No published case of Wolman's disease has described the prenatal sonographic 
findings. We present a case in which a third-trimester sonographic examination 
demonstrated fetal hepatomegaly and bilateral adrenal echogenicity suggestive of 
diffuse calcification. Wolman's disease, also known as lysosomal acid lipase 
(LIPA) deficiency, is a rare autosomal-recessive disorder characterized by 
complete absence of the LIPA enzyme. The diagnosis of Wolman's disease was made 
postnatally by biochemical testing, which indicated absence of LIPA enzyme 
activity and gene sequencing, which confirmed homozygosity for the G66V mutation 
within the LIPA gene. © 2017 Wiley Periodicals, Inc. J Clin Ultrasound 46:66-68, 
2018.