vox--2020-12-30--Asian American voters could decide the Georgia Senate runoffs

James Woo , a 35-year-old marketing manager based in Peachtree Corners , has seen Georgia ’ s Asian American community change a lot since he moved there in middle school .
“ Growing up here , there was like one big Asian supermarket , ” Woo told Vox .
Now , “ People talk about Atlanta having the third-biggest Koreatown in the US.
” Woo , a spokesperson for the nonprofit Asian Americans Advancing Justice-Atlanta ( AAAJ ) , has watched representation in government grow , too : When he started his job at AAAJ five years ago , there @ @ @ @ @ @ @ Islander ( AAPI ) lawmaker in the state legislature .
In 2021 , there will be six .
As a kid , “ I didn ’ t even know that was an opportunity , ” Woo said .
The AAPI population in Georgia has increased by 138 percent in the last 20 years , according to APIAVote , an organization focused on voter engagement .
As more people move to the state to pursue employment opportunities and a more-affordable cost of living , Georgia has seen a large uptick in Black , Latino @ @ @ @ @ @ @ corresponding gains in these groups ’ political influence .
Per the Pew Research Center , eligible AAPI voters now account for roughly 3 percent of the state ’ s electorate , a notable jump from the 1 percent they comprised in 2000 .
And APIAVote estimates that about 238,000 eligible AAPI voters currently live in Georgia , including many new voters who ’ ve aged into the electorate or become naturalized citizens this cycle .
Such shifts were evident during the 2020 presidential election , when AAPI turnout increased more than that of @ @ @ @ @ @ @ helping President-elect Joe Biden clinch a win in the state .
Compared with 2016 , the number of AAPI people who voted early tripled , going from 40,000 to roughly 120,000 in 2020 , according to the progressive data firm Catalist .
And based on early exit polls , AAPI voters nationwide backed Biden by a 2-1 margin .
Now , AAPI voter engagement — the product of years of organizing by local groups including AAAJ-Atlanta , Fair Fight Action , and the New Georgia Project — could be decisive in the state @ @ @ @ @ @ @ determine which party controls the upper chamber for the next two years .
As Biden ’ s narrow 12,000-vote margin of victory highlighted , AAPI voter support could help make the difference in what ’ s expected to be another close election .
“ We made history just a few weeks ago , ” said Linh Nguyen , the AAPI coalition director for the Georgia Democratic Party , “ and we want to make history a second time.
” Organizers have been building to this moment for years AAPI voters , a group @ @ @ @ @ @ @ different ethnicities , are far from a monolith : The largest AAPI ethnic groups in Georgia are Indian Americans , Chinese Americans , Korean Americans , Vietnamese Americans , and Filipino Americans , per APIAVote , and they encompass a wide range of ideological preferences as well as generational and cultural differences .
Although the majority of AAPI voters nationwide backed Biden , roughly a third supported Trump in the general election .
Local organizers have invested heavily in targeted outreach that considers the community ’ s diversity and many credit them with @ @ @ @ @ @ @ “ The disproportionate increase in Asian American voter turnout is [ part of ] a multiyear process of empowering nonwhite voters in Georgia to really have control over the political process and their lives , ” said Bernard Fraga , an associate professor of political science at Emory University .
Historically , political campaigns have focused less on AAPI voters because of their lower turnout rates and the smaller proportion of the electorate they ’ ve comprised , an approach that can turn into a self-fulfilling prophecy .
“ Many of the voters @ @ @ @ @ @ @ had never had anyone talk to them before , ” said Georgia state Rep. Bee Nguyen , referring to outreach she conducted in 2016 , when she led state Rep. Sam Park ’ s campaign .
In the years since , it ’ s become apparent that AAPI voters are a key part of a diverse coalition that candidates need to win in Georgia .
Aisha Yaqoob Mahmood , director of the Asian American Advocacy Fund ( AAAF ) , cites 2015 and 2016 as a major turning point in AAPI organizing efforts @ @ @ @ @ @ @ .
“ 2016 was the first year we had actual numbers to showcase as a voting bloc , ” she noted .
Since then , more groups like the AAAF — a 501 ( c ) ( 4 ) that can participate in partisan activities — have been established , and campaigns have increasingly taken notice .
Stacey Abrams ’ s 2018 gubernatorial campaign is frequently held up as one of the earliest — and most prominent — to place significant emphasis on AAPI voters in the state , driven by Abrams ’ @ @ @ @ @ @ @ increasing turnout among voters of color .
“ We tripled Asian Pacific Islander voting rates , ” Abrams said in a 2019 speech highlighting how such efforts helped her come within less than 2 percentage points of now-Gov .
Brian Kemp .
“ Stacey was the first statewide candidate who talked about this broad-based coalition that included Black voters , brown voters , AAPI voters , ” said Bee Nguyen .
Jon Ossoff ’ s campaign for the US House of Representatives in a 2017 special election also focused on AAPI voters , @ @ @ @ @ @ @ plan to keep up the momentum for the Georgia runoffs According to a RealClearPolitics average , candidates in both Georgia Senate races — Ossoff and Rev .
Raphael Warnock are running against incumbent Sens .
David Perdue and Kelly Loeffler , respectively — are currently polling within roughly 1 or 2 percentage points of each other , which means outreach to every voter is critical .
Both Ossoff and Warnock have hired AAPI outreach directors , in addition to holding events centered around AAPI-owned small businesses , pushing ads through ethnic media , @ @ @ @ @ @ @ ’ s Democratic Party , too , has a designated team working on AAPI voter turnout and coordinating with local leaders , including small-business owners and health care advocates .
“ It ties back into having these really trusted messengers in the community , ” said Jennifer Baik , APIAVote ’ s communications and policy associate .
“ Being able to enter these circles where the community gathers , being able to understand their specific needs.
” Neither Perdue nor Loeffler ’ s campaign immediately responded to Vox ’ s request for comment @ @ @ @ @ @ @ seen members of both parties trying to rally AAPI voters for the runoffs .
