized phototherapy, oral treatments, and biologic agents, 
with new oral and biologic agents on the horizon. Dermatologists and primary 
care providers share roles in screening for associated comorbidities (including 
cardiovascular disorders, chronic kidney disease, Crohn disease, dyslipidemia, 
diabetes mellitus/insulin resistance, depression, metabolic syndrome, obesity, 
and psoriatic arthritis), managing patients' treatments, and reevaluating 
treatment needs as new therapies are approved. Continued advancements in 
psoriasis treatment and improvement in coordinated care will allow better 
overall care of patients with psoriasis.