The advent of whole-genome sequencing has led to methods that infer protein 
function and linkages. We have combined four such algorithms (phylogenetic 
profile, Rosetta Stone, gene neighbor and gene cluster) in a single 
database--Prolinks--that spans 83 organisms and includes 10 million 
high-confidence links. The Proteome Navigator tool allows users to browse 
predicted linkage networks interactively, providing accompanying annotation from 
public databases. The Prolinks database and the Proteome Navigator tool are 
available for use online at http://dip.doe-mbi.ucla.edu/pronav.