The Melkersson-Rosenthal Syndrome consists of recurrent edema of the lips, 
intermittent facial edema and a furrowed tongue. This is the classic triad which 
defines the syndrome, although it is accepted that the presence of two 
manifestations is sufficient to make the diagnosis. Distribution is universal 
although the majority of the cases are described in the European literature. The 
case of a 37 year-old female is presented. She came to consult for persistent 
edema of the upper lip, of a three-year duration, which started abruptly without 
any clear etiologic correlation with acute episodes that disappear spontaneously 
or with corticoid treatment. Associated symptoms included migraine headaches 
which started years earlier. The complimentary examinations were normal except 
for a mild elevation of the sedimentary rate, and the biopsy was compatible with 
granulomatous cheilitis. In conclusion, MRS has to be considered as a diagnostic 
possibility in a patient who consulted for recurrent edema associated with other 
dermatologic and neurologic manifestations, although not necessarily having the 
complete triad.