OBJECTIVE: Preeclampsia is associated with increased risk of cardiovascular 
disease. The aim of this pilot study was to assess whether the presence of 
thrombophilia results in a greater tendency to develop endothelial dysfunction 
and cardiovascular diseases.
METHODS: Ten women with thrombophilia were matched with 10 women without 
thrombophilia for a history of hypertensive disorders during pregnancy. 
Laboratory measurements: blood pressure, insulin sensitivity, and micro- and 
macrovascular function were determined.
RESULTS: Women with thrombophilia had significant lower total- and low-density 
cholesterol, were more insulin sensitive, and had better microvascular function.
CONCLUSION: This study suggests that thrombophilia "mediates" in lowering of 
cardiovascular risk factors in women with a history of preeclampsia.