Bartter syndrome is an autosomal recessive disorder caused by gene mutations 
that involve hypokalaemia, hypochloraemia and metabolic alkalosis along with 
raised serum renin, hyperaldosteronism and normal blood pressure. We report two 
cases of neonatal Bartter syndrome. Case 1 was a product of non-consanguineous 
marriage and mother had unexplained polyhydramnios in pregnancy while case 2 was 
a product of consanguineous marriage. Both cases were diagnosed based on 
hypokalaemia, hypochloraemia and metabolic alkalosis along with elevated serum 
renin and aldosterone levels. Case 1 positively responded to indomethacin while 
case 2 had Protein C and S deficiency and sepsis as coexisting diseases and thus 
could not be given indomethacin and expired. Regular antenatal visits can help 
in diagnosis of the syndrome particularly if unexplained poly hydramniosis 
investigated .