Huntington's disease (HD) is a neurological condition of progressive course that 
results from abnormally increased number of CAG repeats within IT-15 gene, 
coding for huntington. The main symptoms consist of choraetic movements, 
dementia, and characteropathy. The aim of the present study was to search for 
possible correlation between the age of the onset of HD, time from the onset, 
clinical status of the patients, and CAG repeats number. Ten patients were 
studied altogether. Modified UHDRS (MUHDRS) was applied for the estimation of 
patients' clinical status. The number of CAG repeats in examination of the IT-15 
gene was determined by polymerase chain reaction (PCR) and separation of 
radioisotope labelled PCR product against DNA size marker in polyacrylamide gel. 
A negative significant correlation was found between the CAG repeats number and 
the disease onset age (r = -0.67; p < 0.05) and MUHDRS score (r = 0.75; p < 
0.05), as well. Negative significant correlation between time from the onset and 
MUHDRS score (r = -0.95; p < 0.05) and negative correlation between summarised: 
time from the onset and CAG number on the one site and MUHDRS on the other (p = 
-0.91) were found, as well. Our findings indicate an interdependence between CAG 
repeats number within the IT-15 gene, the course of the disease and the clinical 
status of HD patients.