Muenke syndrome caused by the FGFR3 Pro250Arg mutation is associated with 
craniosynostosis, hearing loss, and various bony anomalies. Although this 
mutation is involved in bone growth and development, bony tumors are rare in 
this condition. We describe a patient with a molecular diagnosis of Muenke 
syndrome who also presented with multiple osteochondromas of the upper and lower 
extremities. This association has only been described once before in a patient 
with an isolated osteochondroma of the proximal tibia. Altered expression of 
FGFR3, an important mediator of chondrocyte proliferation and differentiation 
during in the growth plates of long bones, may help to explain the development 
of osteochondromatous lesions in this patient.