Pupil is richly innervated by autonomic nerves. Therefore, its size or movement 
well reflects the autonomic nervous function. By analyzing dynamics of pupil 
movement for light stimulus followed by infrared video-pupillography, the 
abnormality of autonomic nervous system can be expressed in a quantitative 
manner. Clinical applications of pupillography and pharmacological examination 
to Horner syndrome, Adie syndrome, diabetes mellitus, pupillary involvement of 
Behçet disease, pupil of brain death and patients with chemical sensitivity have 
been described. Segmental spasm of iris in Horner and Aide syndrome, especially, 
nasal side of iridoplegia was seen in early stage of Aide syndrome from 
pupillary dynamics to light stimulus. An involvement of sympathetic nerve 
subserving iris dilator muscle was confirmed from pupillography, drug reaction 
to topically applied l-epinephrine in the diabetics. An involvement of 
cholinergic nerve which subserve the iris sphincter muscle was seen in Behçet 
disease when there was no manifest eye involvement. Mild mydriasis in brain 
death patients was seen under denervation of central nervous system. Dysfunction 
of sympathetic nerve from pupillary light reflex in chemically sensitive 
patients for cholinated hydrocarbon pesticides.