Holoprosencephaly is a rare congenital disorder which results from failure of 
cleavage or incomplete differentiation of the forebrain structures at various 
levels or to various degrees. Depending on the degree of involvement, it is 
classified into 4 types: Alobar, Semilobar, Lobar and Middle interhemispheric 
fusion variant. A male child was born to 28-year-old female at 34 weeks of 
gestation. The mother on antenatal follow-up was detected to have a fetus with 
multiple congenital anomalies on Ultrasonography (USG) done at 34weeks of 
gestation. The baby died after 12 hours of birth. A complete autopsy was 
performed. On external examination, multiple congenital anomalies were seen 
including cleft lip and palate, absent nasal bridge, proptosis of right eye, 
micropenis, left undescended testis, bilateral rocker bottom feet, omphalocele 
and sacral meningomyelocele. Internal examination of the brain revealed 
hydrocephalus and features of alobar holoprosencephaly. This case is presented 
for its rarity. In addition, it is unusual for a fetus with alobar 
holoprosencephaly to survive till term as this is the most severe type. Though 
facial malformations are usually present in a case of holoprosencephaly, its 
association with sacral meningomyelocele and omphalocele has rarely been 
described in literature.