Mutations in BRCA genes elevate risk for breast and ovarian cancer. These 
mutations are population specific. As there are no data on BRCA mutation 
screening on larger number of probands in Serbia to date, aim of this study was 
to determine types and frequencies of BRCA mutations in individuals from 
high-risk families from Serbia, as well as to determine which BRCA mutations may 
be considered as founder for Serbian population. We analyzed 94 probands and 
detected 9 frameshift mutations in 12 individuals, 1 benign BRCA2 nonsense 
mutation and numerous missense and synonymous mutations in both genes. Frequency 
of frameshift mutations is 12.77%. In addition to two novel mutations detected 
in our population we reported previously, we detected another novel 
mutation--c.7283delT in BRCA2 exon 14. None of the detected deleterious 
mutations may be considered as founder mutations for Serbian population, as each 
of them was found in no more than two high-risk families. This mutation 
diversity is most probably due to high migration rate in history of this part of 
Europe. Interpretation of genetic testing results with missense mutations of 
unknown clinical importance is very challenging and should be approached with 
caution, using all available data sources for results' interpretation.