Mowat-Wilson syndrome (MWS) is a genetic disease caused by heterozygous 
mutations or deletions of the ZEB2 gene rarely diagnosed prenatally and with 
little fetal description reported. It is mainly characterized by 
moderate-to-severe intellectual disability, epilepsy, facial dysmorphism and 
various malformations including Hirschsprung disease and corpus callosum 
anomalies. Here we report a fetal case of MWS well described, suspected at 
standard autopsy. The association of a corpus callosum hypoplasia with a 
histological Hirschsprung disease and a typical facial gestalt allowed the 
guiding of genetic testing. Classical fetopathological examination still keeps 
indications in cases of syndromic association in the era of virtual autopsy.