Three-dimensional (3D) chromatin structure is an emerging paradigm for 
understanding gene regulation mechanisms. Hi-C (high-throughput chromatin 
conformation capture), a method to detect long-range chromatin interactions, 
allows extensive genome-wide investigation of 3D chromatin structure. However, 
broad application of Hi-C data have been hindered by the level of complexity in 
processing Hi-C data and the large size of raw sequencing data. In order to 
overcome these limitations, we constructed a database named 3DIV (a 3D-genome 
Interaction Viewer and database) that provides a list of long-range chromatin 
interaction partners for the queried locus with genomic and epigenomic 
annotations. 3DIV is the first of its kind to collect all publicly available 
human Hi-C data to provide 66 billion uniformly processed raw Hi-C read pairs 
obtained from 80 different human cell/tissue types. In contrast to other 
databases, 3DIV uniquely provides normalized chromatin interaction frequencies 
against genomic distance dependent background signals and a dynamic browsing 
visualization tool for the listed interactions, which could greatly advance the 
interpretation of chromatin interactions. '3DIV' is available at 
http://kobic.kr/3div.