Diversified histone modifications (HMs) are essential epigenetic features. They 
play important roles in fundamental biological processes including 
transcription, DNA repair and DNA replication. Chromatin regulators (CRs), which 
are indispensable in epigenetics, can mediate HMs to adjust chromatin structures 
and functions. With the development of ChIP-Seq technology, there is an 
opportunity to study CR and HM profiles at the whole-genome scale. However, no 
specific resource for the integration of CR ChIP-Seq data or CR-HM ChIP-Seq 
linkage pairs is currently available. Therefore, we constructed the CR Cistrome 
database, available online at http://compbio.tongji.edu.cn/cr and 
http://cistrome.org/cr/, to further elucidate CR functions and CR-HM linkages. 
Within this database, we collected all publicly available ChIP-Seq data on CRs 
in human and mouse and categorized the data into four cohorts: the reader, 
writer, eraser and remodeler cohorts, together with curated introductions and 
ChIP-Seq data analysis results. For the HM readers, writers and erasers, we 
provided further ChIP-Seq analysis data for the targeted HMs and schematized the 
relationships between them. We believe CR Cistrome is a valuable resource for 
the epigenetics community.