Degenerative process in Parkinson's disease affects substantia nigra and other 
central structures of an extrapyramidal system but it can also affect central 
and peripheral autonomic centres. One of the most frequent late complications in 
levodopa therapy is a wearing off phenomenon. We present a patient treated for 
Parkinson's disease in whom during the period of levodopa wearing off we 
observed a paroxysmal abdominalgia apart from other features of a typical 
movement disorders like: increasing rigidity, gait disturbances and tremor. 
Abdominalgia consisted of stomach cramps, with variable localization in epi-, 
meso- and hypogastrium. Rectal tenesmus was also present. The patient was 
treated with analgesics, spasmolytics and carminative drugs with no effect. 
Abdominal pains regressed after an intake of the next levodopa dose. The patient 
presented with other features of a gastrointestinal tract autonomic system 
dysfunction like: chronic constipation, preterm satiety resulting in food intake 
reduction and a decrease in body weight. There was no organic lesions of the 
gastrointestinal system that could explain such disturbances. Pharmacologic 
treatment modification (more frequent levodopa dosage, additional dopamine 
agonist) resulted in some improvement.
CONCLUSION: It is possible that the abdominal pains could be a clinical 
manifestation of a digestive tract dyskinesias, occurring during