Long noncoding RNA (lncRNA) within mRNA sequences of Alzheimer's disease genes, 
namely, APP, APOE, PSEN1, and PSEN2, has been analyzed using fractal dimension 
(FD) computation and correlation analysis. We examined lncRNA by comparing mRNA 
FD to corresponding coding DNA sequences (CDSs) FD. APP, APOE, and PSEN1 CDSs 
select slightly higher FDs compared to the mRNA, while PSEN2 CDSs FDs are lower. 
The correlation coefficient for these sequences is 0.969. A comparative study of 
differentially expressed MAPK signaling pathway lncRNAs in pancreatic cancer 
cells shows a correlation of 0.771. Selection of higher FD CDSs could indicate 
interaction of Alzheimer's gene products APP, APOE, and PSEN1. Including 
hypocretin sequences (where all CDSs have higher fractal dimensions than mRNA) 
in the APP, APOE, and PSEN1 sequence analyses improves correlation, but the 
inclusion of erythropoietin (where all CDSs have higher FD than mRNA) would 
suppress correlation, suggesting that HCRT, a hypothalamus neurotransmitter 
related to the wake/sleep cycle, might be better when compared to EPO, a 
glycoprotein hormone, for targeting Alzheimer's disease drug development. 
Fractal dimension and entropy correlation have provided supporting evidence, 
consistent with evolutionary studies, for using a zebrafish model together with 
a mouse model, in HCRT drug development.