The molecular clockwork drives rhythmic oscillations of signaling pathways 
managing intermediate metabolism; the circadian timing system synchronizes 
behavioral cycles and anabolic/catabolic processes with environmental cues, 
mainly represented by light/darkness alternation. Metabolic pathways, bile acid 
synthesis, and autophagic and immune/inflammatory processes are driven by the 
biological clock. Proper timing of hormone secretion, metabolism, bile acid 
turnover, autophagy, and inflammation with behavioral cycles is necessary to 
avoid dysmetabolism. Disruption of the biological clock and mistiming of body 
rhythmicity with respect to environmental cues provoke loss of internal 
synchronization and metabolic derangements, causing liver steatosis, obesity, 
metabolic syndrome, and diabetes mellitus.