Cancer-related fatigue is a common yet underappreciated problem with a 
significant impact on functional ability and quality of life. Practice 
guidelines mandate that all cancer patients and survivors be screened for 
cancer-related fatigue (CRF) at regular intervals. Comorbidities that could 
contribute to fatigue should be treated, and patients with moderate to severe 
fatigue should undergo a comprehensive evaluation. Nonpharmacologic 
interventions are important tools to combat CRF and should be incorporated into 
routine practice. Physical activity, educational interventions, and 
cognitive-behavioral therapy have the most supportive data and can be 
recommended to patients with confidence. From a practical standpoint, general 
education on CRF is something that most care providers can readily offer 
patients as part of routine care. Other interventions that appear promising but 
are as yet lacking convincing evidence include mindfulness-based stress 
reduction, yoga, and acupuncture. Reiki, Qigong, hypnosis, and music therapy may 
be worthy of further investigation.