ArachnoServer (www.arachnoserver.org) is a manually curated database providing 
information on the sequence, structure and biological activity of protein toxins 
from spider venoms. These proteins are of interest to a wide range of biologists 
due to their diverse applications in medicine, neuroscience, pharmacology, drug 
discovery and agriculture. ArachnoServer currently manages 1078 protein 
sequences, 759 nucleic acid sequences and 56 protein structures. Key features of 
ArachnoServer include a molecular target ontology designed specifically for 
venom toxins, current and historic taxonomic information and a powerful advanced 
search interface. The following significant improvements have been implemented 
in version 2.0: (i) the average and monoisotopic molecular masses of both the 
reduced and oxidized form of each mature toxin are provided; (ii) the advanced 
search feature now enables searches on the basis of toxin mass, external 
database accession numbers and publication date in ArachnoServer; (iii) toxins 
can now be browsed on the basis of their phyletic specificity; (iv) rapid BLAST 
searches based on the mature toxin sequence can be performed directly from the 
toxin card; (v) private silos can be requested from research groups engaged in 
venoms-based research, enabling them to easily manage and securely store data 
during the process of toxin discovery; and (vi) a detailed user manual is now 
available.