prepareforchange--2020-03-29--Hollywood Sex Abuse is a Century Old, Charlie Chaplin Raped Kids and He’s Hailed As a Hero

As the curtain gets pulled back and the predators in Hollywood scatter like cockroaches , every new finding leads to more questions .
As the Harvey Weinstein scandal snowballed into Hollywood pedogate , Americans are finding out that children have long been the prey of Tinseltown ’ s elite .
But how far back does this depraved madness go ?
According to many horrifying cases over the 20th century , the answer to that question is at least 100 years .
Hollywood ’ s proclivity for underage sex dates back ages—if he were alive , you could just ask Charlie @ @ @ @ @ @ @ Bernard Shaw called “ the only true genius motion pictures ever produced ” had a depraved affinity for children .
Only because of his status and money did this Hollywood legend avoid being locked up .
Chaplin ’ s first underage victim was Mildred Harris .
While it is unclear as to when their relationship began , at the ripe young age of 16 , Harris gave birth to Chaplin ’ s child .
To avoid being prosecuted for statutory rape , Chaplin married Harris—a trend he would use the rest of his @ @ @ @ @ @ @ to her rapist , the couple divorced when Harris finally turned legal age .
That ’ s when Chaplin set his sights on an even younger victim , Lita MacMurray—she was 6 when they first met .
When Lita was 12 , Chaplin had the pre-pubescent Lita portray an angel dangling from wires in a scene set in celluloid heaven in his movie “ The Kid.
” Chaplin openly obsessed over MacMurray who lied to the press and told everyone she was 19 as he brought the pre-teen girl on public dates .
@ @ @ @ @ @ @ by Chaplin at the age of 16 .
Chaplin responded making MacMurray have an abortion and removed her from the film when she refused .
Grey ’ s family threatened to turn him in for statutory rape .
Chaplin married the starlet under duress and in secret in 1924 , telling friends that “ marriage was a better option than prison.
” The move led to a life of misery for his wife who gave birth to two sons during the three-year marriage .
While Chaplin had the young girl under his control @ @ @ @ @ @ @ court documents that she was essentially a child sex slave .
According to a report , an original copy of the 1927 divorce papers filed by Grey emerged in April 2015 .
In the documents , she describes his “ revolting ” and “ inhumane ” treatment of her .
The papers reveal she was forced to perform sexual acts that were illegal in California during the 1920s .
Chaplin demanded she take part in a threesome with another woman .
On one occasion , he screamed at her : “ All married @ @ @ @ @ @ @ You are my wife and you have to do what I want you to do.
” At the time of the divorce , details were leaked to the press of his “ perverted sexual desires ” which left Chaplin on the verge of a nervous breakdown as calls for his films to be banned grew .
Instead of getting banned , however , Chaplin would go on to be hailed as a hero .
In 1972 , he was even given an honorary Oscar .
Chaplin is not alone to have his lust @ @ @ @ @ @ @ be hailed as a hero in Hollywood .
On March 10 , 1977 , director Roman Polanski , then aged 44 , photographed a 13-year-old girl named Samantha Gailey ( now Geimer ) , fed her drugs and alcohol , then raped her .
Polanski pleaded guilty to unlawful sexual intercourse with a minor .
However , due to his elite status , he was allowed to flee to his home in France just before he was sentenced .
To this day , Polanski remains a free man and is still a highly @ @ @ @ @ @ @ in 2003 , Polanski was given an Oscar for directing “ The Pianist ” at the 75th Academy Awards—the admitted child rapist received a standing ovation .
Chaplin and Polanski are just two drops in a bucket that is the depraved underworld in Hollywood .
Rest assured , that unless this depravity is exposed and brought to a halt , even Weinstein will likely receive a lifetime achievement award in a few years .
Disclaimer : We at Prepare for Change ( PFC ) bring you information that is not offered by the @ @ @ @ @ @ @ controversial .
The opinions , views , statements , and/or information we present are not necessarily promoted , endorsed , espoused , or agreed to by Prepare for Change , its leadership Council , members , those who work with PFC , or those who read its content .
However , they are hopefully provocative .
Please use discernment !
Use logical thinking , your own intuition and your own connection with Source , Spirit and Natural Laws to help you determine what is true and what is not .
By sharing information @ @ @ @ @ @ @ goal to raise consciousness and awareness of higher truths to free us from enslavement of the matrix in this material realm .

