The antiphlogistic Ibuprofen incorporated in liposomes caused a decrease of the 
inflammatory edema induced by Carrageenan in the distal part of the rat's hind 
leg after both the intramuscular and percutaneous administration. The 
antiphlogistic effect of free Ibuprofen in the cream was weaker. Intramuscular 
administration of empty liposomes slowed down in the initial stages the 
development of inflammation and slightly diminished the size of edema.