Williams syndrome (WS) is a well-known microdeletion syndrome characterized by 
specific facial features, retardation in growth and development, typical 
personality and cardiac defects. Poor growth potential is further affected by 
central precocious puberty (CPP) which is frequent in these patients. A WS 
patient with CPP is presented, whose pubertal development and bone age 
progression were arrested by administration of GnRH analogues. The case is 
reported to discuss the role of GnRH analogues for management of CPP in patients 
with WS.