Chronic kidney disease (CKD) increases the risk of all-cause mortality and 
cardiovascular disease as well as progression to end stage kidney failure. The 
relationship of glomerular filtration rate (GFR) and albuminuria with clinical 
outcomes in the general population are revealed. This allows to present levels 
of GFR and microalbuminuria (MA), which increases the risk of mortality. Renal 
dysfunction, which revealed by the level of GFR and creatinine, can have 
definite role in hemodynamic changes and heart failure progression. For 
mentioning the interaction of cardiovascular and renal diseases the cardiorenal 
syndrome (CRS) term was introduced, with its classification on 5 types, 
according to the presence of acute/chronic heart failure and primary/secondary 
origination of heart and kidney injury. We study interrelations between 
echocardiographic data of left ventricular remodeling, MA level and degree of 
renal dysfunction in 115 patients with CRS. MA was measured with diagnostic 
strips, contractile function of left ventricle (LV) - by echocardiography and 
GFR was assessed by Cocroft-Gault method. The association between MA with 
decreased GFR and elevated creatinine levels and its connection with increased 
LV myocardial mass and preclinical disturbances of LV systolic function was 
revealed. We determined direct correlation between MA and myocardial mass index 
and indirect - between ejection fraction of LV and MA. Obtained data allow to 
mention the level of MA (25,4±5,8 ng/ml) in which there is more probability of 
LV contractile functional changes, which will allow early prediction and 
prevention of CRS progression and pathogenetically approved pharmacotherapy 
organization in this category patients.