Timothy syndrome, long QT syndrome type 8, is highly malignant with ventricular 
tachyarrhythmia. A 30-month-old boy had sudden cardiac arrest during anesthesia 
induction before plastic surgery for bilateral cutaneous syndactyly. After 
successful resuscitation, prolonged QT interval (QTc, 0.58-0.60 sec) and T-wave 
alternans were found in his electrocardiogram. Starting β-blocker to prevent 
further tachycardia and collapse event, then there were no more arrhythmic 
events. The genes KCNQ1, KCNH2, KCNE1 and 2, and SCN5A were negative for long QT 
syndrome. The mutation p.Gly406Arg was confirmed in CACNA1C, which maintains 
L-type calcium channel depolarization in the heart and other systems.