INTRODUCTION: Multisystem inflammatory syndrome in children (MIS-C) is a unique 
clinical complication of SARS-CoV-2 infection observed in pediatric patients. 
COVID-19 is emerging as a potential trigger for the development of diabetes in 
children. Here, we report a patient presenting with MIS-C and new onset 
diabetes, and discuss the implication and clinical management of these 
concomitant conditions.
CASE PRESENTATION: An eight-year-old female presented with hyperglycemia, 
ketosis and metabolic acidosis consistent with diabetic ketoacidosis (DKA) in 
the setting of fever, rash, respiratory distress, hemodynamic instability, 
reduced systolic function with dilation of the left anterior descending artery, 
and positive SARS-CoV-2 antibodies suggestive of MIS-C.