The sotagliflozin molecule exhibits two fundamentally different molecular 
conformations in form 1 {systematic name: 
(2S,3R,4R,5S,6R)-2-[4-chloro-3-(4-ethoxybenzyl)phenyl]-6-(methylsulfanyl)tetrahydro-2H-pyran-3,4,5-triol, 
C21H25ClO5S, (I)} and the monohydrate [C21H25ClO5S·H2O, (II)]. Both crystals 
display hydrogen-bonded layers formed by intermolecular interactions which 
involve the three -OH groups of the xyloside fragment of the molecule. The layer 
architectures of (I) and (II) contain a non-hydrogen-bonded molecule-molecule 
interaction along the short crystallographic axis (a axis) whose total PIXEL 
energy exceeds that of each hydrogen-bonded molecule-molecule pair. The 
hydrogen-bonded layer of (I) has the topology of the 4-connected sql net and 
that formed by the water and sotagliflozin molecules of (II) has the topology of 
a 3,7-connected net.