Choroid plexus neoplasms are rare epithelial tumors of the central nervous 
system. A carcinoma of the choroid plexus occurred in a child from a family with 
the breast cancer-sarcoma syndrome (Li-Fraumeni or SBLA syndrome), an inherited 
condition characterized by the development of diverse neoplasms (sarcoma, breast 
cancer, brain tumors, leukemia, adrenal cortical carcinoma, and others). Choroid 
plexus carcinomas were identified in two kindreds previously reported with the 
syndrome. The literature contains reports of choroid plexus neoplasms occurring 
in families and in individuals with multiple primary tumors. Choroid plexus 
neoplasm may be a manifestation of the inherited proclivity to tumor development 
in the breast cancer-sarcoma syndrome.