OBJECTIVE: To clarify the effects of Astragalus Membranaceus (AM) combined with 
taurine and/or coenzyme Q10(CoQ10) on coxsackievirus B3 (CVB3) murine 
myocarditis.
METHODS: Viral myocarditis model was created by intraperitoneal inoculation with 
CVB3 solution and were treated by saline, AM, taurine, CoQ10, AM + taurine, AM + 
CoQ10, AM + taurine + CoQ10, respectively. The mortality, ECG, CVB3-RNA in 
myocardium and myocardial histopathologic changes were observed.
RESULTS: AM combined with taurine and CoQ10 could significantly reduce the 
mortality of the mice and the incidence of abnormal ECG at acute stage. CVB3-RNA 
was significantly reduced in AM treated group, especially in AM + taurine group. 
No anti-virus effect was found in CoQ10 group. All drugs could lighten 
myocardial histopathologic changes and the effect could be enhanced by combined 
treatment.
CONCLUSIONS: AM, taurine and CoQ10 have some curative effects on CVB3 murine 
myocarditis, AM combined with taurine and CoQ10 is the best.