This review focuses on the interrelationship between ageing and autophagy. There 
is a striking similarity between the signalling aspects of these two processes. 
Both ageing and autophagy involve several of the signalling components such as 
insulin/IGF-1, AMPK, Ras-cAMP-PKA, Sch9 and mTOR. Ageing and ageing-mediated 
defective autophagy involve accumulation of lipofuscin. Components of 
anti-ageing and autophagy include SirTs and FoxOs. Nutritional deprivation or 
calorie restriction as well as several nutriceuticals including resveratrol, 
spermidine, curcumin and piperine can enhance autophagy and increase lifespan. 
Such striking similarities indicate that lifespan is strongly dependent on 
autophagy.