The interaction of proteins with chromatin is fundamental for several essential 
cellular processes. During the development of an organism, genes must to be 
tightly regulated both temporally and spatially. This is achieved through the 
action of chromatin-binding proteins such as transcription factors, histone 
modifiers, nucleosome remodelers, and lamins. Furthermore, protein-DNA 
interactions are important in the adult, where their perturbation can lead to 
disruption of homeostasis, metabolic dysregulation, and diseases such as cancer. 
Understanding the nature of these interactions is of paramount importance in 
almost all areas of molecular biological research. In recent years, DNA adenine 
methyltransferase identification (DamID) has emerged as one of the most 
comprehensive and versatile methods available for profiling protein-DNA 
interactions on a genomic scale. DamID has been used to map a variety of 
chromatin-binding proteins in several model organisms and has the potential for 
continued adaptation and application in the field of genomic biology. WIREs Dev 
Biol 2016, 5:25-37. doi: 10.1002/wdev.205 For further resources related to this 
article, please visit the WIREs website.