INTRODUCTION: Necrobiosis lipoidica diabeticorum is a rare disease of unclear 
etiology, that occurs in about 1% of diabetic patients.
CASE REPORT: We present case of granulomatosis disciformis chronica et 
progressiva Miescher with good response to systemic corticosteroids 
therapy.Patient 45 years old woman, with primary yellow-brown areas skin 
lesions, with foci well separated from surroundings on both lower legs, that 
occurred 5 years ago. In laboratory tests there was no abnormalities. Because of 
advance suggestion (after last admit in dermatological ward) of observation 
according to xantogranuloma necrobioticum tests for paraproteinemia were made. 
Immunoelectrophoresis, IgG, IgM, IgA levels, kappa light chain, lambda heavy 
chain; were correct, Bence-Johns protein-negative. During hospitalization in 
Clinic methylprednisolone in dose of 32 mg od, vascular drugs and local 
steroidotherapy was applied with good therapeutic response.
CONCLUSION: We described case of typical clinical and histological characters of 
necrobiosis lipoidica. without diabetes-granulomatosis disciformis chronica et 
progressiva Miescher that despite of suspicion of proper diagnosis for a long 
time was not treat effective.