The aim of this study is to determine the effects of intrastriatal 
administration of MnCl2, on the extracellular levels of dopamine (DA) and 
metabolites dihydroxyphenylacetic acid (DOPAC) and homovanillic acid (HVA) in 
basal conditions and stimulated by depolarization with KCl and pargyline 
administration. Also, we studied the effect of MnCl2 on extracellular levels of 
l-Dopa in the presence of aromatic amino acid decarboxylase (AADC) inhibitor 
3-hydroxybencilhydracine-HCl (NSD 1015). This study concluded that MnCl2, 
reduced the basal and K+-stimulated DA-release in striatum, without notably 
affecting the DOPAC and HVA levels. Intraperitoneal injection of pargyline 
increased striatal DA levels, decreasing DOPAC and HVA levels. The infusion of 
MnCl2 removed the increase in DA levels, without affecting DOPAC and HVA levels. 
Perfusion of NSD 1015 increased the extracellular levels of L-DOPA in striatum, 
and MnCl2 increased the effect of NSD1015 on L-Dopa.