Sjogren's syndrome (SS) is a chronic autoimmune disorder with the highest risk 
for lymphoma development among all autoimmune diseases. In order to evaluate 
whether the presence of the recently described MYD88 L265P mutation in patients 
with Waldenström's macroglobulinemia (WM) is contributory to SS-associated 
lymphomagenesis, a quantitative allele-specific PCR method was performed in 
peripheral blood derived from 90 SS patients as well as in minor salivary gland 
tissues derived from 12 primary SS patients with or without lymphoma. MYD88 
L265P was not detected in either of the samples tested. Although the absence of 
the MyD88 L265P somatic mutation in our SS cohort does not exclude a common 
germline susceptibility gene in SS, it might suggest a distinct operating 
pathogenetic mechanism in SS-related lymphoma compared with WM and other 
hematological malignancies.