Asymmetric division of neural progenitor cells is a crucial event in the 
generation of neuronal diversity and involves the segregation of distinct 
proteins into daughter cells, thereby promoting unique differentiation programs. 
Although it was known that Notch signaling acts postmitotically to orchestrate 
differentiation of daughter cells from asymmetrically dividing precursor cells, 
Bhat reported a previously uncharacterized role for Notch that occurs before 
cell division to promote the asymmetric localization of the protein Numb and the 
positioning of the cleavage furrow. Numb is an inhibitor of Notch activity; 
thus, this mechanism forms a regulatory feedback loop to control asymmetric 
cytokinesis and differentiation.