The efficacy and safety of gabapentin as add-on therapy for refractory partial 
seizures in 237 children, aged 3 to 12 years were evaluated over a 6-month 
period. All children received gabapentin at 24 to 70 mg/kg/day. Efficacy 
variables included the percent change in seizure frequency and the responder 
rate (defined as those patients who showed >50% reduction in seizure frequency). 
For all partial seizures, the median percent change in seizure frequency was 
-34% and the overall responder rate was 34%. Simple partial seizures showed a 
median reduction of -53%; complex partial seizures, -38%; and secondarily 
generalized tonic-clonic seizures, -35%. Thirteen patients (5%) withdrew during 
the 6-month period because of adverse events. Concurrent antiepileptic 
medication remained unchanged in 185 patients (78%), was decreased in 27 (11%), 
and increased in 25 (11%) patients. This 6-month follow-up study has 
demonstrated that gabapentin was well tolerated and appeared to show a sustained 
efficacy in a large population of children with refractory partial and 
secondarily generalized tonic-clonic seizures.