Shapiro syndrome is an extremely rare condition consisting the clinical triad of 
recurrent hypothermia, hyperhydrosis and agenesis of the corpus callosum. On the 
other hand, reverse Shapiro's sydrome is characterized periodic hyperthermia and 
agenesis of the corpus callosum. Here, we describe a 3.5-year-old girl with 
complete agenesis of corpus callosum presenting with recurrent fever and 
vomiting. She also had hypothermia attacks with accompanying diaphoresis. To the 
best of our knowledge, there is no described case with episodes of hyperthermia, 
hypothermia, and vomiting associated with agenesis of the corpus callosum. 
Recurrent vomiting may be a newly defined symptom associated with these 
syndromes.