We report a case with refractory insomnia. We diagnosed her case as depression 
with high levels of anxiety, weakness, with diminished ability to think or 
concentrate and with a sensory-motor disorder. Although this last symptom was 
very distressing, it did not satisfy the criteria for RLS (Restless Legs 
Syndrome). After treatment with paroxetine (20 mg) and zolpidem (10 mg), anxiety 
and mood deflection were attenuated. Nevertheless, a mild depression, an 
intermittent awakening (fragmentation of the sleep-wake rhythm) and subsyndromal 
RLS persisted. Her resistant insomnia was treated with benzodiazepine sleeping 
drugs (triazolam 0.25 mg, lorazepam 2.5 mg, fluorazepam 30 mg) with only partial 
insomnia remission, antidepressants (trazodone 150 mg RP, mirtazapine 15-30 mg, 
agomelatine 50 mg) and antipsychotics (levomepromazine 25 mg, zuclopentixol 25 
mg) without results. Her intractable insomnia was markedly responsive to 
pregabalin without side effects. Our hypothesis is that the therapy with 
pregabalin may be indicated for resistant insomnia associated with subsyndromal 
RLS, even when the latter does not satisfy fully all the criteria for diagnosis.