New evidence from three separate laboratories, published recently in Science, 
has shown that centromere positioning of the CPC (chromosomal passenger complex) 
during early mitosis is achieved through direct interaction between the CPP 
(chromosomal passenger protein) survivin and histone H3. In essence, an acidic 
pocket in the BIR (baculovirus inhibitor of apoptosis repeat) domain of survivin 
binds to the NH2 tail of histone H3 specifically when it is phosphorylated at 
threonine 3, a mark that is placed by the mitotic kinase, haspin. These data are 
significant, as they describe a fundamental mechanism, conserved throughout 
eukaryotes, which is essential for chromosome biorientation and the maintenance 
of genome stability during mitosis.