BACKGROUND: CyberKnife® stereotactic radiosurgery is a new treatment option for 
uveal melanoma.
OBJECTIVE: This review outlines the technique of robot-assisted CyberKnife® 
therapy, as well as the pros and cons in the treatment of uveal melanoma.
METHODS: The study provides a PubMed literature review and own preliminary 
clinical experiences.
RESULTS: CyberKnife® therapy for choroidal and ciliary body melanomas shows 
comparable results concerning local tumor control and overall survival matching 
those of conventional therapies. With only low complication rates, a high level 
of quality of life can be conserved by possible preservation of visual acuity as 
well as the ocular globe.
CONCLUSION: Stereotactic radiosurgery using CyberKnife® seems to be an efficient 
and safe therapeutic option for malignant melanomas affecting the choroid and 
ciliary body. Comparative studies with conventional radiation strategies are now 
a high priority.