A limited number of overexpressed transcription factors are associated with 
cancer progression in many types of cancer. BTB and CNC homology 1 (BACH1) is 
the first mammalian heme-binding transcription factor that belongs to the basic 
region leucine zipper (bZIP) family and a member of CNC (cap 'n' collar). It 
forms heterodimers with the small musculoaponeurotic fibrosarcoma (MAF) proteins 
and stimulates or suppresses the expression of target genes under a very low 
intracellular heme concentration. It possesses a significant regulatory role in 
heme homeostasis, oxidative stress, cell cycle, apoptosis, angiogenesis, and 
cancer metastasis progression. This review discusses the current knowledge about 
how BACH1 regulates cancer metastasis in various types of cancer and other 
carcinogenic associated factors such as oxidative stress, cell cycle regulation, 
apoptosis, and angiogenesis. Overall, from the reported studies and outcomes, it 
could be realized that BACH1 is a potential pharmacological target for 
discovering new therapeutic anticancer drugs.