BACKGROUND: Pathogenic mutations in leucine-rich repeat kinase 2 (LRRK2; PARK8) 
encoding dardarin, implicated in patients with autosomal dominant and sporadic 
Parkinson's disease (PD) among different ethnic groups (Ashkenazi Jews, North 
African Arabs, Basques) might be of some help in diagnostic screening and 
genetic counseling.
AIM OF THE STUDY: We investigated the seven common mutations spanning exons 31, 
35, and 41 reported in the LRRK2 gene among Eastern Indian patients with PD.
METHODS: Mutations R1441G, R1441C, R1441H, G2019S, Y1699C, I2020T, and I2012T 
were screened in 320 individuals (PD, 150 and controls, 170) by direct 
sequencing.
RESULTS: We did not observe any of these abovementioned mutations in our studied 
individuals.
CONCLUSION: We conclude that these mutations are rare causes of PD in the 
Eastern Indian population and, therefore, of little help for genetic counseling 
and diagnostic purposes.