Objective. To describe obstetrical and neonatal outcomes in Canadian women with 
rheumatoid arthritis (RA) or systemic lupus erythematosus (SLE). Methods. An 
administrative database of hospitalizations for neonatal delivery (1998-2009) 
from Calgary, Alberta was searched to identify women with RA (38 pregnancies) or 
SLE (95 pregnancies), and women from the general population matched on maternal 
age and year of delivery (150 and 375 pregnancies, resp.). Conditional logistic 
regression was used to calculate odds ratios (OR) for maternal and neonatal 
outcomes, adjusting for parity. Results. Women with SLE had increased odds for 
preeclampsia or eclampsia (SLE OR 2.16 (95% CI 1.10-4.21; P = 0.024); RA OR 2.33 
(95% CI 0.76-7.14; P = 0.138)). Women with SLE had increased odds for cesarean 
section after adjustment for dysfunctional labour, instrumentation and previous 
cesarean section (OR 3.47 (95% CI 1.67-7.22; P < 0.001)). Neonates born to women 
with SLE had increased odds of prematurity (SLE OR 6.17 (95% CI 3.28-11.58; P < 
0.001); RA OR 2.66 (95% CI 0.90-7.84; P = 0.076)) and of SGA (SLE OR 2.54 (95% 
CI 1.42-4.55; P = 0.002); RA OR 2.18 (95% CI 0.84-5.66; P = 0.108)) after 
adjusting for maternal hypertension. There was no excess risk of congenital 
defects in neonates. Conclusions. There is increased obstetrical and neonatal 
morbidity in Canadian women with RA or SLE.