A polymorphism in high-affinity receptor of TNF (TNFR2) gene, Met196Arg, was 
reported to be associated with systemic lupus erythematosus (SLE) in Japanese, 
whereas the association could not be found in Europeans at all and this 
represents an apparent discrepancy. The association, then, should be tested in 
other populations to clarify the possible involvement, if any, of the TNFR2 
polymorphism in SLE or other related autoimmune diseases. The purposes of this 
study were to examine the TNFR2 polymorphism in Japanese patients with SLE and 
to investigate its association with other autoimmune diseases accompanied by 
vasculitis, mixed connective tissue disease, Buerger's disease, and Takayasu's 
arteritis. We found no association at all between the TNFR2 polymorphism and any 
autoimmune diseases including SLE in Japanese.