Systemic lupus erythematosus (SLE) is a chronic autoimmune disease that affects 
multiple organ systems. Although the etiology of SLE remains unclear, it is 
widely accepted that genetic factors could be involved in its pathogenesis. A 
number of genome-wide association studies (GWASs) have identified novel 
single-nucleotide polymorphisms (SNPs) associated with the risk of SLE in 
diverse populations. However, not all the SNP candidates identified from 
non-Asian populations have been validated in Koreans. In this study, we aimed to 
replicate the SNPs that were recently discovered in the GWAS; these SNPs have 
not been validated in Koreans or have only been replicated in Koreans with an 
insufficient sample size to conclude any association. For this, we selected five 
SNPs (rs1801274 in FCGR2A and rs2286672 in PLD2, rs887369 in CXorf21, rs9782955 
in LYST, and rs3794060 in NADSYN1). Through the replication study with 656 cases 
and 622 controls, rs1801274 in FCGR2A was found to be significantly associated 
with SLE in Koreans (odds ratio, 1.26, 95% confidence interval, 1.06 to 1.50; p 
= 0.01 in allelic model). This association was also significant in two other 
models (dominant and recessive). The other four SNPs did not show a significant 
association. Our data support that FCGR polymorphisms play important roles in 
the susceptibility to SLE in diverse populations, including Koreans.