BACKGROUND: The purpose of the present study was to investigate the relationship 
between serum concentrations of the immunoglobulin-like superfamily, selectins, 
hsCRP, and the development of DIND in patients with aneurysmal SAH.
METHODS: Serum ICAM-1, VCAM-1, E-selectin, P-selectin, L-selectin, and hsCRP 
were measured in 33 patients with SAH who underwent aneurysmal clipping within 
48 hours of the onset of symptoms. Serum samples were obtained during the early 
period (day 0) and the late period (day 7).
RESULTS: The serum concentrations of ICAM-1 (P = .009), VCAM-1 (P = .0383) and 
hsCRP (P = .0014) during the early period were significantly higher in patients 
with SAH than in control patients. Further, serum hsCRP concentration during the 
late period was significantly higher in patients with SAH than in control 
patients (P = 0033). Finally, serum concentrations of ICAM-1, VCAM-1, and hsCRP 
during the early (P = .0055, P = .0266, and P = .0266) and late (P = .0423, P = 
.0041, and P = .0004) period were significantly higher in patients with DIND 
than in patients without DIND.
CONCLUSIONS: Serum levels of ICAM-1, VCAM-1 and hsCRP during the early and late 
period following SAH correlate with DIND.