Following reports by ENCyclopedia Of DNA Elements (ENCODE; GENCODE) Consortium 
and others, it is now fairly evident that the majority (70-80%) of the mammalian 
genome has the potential to be transcribed into non-protein-coding RNAs 
(ncRNAs). Critical to our understanding of genetic processes is the mechanism by 
which ncRNAs exert their roles. Accordingly, ncRNAs are shown to regulate the 
expression of protein-coding loci (i.e., genes) at the transcriptional as well 
as post-transcriptional stages. We recently reported on a widespread 
transcription at the DNA enhancer elements in myogenic cells. In our study, we 
found certain enhancer RNAs (eRNAs) regulate chromatin accessibility of the 
transcriptional machinery at loci encoding master regulators of myogenesis 
(i.e., MyoD/MyoG), thus suggesting their significance and site-specific impact 
in cellular programming. Here, we examine recent discoveries pertinent to the 
proposed role(s) of eRNAs in regulating gene expression. We will highlight 
consistencies, discuss confounding observations, and consider a lack of critical 
information in a way to prioritize future objectives.