IMPORTANCE OF THE FIELD: Herpes zoster or shingles is a condition with the 
potential to result in severe debilitation. It affects approximately 10 - 30% of 
the population. Until recently there were only treatments to shorten the 
duration and lessen the symptoms of herpes zoster, but no practical or approved 
method of prevention for susceptible immunocompetent adults. The live attenuated 
zoster vaccine (Zostavax, Merck & Co., Inc.) is effective in preventing shingles 
in individuals 60 years of age and older and recommended by the Center for 
Disease Control's (CDC) Advisory Committee for Immunization Practices (ACIP).
AREAS COVERED IN THIS REVIEW: Literature related to the live attenuated zoster 
vaccine is reviewed from its beginnings in the early 1970s through to the 
present.
WHAT THE READER WILL GAIN: Background information on herpes zoster and up to 
date information on the live attenuated zoster vaccine including pharmacology, 
efficacy and safety are covered. New areas of research in zoster vaccination are 
also discussed.
TAKE HOME MESSAGE: The live attenuated zoster vaccine is an effective and 
well-tolerated method of preventing zoster and the potentially debilitating 
sequelae and is recommended for immunocompetent patients 60 years of age and 
older. Ongoing clinical trials are investigating new means of effective 
prevention.