PURPOSE: To explore the concentration of squamous cell carcinoma antigen (SCCA), 
cytokeratin fragment antigen 21-1 (CYFRA21-1) in patients with laryngeal 
squamous cell carcinoma (LSCC) and its correlation with tumorigenesis and 
progression.
METHODS: A total of 78 patients with LSCC admitted to our hospital from February 
2010 to January 2016 were enrolled as the research group (RG), and another 41 
healthy volunteers from the same period were selected as the control group (CG). 
The serum concentrations of SCCA and CYFRA21-1 in patients with LSCC were 
detected by ELISA, whose diagnostic value in LSCC were further analyzed by ROC 
curve. The prognosis and survival curves of patients with LSCC were observed 
according to the median value of serum SCCA and CYFRA21-1 concentrations.
RESULTS: The concentration of CYFRA21-1 and SCCA in the RG was significantly 
higher than that in the CG (p < 0.050). The SCCA and CYFRA21-1 identified a 
significant difference in smoking, lymphatic metastasis, TNM staging, and 
differentiation degree (p < 0.050). The survival rate of the SCCA 
low-concentration group was significantly better than that of the 
high-concentration group, p < 0.050. The survival rate of the CYFRA21-1 
low-concentration group was markedly better than that of the high-concentration 
group, p < 0.050.
CONCLUSIONS: SCCA and CYFRA21-1 are highly concentrated in LSCC patients, which 
have good diagnostic efficacy for LSCC. In addition, they play some certain role 
in the occurrence and development of LSCC, and are expected to be markers for 
early diagnosis and prognosis of this disease.