The single genomic locus, AbetaH-J-J, encodes three functionally distinct 
proteins aspartyl beta-hydroxylase, junctin and junctate by alternative 
splicing. Among these three proteins, junctin and junctate could play important 
roles in the regulation of intracellular Ca(2+) by regulating either Ca(2+) 
release from intracellular Ca(2+) stores or Ca(2+) influx in various biological 
processes. Here we review recent findings concerning the expressional 
regulations and the proposed functions of junctin and junctate.