Pregabalin is approved for the treatment of a variety of clinical conditions and 
its analgesic, anxiolytic and anticonvulsant properties are well documented. 
Pregabalin's effects on sleep, however, are less well known. This review 
summarizes the published data on the effects of pregabalin on sleep disturbance 
associated with neuropathic pain, fibromyalgia, restless legs syndrome, partial 
onset seizures and general anxiety disorder. The data demonstrate that 
pregabalin has a positive benefit on sleep disturbance associated with several 
different clinical conditions. Polysomnographic data reveal that pregabalin 
primarily affects sleep maintenance. The evidence indicates that pregabalin has 
a direct effect on sleep that is distinct from its analgesic, anxiolytic and 
anticonvulsant effects.