BACKGROUND: Corynebacterium spp. are diphtheroid bacteria responsible for pitted 
keratolysis, a common plantar infection confined to the thick stratum corneum.
AIM: To study a series of demographic features of patients suffering from pitted 
keratolysis, and to present a review of the Corynebacterium-associated 
infections, including pitted keratolysis, erythrasma, and trichobacteriosis.
MATERIALS AND METHODS: A 2-year, two-center, prospective survey assessed the 
demographics of pitted keratolysis, including age, gender, site of infection, 
symptoms, patients' complaints, the use of protective and/or occlusive shoes, 
seasonality of diagnosis, drug intake, associated skin signs (including 
dyshidrosis, erythrasma, and trichobacteriosis), recurrences, and previous 
diagnoses and treatments.
RESULTS: The mean age of the 53 patients with pitted keratolysis was 24.9 years 
(range, 10-57 years). The male to female ratio was 7.8:1. The soles of both feet 
were commonly involved (92.4%). Pressure-bearing areas were the usual sites of 
infection, ranging from restricted involvement of the toes (12/53, 22.6%) to 
spreading to the entire plantar surface (15/53, 28.3%). A total of 36 (68%) of 
the 53 patients complained of hyperhidrosis. An unpleasant smell and pain were 
noted by 35 (66%) and 25 (47%) of the 53 patients, respectively. Occlusive and 
protective shoes were worn in 51 (96.2%) and 31 (58.4%) of the 53 cases, 
respectively.
CONCLUSION: Pitted keratolysis commonly affects young male patients wearing 
protective shoes for professional reasons, inducing a moist and warm 
environment. Hyperhidrosis, an unpleasant smell, and pain are the main clinical 
complaints.