13 patients with amyotrophic lateral sclerosis (ALS) were treated with 
intravenous infusion of thyrotropin-releasing hormone (TRH). In 6 patients 2 
mg/day of TRH was i.v. given over 2 hours for 10 days. In 7 others 2 mg/day of 
TRH was continuously infused by means of a pump. An increase of thyroid hormones 
related to the duration of the treatment was observed. A surprising finding was 
the onset of prolactin (PRL) response to growth hormone releasing hormone 
(GHRH), previously absent.