Conflict of interest statement: CONFLICT OF INTEREST: SS has received speaking 
fees from Chugai Pharmaceutical, Eisai, Bristol–Myers K.K, Asahikasei Pharma 
Corp, Pfizer Japan, and consultant fees from Asahikasei Pharma Corp. TT has 
received research grants from Astellas Pharma Inc, Bristol–Myers K.K., Chugai 
Pharmaceutical Co, Ltd., Daiichi Sankyo Co., Ltd., Takeda Pharmaceutical Co., 
Ltd., Teijin Pharma Ltd., AbbVie GK, Asahikasei Pharma Corp., Mitsubishi Tanabe 
Pharma Co., Pfizer Japan Inc., and Taisho Toyama Pharmaceutical Co., Ltd., Eisai 
Co., Ltd., AYUMI Pharmaceutical Corporation, speaking fees from AbbVie GK., 
Bristol–Myers K.K., Chugai Pharmaceutical Co,. Ltd., Mitsubishi Tanabe Pharma 
Co., Pfizer Japan Inc., and Astellas Pharma Inc, and Daichi Sankyo Co., Ltd, and 
consultant fees from Astra Zeneca K.K., Eli Lilly Japan K.K., Novartis Pharma 
K.K., Mitsubishi Tanabe Pharma Co., Abbvie GK, Nipponkayaku Co., Ltd, Janssen 
Pharmaceutical K.K., Astellas Pharma Inc.