A selective estrogen receptor modulator (SERM) for the potential treatment of 
hot flushes is described. 
(R)-(+)-7,9-difluoro-5-[4-(2-piperidin-1-ylethoxy)phenyl]-5H-6-oxachrysen-2-ol, 
LSN2120310, potently binds ERalpha and ERbeta and is an antagonist in MCF-7 
breast adenocarcinoma and Ishikawa uterine cancer cell lines. The compound is a 
potent estrogen antagonist in the rat uterus. In ovariectomized rats, the 
compound lowers cholesterol, maintains bone mineral density, and is efficacious 
in a morphine dependent rat model of hot flush efficacy.