Glioblastoma is the most common and most lethal brain tumour in humans. 
Illustrating the functions being disturbed during carcinogenesis and how they 
are deregulated is very important for us to understand its underlying mechanism. 
Transcriptional aberrations may play a vital role in the etiology of 
glioblastoma, which might be caused by both genomic alterations and other 
regulation molecules. In this study, we investigated possible cooperative 
deregulation of microRNAs (miRNAs) and transcription factors (TFs) in 
glioblastoma, under the hypothesis that miRNAs and TFs might have a 
combinational regulatory effect on glioblastoma genes. We searched 
glioblastoma-specific regulatory networks by integrating glioblastoma related 
miRNAs, TFs and genes, and identified 54 feed-forward loops (FFLs). Follow up 
functional enrichment analysis of these FFLs uncovered some functions important 
to carcinogenesis but also some unique functions specific to the FFLs we 
identified.