Majority of eukaryotic proteins are glycosylated and their glycan moieties have 
numerous important structural, functional and regulatory roles. Because of 
structural complexity of glycans and technological limitations glycomics, and 
particularly glycoproteomics was not able to follow rapid progress in genomics 
and proteomics over last 30 years. However, the field of glycan has been 
progressing rapidly and first large-scale studies of the glycome have been 
completed recently. These studies have revealed significant differences in 
glycome composition between individuals, which may contribute to the human 
phenotypic variability. The current state-of-the-art in high-throughput 
glycomics and its integration with genomics, epigenomics and lipidomics is 
reviewed in this article.