Pyostomatitis vegetans is a disease of the gingiva and the oral mucosa with 
noticeable, uncommon morphology. Clinical characteristics of this rare disease 
and considerations regarding differential diagnosis are described. Pyostomatitis 
vegetans is frequently associated with chronic inflammatory bowel diseases and 
can, thus, give a diagnostic hint at an existing ulcerative colitis or Crohns 
disease. A therapy plan for pyostomatitis vegetans is presented, which led to 
remission using local treatment only. The follow-up examination after one year 
showed that the treatment outcome had remained stable. An unexpected clinical 
appearance of the gingiva with small, pale pink thickenings after therapy and at 
follow-up is portrayed.