Thrombocytopenia, anasarca, fever, reticulin fibrosis, and organomegaly (TAFRO) 
syndrome is considered as a unique clinicopathologic variant of multicentric 
Castleman's disease and is recently reported in Japan. This entity represents a 
severe inflammatory state leading to organ failures such as severe liver 
dysfunction seen in our case, and can be treated by immunosuppressive agents, 
steroids, and cyclosporine shown in several case reports. A systematic review 
and our case suggest the potential utility of tocilizumab as a treatment for 
TAFRO syndrome.