TAGS trial revealed the efficacy and safety of 
trifluridine/tipiracil(Lonsurf®)treatment in patients with metastatic gastric 
cancer following gastrectomy. Here, we successfully treated 38 months survival 
case after recurrences following radical gastrectomy for advanced adenocarcinoma 
of esophago-gastric junction using historical recommended chemotherapy regimens 
and trifluridine/tipiracil as a fifth-line chemotherapy. Trifluridine/tipiracil 
therapy contributed to effective and safety treatment even in late-line 
chemotherapy for recurrent gastric cancer.