Giant bullous emphysema, or vanishing lung syndrome, typically occurs in young, 
thin male smokers with large bullae in one or more upper lobes occupying at 
least one-third of the hemithorax. We present here a rare case of giant bullous 
emphysema in a mid-age nonsmoking female who was seen for progressive shortness 
of breath and cough. Chest computed tomography found a giant bulla in the middle 
lobe of right lung. The patient underwent successful thoracoscopic bullectomy 
and is currently without residual symptoms.