Our previously reported cDNA array datasets from neonatal wild-type and Cx43-/- 
(approved gene symbol Gja1) mouse brains were further analyzed to identify 
underlying interlinkages in the brain transcriptome. The analysis revealed that 
no gene cohort sharing either primary function or chromosomal location was 
significantly altered (up-and down-regulation were roughly balanced) in Cx43-/- 
brains, but each cohort exhibited significant perturbation of transcript 
abundance proportions and reduced expression variability and coordination. By 
comparing pairwise expression correlations of all genes with one another in 
wild-type brains, we found genes exhibiting remarkable similarity or opposition 
to the coordination profile (set of synergistically, antagonistically, and 
independently expressed partners) of Cx43, one of the most similar being 
pannexin1, a vertebrate homolog of invertebrate gap junction proteins. This 
study indicates striking redundancy of expression controls over functional 
pathways and suggests that certain genes may play roles similar to or opposite 
that of Cx43 in organizing the brain transcriptome.