AIM: We assessed the ability of the Out-of-Hospital Cardiac Arrest (OHCA) and 
the Cardiac Arrest Hospital Prognosis (CAHP) scores to predict neurological 
outcome following in-hospital cardiac arrest (IHCA).
METHODS: Retrospective review of a seven-year French multicentric database 
including ten intensive care units. Primary endpoint was the outcome at hospital 
discharge using the Cerebral Performance Category score (CPC) in all IHCA 
patients. OHCA and CAHP scores, sequential organ failure assessment (SOFA) score 
and the simplified acute physiological score 2 (SAPS-2) were compared using area 
under ROC curves (AUROC) and Delong tests.
RESULTS: Among 381 included patients, 125 (33%) were discharged alive with 
favourable outcome (CPC 1-2). Among 256 patients (77%) with unfavourable outcome 
(CPC 3-5), 10 were discharged alive with CPC 3 (4%), 130 died from withdrawal of 
life sustaining therapies because of severe neurological impairment (51%), 107 
died from multiorgan failure (42%) and 9 died after discharge from complications 
and comorbidities (3%). OHCA and CAHP scores were independently associated with 
unfavourable outcome. The AUROCs to predict unfavourable outcome for OHCA, CAHP, 
SAPS-2 and SOFA scores were 0.76 [0.70-0.80], 0.74 [0.69-0.79], 0.72 
[0.67-0.77], and 0.69 [0.64-0.74] respectively, with a significant difference 
observed only between OHCA and SOFA scores AUROCs (p = 0.04).
CONCLUSION: In parallel with CAHP score, OHCA score could be used to early 
predict outcome at hospital discharge after IHCA. However, prediction accuracy 
for all scores remains modest, suggesting the use of other dedicated means to 
early predict IHCA patients' outcome.