BACKGROUND: Patient-reported control of chronic rhinosinusitis (CRS) symptoms is 
associated with the quality of life impact of CRS. We sought to determine if 
22-item Sino-Nasal Outcome Test (SNOT-22) score is predictive of 
patient-perceived CRS symptom control.
METHODS: Prospective cross-sectional study of 202 patients with CRS. 
Participants were asked to rate their CRS symptom control as "not at all," "a 
little," "somewhat," "very," and "completely." The severity of patient CRS 
symptomatology was measured using the SNOT-22. The relationship between SNOT-22 
score and patient-reported CRS symptom control was determined using regression, 
analysis of variance (ANOVA), and receiver operating characteristic (ROC) curve 
analysis.
RESULTS: SNOT-22 was negatively associated with patient-reported CRS symptom 
control (adjusted β = -0.03; 95% CI, -0.04 to -0.02; p < 0.001), after 
controlling for demographic and clinical characteristics. There was a 
significant difference in SNOT-22 scores of participants reporting each level of 
symptom control (p < 0.001) with the greatest differences between participants 
who rated their CRS symptom control as "not at all," "a little," and "somewhat," 
which we deem poor CRS symptom control, and the group who described their level 
of CRS symptom control described as "very" and "completely," which we deem 
well-controlled CRS symptoms. These results were true across all SNOT-22 
subdomains scores as well. Using ROC analysis, a SNOT-22 score of 35 identified 
patients reporting poor vs well-controlled CRS symptom control with 71.4% 
sensitivity and 85.5% specificity.
CONCLUSION: SNOT-22 score is associated with how well patients feel their CRS 
symptomatology is controlled. Moreover, SNOT-22 score can be used to accurately 
distinguish patients with poor vs well-controlled CRS symptoms.