Piebaldism is a rare disorder present at birth and inherited as an autosomal 
dominant trait. It results from a mutation in the c-kit proto-oncogene and is 
associated with a defect in the migration and differentiation of melanoblasts 
from the neural crest. Clinical manifestations and phenotypic severity strongly 
correlates with the site of mutation within the KIT gene. Here we report a 
3-year-old boy and his 33-year-old father with leukoderma and poliosis 
associated with clinical criteria for Neurofibromatosis type 1. Genetic study of 
both revealed a p.Gly610Asp mutation in the KIT gene. This familiar mutation has 
not yet been reported in the literature. There are rare reports of piebaldism in 
association with neurofibromatosis type I.