OBJECTIVE: The objective of our study was to describe the ophthalmic features 
and histologic eyelid findings of Melkersson-Rosenthal syndrome.
DESIGN: Three patients with eyelid edema underwent eyelid biopsy to establish 
the diagnosis of Melkersson-Rosenthal syndrome.
RESULTS: Of the three patients, only one patient manifest the classic triad of 
facial edema, facial paralysis, and furrowed tongue. Histoloppgically, the 
eyelid skin in all patients showed characteristic perilymphatic granulomas with 
marked dermal edema.
CONCLUSIONS: The histopathologic features assist in establishing the diagnosis 
of Melkersson-Rosenthal syndrome in oligo- and monosymptomatic patients. 
Melkersson-Rosenthal syndrome should be considered in patients presenting with 
eyelid edema of unknown etiology and biopsy performed.