INTRODUCTION: Isolated left ventricular non-compaction is a recently described 
form of cardiomyopathy that is associated with a significant risk of 
life-threatening arrhythmia and thromboembolic complications.
CASE PRESENTATION: We report the presentation, diagnosis and management of 
isolated left ventricular non-compaction in a 54-year-old Caucasian woman 
presenting with progressive symptoms of heart failure.
CONCLUSION: Advances in diagnostic imaging have undoubtedly led to an increase 
in the detection of isolated left ventricular non-compaction. Diagnosing and 
differentiating this uncommon condition from other forms of cardiomyopathy are 
important as treatment and prognosis may differ significantly. Our current 
understanding of isolated left ventricular non-compaction, including diagnostic 
criteria, management and prognosis, is discussed.