Calciphylaxis is a rare complication that occurs in 1% of patients with 
end-stage renal disease (ESRD) each year. Extensive microvascular calcification 
and occlusion/thrombosis lead to violaceous skin lesions, which progress to 
nonhealing ulcers with secondary infection, often leading to sepsis and death. 
The lower extremities are predominantly involved (roughly 90% of patients). 
Although most calciphylaxis patients have abnormalities of the calcium-phosphate 
axis or elevated levels of parathyroid hormone, these abnormalities do not 
appear to be fundamental to the pathophysiology of the disorder. We report on a 
case of histologically proven calciphylaxis in a 54-year-old woman with normal 
renal function and normal calcium-parathyroid homeostasis. She had a history of 
alcoholic cardiomyopathy, and was treated with warfarin anticoagulation. She has 
been successfully treated with antibiotics, i.v. biophosphonates and intensive 
local wound care. We recorded a complete wound healing in contrast to what is 
reported in other series.