The tertiary structures of protein complexes provide a crucial insight about the 
molecular mechanisms that regulate their functions and assembly. However, 
solving protein complex structures by experimental methods is often more 
difficult than single protein structures. Here, we have developed a novel 
computational multiple protein docking algorithm, Multi-LZerD, that builds 
models of multimeric complexes by effectively reusing pairwise docking 
predictions of component proteins. A genetic algorithm is applied to explore the 
conformational space followed by a structure refinement procedure. Benchmark on 
eleven hetero-multimeric complexes resulted in near-native conformations for all 
but one of them (a root mean square deviation smaller than 2.5Å). We also show 
that our method copes with unbound docking cases well, outperforming the 
methodology that can be directly compared with our approach. Multi-LZerD was 
able to predict near-native structures for multimeric complexes of various 
topologies.