OBJECTIVE: To study whether pregnant women would like to be informed if sex 
chromosomal abnormalities (SCA) were suspected with the non-invasive prenatal 
diagnosis of fetal Down syndrome (the NIFTY) test.
METHODS: Two hundred and one patients carried a singleton pregnancy requesting 
the NIFTY test were invited to give their preferences if there was suspicion of 
SCA by the NIFTY test.
RESULTS: Over 93.5% were ethnic Chinese, with a mean age of 36. Prior Down 
screening was positive in 66 (32.8%). Over 50% of subjects considered SCA to be 
better in terms of disability compared to Down syndrome, and only 5.2% 
considered SCA to be worse. Yet, the majority (198, 98.5%) indicated that they 
wanted to be informed if there was suspicion of SCA. Of whom 34.8% would have an 
amniocentesis for confirmation, while 57.1% were not certain, indicating the 
possibility of accepting these conditions.
CONCLUSION: Besides screening Down syndrome by NIFTY, most pregnant women would 
also like to be informed if there was suspicion of SCA. Those screened positive 
should be counseled by those with experience in genetics to avoid unnecessary 
pregnancy termination.