Cytogenetic re-evaluation of a fibroblast cell line from a female Hunter's 
syndrome case with a balanced X;autosome translocation, which had previously 
been reported to have a breakpoint in Xq26 to Xq27, showed the breakpoint to be 
either between Xq27 and Xq28 or within Xq28. The normal X chromosome was 
preferentially inactivated, supporting the view that the translocation had 
disrupted the Hunter gene. The new localisation is now in full agreement with 
our previous linkage work and other published data. Results of further linkage 
studies using probes defining the loci DXS86, DXS144, DXS100, DXS102, DXS105, 
F8C, and DXS134 are also consistent with our original conclusion that the Hunter 
locus lies within the distal region of the X chromosome long arm.