POEMS syndrome is a paraneoplastic manifestation associated with hematopoietic 
disorders such as multiple myeloma and Castleman disease. POEMS is an acronym 
for the main clinical features of the syndrome, namely, Polyneuropathy, 
Organomegaly, Endocrinopathy, M protein, and Skin abnormalities. Glomeruloid 
hemangiomas are considered to be a specific clinical marker of POEMS syndrome. 
However, while they are not pathognomonic, their presence should raise suspicion 
of this syndrome or alert clinicians to its possible future development, as 
these lesions can appear years before the onset of the syndrome. We report the 
cases of 2 women with plasma cell dyscrasias and sudden onset of lesions with a 
vascular appearance and histologic findings consistent with glomeruloid 
hemangioma. Recognition of this vascular tumor is important for the early 
diagnosis of POEMS syndrome.