Febrifugine and its derivatives are effective against Plasmodium falciparum. 
Using PHASE algorithm, a five-point pharmacophore model with two hydrogen bond 
acceptor (A), one positively ionizable (P) and two aromatic rings (R), was 
developed to derive a predictive ligand-based statistically significant 
3D-quantitative structure-activity relationship (QSAR) model (r(2) = 0.972, SD = 
0.3, F = 173.4, Q(2) = 0.712, RMSE = 0.3, Person-R = 0.94, and r(2) pred = 0.8) 
to explicate the structural attributes crucial for antimalarial activity. The 
developed pharmacophore model and 3D QSAR model can be a substantial tool for 
virtual screening and related antimalarial drug discovery research.