Eight patients with amyotrophic lateral sclerosis received 500 mg TRH by IV 
infusion, at a progressive rate during 3 hours. Only 3 patients noted subjective 
improvement of strength. Clinical muscular testing and H response study failed 
to show any change. Moreover modifications of the prolactin, growth hormone, TSH 
and T3 serum levels raise a question concerning the tolerance with long term 
utilization of TRH.