OBJECTIVE: To review about this disorder, with emphasis on the intensive care of 
severe Guillain Barr syndrome (GBS).
DEVELOPMENT: GBS is an acute immune mediated inflammatory polyneuropathy that 
may lead to quadriparesis, ventilatory failure, and autonomic dysfunction but 
also to many general medical problems that have great bearing on outcome. 
Therefore severe GBS patients require admission into an intensive care unit 
(ICU), where in addition to the disorders mentioned before, other complications 
can arise. The neurologist who plans to deal comprehensively with these patients 
must be familiar with therapy for infections, nutrition, fluid management, and 
selected aspects of pulmonary medicine as well as the indications for and 
complications of plasma exchange and gammaglobulin infusion.
CONCLUSIONS: With modern intensive care support, the outcome is excellent (>80% 
recovery), although in many cases a persistent residual paresis occurs. Because 
GBS is largely self limited, the skill daily cares of these patients in an ICU 
contributes as much, or more, to the overall outcome of an individual patient as 
do specific immune therapies.