Diamond-Blackfan anemia is an autosomal dominant syndrome, characterized by 
anemia and a predisposition for malignancies. Ribosomal proteins are responsible 
for this syndrome, and the incidence of colorectal cancer in patients with this 
syndrome is higher than the general population. This patient's Diamond-Blackfan 
anemia was caused by a novel ribosomal protein S19 gene mutation, and he 
received chemotherapy for colorectal cancer caused by it. In his cancer, 
ribosomal proteins S19 and TP53 were overexpressed. He received 5FU and 
cetuximab; however, his anemia made chemotherapy difficult, and he did not 
survive long. Patients with Diamond-Blackfan anemia should be screened earlier 
and more often for colorectal cancer than usual.