We examined the therapeutic effect of 15-DOS in the two models of acute and 
chronic relapsing EAE in Lewis rats. In the first model adult rats developed an 
acute severe EAE and by day 16 all animals died. Lewis rats treated with 15-DOS 
showed a delayed and reduced onset of clinical symptoms and mortality was 
prevented. In the second model Lewis rats (aged animals) developed a chronic 
relapsing EAE with up to three relapses. The second and third episodes were both 
milder and shorter in duration. All animals treated with 15-DOS survived the 
delayed first attack and developed no further relapses.