Congenital leukemia is a rare but a well-documented disease in which leukemic 
process is detected at birth or very shortly thereafter (Philip McCoy and Roy 
Overton, Commun Clin Cytom 22:85-88, 1995). These leukemias represent 
approximately 0.8 % of all childhood leukemias. We present a case of congenital 
acute myeloid leukemia manifesting from the very first day of birth. Diagnosis 
of acute myeloid leukemia was suspected by the presence of blasts in the 
peripheral blood smear and was confirmed on bone marrow by flowcytometry. 
Karyotyping revealed Trisomy 21.