Cancer is the third cause of death worldwide, with complex etiology, and is 
defined as an uncontrolled growth of cells. A high proportion of cancer 
incidence and deaths are due to different environmental and genetic factors such 
as high body mass index, low fruit and vegetable intake, lack of physical 
activity, tobacco use, alcohol consumption, exposure to radiation, chronic 
infections, and heredity also. In addition, oxidative stress plays a crucial 
role in the pathophysiology of different types of cancer. Hence, screening and 
testing of more effective compounds with minimum side effects for the prevention 
and treatment of cancers started a few decades ago. Regarding this, much 
attention has been paid to natural antioxidants as a novel prevention and 
treatment strategy for cancer. Flavonoids are one of the most important 
ingredients in vegetables and fruits, especially in the genus Citrus. Hesperidin 
is a flavonone glycoside, belonging to the flavonoid family, which is widely 
found in Citrus species and acts as a potent antioxidant and anticancer agent. 
In the present review, we attempt to provide an overview and summarize the 
scientific literature about the cancer chemoprotective effects of hesperidin 
with an emphasis on its relation to the protection roles against oxidative 
stress.