AIMS: The purpose of this study was to investigate the potential correlation 
between metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and the 
transcription factor BTB and CNC homology 1 (BACH1) and their 
clinicopathological significance in triple-negative breast cancer (TNBC).
SUBJECTS AND METHODS: MALAT1 and BACH1 were detected by immunohistochemistry 
using TNBC tissue microarrays of 240 patients. The association between MALAT1 
and BACH1 expression levels was statistically analyzed. Moreover, the prognostic 
roles as well as clinical and pathological significance of MALAT1 and BACH1 
expression in TNBC were determined.
STATISTICAL ANALYSIS USED: Two-tailed Pearson correlation was used to examine 
the correlation of BACH1 and MALA1 expression. Comparisons of 
clinicopathological variables between different BACH1 and MALA1 expression 
groups were performed using χ2 tests. Overall survival (OS) and disease-free 
survival (DFS) curves were plotted with the Kaplan-Meier method and the 
differences in OS and DFS between three groups were compared by the log-rank 
test. Multiple comparisons were performed using χ2 tests for subsequent 
individual group comparisons.
RESULTS: MALAT1 and BACH1 expression was significantly correlated with 
tumor-node-metastasis stage, distant metastasis, pathological stage, and 
survival outcomes of patients. Patients with high MALAT1 and BACH1 expression 
exhibited shorter overall survival and disease-free survival.
CONCLUSIONS: These findings provide further insight into the expression pattern 
of MALAT1 and BACH1 in TNBC and suggest them as prognostic biomarkers for TNBC.