Amniotic band sequence (ABS) is an uncommon and heterogeneous congenital 
disorder caused by entrapment of fetal parts by fibrous amniotic bands, causing 
distinctive structural abnormalities involving limbs, trunk, and craniofacial 
regions. The incidence ranges between 1/1200 and 1/15,000 live births, but is 
higher in stillbirths and previable fetuses. The intrinsic theory attributes the 
constriction band syndrome as an inherent development defect of embryogenesis 
while the extrinsic theory proposes that an early amnion rupture is responsible 
for the adherent bands. It is also suggested that amputations and constriction 
rings might be due to vascular disturbances. Anomalies resulting from amniotic 
bands are quite variable and sometimes may simulate chromosomal abnormalities. 
The authors report a case of a 36-week-gestation male neonate who lived for 29 
hours after a vaginal delivery with an Apgar score of 8/9/9. The mother was 
primipara, and the prenatal was uneventful except for two episodes of urinary 
tract infections. The newborn examination depicted multiple anomalies 
characterized by exencephaly, bilateral labial cleft with distorted nostrils and 
palate cleft. There was also facial skin tag band, exophthalmos with hypoplasia 
of the eyelids. The limbs showed distal amputation of the fingers in both hands 
and feet, oligodactyly associated with syndactyly in the left foot, ring 
constriction in the right leg, the presence of right hyperextension, and 
clubfoot. The upper limbs showed length discrepancies. Karyotype analysis was 
normal at 46 XY. The authors conclude that the recognition of the malformations 
secondary to ABS is important in genetic counseling to prevent misdiagnosis 
between chromosomal and secondary disruption disorders.