Frailty syndrome is frequently encountered in elderly populations. Frailty has 
been defined as a geriatric syndrome of increased vulnerability to environmental 
factors. Although knowledge of this syndrome continues to develop, there are 
still many areas of uncertainty. The pathophysiological pathways, role of 
biomarkers in the early identification of this syndrome and best management 
strategies are still under investigation. This study is a literature review of 
articles published on frailty syndrome in English, French and Spanish. Frailty 
and aging are similar processes with some differences. Multiple 
pathophysiological models of frailty have been studied. Factors associated with 
frailty include hormonal adjustments, sarcopenia and vitamin deficiencies among 
others. Biomarkers have been studied, but they are not specific. Phenotypes have 
been developed, but early recognition and prevention of this syndrome are still 
difficult. In conclusion, early recognition of this syndrome is of paramount 
importance. Preventative strategies need to be studied. The role of specific 
biomarkers in early detection of frailty needs to be defined. Clinical trials 
are needed to find better interventions for this syndrome.