The results of the various studies and an analysis of the methodology are 
presented in TABLE 1. As can be seen, there was no "perfect" study. In five of 
the studies enough information was presented with regard to the measurements and 
the behavior of control patients that a statistical analysis could be performed. 
Three of the studies showed a transient, statistically significant effect in at 
least some muscles. The two studies that demonstrated no such effect both used 
TRH in very small doses. It therefore seems reasonable to conclude that the 
effect of TRH in ALS is a definite, acute, and transient response. The cause of 
this response, however, has not been documented, and whether it is associated 
with an effect of the drug on the disease process remains to be seen.