BACKGROUND: The overall severity of cardiac disease secondary to acute 
SARS-CoV-2 (severe acute respiratory syndrome coronavirus-2) infection in 
children appears to be much lower when compared with adults. However, the newly 
described multisystem inflammatory syndrome in children (MIS-C) associated with 
coronavirus disease 2019 (COVID-19) has been associated with cardiac 
complications.
METHODS: We reviewed the clinical course and cardiac testing results in 
pediatric patients hospitalized with MIS-C at 2 large hospital systems in the 
New York City metropolitan area over a 3-month period.
RESULTS: Of the 33 patients (median age 2.8 years) in the study cohort, 24 (73%) 
had at least one abnormality in cardiac testing: abnormal electrocardiogram 
(48%), elevated brain natriuretic peptide (43%), abnormal echocardiogram (30%), 
and/or elevated troponin (21%). Electrocardiogram and echocardiogram 
abnormalities all resolved by the 2-week outpatient follow-up cardiology visit.
CONCLUSION: While 73% of pediatric patients with MIS-C had evidence of abnormal 
cardiac testing on hospital admission in our study, all cardiac testing was 
normal by outpatient hospital discharge follow-up. Cardiac screening tests 
should be performed in all patients diagnosed with MIS-C given the high rate of 
abnormal cardiac findings in our study cohort.