INTRODUCTION: MicroRNAs (miRNAs) are a group of noncoding RNAs,∼ 20 - 22 
nucleotides in length, that repress target gene expression through mRNA 
degradation and translation inhibition. The gene encoding miR-323-3p, which is a 
biomarker in immune and inflammatory responses, exists in a miRNA cluster in 
chromosomal region 14q32.31. It has been shown that miR-323-3p associates with 
the pathogenesis of several diseases, such as rheumatoid arthritis, Alzheimer's 
disease and ectopic pregnancy.
AREAS COVERED: This review provides a current view on the association of 
miR-323-3p with several human diseases and is focused on the recent studies of 
miR-323-3p regulation, discussing its potential as an epigenetic biomarker and 
therapeutic target for these diseases. In particular, the mechanisms of 
miR-323-3p in these diseases and how miR-323-3p is regulated are also discussed.
EXPERT OPINION: Although the exact role of miR-323-3p in these diseases has not 
been fully elucidated, targeting miR-323-3p may serve as a promising therapy 
strategy.