By Matt Agorist,
As the curtain gets pulled back and the predators in Hollywood scatter like cockroaches, every new finding leads to more questions. As the Harvey Weinstein scandal snowballed into Hollywood pedogate, Americans are finding out that children have long been the prey of Tinseltown’s elite. But how far back does this depraved madness go? According to many horrifying cases over the 20th century, the answer to that question is at least 100 years.
Hollywood’s proclivity for underage sex dates back ages—if he were alive, you could just ask Charlie Chaplin.
Chaplin, the man George Bernard Shaw called “the only true genius motion pictures ever produced” had a depraved affinity for children. Only because of his status and money did this Hollywood legend avoid being locked up.
Chaplin’s first underage victim was Mildred Harris. While it is unclear as to when their relationship began, at the ripe young age of 16, Harris gave birth to Chaplin’s child. To avoid being prosecuted for statutory rape, Chaplin married Harris—a trend he would use the rest of his life.
Not wanting to be married to her rapist, the couple divorced when Harris finally turned legal age. That’s when Chaplin set his sights on an even younger victim, Lita MacMurray—she was 6 when they first met.
When Lita was 12, Chaplin had the pre-pubescent Lita portray an angel dangling from wires in a scene set in celluloid heaven in his movie “The Kid.”
Chaplin openly obsessed over MacMurray who lied to the press and told everyone she was 19 as he brought the pre-teen girl on public dates. Just like Harris, MacMurray was impregnated by Chaplin at the age of 16. Chaplin responded making MacMurray have an abortion and removed her from the film when she refused. Grey’s family threatened to turn him in for statutory rape. Chaplin married the starlet under duress and in secret in 1924, telling friends that “marriage was a better option than prison.” The move led to a life of misery for his wife who gave birth to two sons during the three-year marriage.
While Chaplin had the young girl under his control, it would later be revealed in court documents that she was essentially a child sex slave.
According to a report, an original copy of the 1927 divorce papers filed by Grey emerged in April 2015. In the documents, she describes his “revolting” and “inhumane” treatment of her.
The papers reveal she was forced to perform sexual acts that were illegal in California during the 1920s. Chaplin demanded she take part in a threesome with another woman. On one occasion, he screamed at her: “All married people do those kinds of things. You are my wife and you have to do what I want you to do.” At the time of the divorce, details were leaked to the press of his “perverted sexual desires” which left Chaplin on the verge of a nervous breakdown as calls for his films to be banned grew.
Instead of getting banned, however, Chaplin would go on to be hailed as a hero. In 1972, he was even given an honorary Oscar.
Chaplin is not alone to have his lust for young victims be exposed and still be hailed as a hero in Hollywood. On March 10, 1977, director Roman Polanski, then aged 44, photographed a 13-year-old girl named Samantha Gailey (now Geimer), fed her drugs and alcohol, then raped her.
Polanski pleaded guilty to unlawful sexual intercourse with a minor. However, due to his elite status, he was allowed to flee to his home in France just before he was sentenced. To this day, Polanski remains a free man and is still a highly respected Hollywood mogul. In fact, in 2003, Polanski was given an Oscar for directing “The Pianist” at the 75th Academy Awards—the admitted child rapist received a standing ovation.
Chaplin and Polanski are just two drops in a bucket that is the depraved underworld in Hollywood. Rest assured, that unless this depravity is exposed and brought to a halt, even Weinstein will likely receive a lifetime achievement award in a few years.
Source: http://thefreethoughtproject.com
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prepareforchange--2020-03-29--Galactic Federation of Light Update

Galactic Federation of Light Update

Your Tax Free Donations Are Appreciated and Help Fund our Volunteer Website and Orphanage Disclaimer : We at Prepare for @ @ @ @ @ you information that is not offered by the mainstream news , and therefore may seem @ @ @ @ @ views , statements , and/or information we present are not necessarily promoted , endorsed , @ @ @ @ @ by Prepare for Change , its leadership Council , members , those who work with @ @ @ @ @ read its content .
However , they are hopefully provocative .
Please use discernment !
@ @ @ @ @ own intuition and your own connection with Source , Spirit and Natural Laws to help @ @ @ @ @ and what is not .
