Sex chromosome meiotic drive has been suggested as a cause of several 
evolutionary genetic phenomena, including genomic conflicts that give rise to 
reproductive isolation between new species. In this paper we present a 
population genetic analysis of X chromosome drive in the stalk-eyed fly, 
Teleopsis dalmanni, to determine how this natural polymorphism influences 
genetic diversity. We analyzed patterns of DNA sequence variation at two 
X-linked regions (comprising 1325 bp) approximately 50 cM apart and one 
autosomal region (comprising 921 bp) for 50 males, half of which were collected 
in the field from one of two allopatric locations and the other half were 
derived from lab-reared individuals with known brood sex ratios. These two 
populations are recently diverged but exhibit partial postzygotic reproductive 
isolation, i.e. crosses produce sterile hybrid males and fertile females. We 
find no nucleotide or microsatellite variation on the drive X chromosome, 
whereas the same individuals show levels of variation at autosomal regions that 
are similar to field-collected flies. Furthermore, one field-caught individual 
collected 10 years previously had a nearly identical X haplotype to the drive X, 
and is over 2% divergent from other haplotypes sampled from the field. These 
results are consistent with a selective sweep that has removed genetic variation 
from much of the drive X chromosome. We discuss how this finding may relate to 
the rapid evolution of postzygotic reproductive isolation that has been 
documented for these flies.