Non-small cell lung cancer (NSCLC) is one of leading causes of cancer-related 
death worldwide. Long noncoding RNAs (lncRNAs) has been identified to modulate 
the tumorigenesis of NSCLC. However, the precise molecular mechanism of lncRNAs 
in the course is still unclear. Results showed that LINC00339 was significantly 
up-regulated in NSCLC tissue and cells, which indicated the poor prognosis of 
NSCLC patients. Loss-of-function experiments showed that LINC00339 silencing 
inhibited the proliferation and invasion, accelerated the apoptosis, and 
suppressed the tumor growth of NSCLC cells in vitro and in vivo. Luciferase 
reporter assay and RNA immunoprecipitation (RIP) revealed that LINC00339 
promoted the NSCLC progression via FOXM1 via targeting miR-145. In conclusion, 
our results identify the important role of the LINC00339/miR-145/FOXM1 axis in 
the NSCLC tumorigenesis, providing neoteric mechanism for the NSCLC 
tumorigenesis.