By sharing information and seeding dialogue , it is our @ @ @ @ @ awareness of higher truths to free us from enslavement of the matrix in this material @ @

Lorie Ladd on current GFOL update:
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prepareforchange--2020-03-29--Patriots Changed The Google Algorithm, Censorship Stripped, It’s Going To Be A Hot Spring

https://www.youtube.com/watch?v=Mydd1yxBrOA&feature=emb_title
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prepareforchange--2020-03-28--MIT Scientist Claims Coronavirus is a “Deep State Fraud”

Says hysteria is being fueled to manipulate global economies and financial markets .
MIT scientist Shiva Ayyadurai claims that coronavirus “ fear mongering ” is a “ Deep State fraud ” to manipulate financial markets .
Ayyadurai , who is noted for his controversial claim to be the “ inventor of email , ” has a PhD in Biological Engineering and is running as a Republican in the 2020 U.S. Senate election in Massachusetts .
Responding to President Donald Trump ’ s claim that Democrats and the media are responsible for inflaming the coronavirus scare “ far beyond what the @ @ @ @ @ @ @ that the panic was being overblown for political and economic reasons .
“ As an MIT PhD in Biological Engineering who studies & does research nearly every day on the Immune System , the # coronavirus fear mongering by the Deep State will go down in history as one of the biggest fraud to manipulate economies , suppress dissent , & push MANDATED Medicine !
” tweeted Ayyadurai .
Indeed , no matter the true scale of the crisis , there ’ s little doubt that Democrats have seized upon it to blame @ @ @ @ @ @ @ almost the point of cheering on the chaos .
While Trump has been blasted for leaving the United States ill-prepared to deal with a potential pandemic , with just 5,000 people in the U.S. being tested for the virus , others have asserted that the crisis has been hijacked by Trump ’ s political adversaries to blame him unfairly .
Whether one treats the outbreak as a significant threat to the world or an over-hyped hysteria does appear to break down along partisan lines .
A Reuters/Ipsos poll released last week found that @ @ @ @ @ @ @ to say that the virus poses an imminent threat to the U.S .
Some have pointed to numbers out of South Korea and Singapore which show those countries have the situation under control , with new cases now on the decline .
China has also declared victory over the virus , with Chinese President Xi Jinping saying the “ tide has turned , ” a sentiment shared by Alfred Wu , associate professor at the National University of Singapore ’ s Lee Kuan Yew School of Public Policy , who asserted that the @ @ @ @ @ @ @ ” Disclaimer : We at Prepare for Change ( PFC ) bring you information that is not offered by the mainstream news , and therefore may seem controversial .
The opinions , views , statements , and/or information we present are not necessarily promoted , endorsed , espoused , or agreed to by Prepare for Change , its leadership Council , members , those who work with PFC , or those who read its content .
However , they are hopefully provocative .
Please use discernment !
Use logical thinking , your own @ @ @ @ @ @ @ , Spirit and Natural Laws to help you determine what is true and what is not .
By sharing information and seeding dialogue , it is our goal to raise consciousness and awareness of higher truths to free us from enslavement of the matrix in this material realm .

Says hysteria is being fueled to manipulate global economies and financial markets.
By Paul Joseph Watson,
MIT scientist Shiva Ayyadurai claims that coronavirus “fear mongering” is a “Deep State fraud” to manipulate financial markets.
Ayyadurai, who is noted for his controversial claim to be the “inventor of email,” has a PhD in Biological Engineering and is running as a Republican in the 2020 U.S. Senate election in Massachusetts.
Responding to President Donald Trump’s claim that Democrats and the media are responsible for inflaming the coronavirus scare “far beyond what the facts would warrant,” Ayyadurai agreed that the panic was being overblown for political and economic reasons.
“As an MIT PhD in Biological Engineering who studies & does research nearly every day on the Immune System, the #coronavirus fear mongering by the Deep State will go down in history as one of the biggest fraud to manipulate economies, suppress dissent, & push MANDATED Medicine!” tweeted Ayyadurai.
https://twitter.com/va_shiva/status/1237036487151177728?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1237036487151177728&ref_url=https%3A%2F%2Fsummit.news%2F2020%2F03%2F10%2Fmit-scientist-claims-coronavirus-is-a-deep-state-fraud%2F
Indeed, no matter the true scale of the crisis, there’s little doubt that Democrats have seized upon it to blame Trump for the recent stock market crash almost the point of cheering on the chaos.
While Trump has been blasted for leaving the United States ill-prepared to deal with a potential pandemic, with just 5,000 people in the U.S. being tested for the virus, others have asserted that the crisis has been hijacked by Trump’s political adversaries to blame him unfairly.
