MOTIVATION: Oxidative stress and protein damage have been associated with over 
200 human ailments including cancer, stroke, neuro-degenerative diseases and 
aging. Protein carbonylation, a chemically diverse oxidative post-translational 
modification, is widely considered as the biomarker for oxidative stress and 
protein damage. Despite their importance and extensive studies, no 
database/resource on carbonylated proteins/sites exists. As such information is 
very useful to research in biology/medicine, we have manually curated a 
data-resource (CarbonylDB) of experimentally-confirmed carbonylated 
proteins/sites.
RESULTS: The CarbonylDB currently contains 1495 carbonylated proteins and 3781 
sites from 21 species, with human, rat and yeast as the top three species. We 
have made further analyses of these carbonylated proteins/sites and presented 
their occurrence and occupancy patterns. Carbonylation site data on serum 
albumin, in particular, provides a fine model system to understand the dynamics 
of oxidative protein modifications/damage.
AVAILABILITY AND IMPLEMENTATION: The CarbonylDB is available as a web-resource 
and for download at http://digbio.missouri.edu/CarbonylDB/.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics 
online.