Presentation of a combination of branch retinal artery occlusion (BRAO)/central 
retinal artery occlusion (CRAO) and central retinal vein occlusion (CRVO) in 
systemic lupus erythematosus (SLE) is extremely rare. Herein, we have presented 
the case of a 29-year-old female with SLE, who simultaneously developed 
bilateral CRVO and BRAO/CRAO in the absence of antiphospholipid syndrome (APS) 
as a catastrophic form of clinical flare. A combinatorial diagnosis of CRVO and 
BRAO/CRAO should be considered during clinical flare-up in a patient with SLE 
who presents with rapidly progressive visual loss.