PURPOSE: To investigate whether rs11190870 near LBX1 correlates with the 
susceptibility or curve progression of adolescent idiopathic scoliosis (AIS) in 
a Han Chinese population.
METHODS: A total of 949 AIS patients and 976 age-matched healthy controls were 
recruited. All the subjects were genotyped using the PCR-based invader assay. 
Case-control study and case-only study were performed to define the contribution 
of rs11190870 to predisposition and curve severity of AIS. Additionally, we 
further conducted a meta-analysis of the study findings together with those of 
previously reported studies.
RESULTS: A significant association of rs11190870 with AIS was observed in the 
Han Chinese population (P = 1.8 × 10(-9); odd ratio = 1.51; 95 % confidence 
interval = 1.33-1.71), and AIS patients with TT genotype had a larger Cobb angle 
than those with TC or CC genotype (P = 0.005). The meta-analysis confirmed that 
the positive association of this SNP with AIS in the East Asian population.
CONCLUSIONS: The SNP rs11190870 near LBX1 is associated with both susceptibility 
and curve progression of AIS.