INTRODUCTION: Werner Syndrome, or adult progeria, is a rare autosomal recessive 
disorder caused by a mutation in the Werner Syndrome Gene belonging to the 
family of RecQ helicase. Malignant mesenchymal tumours and atherosclerosis are 
typical causes of death. Intracranial meningiomas are frequently described in 
these patients.
CLINICAL PRESENTATION: We present the case of a 46-year-old man with Werner 
Syndrome and a convexity meningioma. The patient had a 2-year history of 
paresthesia and paresis in his right leg, which had worsened in recent months. 
He underwent surgery with Simpson grade II removal, with improvement of the 
slight paresis and no other neurological defects. The patient then underwent 
radiotherapy (60 Gy). Histological examination revealed an atypical meningioma. 
Cytogenetic analysis showed a hypodiploid clone with a complex karyotype 
characterized by monosomy 22 and deletion 1p. After 3 years' follow-up no 
relapses had occurred.
CONCLUSION: 1p deletion correlates with meningioma progression and in this case 
correlates with histological examination. The chromosomal instability underlying 
Werner Syndrome could have fostered the complex karyotype.