Dengue is a mosquito-borne disease caused by four closely related dengue virus 
(genus Flavivirus)serotypes (DENV-1–4). The clinical outcomes vary from mild 
febrile illness to life-threatening haemorrhagic manifestations. DENVs are 
endemic in the tropics and subtropics globally and currently no specific 
treatment or vaccines are available. In Venezuela, the American-Asian genotype 
of DENV-2 is the most prevalent and has been associated with severe disease 
outcomes.We aimed to follow-up the molecular epidemiology of DENV-2 in Venezuela 
to investigate if the evolution of the virus has remained the same throughout 
time or if the same dynamics documented in Brazil (hyperendemic co-circulation) 
also occurred. The results show that whereas the epidemiology of DENV in several 
endemic areas is characterized by serotype replacements through time, in 
Venezuela the American-Asian genotype DENV-2 has evolved into several genetic 
lineages and has remained in hyperendemic co-circulation with the other 
serotypes.