Cardiovascular disease (CVD) is the leading cause of death throughout the world. 
The increase in new patients every year leads to a demand for the identification 
of valid and novel prognostic and diagnostic biomarkers for the prevention and 
treatment of cardiovascular diseases. MicroRNAs (miRNAs) are critical endogenous 
small noncoding RNAs that negatively modulate gene expression by regulating its 
translation. miRNAs are implicated in most physiological processes of the heart 
and in the pathological progression of cardiovascular diseases. miR-214 is a 
deregulated miRNA in many pathological conditions, and it contributes to the 
pathogenesis of multiple human disorders, including cancer and cardiovascular 
diseases. miR-214 has dual functions in different cardiac pathological 
circumstances. However, it is considered as a promising marker in the prognosis, 
diagnosis and treatment of cardiovascular diseases. In this review, we discuss 
the role of miR-214 in various cardiac disease conditions, including ischaemic 
heart diseases, cardiac hypertrophy, pulmonary arterial hypertension (PAH), 
angiogenesis following vascular injury and heart failure.