The preterm premature rupture of membranes (PPROM) is a common condition in 
pregnant women and is associated with significant maternal and perinatal 
morbidity. Most of the time, the diagnosis is done during physical examination. 
However, in 10%-20% of equivocal cases, biological markers are needed to confirm 
the diagnosis, especially when leakage of fluid is low or intermittent. In these 
cases, a quick and reliable diagnosis is necessary for applying the appropriate 
measures to reduce perinatal complications. The prognosis in PPROM is linked to 
maternal inflammatory markers that might predict perinatal infection, and 
therefore be helpful to decide the timing of the delivery. Nevertheless, further 
research is needed to identify robust biological markers for the diagnosis of 
PPROM in equivocal cases and for the prognosis.