The CCAAT/enhancer-binding protein beta (C/EBPbeta) is a critical transcription 
factor that regulates gene expression during numerous biological processes, 
including differentiation, metabolism, homeostasis, proliferation, 
tumorigenesis, inflammation, and apoptosis. In this study, interactions between 
C/EBPbeta and either the Abelson murine leukemia viral oncogene homolog 1 
(c-Abl) or the Abl-related gene (Arg) were demonstrated in vitro and in vivo 
with a direct binding assay and by co-immunoprecipitation, respectively. The Y79 
amino acid residue of C/EBPbeta was phosphorylated by c-Abl or Arg. The 
phosphorylation of C/EBPbeta resulted in an increased C/EBPbeta stability and a 
potentiation of C/EBPbeta transcription activation activity in cells. Expression 
of the C/EBPbeta(Y79F) mutant in HEK293, and K562, and in other cell lines, 
resulted in less of a delay in the cell cycle compared to the wild type 
C/EBPbeta; furthermore, the C/EBPbeta (Y79F) mutant induced an increased 
apoptosis compared to the wild type C/EBPbeta. These findings suggest that the 
c-Abl family non-receptor tyrosine kinases have a role in the regulation of the 
C/EBPbeta transcription factor.