The Morel-Lavallée lesion (MLL) is a posttraumatic close degloving injury, which 
is often underdiagnosed at first. Patients with MLLs usually present with tender 
and enlarging soft tissue swelling with fluctuation, decreased skin sensation, 
ecchymosis, or even skin necrosis hours to days after the inciting injury. The 
lesion can lead to intractable morbidity if it remains untreated. There is no 
consensus regarding the treatment for MLL at present. Here, we report an MLL in 
the pretibial region of a 43-year-old woman who experienced a low-energy 
contusion in a motorbike accident. The pretibial lesion was diagnosed using 
sonography and fine-needle aspiration. We successfully treated the patient by 
performing percutaneous debridement via a small incision and injections of 
fibrin after conservative treatment failed. The method we herein propose 
achieved the goal of open surgical debridement, providing faster recovery and a 
high degree of patient comfort. We reviewed the available pertinent literature 
and propose our own treatment protocol with the aim to establish common 
therapies ofMLL.