The impact of interleukin (IL)-1beta on tumor necrosis factor alpha-induced 
adipose-related protein (TIARP)/six-transmembrane protein of prostate 2 (STAMP2) 
was determined in adipocytes. TIARP/STAMP2 mRNA synthesis was significantly 
stimulated by IL-1beta in a dose- and time-dependent fashion in 3T3-L1 
adipocytes. Signaling studies suggested that janus kinase 2, nuclear factor 
kappaB, and p44/42 mitogen-activated protein kinase are involved in 
IL-1beta-induced TIARP/STAMP2 mRNA expression. Furthermore, IL-1beta, TNFalpha, 
and IL-6 showed synergistic stimulatory effects on TIARP/STAMP2 gene expression. 
Moreover, both TIARP/STAMP2 mRNA synthesis and protein expression were induced 
by IL-1beta in fully differentiated human mesenchymal stem cell-derived 
adipocytes (hMSC-Ad). Taken together, TIARP/STAMP2 is highly upregulated in 
3T3-L1 cells and hMSC-Ad by IL-1beta and might, therefore, modulate 
proinflammatory and insulin resistance-inducing effects of IL-1beta.