Bisphenol A (BPA) is an endocrine-disruptor compound that exhibits estrogenic 
activity. BPA is used in the production of materials such as polycarbonate 
plastics, epoxy resins and dental sealants. Whereas, the endocrine modulating 
activity of BPA and its effects on reproductive health have been widely studied, 
its effects on the function of the immune system are poorly characterized. This 
might be attributable to the different BPA doses used in a diversity of animal 
models. Moreover, most studies of the effect of BPA on the immune response are 
limited to in vitro and in vivo studies that have focused primarily on the 
impact of BPA on the number and proportion of immune cell populations, without 
evaluating its effects on immune function in response to an antigenic challenge 
or infectious pathogens. In this review, we discuss the current literature on 
the effects of BPA on the function of immune system that potentially increases 
the susceptibility to infections by the virtue of acting as a pro-inflammatory 
molecule. Thus, it appears that BPA, while by such an impact might be useful in 
the control of certain disease states that are helped by an inflmmatory 
response, it can worsen the prognosis of diseases that are adversely affected by 
inflammation.