Pregnancy is an acquired state of hypercoagulation. An association has been 
found between various pregnancy complications and thrombophilia. Among those 
complications are: preeclampsia, intrauterine fetal death, intrauterine growth 
retardation and placentaL abruption. This article will present a novel scoring 
system estimating pregnancy complications in women with thrombophilia. The 
biological and epidemiological background of the association between pregnancy 
complications and thrombophilia will be discussed and the therapeutic options 
will be evaluated. Finally, for illustrative purposes, a patient presenting with 
combined thrombophilia--both genetic and acquired--will be discussed. This 
patient had suffered severe gestational complications that led to devastating 
obstetrical outcome.