We have provided an in-depth, longitudinal, clinical/genetic/pathologic 
investigation of a family consonant with the sarcoma, breast cancer and brain 
tumors, lung and laryngeal cancer, leukemia, lymphoma, and adrenalcortical 
carcinoma syndrome. The pattern of cancer expression involves all three germinal 
layers with transmission through multiple generations. Segregation of these 
cancers occur in a manner consonant with an autosomal dominant mode of genetic 
transmission. It is hoped that recognition of the significance of this tumor 
pattern within families will provide an impetus for cancer surveillance, 
control, and laboratory research in the quest for clues to biomarkers which 
correlate with its cancer-prone genotype.