We report on a girl with growth and mental retardation, peculiar face with 
ptosis, epicanthus, broad nasal bridge, low-set and abnormal ears, cleft uvula, 
congenital heart defect, and anal atresia. A similar condition was reported 
previously by Wiedemann et al. [1982: An atlas of characteristic syndromes: a 
visual aid to diagnosis, 2nd ed. p 114-115]. We confirm the existence of this 
condition that, although similar to Ohdo syndrome, seems to be an independent 
clinical entity. We propose that, based on the principal clinical 
manifestations, this condition should be identified with the acronym ROCA 
(retardation of growth and development, ocular ptosis, cardiac defect, and anal 
atresia).