OBJECTIVE: To determine the prevalence of thrombophilic genetic variants in an 
American Indian population and determine if they are associated with 
preeclampsia.
METHODS: A total of 87 cases, 165 controls and an additional 75 population-based 
controls were genotyped for two thrombophilic polymorphisms.
RESULTS: The allelic prevalence of the factor V Leiden and 20210 G/A prothrombin 
variants in this population was 2.1% and 0.5% respectively. No statistically 
significant associations between these genetic variants and preeclampsia were 
found.
CONCLUSION: The prevalence of thrombophilic variants is of possible public 
health significance for other morbidity; but perhaps not in relation to 
preeclampsia.