Central retinal artery occlusion (CRAO) is a neuro-ophthalmological emergency. 
There is a finite time window for acute interventions such as revascularization 
(e.g. intravenous thrombolysis-IVT) and retinal oxygenation (e.g. hyperbaric 
oxygen therapy-HBOT) therapies. Case 1: A 35-year-old female presented with CRAO 
in the right eye (OD) confirmed by fluorescein angiography (FA) and optical 
coherence tomography (OCT). She underwent 4 sessions of HBOT (100% O2 at 2.4 
atmosphere absolute for 90 min). Afterwards, visual defect on the nasal field 
was kept but visual acuity (VA) improved from counting fingers to 1.0. Case 2: A 
65-year-old male presented with CRAO in his left eye (OS) with 1.5 h of 
evolution. Orbital sonography and OCT confirmed the presence of an embolus and 
he underwent IVT with rTPA (0.9 mg/kg). VA improved from light perception to 
0.1. Case 3: A 21-year-old male presented acute visual loss in his OD with 2.5 h 
of evolution. OCT and retinography identified CRAO. He was submitted to IVT 
(rTPA-0.9 mg/kg) followed by 12 sessions of HBOT. VA improved from hand motion 
to 1.0. Our case series depicts the approaches and possible outcomes in acute 
management of an infrequent, but highly morbid, cerebroretinovascular disorder. 
Future clinical trials are warranted to tackle current difficulties in CRAO 
treatment.