The structure of several lysosomal membrane glycoproteins (lamp1, lamp2, limpI 
and limpII) has been described. The significance of the receptor glycoprotein 
lamp2a in the chaperone-mediated autophagy of cytosolic proteins with KFERQ 
motif has been described in details as well as the chaperone protein Hsc73 and 
other chaperones involved in this process. Several modulatory mechanisms of the 
chaperone-mediated autophagy, which is activated in condition of stress and 
starvation, were also outlined.