In December 2019, a novel coronavirus, COVID-19, was discovered to be the causal 
agent of a severe respiratory infection named SARS-CoV-2, and it has since been 
recognized worldwide as a pandemic. There are still numerous doubts concerning 
its pathogenesis and particularly the underlying causes of the various clinical 
courses, ranging from severe manifestations to asymptomatic forms, including 
acute respiratory distress syndrome. The major factor responsible for acute 
respiratory distress syndrome is the so-called "cytokine storm," which is an 
aberrant response from the host immune system that induces an exaggerated 
release of proinflammatory cytokines/chemokines. In this review, we will discuss 
the role of cytokine storm in COVID-19 and potential treatments with which 
counteract this aberrant response, which may be valuable in the clinical 
translation.