Author information:
(1)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario 
M5G 1X8, Canada.
(2)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario 
M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for 
Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Molecular 
Genetics, University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
(3)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario 
M5G 1X8, Canada; Centre for Computational Medicine, The Hospital for Sick 
Children, Toronto, Ontario M5G 1X8, Canada.
(4)Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, 
Toronto, Ontario M5G 1X8, Canada; Department of Pediatrics, University of 
Toronto, Toronto, Ontario, M5S 1A1, Canada.
(5)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario 
M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The Hospital for 
Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Pediatrics, 
University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
(6)Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, 
Toronto, Ontario M5G 1X8, Canada; Department of Molecular Genetics, University 
of Toronto, Toronto, Ontario, M5S 1A1, Canada; Department of Pediatrics, 
University of Toronto, Toronto, Ontario, M5S 1A1, Canada; Prenatal Diagnosis and 
Medical Genetics Program, Mount Sinai Hospital, Toronto, Ontario, M5G 1X5, 
Canada.
(7)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, Ontario 
M5G 1X8, Canada; The Centre for Applied Genomics, The Hospital for Sick 
Children, Toronto, Ontario M5G 1X8 Canada.
(8)PreventionGenetics, Marshfield, WI, 54449, USA.
(9)Department of Medical Genetics, University of Alberta, Edmonton, Alberta, T6G 
2R3, Canada.
(10)Division of Clinical and Metabolic Genetics, The Hospital for Sick Children, 
Toronto, Ontario M5G 1X8, Canada.
(11)Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, 
L8S 4L8, Canada.
(12)National Centre for Medical Genetics, Our Lady's Children's Hospital, 
Crumlin, Dublin 12, Ireland.
(13)Service de Génétique, Centre de Référence Anomalies du Développement de 
l'Ouest, CHU Poitiers, 86021 Poitiers, France; EA3808, Université de Poitiers, 
France.
(14)Département de Génétique, APHP-Hôpital Robert DEBRE, 75019 Paris, France.
(15)Center for Human Genetics Inc., Cambridge, MA 02139, USA.
(16)Paediatric Laboratory Medicine, The Hospital for Sick Children, Toronto, 
Ontario M5G 1X8 Canada; Laboratory Medicine and Pathobiology, University of 
Toronto, Toronto, Ontario, M5S 1A1, Canada.
(17)Otolaryngology, The Hospital for Sick Children, Toronto, Ontario M5G 1X8, 
Canada; Department of Otolaryngology, University of Toronto, Toronto, Ontario, 
M5S 1A1, Canada; Institute of Medical Sciences, University of Toronto, Toronto, 
Ontario M5S 1A8, Canada.
(18)Laboratory Medicine and Pathobiology, University of Toronto, Toronto, 
Ontario, M5S 1A1, Canada; Genome Diagnostics, Department of Clinical Laboratory 
Genetics, University Health Network, Canada.
(19)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, 
Ontario M5G 1X8, Canada; Department of Molecular Genetics, University of 
Toronto, Toronto, Ontario, M5S 1A1, Canada; The Centre for Applied Genomics, The 
Hospital for Sick Children, Toronto, Ontario M5G 1X8 Canada; McLaughlin Centre, 
University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
(20)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, 
Ontario M5G 1X8, Canada; Centre for Computational Medicine, The Hospital for 
Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of Computer Science, 
University of Toronto, Toronto, Ontario, M5S 1A1, Canada.
(21)Genetics and Genome Biology, The Hospital for Sick Children, Toronto, 
Ontario M5G 1X8, Canada; Division of Clinical and Metabolic Genetics, The 
Hospital for Sick Children, Toronto, Ontario M5G 1X8, Canada; Department of 
Molecular Genetics, University of Toronto, Toronto, Ontario, M5S 1A1, Canada; 
Department of Pediatrics, University of Toronto, Toronto, Ontario, M5S 1A1, 
Canada; Institute of Medical Sciences, University of Toronto, Toronto, Ontario 
M5S 1A8, Canada. Electronic address: rweksb@sickkids.ca.