A trial of Thyrotropin Releasing Hormone (TRH) 5.0 mg/kg body weight 
subcutaneously every other day for two weeks produced transient increased tone 
in muscles, along with other (side-) effects in patients with Amyotrophic 
Lateral Sclerosis (ALS). One patient's extensor plantar transiently changed to a 
flexor plantar reflex after injection, probably due to disproportionate increase 
in tone of the calf muscles. No significant changes in F-waves or H-reflexes 
were seen. No increase in useful voluntary strength, or in strength measured by 
Medical Research Council (MRC) testing or strain gauge isometric strength 
testing was seen. However, dyspnea was seen within 10 minutes of TRH injection.