Systemic lupus erythematosus (SLE) is a chronic, multisystem, autoimmune disease 
that can affect any part of the human body including the eyes. Common blinding 
ocular manifestations include central retinal artery occlusion (CRAO), central 
retinal vein occlusion (CRVO), severe vaso-occlusive retinopathy, and optic 
nerve involvement. Antiphospholipid syndrome (APS) in lupus is usually 
associated with large vessel occlusions and needs prompt treatment with 
anticoagulant. We are reporting two cases of APS in SLE patients that presented 
with CRVO (case 1) and vaso-occlusive lupus retinopathy (case 2). Both cases 
were positive for antiphospholipid antibody (APA) and were treated with 
immunosuppression, anticoagulant, and laser treatment. Thus, screening for APA 
is vital in SLE patients with lupus retinopathy, as prompt treatment with 
anticoagulants is important to prevent further vascular thrombosis, which 
worsens the visual prognosis.