BACKGROUND This study analyzed the macular 3D-OCT images of Vogt-Koyanagi-Harada 
disease (VKH) in uveitis, explored the characteristics of 3D-OCT images of the 
macular region of VKH, and assessed which characteristics contribute most to VKH 
diagnosis. MATERIAL AND METHODS The 3D-OCT examination of 25 cases of VKH was 
performed on the macular area, and the image characteristics were analyzed. 
RESULTS Our study included a total of 50 eyes from 25 cases of VKH patients, 10 
males and 15 females, aged 17 to 64 years, mean (39.44±11.60) years old. 
According to OCT B-scan images, 49 (98%) eyes had ERD, 49 (98%) eyes had nerve 
retinal edema, 36 (72%) eyes had endometrium-like structure (including cysts), 5 
(10%) eyes had RPE folds, 35 (70%) eyes had changes in the internal septum, 49 
(98%) eyes had RPE monolayer structure outside the ERD region. In ILM-RPE 
thickness, 49 (98%) eyes had retinal irregular thickening and 31 (62%) eyes had 
radial stripe changes. In ILM contour figure, 50 eyes (100%) showed exceptional 
uplift, 5 (10%) eyes had small focal uplift for PED on the RPE surface, and 48 
(96%) eyes had wavy ups and downs. CONCLUSIONS In OCT B-scan imaging, the ERT, 
retinal edema of the retina, and the RPE monolayer structure outside the range 
are most likely to occur in VKH. The ILM-RPE thickness chart in 3D 
reconstruction showed irregular thickening of the retina. The ILM contour graph 
showed abnormal uplift, and RPE surface wavy ups and downs in VKH most likely to 
occur.