Osteosarcomas arising in irradiated tissues are uncommon but important 
complications of radiotherapy. Radiation-induced osteosarcomas generally occur 
3-30 years after exposure and are most common after radiotherapy for cervical or 
breast carcinoma. These tumors are usually rapidly growing, extremely painful, 
and histologically high grade. In this paper, we report two cases of high-grade 
post-radiation osteosarcoma of the scapula. Despite being almost identical 
radiologically and pathologically, one case had a typical clinical presentation 
whereas the second case had two unusual features, being non-painful and arising 
in a field initially irradiated for bronchogenic carcinoma.