We report a case of meningioma diagnosed 23 years after high-dose cranial and 
whole-body irradiation for the treatment of acute lymphocytic leukemia (ALL). 
Radiotherapy in this case also caused early radiation injury to the lenses and 
the pituitary gland, with growth retardation and mineralizing angiopathy. 
Radiation-induced meningiomas are more commonly malignant, more commonly 
multiple, and more likely to recur after resection than non-radiation-induced 
meningiomas. Survivors of childhood ALL treated with high-dose cranial 
irradiation are at risk both for early radiation injury in radiosensitive 
organs, such as the lens and pituitary gland, and for the later development of a 
radiation-induced meningioma.