TRPM2 is a recently identified TRPM family cation channel which is unique among 
known ion channels in that it contains a C-terminal domain which is homologous 
to the NUDT9 ADP-ribose hydrolase and possesses intrinsic ADP-ribose hydrolase 
activity. Here, available information on the TRPM2 gene, transcripts, predicted 
protein products, and assembled multimeric channels is comprehensively reviewed 
and synthesized to highlight important areas for future work and provide insight 
into potential biological function(s) of TRPM2 channels.