OBJECTIVE AND IMPORTANCE: Ameloblastoma is a locally aggressive benign tumor, 
commonly occurring in the mandible. While giant ameloblastoma of multicystic or 
plexiform variant have been reported, the authors report a rare case of giant 
unicystic ameloblastoma of luminal variant, which was treated by compartmental 
resection and planned for delayed reconstruction.
CLINICAL PRESENTATION: A 46 year old male patient reported to the oral surgery 
out-patient department with a swelling of the left side mandible region of 
2 years duration. He had undergone ayurvedic treatment for the same with no 
improvement. The size of the lesion on presenting was approximately 9 × 12 cm.
INTERVENTION: Compartmental resection with plan for secondary reconstruction, 
after adequate follow up period.
CONCLUSION: While conservative management is being explored as a treatment 
option for unicystic ameloblastoma, resection is still the standard of care 
regardless of the histopathological subtype for giant lesions.