Cardiac arrhythmias are associated with abnormal channel function due to 
mutations in ion channel genes. Epilepsy is a disorder of neuronal function also 
involving abnormal channel function. It is increasingly demonstrated that the 
etiologies of long QT syndrome and epilepsy may partly overlap. However, only a 
few genetic studies have addressed a possible link between cardiac and neural 
channelopathies. We describe a family showing the association between Brugada 
syndrome and epilepsy in which a known mutation in the SCN5A gene (p.W1095X, 
c.3284G>A) was identified. We suggest that this mutation can be responsible for 
cardiac and brain involvement, probably at different developmental age in the 
same individual. This observation confirms the possibility that SCN5A mutations 
may confer susceptibility for recurrent seizure activity, supporting the 
emerging concept of a genetically determined cardiocerebral channelopathy.