Food, dietary fibre and espresso coffee interfere with the absorption of 
levothyroxine. Malabsorptive disorders reported to affect the absorption of 
levothyroxine include coeliac disease, inflammatory bowel disease, lactose 
intolerance as well as Helicobacter pylori (H. pylori) infection and atrophic 
gastritis. Many commonly used drugs, such as bile acid sequestrants, ferrous 
sulphate, sucralfate, calcium carbonate, aluminium-containing antacids, 
phosphate binders, raloxifene and proton-pump inhibitors, have also been shown 
to interfere with the absorption of levothyroxine.