A 3-year-old child diagnosed as having acute lymphatic leukemia (ALL), developed 
meningeal leukemia 36 months after the onset of the disease. He was twice 
subjected to cranial irradiation plus intrathecal methotrexate (i.t. MTX). Skull 
radiology showed bilateral gyriform calcification of both cerebral hemispheres. 
Hematological relapse was first detected 5 years after diagnosis and the child 
died 5 months later. The most striking findings of a right frontal lobe biopsy 
and the postmortem examination were wide calcium deposits located in the cortex 
and in the adjacent white matter. Intense demyelination as well as areas of 
neuron poverty were apparent in the necropsy but in the biopsy specimen. The 
possible interrelationship between such deposition and cranial irradiation 
and/or i.t. MTX suggests a new iatrogenic disorder.