INTRODUCTION: Drug use is a well-kown risk factor for cerebrovascular disease in 
young people. Cannabis is the most widely consumed among the illicit drugs 
worldwide, but it has only exceptionally been associated to cerebrovascular 
disease.
CLINICAL CASE: We here describe 2 young patients (26 and 29 years, respectively) 
who suffered from ischemic stroke in temporal relation with cannabis 
consumption.
CONCLUSIONS: The review of the literature on this topic reveals another 18 
patients with stroke in association to cannabis use. They all were young people 
with ischemic stroke. Although a causal relationship is difficult to establish 
due to the widespread use of cannabis, this drug may play an etiologic role in 
ischemic stroke.