Tumor suppressor p53, known as 'the guardian of the genome', has the ability to 
prevent the emergence of transformed cells by the induction of cell cycle arrest 
and apoptosis. Otherwise, there were researches about the function of p53, such 
as NDA repair, regulating metabolism and maternal reproduction in recent years. 
Furthermore, there was a new function for p53 in antiviral apoptosis mentioned 
in the research, Integration of interferon-alpha/beta signaling to p53 responses 
in tumour suppression and antiviral defense. In order to define the antiviral 
function of p53, many target genes has been defined, such as IRF9, IRF5, ISG15 
and TLR3. All of these implied there must be a complex mechanism for role of p53 
in antiviral innate immunity, adaptive immunity and inflammation.