Materials from the Perdue and Loeffler campaigns echo the attacks against Ossoff and Warnock from national Republicans , who have tried to paint them as “ radical leftists ” with ties to China — a message that , in the past , has resonated with some more right-leaning AAPI voters , especially those who have immigrated from countries with Communist governments , such as China and Vietnam .
One of Democrats ’ main messages , meanwhile , is the @ @ @ @ @ @ @ the pandemic — a core issue for many AAPI voters as a result of Georgia being hit hard by the coronavirus .
“ We need people who recognize that we ’ re in a pandemic and follow science , ” Bee Nguyen said .
“ People … who are not racist and xenophobic and believe that immigrants are part of this country.
” Immigration reform is another policy area of importance to voters and organizers .
Specific issues they ’ ve highlighted include establishing a pathway to citizenship for DACA recipients — thousands @ @ @ @ @ @ @ as changes to local policies such as participation in the 287 ( g ) program , which allows law enforcement agencies to work with ICE and detain immigrants .
During both the presidential and Senate races , organizers have also made in-language communication a chief focus , since 43 percent of AAPI voters in Georgia say they don ’ t speak English well .
AAAF currently does phone banking and texting in 11 different languages , including Hindi , Chinese , Korean , Vietnamese , Tagalog , and Japanese .
And it ’ @ @ @ @ @ @ @ and other groups to provide accessible and translated information about voter registration , absentee ballot requests , and polling locations , since that ’ s not readily available in much of the state .
DeKalb County , which encompasses part of Atlanta and its suburbs , is one of the few that provides a translated ballot , said Woo .
“ There ’ s almost an immediate level of trust and an immediate relationship that can be built because the voter is talking with someone they can relate to , ” said Nina @ @ @ @ @ @ @ the National Asian Pacific American Women ’ s Forum , regarding in-language outreach .
Organizers have also used multiple platforms to connect with new voters .
Aside from ethnic print , radio , and television outlets , they ’ re on social media apps like WeChat , KakaoTalk , and WhatsApp , which are popular among Chinese Americans , Korean Americans , and Indian Americans , respectively .
AAAF is working with 15 to 20 community leaders , including church heads , to amplify messages on social media and help counter inaccurate reports @ @ @ @ @ @ @ group chats that have over a hundred people and we can use them to combat a lot of this misinformation that ’ s going out , ” Woo said of AAAJ-Atlanta ’ s work .
As Vox ’ s Terry Nguyen previously reported , misinformation specifically aimed at AAPI voters , including stories about voter fraud , spread rampantly on social media during the general election .
Many organizers say they ’ re bringing back in-person door-knocking for the runoffs as well , while ensuring that those involved are equipped with the protection @ @ @ @ @ @ @ We can ’ t just rely on phones and text messages , our community is limited English proficient , and we have a lot of elders , ” said AAAF ’ s Yaqoob Mahmood .
Getting existing AAPI voters to turn out their friends and family is another way they ’ ve tried to mobilize more people , too .
“ If we ’ re able to talk to someone in their family , it becomes more of a family activity , ” Reddy said .
The pressure to turn out the same @ @ @ @ @ @ @ is immense , given how high the stakes are .
“ More than ever , Asian American voters have been outreached to during the runoffs , ” Reddy added .
Georgia has highlighted the power of AAPI voters In the general election — and , likely , in the runoffs — Georgia has offered a glimpse of the influence AAPI voters can have , sending a pointed message to both parties about investing in them .
Even in the most recent presidential cycle , about half of AAPI voters nationwide said they hadn @ @ @ @ @ @ @ Republicans , highlighting a key gap .
“ The AAPI community hasn ’ t flexed its full voting potential just yet .
We are only just starting to invest in this outreach with real resources and making sure it ’ s not just one AAPI person overseeing this incredibly complex and nuanced community , ” said Linh Nguyen .
Organizers plan to keep on mobilizing the AAPI community after the runoffs , including training for more AAPI candidates , mutual aid efforts , and advocacy around immigration policy .
“ We ’ re @ @ @ @ @ @ @ election , ” Yaqoob Mahmood said .
AAPI voter engagement in Georgia is also a sign of how much sway they could have in other swing states , such as North Carolina and Pennsylvania , both of which have growing AAPI electorates as well .
“ AAPI nationwide are the fastest-growing demographic population in the country , ” said Roshni Nedungadi , a partner at HIT Strategies .
“ In a lot of key states and congressional districts , AAPI vote could be the margin between a win and loss .
”

James Woo, a 35-year-old marketing manager based in Peachtree Corners, has seen Georgia’s Asian American community change a lot since he moved there in middle school.
“Growing up here, there was like one big Asian supermarket,” Woo told Vox. Now, “People talk about Atlanta having the third-biggest Koreatown in the US.”
Woo, a spokesperson for the nonprofit Asian Americans Advancing Justice-Atlanta (AAAJ), has watched representation in government grow, too: When he started his job at AAAJ five years ago, there was just one Asian American and Pacific Islander (AAPI) lawmaker in the state legislature. In 2021, there will be six.
As a kid, “I didn’t even know that was an opportunity,” Woo said.
The AAPI population in Georgia has increased by 138 percent in the last 20 years, according to APIAVote, an organization focused on voter engagement. As more people move to the state to pursue employment opportunities and a more affordable cost of living, Georgia has seen a large uptick in Black, Latino, and AAPI residents, along with corresponding gains in these groups’ political influence.
Per the Pew Research Center, eligible AAPI voters now account for roughly 3 percent of the state’s electorate, a notable jump from the 1 percent they comprised in 2000. And APIAVote estimates that about 238,000 eligible AAPI voters currently live in Georgia, including many new voters who’ve aged into the electorate or become naturalized citizens this cycle.
Such shifts were evident during the 2020 presidential election, when AAPI turnout increased more than that of any other demographic group in Georgia — helping President-elect Joe Biden clinch a win in the state. Compared with 2016, the number of AAPI people who voted early tripled, going from 40,000 to roughly 120,000 in 2020, according to the progressive data firm Catalist. And based on early exit polls, AAPI voters nationwide backed Biden by a 2-1 margin.
