Immune cells secrete small protein molecules that aim for cell-cell 
communications. These small molecules are called cytokines. Targeting cancer 
cells with administration of bispecific antibodies and natural extracts results 
in elevated circulating levels of inflammatory cytokines, including interferon-γ 
and interleukin (IL)-6, which lead to cell toxicity. Sustained release of 
cytokines due to immunotherapy or hormonal issues causes various diseases. Novel 
T cell-engaging therapies and monoclonal antibodies cause cytokine release 
syndrome. Efforts are being carried out to maximize the chance for therapeutic 
benefit from immunotherapy while minimizing the risk for life-threatening 
complications of sustained cytokine release. Neurodegeneration and cardiac 
diseases are the prominent diseases caused by inflammatory cytokines. The 
phenomenon is called cytokine storm. Cytokines can act antagonistically or 
synergistically. Constitutive expression of proinflammatory cytokines such as 
IL-3 and IL-6 causes organ damage and unbearable pain. In this review, we will 
discuss the regulators of cytokine release, its types, its implications on human 
health, and treatment.