Resveratrol is indicated to be involved in neuroprotection and anti-inflammation 
in epileptic rats. The molecular mechanism is still not fully understood. In 
this study, we investigated the role of resveratrol in nuclear factor-kappa B 
associated inflammatory responses induced by status epilepticus. Our data showed 
that seizures activated mammalian target of rapamycin (mTOR), increased the 
activity of nuclear factor-kappa B and promoted the expressions of inflammatory 
molecules including inducible nitric oxide synthase, cyclooxygenase-2 and 
interleukin-1β. Futhermore, resveratrol significantly inhibited the activation 
of nuclear factor-kappa B and the production of proinflammatory molecules via 
mTOR pathway. Additionally, we also proved that the inhibition of mTOR signal by 
resveratrol was mostly attributed to AMP-activated kinase (AMPK) activation. 
Altogether, our results suggest that resveratrol suppresses inflammatory 
responses induced by seizures partially via AMPK/mTOR pathway.