The nonnucleoside reverse transcriptase inhibitors UC-781 and TMC120-R147681 
(Dapivirine) effectively prevented human immunodeficiency virus (HIV) infection 
in cocultures of monocyte-derived dendritic cells and T cells, representing 
primary targets in sexual transmission. Both drugs had a favorable therapeutic 
index. A 24-h treatment with 1,000 nM UC-781 or 100 nM TMC120-R147681 prevented 
cell-free HIV infection, whereas 10-fold-higher concentrations blocked 
cell-associated HIV.