Steele, Richardson and Olszweski in 1964 described a distinctive clinical and 
pathological entity they called progressive supranuclear palsy (PSP). Now on 
Guadeloupe in the Carribbean French West Indies, Caparros-Lefebvre is 
identifying many patients with similar clinical and histological features. 
Others have a clinical syndrome of atypical parkinsonism that resembles the 
parkinsonism-dementia complex (PDC) of Guam and the Kii peninsula of Japan 
(PDC). But in those Pacific foci the histology is different and the abnormal tau 
is of Alzheimer's type rather than the PSP type of Guadeloupe. In both locales, 
neurotoxins of local foods are implicated in etiology. Future studies will 
confirm if Guadeloupean parkinsonism is truly a geographic focus of PSP, and if 
dietary factors account for both.