The use of fecal microbiota transplantation in recurrent Clostridium difficile 
infection and coexistent inflammatory bowel disease remains unclear. A 
61-year-old man with ulcerative pancolitis was diagnosed with a third recurrence 
of Clostridium difficile infection, previously treated with metronidazole, 
vancomycin and fidaxomicin. Fecal microbiota transplantation of an unrelated 
healthy donor was performed by the lower route. After a twelve month follow-up, 
the patient remains asymptomatic without Clostridium difficile infection 
relapses or inflammatory bowel disease flare-ups. Fecal microbiota 
transplantation is relatively simple to perform, well-tolerated, safe and 
effective in recurrent Clostridium difficile infection with ulcerative 
pancolitis, as an alternative in case of antibiotic therapy failure.