An 18-year-old Indian girl with upper lip deformity presented with on and off 
painless swelling of her both upper eyelids for 3 years. Clinical evaluation 
revealed bilateral blepharochalasis, narrowing of horizontal palpebral fissure, 
decreased outer intercanthal distance, iris coloboma, cleft soft palate, bifid 
uvula, sensorineural deafness and double upper lip. Clinical examination of the 
thyroid, thyroid hormone assay and ultrasonography revealed normal thyroid gland 
structure and function. Ascher's syndrome was diagnosed. To our knowledge, this 
is the first reported case of Ascher's syndrome associated with iris coloboma, 
heterochromia iridum, and narrowing of horizontal palpebral fissure and 
decreased outer intercanthal distance secondary to lengthening of lateral 
canthal ligament.