Blood cells are derived from a common set of hematopoietic stem cells, which 
differentiate into more specific progenitors of the myeloid and lymphoid 
lineages, ultimately leading to differentiated cells. This developmental process 
is controlled by a complex regulatory network involving cytokines and their 
receptors, transcription factors, and chromatin remodelers. Using public data 
and data from our own molecular genetic experiments (quantitative PCR, Western 
blot, EMSA) or genome-wide assays (RNA-sequencing, ChIP-sequencing), we have 
assembled a comprehensive regulatory network encompassing the main transcription 
factors and signaling components involved in myeloid and lymphoid development. 
Focusing on B-cell and macrophage development, we defined a qualitative 
dynamical model recapitulating cytokine-induced differentiation of common 
progenitors, the effect of various reported gene knockdowns, and the 
reprogramming of pre-B cells into macrophages induced by the ectopic expression 
of specific transcription factors. The resulting network model can be used as a 
template for the integration of new hematopoietic differentiation and 
transdifferentiation data to foster our understanding of lymphoid/myeloid 
cell-fate decisions.