High-intensity resistance (HIR) training has been associated with muscle 
hypertrophy and decreased microvascular density that might produce a blood flow 
limitation. The effect of HIR training on lower leg maximal blood flow and 
minimum vascular resistance (Rmin) during reactive hyperemia were investigated 
in 7 healthy males. The gastrocnemius-soleus muscles of one leg were trained 
using maximal isokinetic concentric contractions for 4 weeks; the nontrained leg 
was the control. Lower leg blood flow was measured by venous occlusion 
plethysmography. Lower leg muscle volume was determined using magnetic resonance 
imaging. Peak isokinetic torque increased in both the trained (T) and nontrained 
(NT) legs (p < .05). Lower leg muscle volume increased by 2% in the T leg only 
(p < .05). In the T leg, maximal blood flow decreased and Rmin increased (p < 
.05); no hemodynamic change was detected in the NT leg. It is concluded that HIR 
training of the calf muscles is associated with a decrease in hyperemia-induced 
blood flow; thereby, indicating a blood flow limitation to the calf muscles.