The IFAP syndrome is characterized by the congenital onset of ichthyosis 
follicularis, absence of hair, and photophobia. A limited number of patients 
with the disorder have been described, and X-linked recessive inheritance has 
been proposed. Two unrelated female patients with a complete IFAP syndrome are 
reported. Both patients show a diffuse distribution of the disorder without 
linear arrangement. Because the suggested X-linked recessive pattern of 
inheritance is unlikely in these patients, a different way of transmission or, 
alternatively, genetic heterogeneity of the disorder has to be considered.