Meningioangiomatosis is a rare, benign, developmental, or hamartomatous lesion 
which may involve the leptomeninges and underlying brain parenchyma. 
Histologically, meningioangiomatosis is marked by a proliferation of blood 
vessels in the parenchyma, rimmed by collars of spindled meningothelial cells. 
There are anecdotal reports of an association of meningioangiomatosis with focal 
cortical dysplasia. We retrospectively analyzed the clinical, histopathologic, 
and treatment outcomes of 16 patients with a diagnosis of meningioangiomatosis, 
specifically investigating these cases for evidence of adjacent focal cortical 
dysplasia. Patients ranged in age from 1 to 34 years (median 18), 12 of whom had 
medically-intractable epilepsy as their presenting symptom. No patients in this 
study had a confirmed diagnosis of neurofibromatosis type II. Four patients 
(25%) were found to have fibrous meningiomas associated with the 
meningioangiomatosis. Ten of the 12 patients (83%) who had adequate tissue 
excised adjacent to the meningioangiomatosis demonstrated evidence of focal 
cortical dysplasia, with 6 of those (60%) classified as Palmini type IA, and 4 
patients (40%) classified as Palmini type IIA. Seven of the patients (44%) had 
no post-operative seizures, and were off anti-epileptic drugs, while 2 patients 
relapsed, and required pharmacologic treatment for seizure control. This study 
therefore presents evidence to support inclusion of meningioangiomatosis as a 
focal cortical dysplasia-associated entity, as suggested by the ILAE 
classification (type IIIc). As focal cortical dysplasia is a developmental 
malformation, its association with meningioangiomatosis supports a developmental 
etiology of sporadic meningioangiomatosis.