Many hormonal dysfunctions were noticed in amyotrophic lateral sclerosis (ALS). 
The study aimed at measuring blood serum level of TSH and PRL after THR loading 
in 10 ALS patients and in the 10 healthy individuals. Mean baseline levels of 
TSH and PRL in ALS patients were with in normal range. After TRH loading, the 
TSH responses in the ALS patients were with in normal range, where as PRL 
responses were diminished. The obtained results could indicate some disorders on 
the dopaminergic neurons level.