Molluscum contagiosum (MC) is a very common benign self-limiting cutaneous viral 
infection caused by molluscum contagiosum virus. Disease is self-limiting in 
immunocompetent individuals, while it is severe and prolonged when associated 
with Human Immunodeficiency Virus (HIV) infection. The widespread and refractory 
mollusca of HIV disease occur especially on the face. In advanced stages of 
immunosuppression, giant or verrucous forms of MC may occur. Molluscum 
contagiosum tends to take a chronic course and is usually not responsive to 
various treatments in immunocompromised patients. Here, we present a HIV 
positive male patient with extensive papulonodular lesions over face, neck, 
bilateral upper limbs since 2 months, diagnosed as giant molluscum contagiosum, 
treated with cryotherapy with little improvement for few weeks after which 
patient did not turn up.