G-Quadruplex, a unique secondary structure in nucleic acids found throughout 
human genome, elicited widespread interest in the field of therapeutic research. 
Being present in key regulatory regions of oncogenes, RNAs and telomere, 
G-Quadruplex structure regulates transcription, translation, splicing, etc. 
Changes in its structure and stability leads to differential expression of 
oncogenes causing cancer. Thus, targeting G-Quadruplex structures with small 
molecules/other biologics has shown elevated research interest. Covering 
previous reports, in this review, we try to enlighten the facts on the 
structural diversity in G-Quadruplex ligands aiming to provide newer insights to 
design first-in-class drugs for the next-generation cancer treatment.