Lipid peroxidation is thought to be one of the major factors involved in 
atherogenesis. There is an increasing evidence is increasing that oxidation of 
LDL cholesterol may be instrumental in atherogenesis. Diabetics are known to be 
at increased risk of cardiovascular diseases, a phenomenon which has previously 
been linked to the lipid peroxidation process. As a result, a number of studies 
have been undertaken to evaluate the effects of antioxidant vitamins on coronary 
heart disease and risks factors of ischaemic heart disease such as diabetes 
mellitus. Lipid peroxidation and antioxidant status were studied in 51 patients 
with ischaemic heart disease and some of with having diabetes mellitus (18%). 
Results were compared before and after supplementation of 450 mg of tocopherol 
acetate for three months. SOD were found to be elevated in patients with 
diabetes and in whole groups of patients after supplementation of tocopherol 
acetate. Also, TAS was found to be elevated in a subgroup of patients without 
diabetes and no significant changes were found in glutathion-peroxidase after 
supplementation. We found statistically significantly decreased mean values of 
glucose after supplementation in all groups of patients. The monitoring of 
antioxidant parameters in diabetic patients could be of vital importance in the 
study of the disease.