Exosomes is a key component of cell paracrine secretion and can exert important 
effects in various disease models. However, the role of exosomes in neuron 
repair of spinal cord injury (SCI) has rarely been reported. In this study, 
Exosomes were isolated from cerebrospinal fluid of SCI and normal, and incubated 
neuron in vitro respectively to research its biological function in cell 
proliferation. The results demonstrated these exosomes all expressed CD9, CD63, 
CD81, Alix and Tsg101; however, only exosomes derived from cerebrospinal fluid 
of SCI could promote proliferation of neuron via ERK signaling pathway, and 
decrease cell apoptosis. Exosomes contain cytosolic content, including proteins, 
mRNAs and non-cording RNAs, and play a role in important biological function. 
Our research showed exosomes derived from cerebrospinal fluid of SCI, they can 
influence neuron cell proliferation in vitro, we did not observe these 
characters in exosome derived from normal cerebrospinal fluid.