PURPOSE: Studies suggest that aspirin, other nonsteroidal anti-inflammatory 
drugs (NSAIDs), and statins may reduce risk of some cancers. However, findings 
have been conflicting as to whether these agents reduce the risk of pancreatic 
cancer.
METHODS: We used data from the Queensland Pancreatic Cancer Study, a 
population-based case-control study. In total, 704 cases and 711 age- and 
sex-matched controls were recruited. Participants completed an interview in 
which they were asked about history of NSAID and statin use. We included 522 
cases and 653 controls who had completed the medication section of the interview 
in this analysis. Unconditional multivariable logistic regression was used to 
estimate associations between medication use and pancreatic cancer.
RESULTS: We found no consistent evidence of an association between use of NSAIDs 
or statins and risk of pancreatic cancer. There was some suggestion of a 
protective effect in infrequent users of selective COX-2 inhibitors, but no 
association in more frequent users. We did not find evidence of protective 
effects in analyses stratified by sex, smoking status, time between diagnosis 
and interview, or presence/absence of metastases.
CONCLUSIONS: Overall, our results do support the hypothesis that use of NSAIDs 
or statins may reduce the odds of developing pancreatic cancer.