The dopaminergic system plays a pivotal role in the central nervous system via 
its five diverse receptors (D1-D5). Dysfunction of dopaminergic system is 
implicated in many neuropsychological diseases, including attention deficit 
hyperactivity disorder (ADHD), a common mental disorder that prevalent in 
childhood. Understanding the relationship of five different dopamine (DA) 
receptors with ADHD will help us to elucidate different roles of these receptors 
and to develop therapeutic approaches of ADHD. This review summarized the 
ongoing research of DA receptor genes in ADHD pathogenesis and gathered the past 
published data with meta-analysis and revealed the high risk of DRD5, DRD2, and 
DRD4 polymorphisms in ADHD.