The prenatal diagnosis is currently widely spread and facilitates the acquiring 
of important genetic information about the fetus by a rate extremely accelerate 
and considered without precedent. In this paper, we like to present our 
experience concerning the genetic diagnosis and counseling offered for 
pregnancies in which a structural chromosomal aberration was found. The study 
group is formed by 528 prenatal samples of amniotic fluid and chorionic villi, 
received by our laboratory from 2006 through October 2012 for cytogenetic 
diagnosis. The appropriate genetic investigation was selected based on the 
indications for prenatal diagnosis. The cases with structural chromosomal 
anomalies and polymorphic variants were analyzed as regard to the maternal age, 
gestational age, referral indications and type of chromosomal anomaly found. A 
total number of 21 structural chromosomal anomalies and polymorphic variants 
were identified in the study group. Out of 21 structural chromosomal anomalies 
and polymorphic variants, six deletions and microdeletions, four situations with 
abnormal long "p" arm of acrocentric chromosomes, two duplications, two 
reciprocal translocations, two inversions, two additions, one Robertsonian 
translocation associating trisomy 13, one 9q heteromorphism and one complex 
chromosome rearrangement were noticed. To the best of our knowledge, this is the 
first Romanian study in which the diagnostic strategies and the management of 
the prenatal cases with structural rearrangements are presented. The data 
provided about the diagnosis strategy and the management of the prenatal cases 
with structural chromosomal anomalies represents a useful tool in genetic 
counseling of pregnancies diagnosed with rare structural chromosomal anomalies.