Cartilage-Hair-Hypoplasia is a rare form of metaphyseal chondrodystrophia. Its 
clinical picture is characterized by dysproportionate deficient growth shift to 
length of upper part of the body. The hair diameter is reduced, and the eyebrows 
are defectly marked. After stimulation by insulin, the levels of somatotropic 
hormone are found in the acromegalic range. The bone structure is rarefied at 
the distal metaphyses of the metacarpals and the proximal metaphyses of the 
finger basal phalanges. The most important roentgenologic symptoms to be found 
are clowdy, cystic rarefactions at the distal femoral metaphyses. As to the 
pathophysiology, deficient proliferation of cartilaginous cells is mentioned in 
literature.