Adipose tissue is a dynamic neuroendocrine organ that is involved in multiple 
physiological and pathological processes, and when excessive, results in 
obesity. Clinical and population-based data suggest that migraine and chronic 
daily headache are associated with obesity, as estimated by anthropometric 
indices. In addition, translational and basic science research shows multiple 
areas of overlap between migraine pathophysiology and the central and peripheral 
pathways regulating feeding. Specifically, neurotransmittors such as serotonin, 
peptides such as orexin, and adipocytokines such as adiponectin and leptin have 
been suggested to have roles in both feeding and migraine. In this article, we 
first review the definition and ascertainment of obesity. This is followed by a 
review of the clinical and population-based studies evaluating the associations 
between obesity and chronic daily headache and migraine. We then discuss the 
central and peripheral pathways involved in the regulation of feeding, where it 
overlaps with migraine pathophysiology, and where future research may be headed 
in light of these data.