Cebocephaly is a very rare congenital midline facial anomaly characterized by a 
blind-ended single nostril and ocular hypotelorism, and is usually combined with 
alobar holoprosencephaly. We report here a case of alobar holoprosencephaly with 
cebocephaly and craniosynostosis. Chromosomal analysis revealed normal 
karyotyping. The facial dysmorphism was characterized by the single nostril, 
hypotelorism, absence of philtrum and small head girth. The failure of cleavage 
of the prosencephalon and the fusion of all cranial sutures except for the 
sagittal suture were documented by computed tomography (CT) and magnetic 
resonance image (MRI). Early detection by the prenatal ultrasound examination is 
important because of poor prognosis of alobar holoprosencephaly.