INTRODUCTION: The EORTC QLQ-INFO25 evaluates the information received by cancer 
patients. This study assesses the psychometric properties of the QLQ-INFO25 when 
applied to a sample of Spanish patients.
MATERIALS AND METHODS: A total of 169 patients with different cancers and stages 
of disease completed the EORTC QLQINFO25, the EORTC QLQ-C30 and the information 
scales of the inpatient satisfaction module EORTC IN-PATSAT32 on two occasions 
during the patients' treatment and follow- up period. Psychometric evaluation of 
the structure, reliability, validity and responsiveness to changes was 
conducted. Patient acceptability was assessed with a debriefing questionnaire.
RESULTS: Multi-trait scaling confirmed the 4 multi-item scales (information 
about disease, medical tests, treatment and other services) and eight single 
items. All items met the standards for convergent validity and all except one 
met the standards of item discriminant validity. Internal consistency for all 
scales (α>0.70) and the whole questionnaire (α>0.90) was adequate in the three 
measurements, except information about the disease (0.67) and other services 
(0.68) in the first measurement, as was test-retest reliability (intraclass 
correlations >0.70). Correlations with related areas of IN-PATSAT32 (r>0.40) 
supported convergent validity. Divergent validity was confirmed through low 
correlations with EORTC QLQ-C30 scales (r<0.30). The EORTC QLQ-INFO-25 
discriminated among groups based on gender, age, education, levels of anxiety 
and depression, treatment line, wish for information and satisfaction. One scale 
and an item showed changes over time.
CONCLUSIONS: The EORTC QLQ-INFO 25 is a reliable and valid instrument when 
applied to a sample of Spanish cancer patients. These results are in line with 
those of the EORTC validation study.