Hutchinson-Gilford progeria syndrome is a rare genetic disorder, characterized 
by progressive premature aging and early death in the first or second decade of 
life, usually secondary to cardiovascular events (myocardial infarction and 
stroke). We report a case of a 14-year-old boy with progeria syndrome and 
cardiac arrest due to myocardial infarction, who was submitted to an immediate 
coronary angiography which revealed left main stem and three-vessel coronary 
artery disease. A prompt double bypass coronary artery grafting surgery was 
performed, and, despite successful coronary reperfusion, the patient remained in 
coma and brain death was declared on fourth day after surgery.