Bacterial extracellular vesicles (EVs) are bilayered lipid membrane structures, 
bearing integral proteins and able to carry diverse cargo outside the cell to 
distant sites. In microorganisms, EVs carry several types of molecules: 
proteins, glycoproteins, mRNAs and small RNA species, as mammalian EVs do, but 
also carbohydrates. Studying EVs opens a whole new world of possibilities to 
better understand the interplay between host and bacteria crosstalks, although 
there are still many questions to be answered in the field, especially when it 
comes to microbiota-derived EVs. In this review, we propose to summarize and 
analyse the current literature about bacterial EVs and possible clinical 
applications, through answering three main questions: (a) What are bacterial 
EVs? (b) What are EV impacts on skin inflammatory disease physiopathology? (iii) 
What are the possible and expected clinical applications of EVs to treat 
inflammatory skin diseases?