Vertebral compression fractures (VFs) are observed in 30-50 % of patients 
affected by steroid-induced osteoporosis, with consequentially severe back pain 
and functional limitation. An alternative treatment to medical therapy for pain 
caused by recent VFs is percutaneous vertebroplasty (PVP). Patients were treated 
by PVP after careful selection, based on the presence of persistent pain not 
resolved by standard medical therapy, correlation between pain and level of the 
VF, and neuroradiological features. We performed PVP in 4 patients with 
generalized MG associated with recent steroid-induced symptomatic VFs. Relief 
from pain was very rapid, usually within 24 h, and retained at a 3-month 
evaluation. No severe complication or MG worsening were observed in the 
post-operative period. Although clinical indication for PVP is still 
controversial, in our experience PVP is a useful and safe tool to be considered 
in the management of recent steroid-induced symptomatic VFs in selected MG 
patients.