C-Jun activation domain-binding protein-1 (Jab1) not only is full but also a 
subunit (CSN5) of the constitutive photomorphogenesis 9 signalosome (CSN), which 
is an evolutionarily conserved and multifunctional protein that involves in 
controlling cellular proliferation and apoptosis, affecting a series of 
pathways, as well as regulating genomic instability and DNA damage and repair. 
The CSN is a highly conservative protein from yeast to human and interacts with 
the cullin-RING family of ubiquitin ligases so that it could be execute a 
process of removing NEDD8, a ubiquitin-like polypeptide (deneddylase activity). 
The role of Jab1/CSN5's multi-function has been proved as being oncogenic in 
nature, what is more, Jab1/CSN5 has been confirmed by much evidence that it 
participates in the carcinogenesis progression and is tightly associated with 
poor prognosis. However, the biologic implication of Jab1/CSN5 activity during 
the cancer's development is unclear. We performed a systematic literature review 
and assessment from PubMed and Medline databases in this article. Jab1/CSN5 is 
participate in a lot of biologic responses, including cell proliferation, 
apoptosis, cell cycle regulation, DNA metabolism, invasion, DNA damage and 
repair, and recurrence. It also promotes cell transformation and tumorigenesis. 
In this review, we mainly expound the progress in the function and research 
advances of Jab1/CSN5 and in untangling the Jab1/CSN5 signaling pathway. Based 
on these bases, its potential as a therapeutic target for cancer can play a 
greater role in future cancer treatment.