Now, AAPI voter engagement — the product of years of organizing by local groups including AAAJ-Atlanta, Fair Fight Action, and the New Georgia Project — could be decisive in the state’s Senate runoffs, which will determine which party controls the upper chamber for the next two years. As Biden’s narrow 12,000-vote margin of victory highlighted, AAPI voter support could help make the difference in what’s expected to be another close election.
“We made history just a few weeks ago,” said Linh Nguyen, the AAPI coalition director for the Georgia Democratic Party, “and we want to make history a second time.”
Organizers have been building to this moment for years
AAPI voters, a group that includes people of more than 15 different ethnicities, are far from a monolith: The largest AAPI ethnic groups in Georgia are Indian Americans, Chinese Americans, Korean Americans, Vietnamese Americans, and Filipino Americans, per APIAVote, and they encompass a wide range of ideological preferences as well as generational and cultural differences. Although the majority of AAPI voters nationwide backed Biden, roughly a third supported Trump in the general election.
Local organizers have invested heavily in targeted outreach that considers the community’s diversity, and many credit them with the 2020 spike in AAPI turnout.
“The disproportionate increase in Asian American voter turnout is [part of] a multiyear process of empowering nonwhite voters in Georgia to really have control over the political process and their lives,” said Bernard Fraga, an associate professor of political science at Emory University.
Historically, political campaigns have focused less on AAPI voters because of their lower turnout rates and the smaller proportion of the electorate they’ve comprised, an approach that can turn into a self-fulfilling prophecy. “Many of the voters I talked to, many of them had never had anyone talk to them before,” said Georgia state Rep. Bee Nguyen, referring to outreach she conducted in 2016, when she led state Rep. Sam Park’s campaign.
In the years since, it’s become apparent that AAPI voters are a key part of a diverse coalition that candidates need to win in Georgia.
Aisha Yaqoob Mahmood, director of the Asian American Advocacy Fund (AAAF), cites 2015 and 2016 as a major turning point in AAPI organizing efforts, thanks in part to increased investment. “2016 was the first year we had actual numbers to showcase as a voting bloc,” she noted.
Since then, more groups like the AAAF — a 501(c)(4) that can participate in partisan activities — have been established, and campaigns have increasingly taken notice.
Stacey Abrams’s 2018 gubernatorial campaign is frequently held up as one of the earliest — and most prominent — to place significant emphasis on AAPI voters in the state, driven by Abrams’s longtime focus on voting rights and increasing turnout among voters of color. “We tripled Asian Pacific Islander voting rates,” Abrams said in a 2019 speech highlighting how such efforts helped her come within less than 2 percentage points of now-Gov. Brian Kemp.
“Stacey was the first statewide candidate who talked about this broad-based coalition that included Black voters, brown voters, AAPI voters,” said Bee Nguyen. A grassroots group called Viets for Ossoff also focused on AAPI voters during Jon Ossoff’s run for the House in 2017.
How campaigns and organizers plan to keep up the momentum for the Georgia runoffs
According to a FiveThirtyEight average, candidates in both Georgia Senate races — Ossoff and Rev. Raphael Warnock are running against incumbent Sens. David Perdue and Kelly Loeffler, respectively — are currently polling within just 1 or 2 percentage points of each other, which means outreach to every voter is critical.
Both Ossoff and Warnock have hired AAPI outreach directors, in addition to holding events centered around AAPI-owned small businesses, pushing ads through ethnic media, and providing translated campaign materials. Georgia’s Democratic Party, too, has a designated team working on AAPI voter turnout and coordinating with local leaders, including small-business owners and health care advocates.
“It ties back into having these really trusted messengers in the community,” said Jennifer Baik, APIAVote’s communications and policy associate. “Being able to enter these circles where the community gathers, being able to understand their specific needs.”
Neither Perdue nor Loeffler’s campaign immediately responded to Vox’s request for comment, though organizers say they’ve seen members of both parties trying to rally AAPI voters for the runoffs.
Materials from the Perdue and Loeffler campaigns echo the attacks against Ossoff and Warnock from national Republicans, who have tried to paint them as “radical leftists” with ties to China — a message that, in the past, has resonated with some more right-leaning AAPI voters, especially those who have immigrated from countries with communist governments, such as China and Vietnam.
One of Democrats’ main messages, meanwhile, is the importance of health care access and combating the pandemic — a core issue for many AAPI voters as a result of Georgia being hit hard by the coronavirus. “We need people who recognize that we’re in a pandemic and follow science,” Bee Nguyen said. “People … who are not racist and xenophobic and believe that immigrants are part of this country.”
Immigration reform is another policy area of importance to voters and organizers. Specific issues they’ve highlighted include establishing a pathway to citizenship for DACA recipients — thousands of whom are AAPI — as well as changes to local policies such as participation in the 287(g) program, which allows law enforcement agencies to work with ICE and detain immigrants.
During both the presidential and Senate races, organizers have also made in-language communication a chief focus, since 43 percent of AAPI voters in Georgia say they don’t speak English well.
AAAF currently does phone banking and texting in 11 different languages, including Hindi, Chinese, Korean, Vietnamese, Tagalog, and Japanese. And it’s worked, alongside efforts by AAAJ-Atlanta and other groups to provide accessible and translated information about voter registration, absentee ballot requests, and polling locations, since that’s not readily available in much of the state. DeKalb County, which encompasses part of Atlanta and its suburbs, is one of the few that provides a translated ballot, said Woo.
“There’s almost an immediate level of trust and an immediate relationship that can be built because the voter is talking with someone they can relate to,” said Nina Reddy, a voter engagement organizer with the National Asian Pacific American Women’s Forum, regarding in-language outreach.
