We are reporting on a 13.5-year-old girl with tuberous sclerosis complex (TSC) 
who was treated with everolimus because of giant cell astrocytoma and bilateral 
angiomyolipoma. She suffered from pharmacoresistant partial epilepsy with 
clusters of tonic and tonic-clonic seizures. Treatment with carbamazepine and 
sulthiame had led to a stable situation for more than 2.5 years. The dosage of 
everolimus had to be increased and refractory status epilepticus followed after 
12 days. In the absence of any other possible cause, we believe that the status 
epilepticus was provoked by everolimus. So far, only a few cases of possible 
seizure aggravation by everolimus have been reported. The clinical relevance of 
possible negative effects in epileptic patients remains unclear. Similar 
observations should be documented and reported.