Allgrove syndrome (triple A syndrome) is an autosomal recessive disorder 
characterised by adrenocortical insufficiency, achalasia and alacrima. Patients 
also suffer from diverse neurological disorders. Allgrove syndrome is caused by 
mutations in the AAAS gene located at chromosome 12q13, which encodes for a 
tryptophan-aspartic acid (WD) repeat protein (aladin). The exact function of 
this protein is still not known.