Organizers have also used multiple platforms to connect with new voters. Aside from ethnic print, radio, and television outlets, they’re on social media apps like WeChat, KakaoTalk, and WhatsApp, which are popular among Chinese Americans, Korean Americans, and Indian Americans, respectively. AAAF is working with 15 to 20 community leaders, including church heads, to amplify messages on social media and help counter inaccurate reports.
“There are a lot of group chats that have over a hundred people and we can use them to combat a lot of this misinformation that’s going out,” Woo said of AAAJ-Atlanta’s work. As Vox’s Terry Nguyen previously reported, misinformation specifically aimed at AAPI voters, including stories about voter fraud, spread rampantly on social media during the general election.
Many organizers say they’re bringing back in-person door-knocking for the runoffs as well, while ensuring that those involved are equipped with the protection they need during the pandemic. “We can’t just rely on phones and text messages, our community is limited English proficient, and we have a lot of elders,” said AAAF’s Yaqoob Mahmood. Getting existing AAPI voters to turn out their friends and family is another way they’ve tried to mobilize more people, too. “If we’re able to talk to someone in their family, it becomes more of a family activity,” Reddy said.
The pressure to turn out the same voters who participated in the general election is immense, given how high the stakes are. “More than ever, Asian American voters have been outreached to during the runoffs,” Reddy added.
Georgia has highlighted the power of AAPI voters
In the general election — and, likely, in the runoffs — Georgia has offered a glimpse of the influence AAPI voters can have, sending a pointed message to both parties about investing in them. Even in the most recent presidential cycle, about half of AAPI voters nationwide said they hadn’t heard from either Democrats or Republicans, highlighting a key gap.
“The AAPI community hasn’t flexed its full voting potential just yet. We are only just starting to invest in this outreach with real resources and making sure it’s not just one AAPI person overseeing this incredibly complex and nuanced community,” said Linh Nguyen.
Organizers plan to keep on mobilizing the AAPI community after the runoffs, including training for more AAPI candidates, mutual aid efforts, and advocacy around immigration policy. “We’re not just closing up shop after an election,” Yaqoob Mahmood said.
AAPI voter engagement in Georgia is also a sign of how much sway they could have in other swing states, such as North Carolina and Pennsylvania, both of which have growing AAPI electorates as well.
“AAPI nationwide are the fastest-growing demographic population in the country,” said Roshni Nedungadi, a partner at market research firm HIT Strategies. “In a lot of key states and congressional districts, AAPI vote could be the margin between a win and loss.”


vox--2020-12-30--The UK coronavirus mutation has been found in the US

A new , seemingly more contagious variety of SARS-CoV-2 — the virus that causes Covid-19 — that has been spreading rapidly in the United Kingdom has now been found in the United States in at least two locations .
California Gov .
Gavin Newsom announced December 30 that the new strain , known as B.1.1.7 ( we ’ ll call it the UK variant , for simplicity ’ s sake ) , was detected in the southern part of the state .
It ’ s the second report of the UK variant in the US in as many days , @ @ @ @ @ @ @ in a male Colorado National Guard member in his 20s with no history of travel , a sign that the virus is spreading locally .
“ There is a lot we don ’ t know about this COVID-19 variant , but scientists in the United Kingdom are warning the world that it is significantly more contagious , ” said Colorado Gov .
Jared Polis , in a statement .
The evidence that this new strain spreads more easily between people is not rock solid , but it ’ s concerning enough to have @ @ @ @ @ @ @ travel from the United Kingdom earlier this month .
But it wasn ’ t enough : The variant has now been detected in Canada , Spain , Sweden , France , and Italy , among others .
At the moment , it doesn ’ t appear as though the new UK variant of SARS-CoV-2 is more dangerous in individuals .
It doesn ’ t seem to make people sicker , nor is it more likely to kill them .
“ I think the key point is that there is no evidence now … @ @ @ @ @ @ @ creates more problems , more morbidity and mortality — than the previous virus , ” Moncef Slaoui , the scientific lead for Operation Warp Speed , said during a December 21 press conference .
What it does appear to do , at least based on preliminary evidence , is spread more quickly among people .
That alone is a problem : The coronavirus spreads fast enough as it is .
Compounding concerns is that the UK variant echoes a similar story in South Africa , where a strain called 501.V2 has become the @ @ @ @ @ @ @ virus .
Scientists are wondering whether that strain is more transmissible , too .
The virus has been continually changing its genetics through the course of the pandemic .
That ’ s what RNA-based viruses like SARS-CoV-2 do — they mutate .
Most of the time , the mutations mean nothing .
But this time , something is different .
“ I ’ ve spent a lot of time this year reminding people that mutations are normal , ” molecular epidemiologist Emma Hodcroft , who works on a project called Nextstrain , said @ @ @ @ @ @ @ the world over have been feeding Nextstrain sequences of the virus , and Hodcroft and her colleagues have been tracking its genetic changes closely .
In the past , mutations haven ’ t warranted big newspaper headlines .
“ I ’ m now finding myself singing a slightly different tune , ” Hodcroft said .
This time , there does seem to be evidence that the new strain is something worth being vigilant about .
“ We probably should consider taking some precautionary measures while we ’ re trying to find out more @ @ @ @ @ @ @ same time , Covid-19 is surging around the world , even without these new mutations .
Scientists are still trying to figure out what these new variants of the coronavirus actually mean for the pandemic .
It ’ s also unclear where else the UK variant may have already spread , aside from the countries where it has been detected .
While it was reported in the US only this week , it could have been in the country for much longer .
“ The variant could already be in the United States @ @ @ @ @ @ @ US Centers for Disease Control and Prevention reported December 22 .
The good news is that we already know how to respond to these new variants : in the same way we ’ ve been responding to the pandemic overall .
The virus still transmits primarily through viral-laden breaths in the air .
Mask-wearing , social distancing , and good indoor ventilation are as critical as ever .
There ’ s a lot about this story that ’ s potentially very alarming or confusing .
And the story is not yet complete , @ @ @ @ @ @ @ whether these new variants pose a new threat .
