Many cases of AR can be miss-diagnosed due to deficiency in the conventional 
laboratory tools. Detection of local Ig E immune response and allergy associated 
genes may aid in diagnosis of these cases. The local immune response and the 
allergy associated genes of these suspected cases must be evaluated as they may 
help in their characterization. This study was conducted on 129 patients with 
chronic rhinitis to determine the frequency of LAR, and analyze the association 
of IgE receptor (FcεR1β) gene polymorphism with LAR. All participants were 
subjected to clinical questionnaire, skin prick test, specific IgE measurement 
in serum and nasal secretions and analysis of FcεR1β gene polymorphism. LAR 
constituted 24.8 % of total rhinitis cases and 44.4% of non-allergic cases. 
Cockroach was the main sensitizing agent in local allergic rhinitis in 
comparison with allergic cases (OR =0.11; 95% CI= 0.04-0.34; P<0.001). In LAR, 
nasal specific Ig E was significantly lower than that in AR patients (P < 
0.001). FcεR1β genotype TT was more frequently expressed in LAR and AR than 
non-allergic rhinitis (NAR) (P< 0.001). It is concluded that LAR is an emerging 
allergic condition that could be diagnosed by nasal specific IgE, and that 
FcεR1β polymorphism is one of the genetic factors associated with AR and LAR.