Despite the considerable advances in the treatment of hypertension that have 
been made over the past few decades, adequate management and control of this 
condition remains poor, and efforts are ongoing to develop new strategies to 
improve related outcomes. Novel therapeutic approaches to the management of 
systemic hypertension fall into two major categories: (i) those that seek to 
improve blood pressure-lowering efficacy using new therapeutic strategies in 
addition to standard non-pharmacological and pharmacological approaches and (ii) 
novel ways to optimize and improve the efficacy and utility of existing 
therapies. Novel procedure- and device-based strategies to control hypertension 
include renal sympathetic denervation and baroreflex sensitization. These two 
techniques will be the focus of the present review.