Amniotic band syndrome is a rare congenital disorder caused by entrapment of 
fetal parts (usually a limb or digits) in fibrous amniotic bands while in utero 
that presents with complex multisystem anomalies. The authors report 2 children 
with amniotic band syndrome who presented to the ophthalmic unit of the authors' 
pediatric hospital. One of them presented with telecanthus, syndactyly, 
amputated toes, and unilateral epiphora diagnosed as congenital nasolacrimal 
duct obstruction. She was managed conservatively with lacrimal sac massage and 
provided with refractive correction while she simultaneously underwent multiple 
surgeries for correction of clubfoot and craniosynostosis. The second patient 
presented with cleft lip, cleft palate, multiple constriction bands in upper 
limbs and fingers with unilateral microphthalmos, microcornea, typical iris 
coloboma, and retinochoroidal coloboma, very similar to a case reported in 
literature. These 2 cases provide an overview of the clinical spectrum of 
ophthalmic manifestations along with their staged optimum rehabilitation.