The gram-positive bacterium Staphylococcus aureus, responsible for a wide 
variety of diseases in human involve all organ systems ranging from localized 
skin infections to life-threatening systemic infections. FtsZ, the key protein 
of bacterial cell division was selected as a potent anti bacterial target. In 
order to identify the new compounds structure based screening process was 
carried out. An enrichment study was performed to select a suitable scoring 
function and to retrieve potential candidates against FtsZ from a large chemical 
database. The docking score and docking energy values were compared and their 
atomic interaction was also evaluated. Furthermore molecular dynamics simulation 
were also been performed to check the stability and the amino acids interacted 
towards the FtsZ. Finally we selected C ID 16284, 25916, 15894, 13403 as better 
lead compounds. From these results, we conclude that our insilico results will 
provide a framework for the detailed in vitro and in vivo studies about the FtsZ 
protein activity in drug development process.