SUMMARY: RNA-Seq data analysis results in lists of genes that may have a similar 
function, based on differential gene expression analysis or co-expression 
network analysis. While tools have been developed to identify biological 
processes that are enriched in the genes sets, there remains a need for tools 
that identify enrichment of tissue-specific genes. Therefore, we developed 
TissueEnrich, a tool that calculates tissue-specific gene enrichment in an input 
gene set. We demonstrated that TissueEnrich can assign tissue identities to 
single cell clusters and differentiated embryonic stem cells.
AVAILABILITY AND IMPLEMENTATION: The TissueEnrich web application is freely 
available at http://tissueenrich.gdcb.iastate.edu/. The R package is available 
through Bioconductor at https://bioconductor.org/packages/TissueEnrich. Both the 
web application and R package are for non-profit academic use under the MIT 
license.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics 
online.