Whether one treats the outbreak as a significant threat to the world or an over-hyped hysteria does appear to break down along partisan lines.
A Reuters/Ipsos poll released last week found that Democrats are twice as likely as Republicans to say that the virus poses an imminent threat to the U.S.
Some have pointed to numbers out of South Korea and Singapore which show those countries have the situation under control, with new cases now on the decline.
China has also declared victory over the virus, with Chinese President Xi Jinping saying the “tide has turned,” a sentiment shared by Alfred Wu, associate professor at the National University of Singapore’s Lee Kuan Yew School of Public Policy, who asserted that the “outbreak has basically ended in China.”
https://www.youtube.com/watch?v=1BiM1YYIPCo&fbclid=IwAR1b6E3kSrjud-hjBCVahmfG1XDm994L8rsAQb9m4QrWGk0fdZCsUlQ0xME
Source: https://summit.news
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prepareforchange--2020-03-28--America Loses 500,000 Millionaires in Pandemic Market Crash

The drop in the stock market since the coronavirus outbreak began has resulted in huge losses for millionaires in the United States .
At the start of the year , there was a record 11 million people in the country with over a million dollars in assets , according to a new study published by research firm Spectrem Group .
However , after the fluctuating losses and gains of the past several weeks , approximately 500,000 people who were on that list are no longer millionaires .
While that number is sure to change from day to day , it @ @ @ @ @ @ @ is said and done there will be fewer millionaires after the pandemic than there were before .
While there are some ripple effects experienced by the general population , the wealthy are most affected by the stock market crash .
The top 1 percent of households owned 53.5 percent of equities and mutual fund shares , according to data from the Federal Reserve .
According to the Bloomberg Billionaire Index , the world ’ s 500 richest people have lost nearly $ 1.3 trillion since the beginning of the year .
The nation @ @ @ @ @ @ @ money in the past few months , but they had much more to lose , and many of them have private bunkers , or at the very least enough resources to get them through this difficult time .
People who live paycheck to paycheck may not have lost much money in the stock market , but many of them have lost their jobs and fear that they won ’ t be able to afford to survive in the coming weeks and months .
It was reported this week that 3.3 million Americans filed @ @ @ @ @ @ @ The Labor Department said in a statement announcing the numbers : The United States government has been working to pass a $ 2 trillion stimulus bill which includes a small payout to some workers , but critics say that the bill has included too much corporate welfare , and not enough cash to the struggling hourly employees who need it the most .
Disclaimer : We at Prepare for Change ( PFC ) bring you information that is not offered by the mainstream news , and therefore may seem controversial .
The opinions @ @ @ @ @ @ @ we present are not necessarily promoted , endorsed , espoused , or agreed to by Prepare for Change , its leadership Council , members , those who work with PFC , or those who read its content .
However , they are hopefully provocative .
Please use discernment !
Use logical thinking , your own intuition and your own connection with Source , Spirit and Natural Laws to help you determine what is true and what is not .
By sharing information and seeding dialogue , it is our goal to raise consciousness @ @ @ @ @ @ @ us from enslavement of the matrix in this material realm .

By John Vibes,
The drop in the stock market since the coronavirus outbreak began has resulted in huge losses for millionaires in the United States. At the start of the year, there was a record 11 million people in the country with over a million dollars in assets, according to a new study published by research firm Spectrem Group.
However, after the fluctuating losses and gains of the past several weeks, approximately 500,000 people who were on that list are no longer millionaires. While that number is sure to change from day to day, it seems safe to assume that when all is said and done there will be fewer millionaires after the pandemic than there were before.
While there are some ripple effects experienced by the general population, the wealthy are most affected by the stock market crash. The top 1 percent of households owned 53.5 percent of equities and mutual fund shares, according to data from the Federal Reserve.
According to the Bloomberg Billionaire Index, the world’s 500 richest people have lost nearly $1.3 trillion since the beginning of the year. The nation’s wealthy certainly lost the most money in the past few months, but they had much more to lose, and many of them have private bunkers, or at the very least enough resources to get them through this difficult time.
People who live paycheck to paycheck may not have lost much money in the stock market, but many of them have lost their jobs and fear that they won’t be able to afford to survive in the coming weeks and months. It was reported this week that 3.3 million Americans filed for unemployment, shattering previous records.
The Labor Department said in a statement announcing the numbers:
This marks the highest level of seasonally adjusted initial claims in the history of the seasonally adjusted series. The previous high was 695,000 in October of 1982.
