Amiodarone, a class III antiarrhythmic drug, is one of the most effective drugs 
used in the treatment of ventricular and paroxysmal supraventricular 
tachyarrhythmia. Adverse effects of amiodarone including pulmonary toxicity, 
hepatotoxicity, aggravation of arrhythmia, and thyroid diseases are well 
understood. A 66-year old woman with acute pancreatitis was admitted to our 
hospital with the complaint of epigastralgia radiating to both flanks for two 
months. Her symptoms and elevation of pancreatic enzymes did not respond to 
conventional medical treatment of pancreatitis for 18 d. No known causal factors 
for pancreatitis such as biliary tract stone, hypertriglyceridemia and alcohol 
consumption could be identified. Under the suspicion of amiodarone-induced acute 
pancreatitis, amiodarone was substituted by propafenone. Her symptoms soon 
alleviated and serum lipase level declined. Three months after hospital 
discharge, the abdominal pain did not recur. Amiodarone was approved to treat 
recurrent ventricular fibrillation or sustained ventricular tachyarrhythmia that 
has been resistant to other medications since 1986. Pancreatitis is a very rare 
adverse effect associated with the use of amiodarone, and only four cases of 
amiodarone-induced pancreatitis have been reported in literature. We report a 
patient who developed acute pancreatitis during amiodarone therapy.