WHAT IS KNOWN AND OBJECTIVE: Calciphylaxis is a rare and potentially 
life-threatening cause of skin necrosis and is poorly recognized by clinicians 
in non-uraemic patients.
CASE DESCRIPTION: We report five cases of warfarin-induced calciphylaxis in 
patients with normal renal function. In four cases, sodium thiosulphate was 
successfully used as a treatment. No other predisposing factors besides obesity 
and warfarin were found in these patients.
WHAT IS NEW AND CONCLUSION: Previously only few cases of solely warfarin-induced 
calciphylaxis have been described. Treatment with sodium thiosulphate has shown 
promising results, and there is thus a need to improve the recognition of 
calciphylaxis.