The United States government has been working to pass a $2 trillion stimulus bill which includes a small payout to some workers, but critics say that the bill has included too much corporate welfare, and not enough cash to the struggling hourly employees who need it the most.
By Source| Creative Commons | TheMindUnleashed.com
Image: Anthony Freda Art
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prepareforchange--2020-03-28--What We Can Learn from Kids About COVID-19:  The melatonin and vitamin C connections

Medical Disclaimer : The information in this article is for general information purposes only and does not constitute medical advice .
Contact your health care provider about any questions concerning your health .
One of the striking characteristics of COVID-19 is that young children seem to resist it .
As of March 2020 , there is not a single report of a child under the age of ten , dying in this pandemic .
The major risk to them seems to be boredom because of the lockdown .
Before age 20 , the risk of fatality remains negligible but rises @ @ @ @ @ @ @ % rate in people over 80 years old .
If there was ever a time to wish you were a six-year-old , this is it .
While this coronavirus is a mild disease in most , it turns ugly if the immune system is slow to confront the infestation and overreacts .
Messenger molecules called cytokines , send too many immune cell and pro-inflammation signals to the lungs .
A cytokine storm ensues which leads to acute respiratory distress syndrome ( ARDS ) , serious lung injury and a stint on a respirator @ @ @ @ @ @ @ oxygen .
A cytokine named IL-1b , has been implicated as a key troublemaker in ARDS .
One of its jobs is to initiate a drop in oxygen levels in the blood .
It does this when NLRP3 inflammasome , another pretentiously named regulating molecule , tells it to .
A 2019 study found NLRP3 inflammasome instigates cytokine storms in other situations and other research suggests coronaviruses activate NLRP3 inflammasomes .
In theory , coronaviruses become dangerous when they take control of NLRP3 inflammasome regulation and signal IL-1bto start a storm .
Melatonin @ @ @ @ @ @ @ gland in the brain .
Most people take it on trips to prevent jet lag or take a milligram or so before bed to help them fall asleep .
It naturally goes up when it gets dark and turns up the , “ its bedtime and you need to sleep ” signal .
It also has immune and antioxidant properties .
Specifically , it inhibits NLRP2 inflammasome .
Children before age 5 can have melatonin levels that are 10 times or more than adults over age 75 .
From age 5 to 11 @ @ @ @ @ @ @ melatonin than the elderly .
This could be why they rarely have symptoms from COVID-19 exposure .
In animal studies , melatonin prevented inflammation in mice with sepsis ( a deadly complication of infection that killed Kermit the Frog creator , Jim Henson ) .
Melatonin also reduced lung damage in infected rats and ventilator-induced lung injury in more rodents conscripted in other studies .
In more good news , vitamin C also inhibits NLRP3 inflammasomes and decreases iL-1b release without any known toxicity .
The effect is dose dependent , but the @ @ @ @ @ @ @ , again so no direct dosing guidelines .
After all , rats and mice make their own vitamin C already , so this nutrient is not essential for them as it is for humans and guinea pigs .
( https : //www.researchgate.net/publication/305624280_Vitamin_C_inhibits_the_activation_of_the_NLRP3_inflammasome_by_scavenging_mitochondrial_ROS ) What is a Human to do ?
The possibility that melatonin and vitamin C can help fight and/or soften the impact of COVID-19 is promising but unproven .
There are antidotal reports of doctors in China using IV vitamin C to successfully treat infected patients , but nobody knows for @ @ @ @ @ @ @ and the adults in my family are doing .
This is not medical advice .
Consult with a knowledgeable medical practitioner before making medical decisions .
For prevention , we take 500-1000mg of vitamin C twice a day .
Vitamin C is in short supply as it is a well-known immune enhancer at many levels .
People absorb as much as they need but will get loose stools/diarrhea once they have crossed their limit .
This is called bowel tolerance .
There is no reason to take more than a person can absorb @ @ @ @ @ @ @ or ester forms for those with touchy tummies .
The amount of calcium or magnesium used to buffer the normally acidic vitamin C is small .
There are food derived vitamin C supplements which contain cofactors that may help the utilization of vitamin C but are less concentrated and much more expensive .
Melatonin production goes up when people are exposed to sunshine during the day .
This may be another reason ( after higher temperatures ) that the flu season is from fall to spring and seems to dribble off in the @ @ @ @ @ @ @ as the weather allows .
