Rheumatoid arthritis (RA) is a chronic and accelerated autoimmune illness with 
proliferative and damaging synovitis, resulting in joint death and cartilage and 
bone erosion. This study focused on the potential therapeutic effect of wogonin 
on complete Freund's adjuvant (CFA) induced RA in rats and the underlying 
mechanisms. Arthritis was experimentally caused in rats by subcutaneously 
injecting 0.1 mL of CFA into the subplantar area of the left hind paw under 
moderate anesthesia on day zero. The regular oral doses of indomethacin/wogonin 
began on day zero and proceeded after injection to day 35. Wogonin reduced 
arthritic score considerably, enhanced body weight, and reduced paw thickness. 
Wogonin also boosted red blood cell considerably along with hemoglobin and 
reduced white blood cell count and erythrocyte sedimentation rate. Wogonin 
substantially improved an altered level of oxidative stress markers, antioxidant 
proteins, and inflammatory cytokines in a dose-dependent way. Wogonin inhibited 
p38 phosphorylation triggered by CFA and p65 nuclear translocation.