Large amounts of epigenomic data are generated under the umbrella of the 
International Human Epigenome Consortium, which aims to establish 1000 reference 
epigenomes within the next few years. These data have the potential to unravel 
the complexity of epigenomic regulation. However, their effective use is 
hindered by the lack of flexible and easy-to-use methods for data retrieval. 
Extracting region sets of interest is a cumbersome task that involves several 
manual steps: identifying the relevant experiments, downloading the 
corresponding data files and filtering the region sets of interest. Here we 
present the DeepBlue Epigenomic Data Server, which streamlines epigenomic data 
analysis as well as software development. DeepBlue provides a comprehensive 
programmatic interface for finding, selecting, filtering, summarizing and 
downloading region sets. It contains data from four major epigenome projects, 
namely ENCODE, ROADMAP, BLUEPRINT and DEEP. DeepBlue comes with a user manual, 
examples and a well-documented application programming interface (API). The 
latter is accessed via the XML-RPC protocol supported by many programming 
languages. To demonstrate usage of the API and to enable convenient data 
retrieval for non-programmers, we offer an optional web interface. DeepBlue can 
be openly accessed at http://deepblue.mpi-inf.mpg.de.