OBJECTIVE: The purpose of this study was to evaluate the efficacy of the topical 
use of benzydamine hydrochloride 0.15% oral mouthwashes in the control of 
burning mouth syndrome symptoms.
STUDY DESIGN: In this double-blind, randomized, longitudinal investigation, each 
of 30 patients with burning mouth syndrome was assigned to one of 3 management 
modalities. Those in group A received an oral rinse solution of benzydamine 
hydrochloride 0.15% 3 times a day for 4 weeks, those in group B received a 
placebo 3 times a day for 4 weeks, and those in group C did not receive any kind 
of treatment. A visual analog scale was used for evaluation of the symptoms; a 
Kruskal-Wallis analysis of variance exact test was performed on the resulting 
data.
RESULTS: The findings of this investigation failed to reveal significant 
differences among the groups.
CONCLUSIONS: The clinical application of benzydamine hydrochloride oral rinses 
in the treatment of patients with burning mouth syndrome did not demonstrate 
significative efficacy in comparison with use of a placebo solution.