Polymorphism of the FTO gene encoding an N(6)-methyladenosine (m(6)A) RNA 
demethylase was robustly associated with human obesity; however, the mechanism 
by which FTO affects metabolism, considering its emerging role in RNA 
modification, is still poorly understood. A new study published in Cell Research 
reports novel functions implicating FTO in the regulation of mRNA alternative 
splicing in the control of adipogenesis.