* A cream containing 0.05% tretinoin (Retinova((R)) is approved for treatment of 
sun-induced skin damage ("photoaging").* Three trials comparing tretinoin with 
the excipient show that the effects of tretinoin cream are at best limited and 
slow to occur. Furthermore, they disappear on treatment cessation, necessitating 
long-term use.* The 0.05% tretinoin cream has poor local tolerability: most 
subjects develop irritation and fragile skin and require longer intervals 
between each application. Systemic adverse effects occur in some circumstances.* 
There are persistent doubts about whether it is safe to use tretinoin during 
pregnancy.