Burning mouth syndrome (BMS) is defined as a chronic pain condition, 
characterized symptomatically by a generalized or localized burning sensation in 
the oral cavity. Various drugs have been used in attempting to treat BMS, but 
there is insufficient evidence to show the effect of any effective treatment. 
The aim of this review was to assess the effectiveness of therapies for BMS. 
Randomized controlled trials (RCTs) enrolling patients with a diagnosis of BMS 
were identified by searching Pubmed and Scoppus databases. The methodological 
quality of included studies was assessed on the basis of the method of 
allocation concealment, blindness of the study, loss of participants, size 
sample, and outcome concealment. A total of 12 relevant articles were analyzed. 
Therapies that used capsaicin, alpha-lipoic acid (ALA), and clonazepam were 
those that showed more reduction in symptoms of BMS. However, many studies of 
therapeutic interventions in BMS lack consistency in their results, because they 
use in their methodology, sample and a relatively short time of therapy and 
often do not provide a follow-up of patients treated. Thus, future studies are 
required to establish the treatment for patients suffering from this chronic and 
painful syndrome.