Proteomics has revealed differential protein expression and glycosylation in 
membrane proteins from premature aging Hutchinson-Gilford progeria syndrome 
fibroblasts (progeria). Progeria is a rare autosomal dominant genetic disorder 
of premature aging characterized by marked growth retardation and specific, 
progressive, premature senescent changes of the skin and other tissues. Affected 
children live to an average age of 13 years. The 1q20-24 region of chromosome 1 
which codes for one of these proteins, lamin A/C, has previously been implicated 
by Brown et al. (1990) who described identical twins with progeria, where 
cytogenetic analysis showed an inverted insertion in the long arm of the 
chromosome in 70% of cells. Luengo et al. (2002) similarly reported an 
interstitial deletion of chromosome 1q23, in a 9-year-old patient with a classic 
clinical picture of progeria.