We describe the clinical presentation and course of a patient with 
autoerythrocyte sensitization (Gardner-Diamond) syndrome, and review the 
literature for similar cases. A 37-yr-old female presented with recurrent 
episodes of painful ecchymotic bruising over the anterior aspect of both thighs. 
These episodes were precipitated by emotional stress. The diagnosis was 
confirmed by induction of similar lesions by intradermal injection of the 
patient's own washed red blood cells and hemoglobin. The lesions did not recur 
for 6 months after the cause of her emotional stress was relieved. 
Autoerythrocyte sensitization (Gardner-Diamond) syndrome should be considered in 
the differential diagnosis of purpura, especially in patients with psychiatric 
problems.