( While practicing social distancing but waving to a lot of people . )
Though I am a sleeping savant , I now take a small dose of melatonin every night before bed .
The strong sleepers and younger adults in my family have added .5 to 1 mg .
The terrible sleepers are adding 2.5 to 5mg even if it has not helped them sleep better in the past .
Melatonin works best to help people fall asleep but not stay asleep .
Typically , the most @ @ @ @ @ @ @ but wake in the middle of the night , have trouble getting back to sleep or do not get restful sleep .
One middle-aged woman in Europe who is infected with COVID-19 and had trouble breathing is consuming gigantic doses of melatonin and vitamin C and to date has stabilized her situation and is at home .
This is one case and she has not shared all the details of what she is doing .
She is still sick and busy at the moment .
My plan if I or a family member @ @ @ @ @ @ @ to 1000mg every few hours to bowel tolerance .
There is some thought that bowel tolerance will be very high if you get this coronavirus .
In my experience , bowel tolerance goes up in illness and people tolerate much more than under normal circumstances .
As for melatonin , I bought a bottle of 10mg tablets to hold in reserve .
If I get infected but have mild symptoms , I will increase melatonin before bed probably to 3 to 5mg .
If I start having trouble breathing , I plan to @ @ @ @ @ @ @ find a doctor who will take me that does IV vitamin C. This is completely theoretical so I don ’ t know what it might take to prevent a cytokine storm but if at any point I feel like I am in danger , I will make a bee line to the hospital .
Research on post-traumatic stress syndrome has found that victims get traumatized while those who are pro-active or do not consider themselves victims , do not .
Nelson Mandela felt free the 25 years he was in prison because he @ @ @ @ @ @ @ he allowed it .
I aspire to his level of mental freedom but recognize this whole virus situation has mental prison potential .
Ultimately , I aspire to Mandela ’ s level of mastery .
In the meantime , I don ’ t know if any of this information will help but noticed a tremendous sense of calm which normally take hours of dedicated meditation after I read about it .
I hope it does the same for you .
Thanks to Doris Loh for her brilliant and well-researched article which inspired and @ @ @ @ @ @ @ And thank you Christiane West for sending it to me .
Disclaimer : We at Prepare for Change ( PFC ) bring you information that is not offered by the mainstream news , and therefore may seem controversial .
The opinions , views , statements , and/or information we present are not necessarily promoted , endorsed , espoused , or agreed to by Prepare for Change , its leadership Council , members , those who work with PFC , or those who read its content .
However , they are hopefully provocative .
@ @ @ @ @ @ @ , your own intuition and your own connection with Source , Spirit and Natural Laws to help you determine what is true and what is not .
By sharing information and seeding dialogue , it is our goal to raise consciousness and awareness of higher truths to free us from enslavement of the matrix in this material realm .

By Guest Writer Kelly Dorfman, MS, LDN
Medical Disclaimer: The information in this article is for general information purposes only and does not constitute medical advice. Contact your health care provider about any questions concerning your health.
One of the striking characteristics of COVID-19 is that young children seem to resist it. As of March 2020, there is not a single report of a child under the age of ten, dying in this pandemic. The major risk to them seems to be boredom because of the lockdown. Before age 20, the risk of fatality remains negligible but rises in a straight line until the 14.8% rate in people over 80 years old. If there was ever a time to wish you were a six-year-old, this is it.
While this coronavirus is a mild disease in most, it turns ugly if the immune system is slow to confront the infestation and overreacts. Messenger molecules called cytokines, send too many immune cell and pro-inflammation signals to the lungs. A cytokine storm ensues which leads to acute respiratory distress syndrome (ARDS), serious lung injury and a stint on a respirator or the sufferer will run out of oxygen.
A cytokine named IL-1b, has been implicated as a key troublemaker in ARDS. One of its jobs is to initiate a drop in oxygen levels in the blood. It does this when NLRP3 inflammasome, another pretentiously named regulating molecule, tells it to. A 2019 study found NLRP3 inflammasome instigates cytokine storms in other situations and other research suggests coronaviruses activate NLRP3 inflammasomes. In theory, coronaviruses become dangerous when they take control of NLRP3 inflammasome regulation and signal IL-1bto start a storm.
