Hitherto unknown efficacy of the peel extracts of Mangifera indica (MI), Cucumis 
melo (CM) and Citrullus vulgaris (CV) fruits in ameliorating the diet-induced 
alterations in dyslipidemia, thyroid dysfunction and diabetes mellitus have been 
investigated in rats. In one study, out of 4 different doses (50-300 mg/kg), 200 
mg/kg of MI and 100 mg/kg for other two peel extracts could inhibit 
lipidperoxidation (LPO) maximally in liver. In the second experiment rats were 
maintained on pre-standardized atherogenic diet CCT (supplemented with 4% 
cholesterol, 1% cholic acid and 0.5% 2-thiouracil) to induce dyslipidemia, 
hypothyroidism and diabetes mellitus and the effects of the test peel extracts 
(200 mg/kg of MI and 100 mg/kg for CM and CV for 10 consecutive days) were 
studied by examining the changes in tissue LPO (in heart, liver and kidney), 
concentrations of serum lipids, thyroid hormones, insulin and glucose. Rats, 
treated simultaneously with either of the peel extracts reversed the CCT-diet 
induced increase in the levels of tissue LPO, serum lipids, glucose, creatinine 
kinase-MB and decrease in the levels of thyroid hormones and insulin indicating 
their potential to ameliorate the diet induced alterations in serum lipids, 
thyroid dysfunctions and hyperglycemia/diabetes mellitus. A phytochemical 
analysis indicated the presence of a high amount of polyphenols and ascorbic 
acid in the test peel extracts suggesting that the beneficial effects could be 
the result of the rich content of polyphenols and ascorbic acid in the studied 
peels.