This cross-sectional study compared the Oral-Health-Related Quality of Life 
(OHRQoL) in HIV negative patients (Group 1, n=129, mean age: 39.9 ± 15.6, 75 
females) and HIV+ patients (Group 2, n=670, mean age: 43.2 ± 9.8, 246 females) 
from the same socio-economic environment using the OHIP-49 questionnaire. OHIP 
total score were determined by simple summing. A multiple linear regression 
model was carried out to predict OHIP scores in which HIV+ patients experienced 
a significantly (p<0.001) worst OHRQoL for total and every dimension. A general 
linear model was used for estimating the means in the two groups adjusted for 
covariates included in the previous model. Adjusted means for subscale and total 
OHIP scores were significantly higher for Group 2 (61.6 ± 6.26 vs. 119.8 ± 3.31) 
with a large effect size (0.94). HIV+ infection, decayed teeth, prosthodontic 
and surgical needs, care index, drug use, employment and age presented an 
independent effect on questionnaire scores. This study shows that HIV+ infection 
has an independent and negative impact on the OHRQoL while care index presents a 
positive impact. Additional factors like high decayed teeth, prosthodontic 
treatment needs and drug use are independently associated with total OHIP 
scores, presenting a negative effect on OHRQoL.