Adolescent idiopathic scoliosis (AIS) is a complex disorder with an unclear 
etiology and pathogenesis. In previous studies, genome-wide linkage and genetic 
association analyses have been carried out to find genetic factors linked with 
AIS. In this study, we examined whether the susceptibility to AIS is associated 
with MATN1 gene polymorphisms in a Korean population, which included 166 
individuals with AIS and 126 controls. We found that there were no statistically 
significant associations between any of the MATN1-linked allele or genotype 
frequencies between AIS and controls. However, statistically significant 
associations were found at single nucleotide polymorphism (SNP) rs1065755 when 
comparing the curve patterns of AIS with the controls. The A allele of SNP 
rs1065755 was associated with a higher risk of AIS than the allele G in the 
genotype-phenotype (curve pattern) analysis (P = 0.029). In addition, the 
frequency of the A allele of SNP rs1065755 in AIS with double major curves was 
higher than in controls (P = 0.021, ORs = 2.56 within 95% CI = 1.12-5.83). 
Additionally, among the predicted common haplotypes, the frequency of the 
haplotype GATT (31.3%) in AIS with double major curves was higher than in 
controls (15.2%) (P = 0.024, ORs = 2.54 within 95% CI = 1.11-5.84). We conclude 
that the A allele of SNP rs1065755 in the MATN1 gene is associated with AIS.