DNA methylation is one of the heritable epigenetic modifications, leading to 
repressed gene expressions and consequent phenotypic alterations without 
changing the DNA sequence. MicroRNA (miRNA) is a novel class of short non-coding 
RNA molecules regulating a wide range of cellular functions through 
translational repression of their target genes. Recently, epigenetic 
dysregulation of tumor-suppressor miRNA genes by promoter DNA methylation has 
been implicated in human cancers, including multiple myeloma (MM). This article 
presents a brief overview of the pathogenesis of MM, the role of DNA methylation 
in cancer biology, methods of DNA methylation analysis, miRNA biology and 
dysregulation of miRNAs in MM and summaries the current data on the role of DNA 
methylation of tumor-suppressive miRNAs in MM.