JASPAR (http://jaspar.genereg.net) is the largest open-access database of 
matrix-based nucleotide profiles describing the binding preference of 
transcription factors from multiple species. The fifth major release greatly 
expands the heart of JASPAR-the JASPAR CORE subcollection, which contains 
curated, non-redundant profiles-with 135 new curated profiles (74 in 
vertebrates, 8 in Drosophila melanogaster, 10 in Caenorhabditis elegans and 43 
in Arabidopsis thaliana; a 30% increase in total) and 43 older updated profiles 
(36 in vertebrates, 3 in D. melanogaster and 4 in A. thaliana; a 9% update in 
total). The new and updated profiles are mainly derived from published chromatin 
immunoprecipitation-seq experimental datasets. In addition, the web interface 
has been enhanced with advanced capabilities in browsing, searching and 
subsetting. Finally, the new JASPAR release is accompanied by a new BioPython 
package, a new R tool package and a new R/Bioconductor data package to 
facilitate access for both manual and automated methods.