CytoTune™-iPS Reprogramming System uses vectors based on replication in 
competent Sendai virus (SeV) to safely and effectively deliver and express key 
genetic factors necessary for reprogramming somatic cells into iPSCs. In 
contrast to many available protocols, which rely on viral vectors that integrate 
into the genome of the host cell, the CytoTune™ Reprogramming System uses 
vectors that are non-integrating and remain in the cytoplasm (i.e., they are 
zero-footprint). In addition, the host cell can be cleared of the vectors and 
reprogramming factor genes by exploiting the cytoplasmic nature of SeV and the 
functional temperature sensitivity mutations introduced into the key viral 
proteins. The CytoTune™-iPS Reprogramming Kit contains four SeV-based 
reprogramming vectors, each capable of expressing one of the four Yamanaka 
factors (i.e., Oct4, Sox2, Klf4, and c-Myc) and are optimized for generating 
iPSCs from human somatic cells. The reprogramming vectors in this kit have been 
engineered to increase biological and environmental safety.