Calciphylaxis is a disease in which metastatic calcification affects small- and 
medium-sized vessels resulting in significant dermatologic manifestations. 
Lesions typically occur over areas of high fat content and progress to black 
leathery eschars. Calciphylaxis is associated with intense pain and markedly 
increased risk of infection, often leading to sepsis requiring hospitalization. 
Diagnosis is made by clinical history and skin biopsy. Management of 
calciphylaxis is interdisciplinary, emphasizing factors such as primary 
prevention, proper wound care, pain control, and hormone and mineral balance. 
Although calciphylaxis carries a high mortality rate, symptomatic treatment has 
shown promise as a method for controlling disease progression.