Melioidosis is a suppurative chronic infection caused by a gramnegative 
bacterium, Burkholderia pseudomallei. We report two patients who presented with 
isolated liver abscesses caused by this pathogen. Both patients presented with 
high-grade fever and abdominal pain. On examination they were toxic and had 
tender hepatomegaly. Investigations showed leucocytosis and a shift to the left. 
Early diagnosis of melioidosis was made by culture and growth of Burkholderia 
pseudomallei from aspirated pus from the abscesses and the patients were treated 
with ceftazidime and co-trimoxazole. Despite institution of antibiotics both the 
patients succumbed to their illness. Melioidosis is an emerging infection in the 
Indian subcontinent and can cause isolated liver abscesses.