Dermatitis herpetiformis (DH) is an autoimmunity-driven inflammatory blistering 
dermatosis associated with a gluten-dependent enteropathy. Tissue 
transglutaminase (tTG) and nonapeptides of gliadin (npG) are considered in its 
pathomechanism/diagnostics. Here, the diagnostic accuracy of anti-tTG/anti-npG 
IgA ELISAs in Slavic DH patients with active skin rash was assessed through 
creating receiver operating characteristic (ROC) curves, determining cutoff 
values, and calculating correlations between levels of anti-tTG/anti-npG IgA in 
DH, IgA/neutrophil-mediated non-DH patients and healthy persons. Altogether, 
sera from 80 Slavic individuals were examined. There were negligible differences 
between cutoff points obtained by the ELISAs manufacturer and those in this 
study. There were statistically significant correlations between levels of 
anti-tTG/anti-npG IgA in both DH group and the group of IgA/neutrophil-mediated 
non-DH dermatoses. There was no such correlation in healthy controls. It seems 
that IgA autoantibodies to tTG and npG in the IgA/neutrophil-mediated DH are 
produced in the coordinated way implying their causal relationship.