Author information:
(1)Institute of Biomedical and Clinical Science, University of Exeter Medical 
School, Royal Devon & Exeter Hospital, Exeter EX2 5DW, UK.
(2)National Heart & Lung Institute and MRC London Institute of Medical Sciences, 
Imperial College London, London W12 0NN, UK; Cardiovascular Research Centre, 
Royal Brompton & Harefield Hospitals NHS Trust, London SW3 6NP, UK.
(3)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 
Madrid, Spain.
(4)Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, 
Hinxton CB10 1RQ, UK.
(5)National Institute for Health Research Oxford Biomedical Research Centre, 
Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
(6)Analytic and Translational Genetics Unit, Massachusetts General Hospital, 
Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad 
Institute of MIT and Harvard, Cambridge, MA 02142, USA.
(7)European Molecular Biology Laboratory, European Bioinformatics Institute 
(EMBL-EBI), Cambridge CB10 1SD, UK.
(8)Sheffield Clinical Genetics Service, Sheffield Children's NHS Foundation 
Trust, Sheffield S10 2TH, UK; Academic Unit of Child Health, Department of 
Oncology & Metabolism, University of Sheffield, Sheffield S10 2TH, UK.
(9)Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester 
University Hospitals NHS Foundation Trust, Health Innovation Manchester, 
Manchester M13 9WL, UK; Division of Evolution and Genomic Sciences, School of 
Biological Sciences, University of Manchester, Oxford Road, Manchester M13 9PL, 
UK.
(10)Manchester Centre for Genomic Medicine, St Mary's Hospital, Manchester 
University Hospitals NHS Foundation Trust, Health Innovation Manchester, 
Manchester M13 9WL, UK.
(11)Division of Evolution and Genomic Sciences, School of Biological Sciences, 
University of Manchester, Oxford Road, Manchester M13 9PL, UK.
(12)Department of Pediatrics, Wake Forest School of Medicine, Winston-Salem, NC 
27101, USA.
(13)UCD Academic Centre on Rare Diseases, School of Medicine and Medical 
Sciences, University College Dublin, and Clinical Genetics, Temple Street 
Children's University Hospital, Dublin D01 XD99, Ireland.
(14)West Midlands Regional Clinical Genetics Service and Birmingham Health 
Partners, Birmingham Women's and Children's Hospitals NHS Foundation Trust, 
Birmingham B4 6NH, UK.
(15)Department of Pediatrics, Saint Louis University School of Medicine, Saint 
Louis, MO 63104, USA.
(16)All Wales Medical Genomics Service, NHS Wales Cardiff and Vale University 
Health Board, Institute of Medical Genetics, University Hospital of Wales, 
Cardiff CF14 4AY, UK.
(17)Oxford Centre for Genomic Medicine, Oxford University Hospitals NHS 
Foundation Trust, Oxford OX3 7LE, UK.
(18)Department of Neurology, University of Kansas School of Medicine-Salina 
Campus, Salina, KS 67401, USA.
(19)National Heart & Lung Institute and MRC London Institute of Medical 
Sciences, Imperial College London, London W12 0NN, UK.
(20)GeneDx, Gaithersburg, MD 20877, USA.
(21)Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, 
Hinxton CB10 1RQ, UK; East Anglian Medical Genetics Service, Cambridge 
University Hospitals NHS Foundation Trust, Cambridge CB2 0QQ, UK.
(22)Centro Nacional de Investigaciones Cardiovasculares Carlos III (CNIC), 28029 
Madrid, Spain; CIBER de enfermedades CardioVasculares (CIBERCV), 28029 Madrid, 
Spain.
(23)Human Genetics Programme, Wellcome Sanger Institute, Wellcome Genome Campus, 
Hinxton CB10 1RQ, UK; Program in Medical and Population Genetics, Broad 
Institute of MIT and Harvard, Cambridge, MA 02142, USA; Wellcome Centre for 
Human Genetics, University of Oxford, Oxford OX3 7BN, UK. Electronic address: 
nwhiffin@well.ox.ac.uk.