The binding of sodium salicylate, sodium mefenamate, ortophen and piroxicam to 
membranes of erythrocyte ghosts and the effects of the drugs on the membrane 
microviscosity in carrageenan-induced inflammation were studied by the 
fluorescent probe method. It was shown that under inflammation the membrane 
microviscosity decreases and concurrently the affinity of the studied compounds 
to them increases. Antiphlogistics were found to enhance the membrane viscosity 
both in control and under inflammation. The possible mechanisms of the described 
effects of non-steroidal anti-inflammatory agents on biomembranes are discussed.