Objective Guillain Barre syndrome (GBS) is an autoimmune-mediated, acute, 
symmetrical, flaccid paralysis. Guillain Barre syndrome has different 
electrophysiological types that carry prognostic significance and tend to differ 
between adults and children. This study aims to compare the clinical outcome of 
Guillain Barre syndrome in Pakistani children based on their 
electrophysiological types to help in understanding and predicting the 
prognosis. Study design Observational comparative study Place & duration The 
pediatric department, Shifa International Hospital, Islamabad; all patients with 
Guillain Barre syndrome seen between 2012 and 2019 Method All children aged one 
to 16 years in whom Guillain Barre syndrome was diagnosed based on clinical 
history, examination, and electrophysiological findings. Institutional review 
board (IRB) approval was taken and data entered on the designed questionnaire. 
Chi-square and non-parametric tests were applied for significant association. 
Results Twenty-three children were included in the study. Of these, 14 were 
males (60.9%) while the mean age was 5.8 (+4.5) years. Acute inflammatory 
demyelinating polyneuropathy (AIDP) was found to be the predominant type (9; 
39.1%) followed by acute motor and sensory axonal neuropathy (AMSAN) (6; 
26.1%), Acute motor axonal neuropathy (AMAN) was diagnosed in four (17.4%) 
patients. Six (26.1%) patients needed mechanical ventilation and 10 patients 
(43.5%) required intensive care unit (ICU) care. The majority of the patients 
(18; 78.3%) received intravenous immunoglobulin (IVIG). Conclusion The study 
highlights varied electrophysiological types of GBS in Pakistani children, which 
differ in predominance from previous studies. However, various indicators of 
poor outcomes that are highlighted in adults, including the older age group, 
need for mechanical ventilation, and electrophysiological evidence of axonal 
degeneration, were not significant predictors of outcome in children.