OBJECTIVE: To investigate the effect of sea cucumber cerebroside(SCC) and its 
long-chain base(LCB) on lipid and glucose metabolism in obese mice.
METHODS: The mouse obese model was established by feeding high fat diet. The 
mice were randomly assigned to 4 groups: control group, model group, SCC group 
and LCB group. After 4 weeks, the glucose tolerance test was undertaken. After 5 
weeks, the body fat content, organic indexes, serum lipid level, glycemic index 
and liver lipid level were determined.
RESULTS: Compared with the model group, the glucose tolerance in the SCC group 
and LCB group was ameliorated significantly (P<0.01, P<0.05); glycemic index 
(P<0.01, P<0.01), the weight of adipose tissue (P<0.05, P<0.01) and the hepatic 
TG were reduced significantly (P<0.05, P<0.05).
CONCLUSION: Sea cucumber cerebroside and its long-chain base can improve the 
glucose and lipid metabolism in obese mice.