Observation's analysis of 5 children in age from 9 months to 4 years 11 months 
with tuberous sclerosis was performed. The initial manifestations of disease 
were following: early children form of epilepsy exactly infantile spasms (West 
syndrome) appearance, dermal alterations in the form of depigmented spots as 
well as nonprogressive delay in psychoverbal development. Together with clinical 
symptoms the main criterion in early form of tuberous sclerosis diagnosis 
determination turned out to be brain's specific alterations (tubers) which were 
revealed by computer tomography. The correlation was observed between epileptic 
seizures polymorphism and frequency as well as brain's morphological 
alterations. Derivatives of valproic acid were the basic drugs in treatment of 
epileptic seizures in patients.