Melatonin Regulates NLRP3 Inflammasomes
Melatonin is a hormone made by the pineal gland in the brain. Most people take it on trips to prevent jet lag or take a milligram or so before bed to help them fall asleep. It naturally goes up when it gets dark and turns up the, “its bedtime and you need to sleep” signal. It also has immune and antioxidant properties. Specifically, it inhibits NLRP2 inflammasome.
Children before age 5 can have melatonin levels that are 10 times or more than adults over age 75. From age 5 to 11 they still make 5 times or more melatonin than the elderly. This could be why they rarely have symptoms from COVID-19 exposure. In animal studies, melatonin prevented inflammation in mice with sepsis (a deadly complication of infection that killed Kermit the Frog creator, Jim Henson). Melatonin also reduced lung damage in infected rats and ventilator-induced lung injury in more rodents conscripted in other studies.
In more good news, vitamin C also inhibits NLRP3 inflammasomes and decreases iL-1b release without any known toxicity. The effect is dose dependent, but the theory was tested in poor little rodents, again so no direct dosing guidelines. After all, rats and mice make their own vitamin C already, so this nutrient is not essential for them as it is for humans and guinea pigs. (https://www.researchgate.net/publication/305624280_Vitamin_C_inhibits_the_activation_of_the_NLRP3_inflammasome_by_scavenging_mitochondrial_ROS)
What is a Human to do?
The possibility that melatonin and vitamin C can help fight and/or soften the impact of COVID-19 is promising but unproven. There are antidotal reports of doctors in China using IV vitamin C to successfully treat infected patients, but nobody knows for sure. I will share what I and the adults in my family are doing. This is not medical advice. Consult with a knowledgeable medical practitioner before making medical decisions.
For prevention, we take 500-1000mg of vitamin C twice a day. Vitamin C is in short supply as it is a well-known immune enhancer at many levels. People absorb as much as they need but will get loose stools/diarrhea once they have crossed their limit. This is called bowel tolerance. There is no reason to take more than a person can absorb. It is available in mineral buffered or ester forms for those with touchy tummies. The amount of calcium or magnesium used to buffer the normally acidic vitamin C is small. There are food derived vitamin C supplements which contain cofactors that may help the utilization of vitamin C but are less concentrated and much more expensive.
Melatonin production goes up when people are exposed to sunshine during the day. This may be another reason (after higher temperatures) that the flu season is from fall to spring and seems to dribble off in the summer. We are all getting outside as the weather allows. (While practicing social distancing but waving to a lot of people.)
Though I am a sleeping savant, I now take a small dose of melatonin every night before bed. The strong sleepers and younger adults in my family have added .5 to 1 mg. The terrible sleepers are adding 2.5 to 5mg even if it has not helped them sleep better in the past. Melatonin works best to help people fall asleep but not stay asleep. Typically, the most challenging toss and turners fall asleep easily but wake in the middle of the night, have trouble getting back to sleep or do not get restful sleep.
From Prevention to Response
One middle-aged woman in Europe who is infected with COVID-19 and had trouble breathing is consuming gigantic doses of melatonin and vitamin C and to date has stabilized her situation and is at home. This is one case and she has not shared all the details of what she is doing. She is still sick and busy at the moment.
My plan if I or a family member gets infected is to increase vitamin C to 1000mg every few hours to bowel tolerance. There is some thought that bowel tolerance will be very high if you get this coronavirus. In my experience, bowel tolerance goes up in illness and people tolerate much more than under normal circumstances.
As for melatonin, I bought a bottle of 10mg tablets to hold in reserve. If I get infected but have mild symptoms, I will increase melatonin before bed probably to 3 to 5mg. If I start having trouble breathing, I plan to take 20-50mg and see if I can find a doctor who will take me that does IV vitamin C. This is completely theoretical so I don’t know what it might take to prevent a cytokine storm but if at any point I feel like I am in danger, I will make a bee line to the hospital.
Research on post-traumatic stress syndrome has found that victims get traumatized while those who are pro-active or do not consider themselves victims, do not. Nelson Mandela felt free the 25 years he was in prison because he knew nobody could imprison his mind unless he allowed it. I aspire to his level of mental freedom but recognize this whole virus situation has mental prison potential.
Ultimately, I aspire to Mandela’s level of mastery. In the meantime, I don’t know if any of this information will help but noticed a tremendous sense of calm which normally take hours of dedicated meditation after I read about it. I hope it does the same for you.
Thanks to Doris Loh for her brilliant and well-researched article which inspired and is the basis of this article. And thank you Christiane West for sending it to me.
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