BACKGROUND: Hyperbilirubinemia in living liver donor is very common, but the 
causes are still unclear.
AIMS: We sought to clarify the risk factors and predictors of nonobstructive 
hyperbilirubinemia among living donors.
METHODS: We divided 210 consecutive right liver lobe donors into two groups 
according to the peak total bilirubin postoperatively. We collected data on 
preoperative, intraoperative, and postoperative biochemical measurements 
retrospectively, performing multivariate logistic regression analysis adjusting 
for potential confounders of the risk of hyperbilirubinemia.
RESULTS: There were significant differences between the two groups in donor age, 
body mass index, operative time, blood loss, macrovescicular steatosis, 
allogeneic blood transfusion rate, intensive care unit stay, hospital stay and 
Clavien score after donation (P < .05). Age, graft/donor weight, operative time, 
and blood loss were significantly associated with the risk of hyperbilirubinemia 
upon logistic regression analysis.
CONCLUSION: Hyperbilirubinemia, one type of hepatic dysfunction after a living 
donor procedure, was associated with multiple independent risk factors.