BACKGROUND: Fitz-Hugh-Curtis syndrome is defined as perihepatitis associated 
with pelvic inflammatory disease. Chlamydia trachomatis is one of its most 
common aetiologies. This syndrome usually presents with right upper quadrant 
abdominal pain mimicking other hepatobiliary and gastrointestinal pathologies, 
hence, posing a diagnostic dilemma in settings with limited diagnostic tools.
CASE REPORT: A 32 year old African female presented with acute right upper 
quadrant abdominal pain and vaginal discharge, for which she had previously 
received treatment in another health center with no improvement. Clinical and 
laboratory findings were suggestive of Fitz-Hugh-Curtis syndrome. Five days 
after treatment with oral doxycycline, the patient showed marked clinical 
improvement.
CONCLUSION: Fitz-Hugh-Curtis syndrome is a common cause of right upper quadrant 
pain which is often under diagnosed in poor communities. Hence, it should be 
included as a differential diagnosis in patients presenting with right upper 
quadrant pain, especially in females of reproductive age.