Sarcoidosis represents a non-caseating, granulomatous disorder of unknown 
aetiology whose clinical manifestation is heterogeneous and frequently 
multisystemic. The portion of patients needing systemic treatment varies: though 
many patients may undergo spontaneous remission, organ-threatening courses 
demand systemic therapy. Corticosteroids are the first-line treatment option; 
however, disease´s progression and/or major corticosteroid side effects may 
require second- and third-line therapeutics. A current stepwise therapeutic 
algorithm to sarcoidosis that characterizes additive and alternative therapeutic 
agents is given in the following review.