Conflict of interest statement: Dr. Jay T. Guevarra and Dr. Robert Hiensch have 
no disclosures. Dr. Andrew W. Varga has previously served as a consultant for 
Merck and Eisai Pharmaceuticals and reports grants, personal fees, and 
non-financial support from Merck, and personal fees from Eisai, outside the 
submitted work. He is supported by: NIH/NIA R01AG056682, R01AG066870, 
R21AG059179, the Alzheimer’s Association, the McClung Foundation, and the Merck 
Investigators Studies Program. Dr. David M. Rapoport receives patent royalties 
from Fisher & Paykel Healthcare Limited and Sefam Medical, Ltd for CPAP 
modifications; consulting fees and grant support from Fisher & Paykel Healthcare 
Limited; and consulting fees from BioMarin Pharmaceutical Inc, Morphy, Inc, and 
Jazz Pharmaceuticals plc. The authors report no other potential conflicts of 
interest for this work.