Keratolenticular dysgenesis (Peters' anomaly) was induced in mice by exposure to 
the human teratogens, ethanol or 13-cis retinoic acid (isotretinoin, Accutane). 
Acute teratogen exposure on the seventh day of gestation (corresponding to the 
third week of human gestation) resulted in an eye malformation incidence of 46% 
to 100% in day 14 fetuses. Of the abnormal eyes, 10% to 29% demonstrated failure 
of detachment of the lens from the surface ectoderm. Delayed lens detachment was 
seen as anterior lenticonus in 33% to 35% of the abnormal eyes. Abnormal lens 
detachment appeared to result in mechanical interference with neural crest 
migration to form the corneal stroma and endothelium, and iris stroma. This 
secondary effect on neural crest derivatives is exhibited in the adult animals 
as corneal opacities associated with defects in Descemet's membrane and 
endothelium, and anterior polar cataracts.