FBW7 (F-box and WD repeat domain-containing 7) is the substrate recognition 
component of an evolutionary conserved SCF (complex of SKP1, CUL1 and F-box 
protein)-type ubiquitin ligase. SCF(FBW7) degrades several proto-oncogenes that 
function in cellular growth and division pathways, including MYC, cyclin E, 
Notch and JUN. FBW7 is also a tumour suppressor, the regulatory network of which 
is perturbed in many human malignancies. Numerous cancer-associated mutations in 
FBW7 and its substrates have been identified, and loss of FBW7 function causes 
chromosomal instability and tumorigenesis. This Review focuses on structural and 
functional aspects of FBW7 and its role in the development of cancer.