We recently reported the association of the allele coding for Arg at the 
position 196 (196R: nucleotide [nt] 587G) of tumor necrosis factor receptor 2 
(TNFR2, TNF-R75) with systemic lupus erythematosus (SLE) in Japanese. In the 
present study, we completed the variation screening of the entire coding region 
of TNFR2. Three new single nucleotide polymorphisms within the coding sequence 
(cSNPs), as well as several variations within the promoter, introns and 
3'-untranslated region (3' UTR), were identified. Among the new SNPs, nt168G, a 
synonymous substitution (K56K), was in tight linkage disequilibrium with nt587G. 
Two other cSNPs, nt543 (C-->T) (P181P) and nt694 (G-->A) (E232K), were not 
significantly associated with SLE. Thus, among the non-synonymous cSNPs, only 
nt587 (T-->G) (M196R) was found to be significantly associated with SLE in 
Japanese.