The organoid model represents a major breakthrough in cell biology that has 
revolutionised biomedical research. Organoids are 3D physiological in vitro 
structures that recapitulate morphological and functional features of in vivo 
tissues and offer significant advantages over traditional cell culture methods. 
Liver organoids are of particular interest because of the pleiotropy of 
functions exerted by the human liver, their utility to model different liver 
diseases, and their potential application as cell-based therapies in 
regenerative medicine. Moreover, because they can be derived from patient 
tissues, organoid models offer new perspectives in personalised medicine and 
drug discovery. In this review, we discuss the current liver organoid models for 
the study of liver disease.