Diamond-Blackfan anemia is a rare, inherited disease that characteristically 
presents as a chronic, normochromic macrocytosis due to red cell lineage bone 
marrow failure. Although studies are elaborating on the genetic basis for its 
associated comorbidities, little has been published comparing this anemia to 
other chronic anemias that have similar laboratory results in children. This 
article offers a global perspective of the disease and compares it with anemia 
due to vitamin B12 and folate deficiency in children.