A 4-year-old cocker spaniel, male, of 12kg body weight was presented because of 
the onset of polyuria or polydipsia. From the first months of its life, the dog 
had exhibited constant serous to mucopurulent nasal discharge, productive cough, 
sneezing, reverse sneezing, otitis, and recurrent episodes of fever. The 
respiratory signs had been treated several times with antibiotics, without ever 
achieving a complete resolution. Clinical examination revealed normal rectal 
temperature (38.3°C), increased respiratory rate (40breaths/min), a copious 
mucous nasal discharge and right deviation of the heart apex beat (ictus 
cordis). Increased respiratory sounds with moist rales and crackles were found 
on chest auscultation. An increase in serum creatinine, urea and phosphorus, 
hypoalbuminemia and proteinuria were found. Lateral and ventrodorsal radiographs 
of the thorax and of the abdomen showed the transposition of the heart, with the 
cardiac apex pointing toward the right (dextrocardia), bronchointerstitial lung 
pattern, areas of consolidation, lesions consistent with bronchiectasis caves 
and a mirror-image of abdominal organs, confirming the diagnosis of complete 
situs inversus (CSI). Respiratory signs, combined with CSI, suggested the 
diagnosis of Kartagener syndrome (KS). Abdominal ultrasound showed an increase 
in the echogenicity of the renal parenchyma, a loss of definition of the 
corticomedullary line, slight bilateral pyelectasis, and decreased cortical 
perfusion. The dog died 2 months later because of a further worsening of the 
clinical condition. Necroscopy demonstrated the existence of CSI, 
rhinosinusitis, bronchitis, and bronchiectasis, so confirming the diagnosis of 
KS, and renal amyloidosis. This is the first case reported in veterinary 
medicine of the presence of renal amyloidosis together with KS in a dog.