Magnetic resonance imaging (MRI) has recently been recognised as the most 
sensitive method with which to detect clinically silent lesions in patients 
affected by multiple sclerosis. Visually guided horizontal saccadic eye 
movements (SEM) were studied, together with MRI, in 57 multiple sclerosis 
patients. A very similar sensitivity was found for both MRI (78.2%) and SEM 
analysis (76.3%). Significant associations between peak saccadic velocity and 
brain stem signs and between saccadic latency and visual signs were observed.