Latent tuberculosis infection (LTBI) is evidence of immunological control of 
tuberculosis. Dormancy survival regulator (DosR) regulon-encoded proteins may 
have a role in the maintenance of LTBI. T cell responses to Rv1733c, Rv0081, 
Rv1735c, and Rv1737c DosR regulon-encoded proteins were found to be most 
frequent among household contacts of TB cases from Uganda compared to other DosR 
proteins, but antibody responses were not described. We characterized antibody 
responses to these proteins in individuals from Uganda. Antibodies to Rv1733c, 
Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins were measured in 68 
uninfected individuals, 62 with LTBI, and 107 with active pulmonary tuberculosis 
(APTB) cases. There were no differences in the concentrations of antibodies to 
Rv0081, Rv1735c, and Rv1737c DosR regulon-encoded proteins between individuals 
with LTBI and APTB and those who were uninfected. LTBI was associated with 
higher concentrations of antibodies to Rv1733c in female participants [adjusted 
geometric mean ratio: 1.812, 95% confidence interval (CI): 1.105 2.973, and p = 
0.019] but not in males (p value for interaction = 0.060). Antibodies to the 
four DosR regulon-encoded proteins investigated may not serve as good biomarkers 
of LTBI in the general population. More of the M.tb proteome needs to be 
screened to identify proteins that induce strong antibody responses in LTBI.