PURPOSE: Androgenetic alopecia (AGA), or male pattern hair loss, affects up to 
96% of Caucasian men. Characterized by gradual thinning and eventual loss of 
hair along frontotemporal, parietal, and vertex areas of the scalp, AGA is 
associated with low self-esteem, depression, and dissatisfaction with body 
appearance.
DATA SOURCES: In this systematic review of the literature, six primary research 
studies conducted in the United States are evaluated for their clinical 
application to primary care provider practice.
CONCLUSIONS: Topical minoxidil 2%-5% 1 mL twice daily or finasteride 1 mg daily 
are recommended as first line treatments, followed by the use of Food and Drug 
Administration-cleared HairMax LaserComb® in patients who do not respond to 
first line modalities.
IMPLICATIONS FOR PRACTICE: Further research in novel and established treatments 
is recommended, along with an evidence-based clinical practice guideline for 
practitioners in the United States.