Primary spinal glioblastoma (GBM) is a rare spinal tumour and is considered to 
have poor prognosis. We describe a case of a 17-year-old adolescent boy with a 
cervical spine GBM presenting with neck pain and right upper limb weakness. 
Initial spinal MRI demonstrated a 4.5 cm lesion extending from C2 to C5 
suspicious for demyelination. Despite high-dose corticosteroids, his weakness 
progressed resulting in quadriparesis. Subsequent laminectomy and biopsy 
confirmed spinal GBM. Shortly after surgery the patient continued to deteriorate 
and was essentially bedbound. Standard chemoradiotherapy as per the Stupp 
protocol, together with multimodal rehabilitation, resulted in substantial 
functional improvement within 6 weeks of initiation. Continued functional 
improvement was observed for a period of 11 months. Although an Eastern 
Cooperative Oncology Group (ECOG) performance score of 4 would normally preclude 
chemoradiotherapy, a prolonged response to treatment and return to independent 
function were observed.