The authors report a male patient, a seller with no detected immunosuppression, 
with an extensive ulcerated skin lesion localized on the left forearm, caused by 
Cryptococcus neoformans var. gattii serotype B. Oral treatment with fluconazole 
was successful. A review of the literature showed the rarity of this 
localization in HIV-negative patients. In contrast, skin lesions frequently 
occurs in HIV-positive patients, with Cryptococcus neoformans var. neoformans 
serotype A predominating as the etiological agent. In this paper, the 
pathogenicity of C. neoformans to skin lesions in patients immunocompromised or 
not, is discussed, showing the efficacy of fluconazole for the treatment of 
these processes.