The oxidized LDL receptor 1 gene (OLR1) rs1050283 single nucleotide polymorphism 
(SNP) has been previously shown to be associated with Alzheimer's disease (AD). 
An association analysis of OLR1 was carried out in a population of 443 patients 
with AD as compared with 393 age-matched controls. In addition, an expression 
analysis of OLR1 and its regulatory hsa-miR369-3p was performed in peripheral 
mononuclear blood cells (PBMC) from 20 patients and 15 controls. Logistic 
regression analysis, adjusted for gender and apolipoprotein E (ApoE) status, 
showed a statistically significant association of OLR1 rs1050283 under the 
assumption of a dominant model (CC and CT individuals versus TT: p = 0.014, OR: 
1.50, 95%CI: 1.08-2.08) and a genotypic model (TC versus TT: p = 0.002, OR: 
1.61, 95%CI: 1.14-2.26). No significant differences in OLR1 expression was 
observed between patients and controls (p > 0.05). However, stratifying patients 
according to the rs1050283 status, significantly decreased relative PBMC 
expression levels of OLR1 were observed in carriers of CC+CT genotypes as 
compared with TT carriers (0.13 ± 0.013 versus 0.46 ± 0.028, p = 0.022), whereas 
no differences in relative expression levels of the hsa-miR369-3p were observed 
(p > 0.05). The effect observed was not due to the presence of the ApoE ε4 
allele. The OLR1 rs1050283 SNP likely acts as a risk factor for sporadic AD. The 
presence of at least one C allele is associated with a decreased expression of 
OLR1 mRNA in the absence of hsa-miR369-3p de-regulation, suggesting that the 
presence of the polymorphic allele influences the binding of hsa-miR369-3p to 
its 3'UTR consensus sequence. Nevertheless, the limited power of the study 
requires further investigations with a larger sample size.