Hutchinson-Gilford progeria syndrome (HGPS) is an autosomal-dominant genetic 
disease that leads to accelerated aging and often premature death caused by 
cardiovascular complications. Till now clinical management of HGPS has largely 
relied on the treatment of manifestations and on the prevention of secondary 
complications, cure for the disease has not yet been established. Addressing 
this need cannot only benefit progeria patients but may also provide insights 
into intervention design for combating physiological aging. By using the 
systematic review approach, this article revisits the overall progress in the 
development of strategies for HGPS treatment over the last ten years, from 2010 
to 2019. In total, 1,906 articles have been retrieved, of which 56 studies have 
been included for further analysis. Based on the articles analyzed, the trends 
in the use of different HGPS models, along with the prevalence, efficiency, and 
limitations of different reported treatment strategies, have been examined. 
Emerging strategies for preclinical studies, and possible targets for 
intervention development, have also been presented as avenues for future 
research.