Recently, the synthesis of radiolabeled plant origin compounds has been 
increased due to their high uptake on some cancer cell lines. Eugenol (EUG), a 
phenolic natural compound in the essential oils of different spices such as 
Syzygium aromaticum (clove), Pimenta racemosa (bay leaves), and Cinnamomum verum 
(cinnamon leaf), has been exploited for various medicinal applications. EUG has 
antiviral, antioxidant, and anti-inflammatory functions and several anticancer 
properties. The objective of this article is to synthesize radioiodinated (131I) 
EUG and investigate its effect on Caco2, MCF7, and PC3 adenocarcinoma cell 
lines. It is observed that radioiodinated EUG would have potential on therapy 
and imaging due to its notable uptakes in studied cells.