Conflict of interest statement: Disclosure and potential conflicts of interest: 
RRT has none. BF reports grants and other from Biogen during the conduct of the 
study and grants from Lilly, Eisai, NIH, Rogers Family Foundation and Spier 
Family Foundation and other from Acadia Pharmaceuticals, outside the submitted 
work. MA reports consulting for Biogen, Otsuka and Eli Lilly. The International 
Committee of Medical Journal Editors (ICMJE) Potential Conflicts of Interests 
form for the authors is available for download at: 
https://www.drugsincontext.com/wp-content/uploads/2021/09/dic.2021-7-3-COI.pdf