Primary Meige syndrome is an idiopathic movement disorder that manifests as 
craniofacial and often cervical dystonias. Deep brain stimulation (DBS) of the 
globus pallidus internus (GPi) has emerged as a powerful surgical option in the 
treatment of primary generalized or segmental dystonia. However, the experience 
with GPi-DBS in Meige syndrome is limited. We followed 5 patients with disabling 
Meige syndrome treated by bilateral GPi-DBS for 49 ± 43.7 (mean ± SD) months. 
All patients were assessed before surgery and at the last follow-up after 
surgery using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS) which 
includes both the movement and disability scales. Bilateral GPi-DBS produced a 
sustained and long-lasting improvement in dystonia symptoms associated with 
Meige syndrome. At the last follow-up, the mean scores of BFMDRS movement and 
disability scales improved significantly by 84 ± 6.8% (range, 75-94%) and 
89 ± 8.1% (range, 80-100%), respectively. Bilateral pallidal stimulation is a 
beneficial therapeutic option for long-term relief of the disabling dystonia 
symptoms in Meige syndrome.