Thrombotic thrombocytopenic purpura (TTP) is a rare clinical entity. It is a 
multi-systemic disorder characterized by a clinical pentad of thrombocytopenia, 
microangiopathic hemolytic anemia, diffuse and nonfocal neurologic symptoms, 
decreased renal function, and fever. Abdominal pain is an uncommon presenting 
symptom for TTP. Pancreatitis may occur from TTP or, in a few cases, may trigger 
TTP. The clinical diagnosis of TTP is generally difficult because there are many 
varied clinical presentations and the full expression of the pentad may be 
prolonged. However, once the diagnosis is suspected or confirmed, immediate 
plasmapherseis with plasma exchange must be performed to reduce the severe 
morbidity from neurologic disability.