The combinatorial action of transcription factors drives cell-type-specific gene 
expression patterns. However, transcription factor binding and gene regulation 
occur in the context of chromatin, which modulates DNA accessibility. 
High-resolution chromatin interaction maps have defined units of chromatin that 
are in spatial proximity, called topologically associated domains (TADs). TADs 
can be further classified based on expression activity, replication timing, or 
the histone marks or non-histone proteins associated with them. Independently, 
other chromatin domains have been defined by their likelihood to interact with 
non-DNA structures, such as the nuclear lamina. Lamina-associated domains (LADs) 
correlate with low gene expression and late replication timing. TADs and LADs 
have recently been evaluated with respect to cell-type-specific gene expression. 
The results shed light on the relevance of these forms of chromatin organization 
for transcriptional regulation, and address specifically how chromatin 
sequestration influences cell fate decisions during organismal development.