Previous studies have shown a consistent association between long-term use of 
mobile and cordless phones and glioma and acoustic neuroma, but not for 
meningioma. When used these phones emit radiofrequency electromagnetic fields 
(RF-EMFs) and the brain is the main target organ for the handheld phone. The 
International Agency for Research on Cancer (IARC) classified in May, 2011 
RF-EMF as a group 2B, i.e. a 'possible' human carcinogen. The aim of this study 
was to further explore the relationship between especially long-term (>10 years) 
use of wireless phones and the development of malignant brain tumours. We 
conducted a new case-control study of brain tumour cases of both genders aged 
18-75 years and diagnosed during 2007-2009. One population-based control matched 
on gender and age (within 5 years) was used to each case. Here, we report on 
malignant cases including all available controls. Exposures on e.g. use of 
mobile phones and cordless phones were assessed by a self-administered 
questionnaire. Unconditional logistic regression analysis was performed, 
adjusting for age, gender, year of diagnosis and socio-economic index using the 
whole control sample. Of the cases with a malignant brain tumour, 87% (n=593) 
participated, and 85% (n=1,368) of controls in the whole study answered the 
questionnaire. The odds ratio (OR) for mobile phone use of the analogue type was 
1.8, 95% confidence interval (CI)=1.04‑3.3, increasing with >25 years of latency 
(time since first exposure) to an OR=3.3, 95% CI=1.6-6.9. Digital 2G mobile 
phone use rendered an OR=1.6, 95% CI=0.996-2.7, increasing with latency >15-20 
years to an OR=2.1, 95% CI=1.2-3.6. The results for cordless phone use were 
OR=1.7, 95% CI=1.1-2.9, and, for latency of 15-20 years, the OR=2.1, 95% 
CI=1.2-3.8. Few participants had used a cordless phone for >20-25 years. Digital 
type of wireless phones (2G and 3G mobile phones, cordless phones) gave 
increased risk with latency >1-5 years, then a lower risk in the following 
latency groups, but again increasing risk with latency >15-20 years. Ipsilateral 
use resulted in a higher risk than contralateral mobile and cordless phone use. 
Higher ORs were calculated for tumours in the temporal and overlapping lobes. 
Using the meningioma cases in the same study as reference entity gave somewhat 
higher ORs indicating that the results were unlikely to be explained by recall 
or observational bias. This study confirmed previous results of an association 
between mobile and cordless phone use and malignant brain tumours. These 
findings provide support for the hypothesis that RF-EMFs play a role both in the 
initiation and promotion stages of carcinogenesis.