Mal de Debarquement Syndrome is a neurological disorder of motion perception, 
triggered by external motion. This study aimed to determine the importance of 
psychosocial factors in relation to depression and quality of life in Mal de 
Debarquement Syndrome. A total of 66 participants with self-reported Mal de 
Debarquement Syndrome completed quality-of-life, symptom severity, stigma, 
depression, and illness intrusiveness measurements in this naturalistic 
correlational study. Mal de Debarquement Syndrome was associated with high 
levels of depression and illness intrusiveness. Illness intrusiveness mediated 
between stigma and quality of life; also the level of stigma moderated the 
effect of illness intrusiveness on quality of life. Targeted interventions aimed 
at alleviating psychological distress may improve quality of life in Mal de 
Debarquement Syndrome.