Werner syndrome (i.e., adult progeria) is a rare autosomal recessive disorder 
caused by mutations of the WRN gene, which is characterized by the premature 
appearance of features associated with normal aging and cancer predisposition. 
Patients with Werner syndrome can present with musculoskeletal complaints, 
associated with suggestive radiographic features with a potential prognostic or 
therapeutic impact. This review illustrates the main radiographic features of 
Werner syndrome, focusing on the musculoskeletal system, such as soft-tissue 
calcification, muscular atrophy, osteoporosis, foot deformities, osteitis and 
osteomyelitis, and bone or soft-tissues malignancies. The identification of 
these features by radiologists can therefore be useful in the clinical screening 
of Werner syndrome.