Radiation-induced sarcomas are recognized complications of radiation therapy and 
are associated with poor prognosis. Radiation-induced osteosarcoma is one of the 
rare types of radiation-induced sarcomas, with the risk of radiation-induced 
osteosarcomas being only 0.01%-0.03% among all patients treated with 
radiotherapy. There have been only four reported cases of radiation-induced 
osteosarcomas after radiotherapy for gliomas. Here, we report a unique case of 
radiation-induced osteosarcomas arising on the skull and extending to the skin, 
with a short latent period. We also review the clinical features of the 
previously reported cases.