MicroRNAs (miRNAs) are short regulatory RNAs that down-regulate gene expression. 
They are essential for cell homeostasis and active in many disease states. A 
major discovery is the ability of miRNAs to determine the efficacy of drugs, 
which has given rise to the field of 'miRNA pharmacogenomics' through 
'Pharmaco-miRs'. miRNAs play a significant role in pharmacogenomics by 
down-regulating genes that are important for drug function. These interactions 
can be described as triplet sets consisting of a miRNA, a target gene and a drug 
associated with the gene. We have developed a web server which links miRNA 
expression and drug function by combining data on miRNA targeting and 
protein-drug interactions. miRNA targeting information derive from both 
experimental data and computational predictions, and protein-drug interactions 
are annotated by the Pharmacogenomics Knowledge base (PharmGKB). Pharmaco-miR's 
input consists of miRNAs, genes and/or drug names and the output consists of 
miRNA pharmacogenomic sets or a list of unique associated miRNAs, genes and 
drugs. We have furthermore built a database, named Pharmaco-miR Verified Sets 
(VerSe), which contains miRNA pharmacogenomic data manually curated from the 
literature, can be searched and downloaded via Pharmaco-miR and informs on 
trends and generalities published in the field. Overall, we present examples of 
how Pharmaco-miR provides possible explanations for previously published 
observations, including how the cisplatin and 5-fluorouracil resistance induced 
by miR-148a may be caused by miR-148a targeting of the gene KIT. The information 
is available at www.Pharmaco-miR.org.