In the context of the design and synthesis of minor groove binding and 
intercalating DNA ligands some new oligopyrrole carboxamides were synthesized. 
These hybrid molecules (combilexins) possess a variable and conformatively 
flexible spacer at the N-terminal end. As intercalating tricyclic systems 
acridone, acridine, anthraquinones and in a special case iminostilbene terminate 
the N-terminal end of the pyrrole chain. The cytotoxicity was examined by the 
NCI antitumor screening, furthermore, biophysical as well as biochemical studies 
were performed in order to get some information about the DNA binding properties 
and topoisomerase inhibition effect of this new series of molecules.