Once formerly thought to be a rare disorder, thrombotic thrombocytopenic purpura 
(TTP) is becoming increasingly recognized. It is characterized by a pentad of 
clinical findings, including microangiopathic hemolytic anemia, thrombocytopenic 
purpura, neurologic and renal abnormalities, and fever. Following a case report, 
the major clinical findings, pathophysiologic findings, diagnoses, and use of 
various therapeutic modalities are discussed.