Acute necrotizing encephalopathy (ANE) is a rapidly progressing neurologic 
disorder that occurs in children after common viral infections of the 
respiratory or gastrointestinal systems. This disease is commonly seen in East 
Asia. Normal healthy infants and children can get affected. The condition 
carries a poor prognosis with high morbidity and mortality rates. We report here 
a case of a 23-year-old female with ANE and describe its neuroimaging findings. 
Magnetic resonance imaging examination performed showed symmetric lesions 
involving the thalami, brainstem, and cerebellum.