Research focusing on the canonical adult myogenic progenitor, the skeletal 
muscle satellite cell, is still an ever-growing field 46 years from their 
initial description. Recent publications revealed numerous new aspects of 
satellite cell biology, starting from their developmental life to their role as 
the principal self-renewing myogenic stem cell in adult skeletal muscle and 
finally their loss during aging. The myogenic potential of satellite cells is 
under the molecular control of specific paired-box and bHLH transcription 
factors whose tightly orchestrated balance accounts for an effective skeletal 
muscle regeneration. New reports also demonstrate satellite cells relationships 
with blood vessels and the high myogenic potential of stem cell subsets related 
to both lineages.