POEMS syndrome, also known as Crow-Fukase syndrome, represents a rare 
multisystem syndrome characterized by polyneuropathy, organomegaly, 
endocrinopathy, M protein, and skin changes. Hypothyroidism is one of the common 
endocrine abnormalities which are central features of POEMS syndrome. The 
clinical data associated with the measurement of thyroid function and its 
clinical significance in POEMS syndrome is still rare. Herein, we report 24 
cases with POEMS syndrome which were studied thyroid function and clinical 
manifestations and performed an associated analysis between hypothyroidism and 
edema/effusions. Of the 24 patients with POEMS syndrome, 17(70.8%) had a 
recognized hypothyroidism (including 11 clinical hypothyroidism and 6 
subclinical hypothyroidism). Fourteen patients (58.3%) had some form of 
extravascular volume overload. In 14 patients with edema/effusions, 12 were 
diagnosed as having hypothyroidism. Hypothyroidism may be one of causes of 
edema/effusions. After thyroid hormone treatment and chemotherapy, symptoms of 
hypothyroidism and edema /effusions were improved greatly.