OBJECTIVES: This study aimed to evaluate the impact of two creatinine 
measurement methods on the Model for End Stage Liver Disease (MELD) score and 
glomerular filtration rate estimation (eGFR) in cirrhotic patients. We focused 
on ID-MS traceable method such as compensated Jaffe (cJafCreat) and enzymatic 
(EnzCreat) methods.
DESIGN AND METHODS: Potential protein-related interferences in creatinine 
determination were evaluated using dialysates spiked with albumin. MELD score, 
CKD-EPI formula creatinine-based eGFR and cystatin C-based eGFR were evaluated 
in 100 cirrhotic patients.
RESULTS: In vitro model demonstrated that low protein levels result in an 
underestimation of creatinine levels using cJafCreat. In patients, cJafCreat 
created a negative bias of -6.1 μmol/L that led to higher eGFR and lower MELD 
scores.
CONCLUSIONS: cJafCreat contributes to an overestimation of renal function in 
cirrhotic patients and may alter cirrhosis-severity assessment. Compensated 
Jaffe assays should therefore be replaced by enzymatic methods.