RNF43 is an oncogenic RING finger protein overexpressed in colorectal cancer. To 
dissect its biological functions, we explored RNF43-interacting proteins by 
pull-down assay and MS. We identified a heterodimer, p54nrb and PSF, as RNF43's 
binding partners and confirmed their physical interaction in vivo by the 
co-immunoprecipitation experiment. Immunofluorescence analysis revealed that 
co-expression of PSF relocates RNF43 from the nuclear periphery to the 
nucleoplasm. Thus, proteomic identification of RNF43-associated proteins sheds 
light on its dynamic interaction network in nuclear events.