The objective of the international Chromosome-Centric Human Proteome Project 
(C-HPP) is to map and annotate all proteins encoded by the genes on each human 
chromosome. The C-HPP consortium was established to organize a collaborative 
network among the research teams responsible for protein mapping of individual 
chromosomes and to identify compelling biological and genetic mechanisms 
influencing colocated genes and their protein products. The C-HPP aims to foster 
the development of proteome analysis and integration of the findings from 
related molecular -omics technology platforms through collaborations among 
universities, industries, and private research groups. The C-HPP consortium 
leadership has elicited broad input for standard guidelines to manage these 
international efforts more efficiently by mobilizing existing resources and 
collaborative networks. The C-HPP guidelines set out the collaborative consensus 
of the C-HPP teams, introduce topics associated with experimental approaches, 
data production, quality control, treatment, and transparency of data, 
governance of the consortium, and collaborative benefits. A companion approach 
for the Biology and Disease-Driven HPP (B/D-HPP) component of the Human Proteome 
Project is currently being organized, building upon the Human Proteome 
Organization's organ-based and biofluid-based initiatives 
(www.hupo.org/research). The common application of these guidelines in the 
participating laboratories is expected to facilitate the goal of a comprehensive 
analysis of the human proteome.