The Transient Receptor Potential Melastatin 2 (TRPM2) is a member of G protein 
coupled receptor superfamily and a novel dual-function protein that possesses 
both ion channel and Adenosine 5'-DiphosPhatase Ribose (ADPR) hydrolase 
function. TRPM2 is involved in Ca2+ signaling in various cells as an endogenous 
redox sensor for oxidative stress and reactive oxygen species, and contributes 
to cytokine production, insulin release, motility, Ca2+ entry and Ca2+-dependent 
cellular reactions such as endothelial hyper-permeability and apoptosis. The 
wide expression of TRPM2 might render it as a potentially significant 
therapeutic target in pathological settings including cardiovascular and 
neurodegenerative diseases and of great relevance in drug design, feed additives 
and other industries. Here, we discuss the TRPM2 gene structure, function, its 
variants, as well as its activators and inhibitors and provide a peptide drug 
design for modulation of oxidative stress.