Two recent studies have reported the association of rs75932628-T in the TREM2 
gene with the risk for Alzheimer's disease (AD). Rs75932628-T is a rare 
nonsynonymous variant (p.R47H) that confers a high risk of AD with an effect 
size similar to that of the APOE ɛ4 allele. However, this association has not 
been replicated in any independent studies to date. The allelic frequency of 
rs75932628 varies according to the population from 0.02% to 0.63% among healthy 
controls. In an attempt to replicate the association between rs75932628-T and AD 
risk, we genotyped rs75932628 in a cohort of 504 AD subjects and 550 healthy 
controls from a Spanish population. Rs75932628-T showed a minor allele frequency 
of 0.3% among this cohort. Interestingly, in our study, rs75932628-T was found 
exclusively in 1.4% of AD cases (7/504), including 4 early-onset AD cases, and 
in none of the controls (n = 0/550). Here, we report the first positive 
replication study in a Spanish population and confirm that TREM2 rs75932628-T is 
associated with the risk for AD.