LRRK2 gene mutations (PARK8) are a common cause of genetic Parkinson disease 
(PD). G2019S, the most frequent mutation, is responsible for both familial and 
sporadic cases of PD. The clinical picture is usually indistinguishable from 
that observed in idiopathic PD; however, a wide range of clinical presentations 
and pathological findings has been described. Restless leg syndrome (RLS) is a 
disabling sleep-related sensorimotor disorder whose pathogenesis is likely 
related to dopaminergic dysfunction. We report a 77-year-old woman with RLS and 
familial history of parkinsonism. The father, one sister, two cousins and one 
uncle were affected by PD. The proband and her sister were analyzed for 
mutations in LRRK2 gene and resulted to carry one heterozygous G2019S mutation 
in LRRK2 gene. The association between RLS and LRRK2 gene mutation may be 
casual, but it can hypothesized that RLS is a possible phenotypic presentation 
in PARK8.