A 12-year-old boy was seen in our department with a three year history of 
eruptions on his back consisting of normal colored or slightly reddish, 
pinhead-sized papules, which had gradually spread to his trunk within the 
previous year. Four days before the first visit, May 13, 1992, the eruption 
involved his entire extremities. On the back side of his lumbar region, 
Koebner's phenomenon was observed. He had received several medications for more 
than two years to treat this eruption in several hospitals, but none were 
effective. He was in good general health. Mantoux reaction was negative two 
months after BCG injection. Histopathologic features of the papules included 
focal epidermal hyperplasia and elongation of the rete ridges in a narrow area 
and a well demarcated dense lymphohistiocytic infiltrate on the papillar layer. 
Biscoclaurine alkaloids (20 mg/day) and Jumi-haidoku-to (TJ-6; 7.5 g/day) were 
administered to the patient after the biopsy. No topical ointments were applied. 
Two weeks after of these treatments, he reported moderate pruritus on the back. 
The eruption diminished rapidly within 2 weeks after the therapy began. Almost 
all the eruptions were cured within one year. Mantoux reaction developed 8 x 8 
mm erythema two and half months after the treatment began, and it was 
significantly positive (23 x 30 mm) 6 months later.