The Biological General Repository for Interaction Datasets (BioGRID: 
https://thebiogrid.org) is an open access database dedicated to the annotation 
and archival of protein, genetic and chemical interactions for all major model 
organism species and humans. As of September 2016 (build 3.4.140), the BioGRID 
contains 1 072 173 genetic and protein interactions, and 38 559 
post-translational modifications, as manually annotated from 48 114 
publications. This dataset represents interaction records for 66 model organisms 
and represents a 30% increase compared to the previous 2015 BioGRID update. 
BioGRID curates the biomedical literature for major model organism species, 
including humans, with a recent emphasis on central biological processes and 
specific human diseases. To facilitate network-based approaches to drug 
discovery, BioGRID now incorporates 27 501 chemical-protein interactions for 
human drug targets, as drawn from the DrugBank database. A new dynamic 
interaction network viewer allows the easy navigation and filtering of all 
genetic and protein interaction data, as well as for bioactive compounds and 
their established targets. BioGRID data are directly downloadable without 
restriction in a variety of standardized formats and are freely distributed 
through partner model organism databases and meta-databases.