Werner's syndrome (WS) or progeria adultorum is a heritable autosomal recessive 
disease in which the aging process is accelerated, just after puberty. It is 
caused by mutations in the WRN gene, which encodes a member of the RECQ family 
of DNA helicases and has a role in DNA repair. WS is being more appropriately 
recognized as a condition in which the lack of WRN protein results in an overall 
decline in the normal physiological functions of various organs rather than 
premature aging. Here, we describe a rare case of WS with a novel mutation from 
India. Our patient was an adult male with a history of growth arrest since 
puberty and other clinical features such as sclerodermatous skin changes, 
premature graying and thinning of hair, bilateral cataract, a single non-healing 
ulcer, hypothyroidism, underdeveloped secondary sexual characters with 
hypogonadism, infertility, squeaky voice, and early signs of arteriosclerosis. 
On genetic analysis, he was found to have a homozygous pathogenic variant 
c.3190C>T in exon 26 of the WRN gene, which has never been reported in WS.