Purpose: We investigated the changes in etiology of uveitis at the Uveitis 
Clinic of Tokyo Medical University Hospital in recent years.Methods: Medical 
records of patients with uveitis diagnosed between 2011 and 2017 (Group A) and 
between 2001 and 2007 (Group B) were reviewed.Results: 1,587 patients in group A 
and 1,507 patients in group B were analyzed. For noninfectious uveitis, 
frequencies of Vogt-Koyanagi-Harada disease, intraocular lymphoma (IOL) and 
iridocyclitis in young girls increased, while those of sarcoidosis and Behçet's 
disease decreased in the recent era. For infectious uveitis, herpetic 
iridocyclitis, ocular toxoplasmosis, ocular syphilis, and bacterial 
endophthalmitis increased, while acute retinal necrosis and ocular toxocariasis 
decreased. Unclassified uveitis decreased, whereas infectious uveitis and IOL 
increased due to the availability of new diagnostic tests.Conclusion: Etiologies 
of uveitis have changed over the years. Further development of novel tests and 
diagnostic criteria would increase definitive diagnosis for unclassified 
uveitis. (147/150 words).