Progeria is sporadic, very rare, autosomal dominant, deadly childhood disorder. 
It is one of the progeroid syndromes also known as Hutchinson-Gilford progeria 
syndrome (HGPS). Aging is a developmental process that begins with fertilization 
and ends up with death involving a lot of environmental and genetic factors. The 
disease firstly involves premature aging and then death from complications of 
atherosclerosis such as myocardial infarction, stroke, atherosclerosis, or heart 
failure. The lifespan of the patient is normally up to teen age or early 
twenties. It is usually not inherited because a patient normally dies before the 
age of reproduction. The most important genetic linkage between progeria and 
aging is shortening of telomere ends with each replication cycle. The patients 
are normally observed to have extremely short telomeres. Currently, 90% of the 
patients are said to have de novo point mutations in the LMNA gene that 
substitute cytosine with thymine and have been found in individuals with HGPS. 
Lmna encodes lamins A and C, and the A-type lamins have important structural 
function in the nuclear envelope. The most common type of HGPS mutation is 
located at codon 608 (G608G). It could not be diagnosed at birth, but after the 
age of 2 years, visible, prominent symptoms can be observed. Still, lot of 
research is needed to solve this mystery; hopefully, future research on HGPS 
would provide important clues for progeria and other fatal age-related 
disorders.