Fanconi anemia (FA) is a rare genetic disease with both autosomal and X-linked 
inheritance, characterized by genomic instability. The cells from individuals 
with FA are highly sensitive to DNA-crosslinking drugs, such as mitomycin C 
(MMC), diepoxybutane (DEB) and so on. Now at least 13 genes (FA-A, B, C, D1, D2, 
E, F, G, I, J, L, M, N) have been identified, whose products participate in a 
DNA damage-response network involving breast cancer susceptibility gene 
products, BRCA1 and BRCA2. The impaired DNA repair due to mutations in FA genes 
is thought to be one of the main pathogenesis of FA, also closely related to the 
development of some cancers. In this review, the advances of study about FA-BRCA 
network are summarized.