Myoglobinuria may follow extreme muscular exertion or disorders that cause 
muscle necrosis. Dystonia has not been implicated previously. We studied an 
8-year-old boy of non-Jewish, Mexican-American descent with autosomal-dominant 
dystonia musculorum deformans who developed rapidly progressive and severe 
generalized dystonia, hyperpyrexia, myoglobinuria, and renal failure. 
Curarization was required. Transient improvement was achieved with tetrabenazine 
and baclofen, but bilateral thalamotomy was then performed. Patients with severe 
dystonia should be observed for evidence of myoglobinuria.