Evolving research has demonstrated that surgical cytoreduction of a high-grade 
glial neoplasm is an important factor in improving the prognosis of these 
difficult tumors. Recent advances in intraoperative imaging have spurred the use 
of stereotactic laser ablation (laser interstitial thermal therapy [LITT]) for 
intracranial lesions. Among other targets, laser ablation has been used in the 
focal treatment of high-grade gliomas (HGGs). The revived application of laser 
ablation for gliomas parallels major advancements in intraoperative adjuvants 
and groundbreaking molecular advances in neuro-oncology. The authors review the 
research on stereotactic LITT for the treatment of HGGs and provide a potential 
management algorithm for HGGs that incorporates LITT in clinical practice.