The aim of this investigation was to assess the effects of 6 wk of 
eicosapentanoic acid (EPA) and docosahexanoic acid (DHA) supplementation on 
resting and exercise-induced lipid peroxidation and antioxidant status in 
judoists. Subjects were randomly assigned to receive a placebo or a capsule of 
polyunsaturated fatty acids (PUFAs; 600 mg EPA and 400 mg DHA). Blood samples 
were collected in preexercise and postexercise conditions (judo-training 
session), both before and after the supplementation period. The following 
parameters were analyzed: α-tocopherol, retinol, lag phase , maximum rate of 
oxidation (Rmax) during the propagating chain reaction, maximum amount of 
conjugated dienes (CDmax) accumulated after the propagation phase, nitric oxide 
(NO) and malondyaldehide (MDA) concentrations, salivary glutathione peroxidase 
activity, and the lipid profile. Dietary data were collected using a 7-day 
dietary record. A significant interaction effect between supplementation and 
time (p < .01) on triglycerides was noted, with values significantly lower in 
the n-3 long-chain-PUFA (LCPUFA) group after supplementation than in the placebo 
group. Significant interaction effects between supplementation and time on 
resting MDA concentrations and Rmax were found (p = .03 and p = .04, 
respectively), with elevated values in the n-3 LCPUFA group after 
supplementation and no change in the placebo group's levels. The authors 
observed a significantly greater NO and oxidative-stress increase with exercise 
(MDA, Rmax, CDmax, and NO) in the n-3 LCPUFA group than with placebo. No main or 
interaction effects were found for retinol and α-tocopherol. These results 
indicate that supplementation with n-3 LCPUFAs significantly increased oxidative 
stress at rest and after a judo-training session.