The H1N1 2009 virus is pandemic in many countries. The genome of this virus 
contains eight segments. Among the eight segments maximum numbers of mutation 
occur at the segment 1 and segment 4 which codes for PB2 subunit and 
hemagglutinin (HA) and less number of mutations occur in segment 6 which codes 
for neuraminidase (NA) protein. Neuraminidase (NA) inhibitors (Oseltamivir and 
Zanamivir) are presently used as an anti-flu drugs. In the present study, the in 
silico efficacy of different drugs was tested against the swine flu virus. 3D 
structures of neuraminidase (NA) proteins of H1N1 2009 were generated using 
Geno3D. The 3D structure of H1N1 1918 was downloaded from PDB. Interaction study 
was done using Arguslab 4 and PyMol view. Oseltamivir and Zanamivir have good 
number of interactions with H1N1 2009 virus and the scoring function also 
support to this result. When compared with the 1918 H1N1 viral protein, 2009 
H1N1 NA protein shows more number of interaction and good scoring function. The 
RMSD value of before and after docking are found to be same at 0.04A° for both 
the drugs. The force field energy of NA protein 2009 was found to be -15603.529 
KJ/mol before docking. The force field energy was found to be decreased after 
docking at -17620.740 KJ/mol with Tamiflu and -17652.242 KJ/mol with Zanamivir. 
The number of interaction and scoring function shows that Oseltamivir and 
Zanamivir will be able to effectively control the present pandemic H1N1 virus 
2009.