In the adult mammalian brain niches for neural stem cells are maintained, which 
enable a steady-state neurogenesis. This process is tightly regulated by 
multiple niche factors, including Notch and NF-κB signaling. The 
NF-κB-activating-protein (NKAP) has previously been shown to act as Notch 
co-repressor component by binding CIR and recruiting HDAC3 in T-cell development 
and furthermore to regulate NF-κB-dependent transcription. Here, we provide 
first evidence for the expression of NKAP in neurogenic cells of the adult 
mammalian brain. NKAP is highly expressed in Mash1(+) transit amplifying cells 
and PSA-NCAM(+) migrating neuroblasts throughout the subventricular zone (SVZ) 
and the rostral migratory stream (RMS), as well as in the hippocampus. We 
further show that NKAP expression levels are downregulated during the course of 
the RMS. Eventually, most differentiated cells in the olfactory bulb (OB) and 
the corpus callosum only display low levels of NKAP expression. Finally, large 
subsets of mature neurons in the OB, the hippocampus and the thalamus express 
NKAP at high levels, suggesting an additional role of NKAP outside of SVZ 
progenitor cells.