Carpal tunnel syndrome (CTS) is a nerve entrapment disorder, involving the 
median nerve when it passes the carpal tunnel at the wrist. Using a case-control 
methodology, 312 electrophysiologically confirmed CTS patients with mean age of 
51.3+/-9.4 (27-74) years (81.7% women) and 100 controls with mean age of 
50.4+/-9.2 (21-88) years (75% women) were examined utilising a questionnaire 
similar to the clinical diagnostic criteria of restless legs syndrome (RLS). 
Forty-four (14.1%) of the CTS patients have symptoms compatible with restless 
hand syndrome compared with none (0%) in the control group (p < 0.0001). The 
severity of CTS was not significantly associated with the motor restlessness. 
Our observations suggest that entrapment syndromes such as CTS can be associated 
with a form of restlessness in the hands, analogous to RLS.