We performed a study to evaluate the role of three single nucleotide 
polymorphisms (SNPs), factor V Leiden G1691A (FVL), prothrombin gene mutation 
G20210A (PRT or FII-G20210A) and methylenotetrahydrofolate reductase variant 
C677T (MTHFRC677T), as risk factors for G6PD in Saudi populations. Our results 
did not show any association with the three Thrombophilic genes with FVL gene, 
no statistical analysis have shown any association with either allele or 
genotype frequencies OR=0.566, p=.0.667, (95% CI=0.014-22.48) and OR=0.569, 
p=0.251¸ (95% CI=0.014-22.96).In PRT gene G20210A for G Vs A, p=0.774; OR=0.566 
(95%CI; 0.011-29.6); AA+GA Vs GG; p=0.502; OR=0.569 (95%CI=0.010-2969). G and A 
allele frequencies were similar between cases and controls with no statistical 
significance. In the MTHFR gene none of the genotypes or allele frequency cannot 
show any association OR=1.281, p=.0.667, (95% CI=0.414-3.958) and OR=1.1.172, 
p=0.800¸ (95% CI=0.343-4.008). Similarly, the difference of T allele frequencies 
between patients and controls was not found any association. In conclusion, our 
finding indicates that the prevalence of G1691A, G20210A and C677T mutations in 
G6PD deficient individuals is not statistically different compared to normal 
subjects and G6PD is not associated with these thrombophilic mutations in Saudi 
population.