Chorion proteins of Lepidoptera have a tripartite structure, which consists of a 
central domain and two, more variable, flanking arms. The central domain is 
highly conserved and it is used for the classification of chorion proteins into 
two major classes, A and B. Annotated and unreviewed Lepidopteran chorion 
protein sequences are available in various databases. A database, named 
LepChorionDB, was constructed by searching 5 different protein databases using 
class A and B central domain-specific profile Hidden Markov Models (pHMMs), 
developed in this work. A total of 413 Lepidopteran chorion proteins from 9 
moths and 1 butterfly species were retrieved. These data were enriched and 
organised in order to populate LepChorionDB, the first relational database, 
available on the web, containing Lepidopteran chorion proteins grouped in A and 
B classes. LepChorionDB may provide insights in future functional and 
evolutionary studies of Lepidopteran chorion proteins and thus, it will be a 
useful tool for the Lepidopteran scientific community and Lepidopteran genome 
annotators, since it also provides access to the two pHMMs developed in this 
work, which may be used to discriminate A and B class chorion proteins. 
LepChorionDB is freely available at 
http://bioinformatics.biol.uoa.gr/LepChorionDB.