We report a family case of type II early-onset Alzheimer's disease (AD) 
inherited over three generations. None of the patients in the family had 
mutations in the genes believed to be the major risk factors for AD, such as 
APP, presenilin 1 or 2. Targeted exome sequencing of 249 genes that were 
previously reported to be associated with AD revealed a rare mutation in 
hemochromatosis (HFE) gene known to be associated with hemochromotosis. Compared 
to previous studies, we show that HFE mutation can possess the risk of AD in 
transferrin-, APOE- and APP-normal patients.