A new born with a mongoloid slant, brachycephaly and low-set ears presented at 
birth with a total leucocyte count of 57 x 10(3)/microL and the differential 
leucocyte count revealed 70% of these to be blasts. The morphology of the blasts 
was not characteristic of myeloid and lymphoid lineage. Cytochemistry showed 
myeloperoxidase (MPO), Sudan Black B (SBB), periodic acid-Schiff (PAS) and 
non-specific esterase (NSE) negativity. Flowcytometry showed blasts that were 
positive for CD-33, CD-34 and CD-7. On second follow-up on the 10th day, the 
same picture persisted on morphology. On subsequent follow-up, the blasts 
disappeared. This was thus confirmed to be a case with transient leukemia with 
Downs syndrome.