INTRODUCTION: Paraneoplastic neurological syndromes are rare non-metastatic 
complications of cancer that have an immune-mediated etiology. The Lambert-Eaton 
myasthenic syndrome (LEMS) is a neuromuscular disorder, often associated with 
small cell lung carcinoma (SCLC), which is characterized by reduced quantal 
release of acetylcholine from the motor nerve terminals. LAMBERT-EATON 
MYASTHENIC SYNDROME: The Lambert-Eaton Myasthenic Syndrome (LEMS) is 
characterized by proximal muscle weakness initially affecting gait, autonomic 
symptoms (dry mouth, constipation, erectile failure) and augmentation of 
strength during initial voluntary activation. Symptomatic treatment of the 
junctional disorder is based on cholinergic drugs, immunosuppression, 
immunomodulation and physical therapy useful in case of unsuccessful 
antineoplastic therapy.
CASE REPORT: A rare case of ovarian cancer with Eaton-Lambert syndrome is 
reported. A 50-year-old woman was admitted to the gynecologic department, 
complaining of weakness and pain in her arms and shoulders. Physical therapy 
resulted in partial improvement. Treatment of paraneoplastic syndrome markedly 
improves the quality of life of cancer patients. Patients presenting with this 
syndrome should undergo a careful evaluation for the presence of an occult 
malignancy.