We report the case of a 71-year-old man with diagnosis of aortic valve stenosis 
for ten years, who came to hospital because of breathlessness during the 
previous two months and recent low intestinal hemorrhage. On admission, 
laboratory tests and upper gastrointestinal endoscopy and colonoscopy revealed 
anemia and bleeding cecal angiodysplasia. The echocardiography study showed a 
severe aortic stenosis. Classical Heyde syndrome is described as the association 
of aortic stenosis, bleeding gastrointestinal angiodysplasia and secondary 
anemia. The antecedent of mediastinal radiotherapy for treatment of Hodgkin's 
disease during his youth, and eventual late cardiac adverse effects that may 
include aortic or mitral valve disturbances are highlighted. Electrocoagulation 
with argonium was performed on the sites of active bleeding during the 
colonoscopy. In sequence, surgical replacement by bioprothesis was done on the 
aortic valve. The patient remains asymptomatic, under long-term outpatient 
surveillance, with normal control evaluations. The aim of this case study is to 
emphasize difficulties related to diagnosis, and to highlight the role of 
endoscopy and imaging studies to confirm a hypothesis of this underestimated 
condition.