CHD7 is a member of the chromodomain helicase DNA binding domain (CHD) family of 
ATP-dependent chromatin remodelling enzymes. It is mutated in CHARGE syndrome, a 
multiple congenital anomaly condition. CHD7 is one of a subset of CHD proteins, 
unique to metazoans that contain the BRK domain, a protein module also found in 
the Brahma/BRG1 family of helicases. We describe here the NMR solution structure 
of the two BRK domains of CHD7. Each domain has a compact betabetaalphabeta 
fold. The second domain has a C-terminal extension consisting of two additional 
helices. The structure differs from those of other domains present in 
chromatin-associated proteins.