Author information:
(1)Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA. 
cousin.margot@mayo.edu.
(2)Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA. 
cousin.margot@mayo.edu.
(3)Department of Cell Biology and Physiology, University of North Carolina at 
Chapel Hill, Chapel Hill, NC, USA.
(4)Department of Pediatrics, Duke University Medical Center, Duke University, 
Durham, NC, USA.
(5)GeneDx, Gaithersburg, MD, USA.
(6)Bioinformatics Research and Development Laboratory, Genomic Sciences and 
Precision Medicine Center, Medical College of Wisconsin, Milwaukee, WI, USA.
(7)Department of Psychiatry, University of North Carolina at Chapel Hill, Chapel 
Hill, NC, USA.
(8)Carolina Institute for Developmental Disabilities, University of North 
Carolina at Chapel Hill, Chapel Hill, NC, USA.
(9)Neuroscience Center, University of North Carolina at Chapel Hill, Chapel 
Hill, NC, USA.
(10)Human Pluripotent Stem Cell Core, University of North Carolina at Chapel 
Hill, Chapel Hill, NC, USA.
(11)Department of Pathology, Yale University, New Haven, CT, USA.
(12)Department of Neurology, Columbia University, New York, NY, USA.
(13)Institute for Genomic Medicine, Columbia University, New York, NY, USA.
(14)Laboratory of Personalized Genomic Medicine, Department of Pathology and 
Cell Biology, Columbia University, New York, NY, USA.
(15)Department of Clinical Genetics, Erasmus MC University Medical Center, 
Rotterdam, the Netherlands.
(16)Institute of Human Genetics, University of Bonn, School of Medicine & 
University Hospital Bonn, Bonn, Germany.
(17)McMaster University, Hamilton, Ontario, Canada.
(18)Department of Genetics, University Medical Center Utrecht, Utrecht, the 
Netherlands.
(19)Spectrum Health Medical Genetics, Grand Rapids, MI, USA.
(20)Division of Neurology, Departments of Neurology and Pediatrics, The 
Children's Hospital of Philadelphia and the Perelman School of Medicine at the 
University of Pennsylvania, Philadelphia, PA, USA.
(21)The Epilepsy NeuroGenetics Initiative, Children's Hospital of Philadelphia, 
Philadelphia, PA, USA.
(22)Department of Biomedical and Health Informatics (DBHi), Children's Hospital 
of Philadelphia, Philadelphia, PA, USA.
(23)Department of Neurology, University of Pennsylvania, Perelman School of 
Medicine, Philadelphia, PA, USA.
(24)Genetics, Driscoll Children's Hospital, Corpus Christi, TX, USA.
(25)Service de Génétique Médicale, CHU Nantes, Nantes, France.
(26)Université de Nantes, CNRS, INSERM, L'Institut du Thorax, Nantes, France.
(27)William Harvey Research Institute, School of Medicine and Dentistry, Queen 
Mary University of London, London, UK.
(28)Department of Clinical Genetics, Cambridge University Hospitals, Cambridge, 
UK.
(29)Wellcome Sanger Institute, Wellcome Genome Campus, Hinxton, UK.
(30)Institute of Human Genetics, University Medical Center Hamburg-Eppendorf, 
Hamburg, Germany.
(31)Neuropediatrics, Department of Pediatrics, University Medical Center 
Hamburg-Eppendorf, Hamburg, Germany.
(32)Division of Medical Genetics, Department of Pediatrics, University of 
California San Francisco, San Francisco, CA, USA.
(33)Institute for Human Genetics, University of California San Francisco, San 
Francisco, CA, USA.
(34)Division of Genetics and Genomics, Boston Children's Hospital, Boston, MA, 
USA.
(35)Nicklaus Children's Hospital, Miami, FL, USA.
(36)Department of Psychiatry and Behavioral Sciences, University of Washington, 
Seattle, WA, USA.
(37)Department of Genome Sciences, University of Washington School of Medicine, 
Seattle, WA, USA.
(38)Howard Hughes Medical Institute, University of Washington, Seattle, WA, USA.
(39)Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.
(40)Department of Clinical Genomics, Mayo Clinic, Rochester, MN, USA.
(41)Department of Quantitative Health Sciences, Mayo Clinic, Rochester, MN, USA.
(42)Divisions of Clinical/Metabolic Genetics and Neurology, The Hospital for 
Sick Children, University of Toronto, Toronto, Ontario, Canada.
(43)Institute of Neurogenomics, Helmholtz Zentrum München, Munich, Germany.
(44)Institute of Human Genetics, Technical University of Munich, Munich, 
Germany.
(45)Department of Neurology, Charles University, 1st Faculty of Medicine and 
General University Hospital in Prague, Prague, Czech Republic.
(46)Lehrstuhl für Neurogenetik, Technische Universität München, Munich, Germany.
(47)Munich Cluster for Systems Neurology, SyNergy, Munich, Germany.
(48)Department of Genetics, University of North Carolina at Chapel Hill, Chapel 
Hill, NC, USA.
(49)Department of Pharmacology, University of North Carolina at Chapel Hill, 
Chapel Hill, NC, USA.
(50)Department of Biochemistry, Medical College of Wisconsin, Milwaukee, WI, 
USA.
(51)Clinical and Translational Sciences Institute, Medical College of Wisconsin, 
Milwaukee, WI, USA.
(52)Department of Biochemistry and Biophysics, University of North Carolina at 
Chapel Hill, Chapel Hill, NC, USA.
(53)Department of Cell Biology and Physiology, University of North Carolina at 
Chapel Hill, Chapel Hill, NC, USA. damaris_lorenzo@med.unc.edu.
(54)Carolina Institute for Developmental Disabilities, University of North 
Carolina at Chapel Hill, Chapel Hill, NC, USA. damaris_lorenzo@med.unc.edu.
(55)Neuroscience Center, University of North Carolina at Chapel Hill, Chapel 
Hill, NC, USA. damaris_lorenzo@med.unc.edu.
(#)Contributed equally