XPC has long been considered instrumental in DNA damage recognition during 
global genome nucleotide excision repair (GG-NER). While this recognition is 
crucial for organismal health and survival, as XPC's recognition of lesions 
stimulates global genomic repair, more recent lines of research have uncovered 
many new non-canonical pathways in which XPC plays a role, such as base excision 
repair (BER), chromatin remodeling, cell signaling, proteolytic degradation, and 
cellular viability. Since the first discovery of its yeast homolog, Rad4, the 
involvement of XPC in cellular regulation has expanded considerably. Indeed, our 
understanding appears to barely scratch the surface of the incredible potential 
influence of XPC on maintaining proper cellular function. Here, we first review 
the canonical role of XPC in lesion recognition and then explore the new world 
of XPC function.