The current evidence does not support the indiscriminate use of vitamins A, C, 
or E or beta carotene to prevent or reduce cardiovascular disease. Despite a 
plausible theory that antioxidants can prevent diseases caused by oxidative 
damage, trials thus far have not proven this. In fact, some studies found 
antioxidants may be harmful in some people. We review important studies of the 
effects of four antioxidants (vitamins A, C, and E, and beta carotene) and 
analyze whether the current evidence supports or confirms or rejects the 
presumed protective role.