The coronavirus disease 2019 (COVID-19) pandemic has impacted the health of 
children worldwide. Although overall mortality from COVID-19 in children remains 
low, an associated multisystem inflammatory disorder has emerged. The disorder 
has been recognized and named multisystem inflammatory syndrome in children 
(MIS-C) by the World Health Organization and the Centers for Disease Control and 
Prevention. This comprehensive review describes the epidemiology, 
pathophysiology, signs and symptoms, other potential diagnoses, and treatments 
relevant to MIS-C. The review also includes patient and family education and 
anticipatory guidance, and discusses nursing implications for nurses working in 
various roles and settings, including direct care, research, and public health.