To add some clarity , here ’ s what researchers have learned so far .
Let ’ s start with the basics .
Viral mutations .
New strains .
Increased transmission .
It all sounds like scary science fiction .
But to demystify things , and to understand why scientists are a little concerned about this new variant — and why most variants don ’ t faze them — it ’ s worth understanding how viruses mutate in the first place .
“ Oftentimes @ @ @ @ @ @ @ general conjures up a lot of things in people ’ s minds , like , you know , Ninja Turtles or X-Men or cancer , like zombie apocalypse-type stuff , ” Angela Rasmussen , a virologist with Georgetown ’ s Center for Global Health Science and Security , said .
“ A mutation is just a lot more mundane than that.
” Viruses mutate because they ’ re constantly making copies of themselves in enormous numbers .
To accomplish this , they have to hijack the hardware of a host cell that they @ @ @ @ @ @ @ be a bit sloppy .
Within a human body , a virus can replicate itself millions or billions of times , Hodcroft explains .
If you were writing a draft of something millions of times on a computer , extremely quickly , you ’ d probably make some typos .
That ’ s what ’ s happening with the viruses .
“ They make a typo ” in their genetic code , she says .
One letter of their ribonucleic acid ( RNA ) chain is replaced with another .
Viruses that use @ @ @ @ @ @ @ SARS-CoV-2 , are particularly vulnerable to mutations since the RNA molecule itself is more unstable than DNA .
The process of copying RNA is also more prone to error .
These typos can be very useful for scientists because they happen at a regular rate , and are passed down through generations of the virus as it spreads through a community .
Often , scientists can use these subtle changes to trace certain strains ’ lineage and their spread through a population .
The majority of these typos are inconsequential when it comes @ @ @ @ @ @ @ , or even a few typos , doesn ’ t usually change how the virus works , ” Hodcroft says .
Some even harm the virus .
“ You ’ re much more likely to break it than to make it better ” when it comes to mutations , she says .
But in rare instances , some mutations can give a virus an advantage , like allowing it to infect cells more readily or spread among people faster .
Those mutant strains can then become dominant within a population .
That might @ @ @ @ @ @ @ here with the UK variant ; this new strain may have accumulated typos that could make it more easily transmitted between people .
Four lines of evidence converging on this new mutation being more transmissible So why do scientists think this variant is more transmissible ?
They don ’ t have this nailed down yet for sure , but four converging streams of evidence are all pointing in the same direction .
“ That ’ s making people feel like maybe there is something here to be worried about , ” Hodcroft says @ @ @ @ @ @ @ on their own , I would say is not necessarily convincing.
” But all together , they paint a concerning picture .
One is that in the areas of the UK where this new variant is spreading , it is accounting for a larger proportion of new cases .
“ What this implies is that this new variant is spreading better than other variants that are circulating in the same region , ” she says .
A second is that the increase didn ’ t co-occur with any overly obvious change in human @ @ @ @ @ @ @ really have strong evidence that everyone in the southeast [ UK where this variant is spreading ] has just ripped their masks off and is , you know , totally violating restrictions , ” she says .
That said , it could be a coincidence .
It could be just that people who happen to have contracted this variant have it are spreading it more often via their behavior .
After all , “ this new variant has emerged at a time of the year when there has traditionally been increased family and @ @ @ @ @ @ @ European Center for Disease Prevention and Control , which estimated that the transmissibility of the new variant has increased by 70 percent compared to prior versions of the virus .
Both Rasmussen and Hodcroft say the 70 percent more transmissible figure is most likely an overestimate .
A recent , not yet peer-reviewed study from the London School of Hygiene & Tropical Medicine used a mathematical model to estimate that the new strain may be 56 percent more infectious .
Third , there ’ s some early data about how this variant acts @ @ @ @ @ @ @ be slightly higher viral loads in patients with the variants , ” Hodcroft says , suggesting the virus has an easier time replicating in the body .
( Viral load refers to the amount of virus in the patient .
Rasmussen also cautions that viral load data is really sensitive to timing and when the patient was sampled in the course of the illness , so there needs to be more data to confirm this . )
Finally , the genetic changes in the UK variant mirror changes in the South African variant @ @ @ @ @ @ @ rising case numbers .
That makes a plausible link : that this particular genetic change may be behind the increased transmissibility in both variants .
However , this is still short of definitive confirmation that the new variant is more transmissible .
According to Slaoui , figuring this out for certain would require laboratory animal testing to see how easily the virus can spread from one organism to another .
But this testing can take several weeks .
In the face of that uncertainty , many urge caution .
Again , there ’ @ @ @ @ @ @ @ causes more severe disease .
The evidence points only to increased transmissibility .
But a more transmissible virus is still a concern .
“ In general , the more people get infected , the number of hospitalizations and deaths rise accordingly as a proportion of that number , ” Hodcroft says .
“ So more cases is also bad news.
” What does the mutation ... do ?
The UK variant of SARS-CoV-2 actually contains 23 mutations in the genome of the virus .
“ We don ’ t really know what they @ @ @ @ @ @ @ , many of these mutations have already been seen in other strains of the virus around the world .
But the combination of these changes in a single virus could be making the new variant more likely to spread .
However , scientists do think that some mutations may be more important than others , and there are several mechanisms by which mutations could make the virus more infectious .
Those include : 1 .
The virus could end up with changes to its spike protein that allow it to enter cells more @ @ @ @ @ @ @ develop a mechanism to replicate more quickly inside a body , which would lead “ to people becoming infectious faster , or contagious faster than they would with another variant , ” Rasmussen explains .
3 .
The virus could theoretically have evolved an ability to counteract the cell ’ s innate immune defenses , making it easier to infect that cell .
One of the pathways scientists suspect may be at work stems from the N501Y mutation , where the amino acid asparagine is replaced by the amino acid tyrosine in the @ @ @ @ @ @ @ .
It ’ s one of several mutations in the virus ’ s spike protein in the UK variant , but N501Y is in the part of the spike that actually comes into direct contact with human cells .
