Marfans syndrome is an Autosomal dominant disorder of the connective tissues 
resulting in abnormalities of the musculoskeletal system, cardiovascular system 
and eyes. It has a prevalence of 1 in 100,000 population1 and occurs in all 
ethnic groups. It may be familial or due to new mutation (30%), in the fibrillin 
gene on arm of chromosome 15. It is estimated that one person in every 3000-5000 
has Marfans syndrome may have cardiovascular abnormalities and may be 
complicated by infective endocartditis. About 90% of Marfan patients will 
develop cardiac complications2. The patient under discussion has musculoskeletal 
(Tall stature, reduced upper-lower segment ratio, arm-span to height ratio > 
1.05, high arched palate) and Cardiovascular features (Severe aortic 
regurgitation complicated with infective endocarditis).