Mutational signatures are patterns in the occurrence of somatic 
single-nucleotide variants that can reflect underlying mutational processes. The 
SomaticSignatures package provides flexible, interoperable and easy-to-use tools 
that identify such signatures in cancer sequencing data. It facilitates 
large-scale, cross-dataset estimation of mutational signatures, implements 
existing methods for pattern decomposition, supports extension through 
user-defined approaches and integrates with existing Bioconductor workflows.
AVAILABILITY AND IMPLEMENTATION: The R package SomaticSignatures is available as 
part of the Bioconductor project. Its documentation provides additional details 
on the methods and demonstrates applications to biological datasets.
CONTACT: julian.gehring@embl.de, whuber@embl.de
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics 
online.