Numerous studies indicate that the serotonergic (5-HT) transmitter system is 
involved in the regulation of impulsive aggression and there is from 
post-mortem, in vivo imaging and genetic studies evidence that the 5-HT2A 
receptor may be involved. We investigated 94 healthy individuals (60 men, mean 
age 47.0±18.7, range 23-86) to determine if trait aggression and trait 
impulsivity were related to frontal cortex 5-HT2A receptor binding (5-HT2AR) as 
measured with [18F]-altanserin PET imaging. Trait aggression and trait 
impulsivity were assessed with the Buss-Perry Aggression Questionnaire (AQ) and 
the Barratt Impulsiveness Scale 11 (BIS-11). Statistical analyses were conducted 
using a multiple linear regression model and internal consistency reliability of 
the AQ and BIS-11 was evaluated by Cronbach's alpha. Contrary to our hypothesis, 
results revealed no significant associations between 5-HT2AR and the AQ or 
BIS-11 total scores. Also, there was no significant interaction between gender 
and frontal cortex 5-HT2AR in predicting trait aggression and trait impulsivity. 
This is the first study to examine how 5-HT2AR relates to trait aggression and 
trait impulsivity in a large sample of healthy individuals. Our findings are not 
supportive of a selective role for 5-HT2AR in mediating the 5-HT related effects 
on aggression and impulsivity in psychiatrically healthy individuals.