Morton's neuroma is a painful lesion of the interdigital nerve, usually at the 
third intermetatarsal space, associated with fibrotic changes in the nerve, 
microvascular degeneration, and deregulation of sympathetic innervation. 
Patients usually present with burning or sharp metatarsalgia at the dorsal or 
plantar aspect of the foot. The management of Morton's neuroma starts with 
conservative measures, usually with limited efficacy, including orthotics and 
anti-inflammatory medication. When conservative treatment fails, a series of 
minimally invasive ultrasound-guided procedures can be employed as second-line 
treatments prior to surgery. Such procedures include infiltration of the area 
with a corticosteroid and local anesthetic, chemical neurolysis with alcohol or 
radiofrequency thermal neurolysis. Ultrasound aids in the accurate diagnosis of 
Morton's neuroma and guides the aforementioned treatment, so that significant 
and potentially long-lasting pain reduction can be achieved. In cases of initial 
treatment failure, the procedure can be repeated, usually leading to the 
complete remission of symptoms. Current data shows that minimally invasive 
treatments can significantly reduce the need for subsequent surgery in patients 
with persistent Morton's neuroma unresponsive to conservative measures. The 
purpose of this review is to present current data on the application of 
ultrasound for the diagnosis and treatment of Morton's neuroma, with emphasis on 
the outcomes of ultrasound-guided treatments.