BACKGROUND: Burning mouth syndrome is a burning sensation or stinging disorder 
affecting the oral mucosa in the absence of any clinical signs or mucosal 
lesions. Some studies have suggested that burning mouth syndrome could be caused 
by the metals used in dental prostheses, as well as by acrylate monomers, 
additives and flavouring agents, although others have not found any aetiologic 
role for hypersensitivity to dental materials.
OBJECTIVE: To evaluate the extent and severity of adverse reactions to dental 
materials in a group of patients with burning mouth syndrome, and investigate 
the possible role of contact allergy in its pathogenesis.
MATERIALS AND METHODS: We prospectively studied 124 consecutive patients with 
burning mouth syndrome (108 males; mean age 57 years, range 41-83), all of whom 
underwent allergen patch testing between 2004 and 2007.
RESULTS: Sixteen patients (13%) showed positive patch test reactions and were 
classified as having burning mouth syndrome type 3 or secondary burning mouth 
syndrome (Lamey's and Scala's classifications).
CONCLUSION: Although we did not find any significant association between the 
patients and positive patch test reactions, it would be advisable to include 
hypersensitivity to dental components when evaluating patients experiencing 
intermittent oral burning without any clinical signs.