P bodies are 100-300 nm sized organelles involved in mRNA silencing and 
degradation. A total of 60 human proteins have been reported to localize to P 
bodies. Several human SNPs contribute to complex diseases by altering the 
structure and function of the proteins. Also, SNPs alter various transcription 
factors binding, splicing and miRNA regulatory sites. Owing to the essential 
functions of P bodies in mRNA regulation, we explored computationally the 
functional significance of SNPs in 7 P body components such as XRN1, DCP2, EDC3, 
CPEB1, GEMIN5, STAU1 and TRIM71. Computational analyses of non-synonymous SNPs 
of these components was initiated using well utilized publicly available 
software programs such as the SIFT, followed by PolyPhen, PANTHER, MutPred, 
I-Mutant-2.0 and PhosSNP 1.0. Functional significance of noncoding SNPs in the 
regulatory regions were analysed using FastSNP. Utilizing miRSNP database, we 
explored the role of SNPs in the context that alters the miRNA binding sites in 
the above mentioned genes. Our in silico studies have identified various 
deleterious SNPs and this cataloguing is essential and gives first hand 
information for further analysis by in vitro and in vivo methods for a better 
understanding of maintenance, assembly and functional aspects of P bodies in 
both health and disease.