We report here the clinical and immunological findings in two patients with 
molluscum contagiosum poxvirus infection and the acquired immunodeficiency 
syndrome (AIDS). These cases support earlier evidence that the molluscum 
contagiosum virus may act as cases support earlier evidence that the molluscum 
contagiosum virus may act as an opportunistic pathogen. There is now evidence 
that members of all five families of double stranded DNA-containing human 
viruses have been associated with unusual clinical manifestations in AIDS 
patients, and the significance of DNA virus infections in patients with AIDS is 
discussed.