The same mutation has been found in the South African variant of SARS-CoV-2 that ’ s also quickly spreading .
Since the virus attaching to a host cell is critical to the virus ’ s reproduction , the virus ’ s spike protein is especially important — and delicate .
“ If you were @ @ @ @ @ @ @ , almost any change you make in that area would result in just a dead virus that can no longer get into the cell , ” said Benjamin Neuman , a virologist at Texas A & M University Texarkana .
“ That fact that this thing is able to spread at all tells you that it ’ s at least as good as the original version .
The fact that it ’ s spreading faster may indicate that it ’ s a little bit better at grabbing on to host cells , which @ @ @ @ @ @ @ process.
” But this particular N501Y mutation has already been detected in strains that have risen and fallen in other parts of the world over the course of the pandemic .
So it may be that the other mutations coupled with N501Y are having some sort of compounding effect .
And scientists still need to do more work to determine if this is actually what ’ s causing the rise of the new SARS-CoV-2 variant in the UK .
Finding out the answer could help researchers come up with ways to counter this @ @ @ @ @ @ @ these coronavirus mutations happen ?
Scientists don ’ t know exactly how the UK variant came to be .
But there may be a clue .
Hodcroft is struck by the sheer number of mutations in the UK variant — 23 in all — which makes her suspect it ’ s possible this variant arose in an immunocompromised person .
“ It ’ s an above-average number of mutations , ” she says .
In most people , she explains , the immune system mounts a full-on assault on the virus , eliminating @ @ @ @ @ @ @ of weeks .
“ In people that have compromised immune systems , though , there ’ s a very different dynamic , ” she says .
“ So , for one thing , the virus could be in them for months instead of weeks.
” That gives the virus more time to evolve , to accumulate mutations that might make it easier to thwart the immune system .
“ It ’ s one scenario , ” she says .
“ We may never know exactly what happened here.
” The basic truth : @ @ @ @ @ @ @ more chances there are for dangerous new variants to emerge .
In any person — or animal , for that matter — the chance for a dangerous new variant to arise is rare .
But rare things can happen when there are so many cases : more than 80 million confirmed cases worldwide .
Since viruses like SARS-CoV-2 are mutating and since Covid-19 has spread in so many people , it ’ s theoretically only a matter of time before a certain set of mutations align in a way to give the virus @ @ @ @ @ @ @ about Covid-19 mutants ?
To stop mutations , quite simply , we need to stop the spread of SARS-CoV-2 in general .
For one , that helps us deal with the pandemic overall .
But “ that ’ s also conveniently how we get fewer emerging variants , ” Rasmussen says .
“ If the virus isn ’ t replicating , it can ’ t mutate .
And if it can ’ t mutate , the new variants can ’ t emerge.
” We fight the new variant as we would any variant @ @ @ @ @ @ @ social distancing , with good hand hygiene .
“ I don ’ t think people should be panicking , ” Hodcroft says .
“ Lower case numbers , no matter what the variant , are better.
” Scientists have one more tool , though : genetic tracking .
At Nextstrain , Hodcroft and her colleagues receive viral genetic sequences from all over the world to try to paint a real-time picture of transmission chains and keep tabs on how the virus is changing .
But not every place in the world is providing @ @ @ @ @ @ @ UK does a lot of viral sequencing , for instance .
It was able to pick up on the new viral strain quickly because of that .
In other locations around the globe , that might not have happened so fast .
“ In the US , it ’ s a really spotty picture , ” Hodcroft says when it comes to sequencing .
“ Some states have really invested in sequencing ; some states haven ’ t .
So for some states , we probably have a fair idea of what ’ @ @ @ @ @ @ @ , we really don ’ t have many sequences.
” Overall , the CDC reports that the US has sequenced only 51,000 of the more than 17 million cases reported in the country .
That ’ s 0.07 percent .
In comparison , the UK aims to sequence 10,000 virus samples per week , and plans to increase that capacity further .
( In addition : The UK sequences the genomes faster than the US , according to infectious disease researcher Trevor Bedford . )
That lack of viral genetic testing creates a @ @ @ @ @ @ @ The UK variant could have already arrived here undetected “ given the small fraction of US infections that have been sequenced , ” the CDC states .
More sequencing , overall , would lead to the faster detection of new strains and faster means to contain them if they were deemed problematic .
With new mutations , there is a concern that a new strain of SARS-CoV-2 could arise that would be different enough from previous versions such that prior exposures — whether through a vaccine or an infection — won ’ t @ @ @ @ @ @ @ it ’ s possible that the coronavirus could someday mutate in a way that would elude a vaccine or previous immunity .
Right now , though , scientists think this UK variant would still fall under the same umbrella of protection as earlier strains .
If someone received a Covid-19 vaccine for an older generation of the virus , they would likely have protection against this one .
To explain why , it helps to understand how the immune system deals with viruses .
When the human body detects a hostile foreign entity @ @ @ @ @ @ @ produce antibodies ( proteins that attach to the virus or to infected cells ) .
Antibodies can then interfere with how the virus works .
They can also flag the virus or virus-infected cells for destruction by other immune cells .
The specific places where the antibodies attach to the virus are called epitopes , and most Covid-19 vaccines target epitopes on the virus ’ s spike protein ( which is what the virus uses to attach to human cells and enter them ) .
“ The good thing with the vaccine is @ @ @ @ @ @ @ several epitopes that have been mapped around the spike protein , ” Slaoui said .
“ The chances that one set of mutations would alter all those epitopes , I think , are extremely very low .
The expectation , scientifically , is that these kinds of variations are unlikely to escape fully the protective response by the vaccine.
” More good news : Scientists at the University of Texas Medical Branch have announced ( via a tweet ) preliminary evidence that antibodies that neutralize the more common strain of the virus also @ @ @ @ @ @ @ ( the one that impacts the part of the virus that comes into direct contact with human cells , as mentioned above ) .
