Cytokine storm is an immune reaction to an acute or chronic injury and may be 
caused by a disease itself or by treatment directed at an underlying disease. 
The result is an overwhelming release of cytokines which can cause a sepsis-like 
response and may lead to multi-system organ failure and even death. Because it 
occurs in various settings, oncology nurses need to be aware of this process 
when assessing the pediatric oncology patient. Early recognition and treatment 
initiation is imperative and may lead to better outcomes for the patient.