Targeted RNA-Seq combines next-generation sequencing with capture of sequences 
from a relevant subset of a transcriptome. When testing by capturing sequences 
from a tumor cDNA library by hybridization to oligonucleotide probes specific 
for 467 cancer-related genes, this method showed high selectivity, improved 
mutation detection enabling discovery of novel chimeric transcripts, and 
provided RNA expression data. Thus, targeted RNA-Seq produces an enhanced view 
of the molecular state of a set of "high interest" genes.