That suggests that an immune system primed — by a natural infection , at least — to fight the old variant can also fight one with this specific mutation .
Texas A & M ’ s Neuman noted that there ’ s also evidence right now showing how well vaccines can protect against mutated forms of the virus in clinical trials .
Many of the vaccines being administered were @ @ @ @ @ @ @ SARS-CoV-2 but are still showing themselves to be highly effective against Covid-19 caused by more recent versions of the virus .
“ All the tests are being done , all the papers being published , are being done with current strains , which have several mutations relative to [ the first iterations of the virus ] , and it does still seem to be working , ” Neuman said .
Covid-19 vaccine developers say they are keeping a close eye on these changes and testing to make sure their vaccines are still effective @ @ @ @ @ @ @ variant , Pfizer and BioNTech are monitoring SARS-CoV-2 sequence changes and the companies are working to generate data on how well serum from people immunized with [ the Pfizer/BioNTech vaccine ] may be able to neutralize the new strain , ” said a Pfizer spokesperson via email .
And the new Covid-19 vaccines are well equipped to adapt .
The two that have received emergency use authorizations from the Food and Drug Administration — the Pfizer/BioNTech vaccine and the Moderna vaccine — both use mRNA as their platform .
These vaccines deliver the @ @ @ @ @ @ @ SARS-CoV-2 to human cells .
Those human cells then manufacture the component themselves , allowing the immune system to use it to prepare for an infection .
One huge advantage of this approach is that the mRNA sequence can be altered quickly ; the first such vaccines for Covid-19 were developed within days after the genetic sequence of the virus was posted online .
Could manufacturers like Moderna or Pfizer/BioNTech then retool their vaccines to target the new variants without going through the whole tedious clinical trial process again ?
Possibly , according @ @ @ @ @ @ @ scientist at the FDA and a professor of medicine at Georgetown University .
He told Vox that vaccines for new variants of the influenza virus are approved every year without large-scale trials .
New versions of a Covid-19 vaccine to accommodate mutations similarly might not need another round of study in tens of thousands of people , but may require some testing to figure out dosing and immune response .
With such a new virus and brand new vaccines , the regulations for these situations have not yet been laid out .
Should @ @ @ @ @ @ @ ?
The UK and South African variants are unlikely to be the last to make headlines .
Coronavirus is constantly evolving .
We should expect it to keep changing slightly .
“ There will be new variants that emerge , ” Rasmussen says .
The thing is , with each new significant strain , scientists will have to do careful work to determine whether it ’ s more dangerous .
And there are some mutations we can perhaps even expect — if not in the coming weeks , over the next several years @ @ @ @ @ @ @ Fred Hutch Cancer Research Center published a preprint ( i.e.
, not yet peer-reviewed ) study , looking at how a coronavirus that causes the common cold evolved from the 1980s onward .
To accomplish that , they got old blood samples , which included antibodies that cling to this particular virus .
They also reconstructed pieces of the cold virus from other eras .
Basically , they wanted to see if older blood could still neutralize newer virus .
If it couldn ’ t , that would indicate the virus has evolved @ @ @ @ @ @ @ .
Here ’ s what the researchers found : “ This other human coronavirus does indeed evolve over the course of multiple years to gradually escape human immunity , ” Jesse Bloom , a virologist who co-authored the study , says .
“ So we think this suggests that there ’ s the potential for SARS-CoV-2 to do the same thing.
” But Bloom stresses that this process takes years .
It ’ s enough time to prepare , to monitor , and to potentially tweak vaccine formulations to keep up with the @ @ @ @ @ @ @ s not like the virus can evolve into an entirely different beast .
“ It can mutate to maybe escape antibodies , ” Rachel Eguia , the study ’ s lead author , says .
But it can ’ t change so much that it alters its ability to enter cells .
Scientists are also keeping their eyes out for a rapid , major mutation event known as recombination .
That ’ s where an individual is infected with two different strains of the virus at the same time , allowing the virus @ @ @ @ @ @ @ viruses could then evade the antibodies that targeted their predecessors .
Some researchers think that recombination might be how SARS-CoV-2 originated in the first place .
“ This is all hypothetical in this particular virus , but it happens in other viruses all the time , ” Neuman said .
Faced with these looming challenges , reducing the transmission of the coronavirus in general is still the best way to protect the fragile progress made in the Covid-19 pandemic so far .
Reducing transmissions is also one of the best ways to make @ @ @ @ @ @ @ for as long as possible .
The fact that multiple Covid-19 vaccines are coming out is not a cause for complacency , and these new variants of SARS-CoV-2 highlight how important it is to remain vigilant .

A new, seemingly more contagious variety of SARS-CoV-2 — the virus that causes Covid-19 — that has been spreading rapidly in the United Kingdom has now been found in the United States in at least two locations.
California Gov. Gavin Newsom announced December 30 that the new strain, known as B.1.1.7 (we’ll call it the UK variant, for simplicity’s sake), was detected in the southern part of the state. It’s the second report of the UK variant in the US in as many days, following news that the variant was found in a male Colorado National Guard member in his 20s with no history of travel, a sign that the virus is spreading locally.
“There is a lot we don’t know about this COVID-19 variant, but scientists in the United Kingdom are warning the world that it is significantly more contagious,” said Colorado Gov. Jared Polis, in a statement.
The evidence that this new strain spreads more easily between people is not rock solid, but it’s concerning enough to have forced dramatic action, like shutting down travel from the United Kingdom earlier this month. But it wasn’t enough: The variant has now been detected in Canada, Spain, Sweden, France, and Italy, among others.
At the moment, it doesn’t appear as though the new UK variant of SARS-CoV-2 is more dangerous in individuals. It doesn’t seem to make people sicker, nor is it more likely to kill them. “I think the key point is that there is no evidence now … that this virus is more pathogenic — creates more problems, more morbidity and mortality — than the previous virus,” Moncef Slaoui, the scientific lead for Operation Warp Speed, said during a December 21 press conference.
