There is growing interest in the effects of exercise on plasma gut hormone 
levels and subsequent energy intake (EI) but the effects of mode and exercise 
intensity on anorectic hormone profiles on subsequent EI remain to be 
elucidated. We aimed to investigate whether circulating peptide YY(3-36) 
(PYY(3-36)) and glucagon-like peptide-1 (GLP-1 or GCG as listed in the HUGO 
Database) levels depend on exercise intensity, which could affect subsequent EI. 
Ten young male subjects (mean+/-s.d., age: 23.4+/-4.3 years, body mass index: 
22.5+/-1.0 kg/m(2), and maximum oxygen uptake (VO(2 max)): 45.9+/-8.5 ml/kg per 
min) received a standardized breakfast, which was followed by constant cycling 
exercise at 75% VO(2 max) (high intensity session), 50% VO(2 max) (moderate 
intensity session), or rest (resting session) for 30 min. At lunch, a test meal 
was presented, and EI was calculated. Blood samples were obtained during three 
sessions for measurements of glucose, insulin, PYY(3-36), and GLP-1, which 
includes GLP-1 (7-36) amide and GLP-1 (9-36) amide. Increases in blood PYY(3-36) 
levels were dependent on the exercise intensity (effect of session: P<0.001 by 
two-way ANOVA), whereas those in GLP-1 levels were similar between two different 
exercise sessions. Of note, increase in area under the curve values for GLP-1 
levels was negatively correlated with decrease in the EI in each exercise 
session (high: P<0.001, moderate: P=0.002). The present findings raise the 
possibility that each gut hormone exhibits its specific blood kinetics in 
response to two different intensities of exercise stimuli and might play 
differential roles in regulation of EI after exercise.