Chronic wasting disease (CWD) is a prion disease of cervids that causes 
neurodegeneration and death. Susceptibility to prion infections, including CWD, 
can be dependent on the amino acid sequence of the host prion protein (PrP). 
Here, CWD agent obtained from a deer expressing the 96SS genotype, associated 
with partial resistance to CWD, was used to infect transgenic (tg) mice 
expressing either 96GG or 96SS deer PrP. Transgenic mice expressing 96GG deer 
PrP succumbed to this agent, but tg mice expressing 96SS deer PrP did not. 
Additional studies using inocula from 96GG deer showed no transmission to 96SS 
PrP mice and delayed disease in 96GS mice. Thus, 96S PrP played an inhibitory 
role in disease progression in tg mice.