SUMMARY: Circular RNAs (circRNAs), a novel class of endogenous RNAs, are 
widespread in eukaryotic cells. Emerging roles in diverse biological processes 
suggest that circRNA is a promising key player in RNA world. Most circRNAs are 
generated through back-splicing of pre-mRNAs, forming a covalently closed loop 
structure with no 5' caps or 3' polyadenylated tails. In addition, most circRNAs 
were not associated with translating ribosomes, therefore, circRNAs were deemed 
to be noncoding. However, the latest research findings revealed that some 
circRNAs could generate proteins in vivo, which expands the landscape of 
transcriptome and proteome. To gain insights into the new area of circRNA 
translation, we introduce an integrated tool capable of detecting circRNAs with 
protein-coding potential from high-throughput sequencing data.
AVAILABILITY AND IMPLEMENTATION: CircPro is available at 
http://bis.zju.edu.cn/CircPro.
CONTACT: mchen@zju.edu.cn.
SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics 
online.