canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused 
knowledgebase for the support of cancer translational research and drug 
discovery. Through the integration of biological, pharmacological, chemical, 
structural biology and protein network data, it provides a single information 
portal to answer complex multidisciplinary questions including--among many 
others--what is known about a protein, in which cancers is it expressed or 
mutated, and what chemical tools and cell line models can be used to 
experimentally probe its activity? What is known about a drug, its cellular 
sensitivity profile and what proteins is it known to bind that may explain 
unusual bioactivity? Here we describe major enhancements to canSAR including new 
data, improved search and browsing capabilities and new target, cancer cell 
line, protein family and 3D structure summaries and tools.