Seven women in three generations of a family have been affected by Turner 
syndrome. Turner phenotype in this family is the result of deletion of the 
entire short arm of one X chromosome. The short arm deletion is transmitted by 
carriers of a balanced X-1 translocation. Autoradiographic findings showed that 
the deleted X chromosome was late labeling in those persons with Turner 
syndrome, whereas the normal X chromosome was late replicating in carriers of 
the balanced translocation. The results of Xga typing of erythrocytes suggest 
that the Xg locus is on the short arm of the X chromosome. Because of the 
clinical implications, we believe that families of persons with structural 
chromosomal abnormalities should be studied to exclude familial transmission.