In this paper we review neurotoxic disorders appearing in patients poisoned with 
organophosphorus pesticides. These compounds cause four important neurotoxic 
effects in humans: the cholinergic syndrome, the intermediate syndrome, 
organophosphate-induced delayed polyneuropathy (OPIDP) and chronic 
organophosphate-induced neuropsychiatric disorder (COPIND). Compared to the 
cholinergic syndrome, that causes millions of cases of poisoning each year, 
other disorders involve much smaller numbers of patients. The review is focused 
on the neurotoxic effects appearing after acute and chronic exposure to 
organophosphates with emphasis on clinical presentation, pathogenesis, molecular 
mechanisms, and possibilities for prevention/therapy.