Mitochondria autophagy (mitophagy) is the process of selective degradation of 
mitochondria that has an important role in mitochondrial quality control. To 
gain insight into the molecular mechanism of mitophagy, we screened a yeast 
knockout library for strains that are defective in mitophagy. We found 32 
strains that showed a complete or partial block of mitophagy. One of the genes 
identified, YLR356W, is required for mitophagy, but not for macroautophagy or 
other types of selective autophagy. The deletion of YLR356W partially inhibits 
mitophagy during starvation, whereas there is almost complete inhibition at 
post-log phase. Accordingly, we hypothesize that Ylr356w is required to detect 
or present aged or dysfunctional mitochondria when cells reach the post-log 
phase.