SARS-CoV-2, a member of the family coronaviridae, has triggered a lethal 
pandemic termed coronavirus disease 2019 (COVID-19). Pediatric patients, mainly 
from families with a cluster of infection or a history of exposure to epidemic 
areas, get infected via direct contacts or air-borne droplets. Children (aged 
below 18 years) are susceptible to COVID-19, with an average incubation period 
of about 6.5 days. Most cases present asymptomatic or common cold symptoms such 
as fever, cough, and myalgia or fatigue, which is milder than adult patients. 
Besides, most abnormal laboratory and radiologic findings in children with 
COVID-19 are non-specific. Since no specific chemotherapeutic agents have been 
approved for children, timely preventive methods could effectively forestall the 
transmission of SARS-CoV-2. To date, mostly studied cases have been adults with 
COVID-19, whereas data on pediatrics patients remain poorly defined. We herein 
conducted a literature review for papers published in PubMed and medRxiv 
(preprints) between December 2019 and December 2020 that reported on pediatrics 
patients (aged below 18 years) with a confirmed COVID-19 diagnosis. In this 
review, we summarized and discussed the pathogenesis, epidemiology, and clinical 
management of COVID-19 in pediatrics patients to improve our understanding of 
this new disease in children.