Long-term levodopa use is associated with the "End of Dose Wearing Off" (EODWO) 
phenomenon wherein Parkinsonian symptoms return before a patient's next 
scheduled dose of levodopa. Wearing off symptoms may include a variety of 
autonomic, emotional, motor, psychological and sensory abnormalities. Abdominal 
pain may be an important wearing off symptom as an early indicator of the 
development of EODWO in Parkinson's disease (PD) patients. In this report, we 
present two patients on levodopa therapy for PD who developed acute abdominal 
pain as a symptom of EODWO.