Giant abdominal hemophilic pseudotumor is exceedingly rare, thus may bring great 
challenges to the timely and proper diagnosis and treatment of clinicians. The 
only definitive management is complete removal of the abdominal hemophilic 
pseudotumor. The objective of this article is to report surgical treatment and 
follow-up outcomes of three unusual cases with giant abdominal hemophilic 
pseudotumor.We describe 3 patients with giant hemophilic pseudotumor involving 
the abdomen who were successfully treated with tumor resection. On presentation 
to our institution, the patients all had signs of giant cystic lesions in 
abdomen, and the patients' most outstanding complaints were aggravated abdominal 
pain. All of three patients underwent complete excision of abdominal hemophilic 
pseudotumor. The patients showed adequate pain relief compared with the previous 
status.Surgical resection is the most effective treatment option for patients 
with giant abdominal hemophilic pseudotumor who can undergo appropriate surgical 
treatment. This represents a safe and reasonable approach to sustainably relieve 
pain and other symptoms with giant hemophilic pseudotumor in the abdomen. 
Perioperative coagulation factor replacement therapy is also of great 
significance in reducing the risks and complications.