The living organism, or part of a living organism, on which an experimental or clinical research study is performed
similar to process, there is normal vs. diseased/pathological, thus isPathological slot e.g. tumoral protease
The part(s) of the biological subject that is visualized in the image and measured in order to create an imaging biomarker.
Note: these slots are not of the study of the biology, but of the disease itself, so may not apply here appropriately - use MESH terms
Living tissue in an artificial environment outside the organism for at least 24 hours or with some alteration of natural conditions
difference between parameter and biomarker_use is that parameter is a quantitative measurement, biomarker_use specifies funcitonal application, e.g. bioimarker: change in tumor diameter, applicaiton: disease monitoring (Tiffany);
A biological target may be targetted by an exogenous material such as an imaging agent, or the target may itself be imageable, thus not requiring the use of an Imaging Agent.
Can be null, if the subject was not treated in any way, such as a human subject receiving an MRI with no prior treatments, etc.
When the measurement is a change in some other parameter, such as an increase in diameter.
Not sure if this is the correct term to use. It is meant to be able to identify a change in some other parameter, such as a "+24%" change [i.e. increase] in size, or a "-25%" change [i.e. decrease] in some rate. In some cases it is a change in some other measurement, which explains the slot, "is a change in measurement."
Still determining name; prior name was Anatomical Measurement
Manipulation of the subject for biological interrogation, but not for imaging purposes. For imaging purposes are in imaging agent.
Import Biological Process class from Gene Ontology (highest level class), or from Biological Process class in NCI Thesaurus. We cannot just Gene ontology for biological process, because some processes are not due to genetic, e.g. macrophage infiltration, intraplaque hemorrhage
Imaging agent directly binds to the biological target, or the biological target is downstream to what imaging agent binds e.g. MRI with magnetic nanoparticles monitors downstream anti-angiogenic effects of mTOR inhibition
An atom with an unstable nucleus that will undergo radioactive decay emitting a gamma ray or a subatomic particle.
Thallium-activated sodium iodide (NaI(TI))
Lutetium yttrium oxyorthosilicate (LYSO)
Ordered-subset expection maxmization (OSEM)
This class - should be removed Either import from corresponding FMA subclasses OR from NCI Thesaurus "Anatomic Structure, System or Substance" class, which includes microanatomic structures.
Target is not expressed in normal cells, e.g. disialoganglioside in micad. These targets may not normally be found in GO.
these are radioactive atoms ... mainly used for SPECT/PET
which mouse strain this mutant mouse derived from. genetic background may be instances of Mouse
Only the biological subject is imaged. We do not consider the Target or the Agent to be imaged, since they are within the subject, which is being imaged.
is a molecule of high relative molecular mass, the structure of which essentially comprises the multiple repetition of units derived, actually or conceptually, from molecules of low relative molecular mass. -- Ontology for Drug Discovery Investigations
Light sheet-based fluorescence microscopy
Is this used for whole animal imaging????
Ultrasmall Superparamagnetic Iron Oxide Nanoparticle
USPIO is composed of iron particles of ~4–6 nm diameters and the hydrodynamic diameter is ~20–40 nm.
Superparamagnetic Iron Oxide Nanoparticle
An algorithm that geometrically aligns two images so that corresponding voxels/pixels can be superimposed on each other
Genetically Manipulated Fusion Protein123
most likely molecular e.g. macrophage content, integrin expression
Ultra-small superparamagnetic iron oxide particle (USPIO)
Metallothionein promoter induced gene expression
Temporo-spatially modified gene expression
molecules that may not endogenously produced
A molecule that is a monomer or short oligomer that is not determined by a genome sequence. - adapted from NCI thesaurus
organic compounds that, like antibodies, can specifically bind antigens, but that are not structurally related to antibodies. They are usually artificial peptides or proteins with a molar mass of about 3 to 20 kDa. --Wikipedia
Standard Superparamagnetic Iron Oxide Nanoparticle
Total Internal Reflection Fluorescence (TIRF)
I put bacterium under cell because it's single cell organism. Since the identity of the cell is not important, but debatable...
MMTV-LTR promoter induced gene expression
Single Photon Emission Computed Tomography
e.g. connected to or adhered to another object
Immaterial component of the animal body. Import Anatomical Space class from FMA
Tgfbr2 (transforming growth factor, beta receptor II)
Living tissue in an artificial environment outside the organism for no more than 24 hours, with minimum alteration of natural conditions
Superparamagnetic iron oxide particle (SPIO)
Biological Intervention is sort of similar to biomarker use/application
Large Superparamagnetic Iron Oxide Nanoparticle
Fluid attenuation inversion recovery (FLAIR)
Import Anatomical Structure class from FMA
Super-resolution fluorescence microscopy
Fluorescence Resonance Energy Transfer (FRET)
Import Portion of Body Substance class from FMA
although transgenic might be targeted as well, but both NCI mouse model database and Jackson lab have two categories: targeted mutant and transgenic mouse