TAL1/SCL (hereafter referred to as TAL1) is a critical transcription factor 
required for hematopoiesis in which hematopoietic stem cells commit and 
differentiate to different lineages. During this process, transcription of many 
genes is turned on and off in part by epigenetic mechanisms. TAL1 has recently 
been shown to differentially recruit LSD1 and other histone modifying complexes 
to regulate its target genes. Here, we focus primarily on epigenetic mechanisms 
that are regulated by TAL1 during normal and malignant hematopoiesis. We discuss 
how different histone modifying enzymes are recruited by TAL1 and how these 
enzymatic activities mediate the activating or repressive function of TAL1. 
Finally, we further explore the possible mechanisms by which dysregulation of 
the recruitment and activity of histone modifying enzymes contribute to 
leukemogenesis.