Treatment of amiodarone-induced thyrotoxicosis (AIT) with thionamide, lithium or 
radioactive iodine is ineffective. This particular form of hyperthyroidism is 
long-lasting because of the slow elimination of amiodarone. Therefore, an 
alternative therapy is necessary, especially for patients who need to continue 
permanent administration of the drug. We report 2 cases of AIT: in one case, 
amiodarone was interrupted; in the other case, amiodarone was continued because 
of recurrent ventricular tachycardia resistant to classical antiarrhythmic 
drugs. Both patients were successfully treated with propylthiouracil (PTU) and 
dexamethasone (DXT).