Anophthalmia is a condition of the absence of an eye and the presence of a small 
eye within the orbit. It is associated with many known syndromes. Clinical 
findings, as well as imaging modalities and genetic analysis, are important in 
making the diagnosis. Imaging modalities are crucial scanning methods. 
Cryptophthalmos, cyclopia, synophthalmia and congenital cystic eye should be 
considered in differential diagnoses. We report two clinical anophthalmic 
siblings, emphasizing the importance of neuroradiological and orbital imaging 
findings in distinguishing true congenital anophthalmia from clinical 
anophthalmia.