The identification of Zika virus as a significant teratogen has raised 
international concern, causing the World Health Organization to declare a Public 
Health Emergency of International Concern. This has allowed a global 
mobilization of experts in tropical infectious diseases, obstetrics, pediatrics, 
virology, public health policy, reproductive health, bioethics, and germ cell 
research to name just a few. This worldwide crisis has also raised awareness of 
health care disparities and concerns regarding the ability of families and 
societies to shoulder the long-term financial burden that the follow-up of 
affected children will require. There is now strong biologic evidence of 
causality between Zika virus and microcephaly and other neurologic abnormalities 
identified. Multiple national and international organizations have collaborated 
to develop guidelines for the management of pregnant women who reside in or who 
are exposed to Zika virus, whether from travel to affected areas or via sexual 
contact with an infected individual. These guidelines are updated frequently as 
data are made available. Testing algorithms are available and though testing is 
fraught with interpretation issues, the development of better diagnostic tests 
is ongoing.