CRNDE is the gene symbol for Colorectal Neoplasia Differentially Expressed 
(non-protein-coding), a long non-coding RNA (lncRNA) gene that expresses 
multiple splice variants and displays a very tissue-specific pattern of 
expression. CRNDE was initially identified as a lncRNA whose expression is 
highly elevated in colorectal cancer, but it is also upregulated in many other 
solid tumors and in leukemias. Indeed, CRNDE is the most upregulated lncRNA in 
gliomas and here, as in other cancers, it is associated with a "stemness" 
signature. CRNDE is expressed in specific regions within the human and mouse 
brain; the mouse ortholog is high in induced pluripotent stem cells and 
increases further during neuronal differentiation. We suggest that CRNDE is a 
multifunctional lncRNA whose different splice forms provide specific functional 
scaffolds for regulatory complexes, such as the polycomb repressive complex 2 
(PRC2) and CoREST chromatin-modifying complexes, which CRNDE helps pilot to 
target genes.