Fanconi's anaemia is a rare autosomal recessive disorder characterized by 
progressive pancytopaenia and a cellular hypersensitivity to DNA crosslinking 
agents. Four genetic complementation groups have been identified so far, and 
here we use a functional complementation method to clone complementary DNAs that 
correct the defect of group C cells. The cDNAs encode alternatively processed 
transcripts of a new gene, designated FACC, which is mutated in group C 
patients. The predicted FACC polypeptide does not contain any motifs common to 
other proteins and so represents a new gene involved in the cellular response to 
DNA damage.