Conflict of interest statement: The authors thank Dr. Alan Pestronk and Dr. 
Abhinav Diwan for technical assistance in interpreting histology, and Dennis J. 
Dietzen for determining plasma creatine kinase (all from Washington University). 
This work was supported by U.S. National Institutes of Health (NIH) National 
Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK078187 and 
NIH National Heart, Lung, and Blood Institute Grant R01 HL119225 (to B.N.F.). 
G.G.S. was supported by NIH National Heart, Lung, and Blood Institute Grants T32 
HL007275, T32 HL007081, and the Washington University Institute of Clinical and 
Translational Sciences NIH Grant UL1 TR000448, Subaward KL2 TR000450, from the 
National Center for Advancing Translational Sciences (NCATS). K.S.M. was 
supported by NIH National Institute of Diabetes and Digestive and Kidney 
Diseases Grant T32-DK007120. J.Y. was supported by Washington University 
Institute of Clinical and Translational Sciences NIH Grant UL1 TR000448, 
Subaward KL2 TR000450. T.E.H. and J.M.E. were supported by NIH National 
Institute of Diabetes and Digestive and Kidney Diseases Grant R01 DK101946. 
C.C.W. and S.K.P were supported by NIH National Institute on Aging Grant R01 
AG031867. This work was also supported by the cores of the Washington University 
Nutrition Obesity Research Center (Grant P30 DK56341), Diabetes Research Center 
(DRC) (Grant P30 DK020579), the Metabolomics Facility at Washington University 
(Grant P30 DK056341), and the Washington University NIH National Institute of 
General Medical Sciences Biomedical Mass Spectrometry Resource (Grant P41 
GM103422) to F.-F.H.; the Washington University Genome Technology Access Center 
in the Department of Genetics (Grant P30 CA91842); and the Department of 
Pathology DRC Electron Microscopy Facility (Grant P60 DK020579). The authors 
declare no conflicts of interest.