Peroxisome proliferator activated receptor-gamma (PPARG) and lipoprotein lipase 
(LPL) play important role in lipid homeostasis, insulin resistance and 
adipogenesis, and their gene variability could be considered as predictive 
genetic markers for metabolic syndrome (MetSy). The aim of the study was to 
estimate possible associations of PPARG (Pro12Ala) and LPL PvuII (+/-) 
polymorphisms with MetSy and its traits. Study included 527 subjects. According 
to the modified National Cholesterol Education Program Adult Treatment Panel III 
definitions, subjects were classified into the metabolic syndrome group and 
control group. Genotyping was performed using polymerase chain 
reaction-restriction fragment length polymorphism methods. In the total sample, 
LPL variants were associated with waist circumference (chi2 = 7.263, d.f = 2, p 
= 0.026) and with BMI (chi2 = 6.549, d.f = 2, p = 0.038), where PvuII (+/+) 
genotype carriers had the highest risk for increased waist circumference 
(specific PvuII (+/+) vs. others analysis chi2 = 7.033, p = 0.008) and increased 
BMI (specific PvuII( +/+) vs. others analysis chi2 = 5.154, p = 0.023). LPL gene 
variants were also associated with HDL-C levels (chi2 = 6.901, d.f = 2, p = 
0.032), where PvuII (-/-) genotype carriers had higher HDL-C values in 
comparison to others (specific Pvu (+/+) vs. others analysis chi2 = 6.504, p = 
0.011). Furthermore, PvuII (-) allele carriers had significantly lower glucose 
(allele based analysis Add Value = -0.0878, chi2 = 5.878, d.f. = 1, p = 0.015). 
Significant interaction was detected between PPARG and LPL that affected HDL-C 
levels in male population (chi2 = 11.790, d.f = 1, p = 0.0006) in the manner 
that Ala/PvuII(+) contributed to the lowest HDL-C values (Specific Ala/ Pvu(+) 
vs. others analysis was chi2 = 11.750, p = 0.0006). According to obtained 
results LPL and PPARG gene variants could be susceptibility factors of obesity 
and lipid status, contributing to development of MetSy, particularly in males. 
Because of antiatherogenic function of HDL-C, the identification of genetic 
variants associated with HDL-C can provide useful information related to 
genotype-phenotype relationships. Since the interplay between PPARG and LPL gene 
and gender seems to be significant it could point to the personalized 
behavioural recommendations for prevention of metabolic and cardiovascular 
diseases.