Heyde's syndrome was first proposed in 1958. It refers to gastrointestinal 
haemorrhage resulting from a combination of aortic stenosis with angiodysplasia. 
This report explores the case of a 93-year-old lady who was admitted to hospital 
following a neck of femur fracture. She suffered from multiple comorbidities 
including renal failure and congestive heart failure secondary to critical 
aortic stenosis. As an inpatient she suffered an exacerbation of both her heart 
and renal failure postoperatively. A week later she suffered from heavy upper 
gastro-intestinal bleeding, which failed to respond to pharmacological and 
endoscopic therapies as well as angiographic embolisation. The pathophysiology 
of Heyde's syndrome: an acquired von Willebrand deficiency syndrome has a much 
wider impact than was commonly thought, both in terms of how common it is and in 
how the association may be extrapolated to a wide range of bleeding disorders, 
rather than simply angiodysplasia associated gastrointestinal haemorrhage.