We report on a 46-year-old black man who resided in Alabama with normal 
transferrin saturation, mild hyperferritinemia, chronic hepatitis C, and 3+ iron 
in hepatocytes and Kupffer cells. Exome sequencing revealed heterozygosity for 
SLC40A1 D270V (exon 7, c.809A→T), a mutation previously reported only in 1 black 
patient with iron overload who resided in the Republic of South Africa. The 
present patient was also heterozygous for: heme transporter FLVCR1 novel allele 
P542S (exon 10, 1624C→T); FLVCR1 T544M (rs3207090); hemopexin (HPX) R371W 
(rs75307540); ferritin scavenger receptor (SCARA5) R471H (rs61737287); and 
transferrin receptor (TFRC) G420S (rs41295879). He had no HFE, TFR2,HJV, or HAMP 
mutations. D270V was not detected in 19 other African Americans with iron 
overload who resided in Alabama. The allele frequency of SLC40A1 D270V in 258 
African American adults who participated in a health appraisal clinic was 0.0019 
(95% confidence interval 0-0.0057). D270V could explain 'classical' ferroportin 
hemochromatosis phenotypes in some African Americans.