Based on present publications we review indications of the therapy of dermatoses 
with thalidomide as well as possible mechanisms of action and side effects of 
this drug. In reactional states of leprosy the use of thalidomide is 
established. Further indications are chronic cutaneous lupus erythematosus, 
prurigo nodularis, and eventually recurrent aphthosis and certain 
photodermatoses not responding to usual treatment. Therapeutical trials of 
thalidomide in diseases in which such a treatment is only occasionally or not at 
all mentioned in the literature will be reported. Concerning the mechanisms of 
action emphasis is put on a possible immunosuppression by thalidomide. Among the 
side effects the thalidomide neuropathy is stressed.