Guillain-Barré syndrome (GBS) is an autoimmune polyneuropathy which presents 
with acute onset and rapid progression of flaccid, hyporeflexi quadriparesis. 
Both sensory and autonomic nerve involvement is seen. GBS has various subtypes 
that vary in their pathophysiology. The pathogenesis involves an immune response 
triggered by a preceding event which may be an infection, immunisation or 
surgical procedure. Clinical diagnosis has been largely the primary diagnosing 
criterion for GBS along with electrodiagnosis, which has several pitfalls and is 
supported by ancillary testing of cerebrospinal fluid (CSF) analysis and Nerve 
Conduction Studies. Measurement of anti-ganglioside antibodies is also an 
effective tool in its diagnosis. Further understanding of pathophysiology and 
better diagnostic methods are required for better management of GBS.