Generalized resistance to thyroid hormone (GRTH) encompasses a heterogeneous 
group of conditions characterized by reduced responses of target tissues to 
thyroid hormone due to defects at the site of hormone action. In the majority of 
patients, GRTH is inherited as a dominant trait associated with mutations in the 
hormone-binding domain of the thyroid hormone receptor. GRTH serves as a 
prototype of other resistance syndromes for hormones that act via nuclear 
receptors.