Gastric cancer is one of the most common tumors of the digestive system. Here, 
analysis of the expression profiles of circular RNAs in advanced gastric 
adenocarcinoma and adjacent normal mucosa tissues revealed differential 
expression of 306 circular RNAs, among which 273 were predicted to exert 
regulatory effects on target microRNAs. The downstream pathway networks of 
circular RNA-microRNA were mapped and the node genes were identified. In 
particular, we found that the expression of hsa_circ_0058246 was elevated in 
tumor specimens of patients with poor clinical outcomes. Our collective findings 
indicate that circular RNAs play a critical role in gastric cancer 
tumorigenesis. Data from this study provide a new perspective on the molecular 
pathways underlying metastasis and recurrence of gastric cancer and highlight 
potential therapeutic targets that may contribute to more effective diagnosis 
and treatment of the disease.