TGF-beta-inducible early-response gene (TIEG) is a family of primary response 
genes induced by TGF-beta, which are well recognized in regulating cellular 
proliferation and apoptosis. However, their expression profile has never been 
investigated during embryogenesis in different organs. In this study, we aimed 
to investigate the transcriptional level of both TIEG1 and TIEG2 during 
development in various mice organs, including the brain cortex, cerebellum and 
stem, brain striatum, muscle, heart, liver, kidney, and lung. Quantitative 
real-time PCR was used to profile the change of transcriptional level of the two 
TIEG members in the mice tissues at six developmental stages. Taken together, 
the expression of TIEG1 and TIEG2 was specific in different organs yet varied 
with different developmental time points. Their dynamic changes were moderately 
consistent in most organs including the brain cortex, striatum, liver, kidney, 
and lung. However, their mRNA expression in both the heart and muscle was 
significantly different at all developmental stages, which might propose a 
compensation of functions in the TIEG family. Nevertheless, our data indicate 
that both the TIEG genes are essential in regulating the normal organ 
development and functioning in murine model, as their expressions were 
ubiquitous and tissue specific at various developmental stages.