The objective of this short review is to identify the particularities of women 
with endometriosis, especially those complaining of pain and with the most 
severe lesions. Genetic aberrations play, with a high probability, a major role 
in the development of this disease, its severity, its tendency to recur and also 
in its capacity to degenerate. The abnormalities of the endometrium, with 
exacerbated biological activities, are an example. The woman with endometriosis 
seems more sensitive to pain through various mechanisms, such as central 
hypersensitivity and decrease threshold to somatoceptive pain and several 
associated psychological disorders. Endometriosis is often associated with other 
painful conditions such as irritable bowel syndrome, interstitial cystitis and 
fibromyalgia. Finally, also appears also to have a higher risk to develop non 
Hodgkin's lymphoma or ovarian cancer. These particularities, some of them being 
still speculative or controversial, should be known in routine practise, in 
order to offer a better multidisciplinary management, not only for short term, 
but also long term issues.