The problem of the drug induced pulmonary toxicity (cytotoxic and non-cytotoxic 
drugs) is discussed. This domain of modern pathology is in continuous 
development, although yet insufficiently delineated. The essential pathogenic 
mechanisms are presented as well as the main histopathological lesions (i.e., 
interstitial pneumonia and pulmonary fibrosis). The usual lesional aspects 
specific to certain drugs are also reviewed. For the principal chemical 
substances in this category, the clinical and radiological aspects are given, 
also the various treatment indicated, the evolution and the prognosis of the 
drugs induced pulmonary disease.