Lemierre's syndrome, a systemic anaerobic infection caused by Fusobacterium 
necrophorum, is characterized by an acute oropharyngeal infection, septic 
thrombophlebitis of the internal jugular vein, sepsis, and multiple metastatic 
infections. It commonly leads to septic arthritis and occasionally to 
osteomyelitis. In the preantibiotic era, this infection was nearly universally 
fatal. Today it still poses a potentially grave threat to the young patients 
affected. Prompt recognition with appropriate debridement and antibiotic 
treatment results in complete recovery in most cases. We report a case of 
anaerobic septic arthritis and multifocal acute hematogenous osteomyelitis as 
part of a classic presentation of Lemierre's syndrome.