Infectious Mononucleosis (IM), a benign lymphoproliferative disease, is the best 
known clinical syndrome caused by Epstein-Barr Virus (EBV). It usually resolves 
over a period of weeks or months without sequelae but may occasionally be 
complicated by a wide variety of neurologic, hematologic, hepatic, respiratory, 
and psychological complications. In this report we describe a patient with acute 
hepatitis following EBV-IM in a previously healthy woman. A 26-year-old woman 
who presented with fever, generalized weakness, nausea, sore throat, yellowing 
of skin, and a generalized skin rash was admitted to our clinic. Tonsillar 
enlargement, pharyngeal erythema, palatal petechiae, lymphadenopathy, and 
jaundice were noted. Significant atypical lymphocytes ( > 10%) were seen on the 
peripheral blood smear. Liver function tests such as ALT: 303 U/L, AST: 172 U/L, 
ALP: 193 U/L and total bilirubin: 7.3 mg/dl were elevated. Serological tests for 
EBV infection were consistent with acute infection (EBV virus capsid antigen was 
reactive with IgM and IgG antibodies). The Monospot test was also positive. On 
the seventh day, liver function tests and bilirubin had risen to peak level and 
platelets were decreased. The patient was managed supportively and her critical 
condition improved and was finally stabilized. Although the prognosis for IM is 
very favorable, a variety of acute complications may occur.