What it does appear to do, at least based on preliminary evidence, is spread more quickly among people. That alone is a problem: The coronavirus spreads fast enough as it is. Compounding concerns is that the UK variant echoes a similar story in South Africa, where a strain called 501.V2 has become the dominant version among new cases of the virus. Scientists are wondering whether that strain is more transmissible, too.
The virus has been continually changing its genetics through the course of the pandemic. That’s what RNA-based viruses like SARS-CoV-2 do — they mutate. Most of the time, the mutations mean nothing. But this time, something is different.
“I’ve spent a lot of time this year reminding people that mutations are normal,” molecular epidemiologist Emma Hodcroft, who works on a project called Nextstrain, said. For the entire pandemic, scientists around the world have been collecting genetic information about SARS-CoV-2 in a public database called GISAID. Hodcroft and her colleagues at Nextstrain draw on this database to closely track genetic changes in the virus.
In the past, mutations haven’t warranted big newspaper headlines. “I’m now finding myself singing a slightly different tune,” Hodcroft said. This time, there does seem to be evidence that the new strain is something worth being vigilant about. “We probably should consider taking some precautionary measures while we’re trying to find out more,” she added.
At the same time, Covid-19 is surging around the world, even without these new mutations. Scientists are still trying to figure out what these new variants of the coronavirus actually mean for the pandemic. It’s also unclear where else the UK variant may have already spread, aside from the countries where it has been detected. While it was reported in the US only this week, it could have been in the country for much longer. “The variant could already be in the United States without having been detected,” the US Centers for Disease Control and Prevention reported December 22.
The good news is that we already know how to respond to these new variants: in the same way we’ve been responding to the pandemic overall. The virus still transmits primarily through viral-laden breaths in the air. Mask-wearing, social distancing, and good indoor ventilation are as critical as ever.
There’s a lot about this story that’s potentially very alarming or confusing. And the story is not yet complete, as scientists need more evidence to understand whether these new variants pose a new threat.
To add some clarity, here’s what researchers have learned so far. Let’s start with the basics.
Viral mutations, explained
Viral mutations. New strains. Increased transmission. It all sounds like scary science fiction. But to demystify things, and to understand why scientists are a little concerned about this new variant — and why most variants don’t faze them — it’s worth understanding how viruses mutate in the first place.
“Oftentimes, I think the word mutation in general conjures up a lot of things in people’s minds, like, you know, Ninja Turtles or X-Men or cancer, like zombie apocalypse-type stuff,” Angela Rasmussen, a virologist with Georgetown’s Center for Global Health Science and Security, said. “A mutation is just a lot more mundane than that.”
Viruses mutate because they’re constantly making copies of themselves in enormous numbers. To accomplish this, they have to hijack the hardware of a host cell that they infect. However, this process can be a bit sloppy.
Within a human body, a virus can replicate itself millions or billions of times, Hodcroft explains. If you were writing a draft of something millions of times on a computer, extremely quickly, you’d probably make some typos. That’s what’s happening with the viruses. “They make a typo” in their genetic code, she says. One letter of their ribonucleic acid (RNA) chain is replaced with another.
Viruses that use RNA as their genetic material, like SARS-CoV-2, are particularly vulnerable to mutations since the RNA molecule itself is more unstable than DNA. The process of copying RNA is also more prone to error.
These typos can be very useful for scientists because they happen at a regular rate, and are passed down through generations of the virus as it spreads through a community. Often, scientists can use these subtle changes to trace certain strains’ lineage and their spread through a population.
The majority of these typos are inconsequential when it comes to human health. “One typo, or even a few typos, doesn’t usually change how the virus works,” Hodcroft says. Some even harm the virus. “You’re much more likely to break it than to make it better” when it comes to mutations, she says.
But in rare instances, some mutations can give a virus an advantage, like allowing it to infect cells more readily or spread among people faster. Those mutant strains can then become dominant within a population.
That might be what we’re looking at here with the UK variant; this new strain may have accumulated typos that could make it more easily transmitted between people.
Four lines of evidence converging on this new mutation being more transmissible
So why do scientists think this variant is more transmissible?
They don’t have this nailed down yet for sure, but four converging streams of evidence are all pointing in the same direction. “That’s making people feel like maybe there is something here to be worried about,” Hodcroft says. “Each one of these things on their own, I would say is not necessarily convincing.” But all together, they paint a concerning picture.
One is that in the areas of the UK where this new variant is spreading, it is accounting for a larger proportion of new cases. “What this implies is that this new variant is spreading better than other variants that are circulating in the same region,” she says.
National testing data shows increased prevalence of the variant in positive cases over time. This is detected incidentally by the commonly used 3-gene PCR test because 69-70del leads to a negative signal. But this does not effect the results of the test. 7/
h/t @The_Soup_Dragon pic.twitter.com/aPpAjjb35W — Muge Cevik (@mugecevik) December 21, 2020
A second is that the increase didn’t co-occur with any overly obvious change in human behavior. “We don’t really have strong evidence that everyone in the southeast [UK where this variant is spreading] has just ripped their masks off and is, you know, totally violating restrictions,” she says. That said, it could be a coincidence. It could be just that people who happen to have contracted this variant have it are spreading it more often via their behavior.
After all, “this new variant has emerged at a time of the year when there has traditionally been increased family and social mixing,” according to the European Center for Disease Prevention and Control, which estimated that the transmissibility of the new variant has increased by 70 percent compared to prior versions of the virus. Both Rasmussen and Hodcroft say the 70 percent more transmissible figure is most likely an overestimate. A recent, not yet peer-reviewed study from the London School of Hygiene & Tropical Medicine used a mathematical model to estimate that the new strain may be 56 percent more infectious.
Third, there’s some early data about how this variant acts in Covid-19 patients. “There may be slightly higher viral loads in patients with the variants,” Hodcroft says, suggesting the virus has an easier time replicating in the body. (Viral load refers to the amount of virus in the patient. Rasmussen also cautions that viral load data is really sensitive to timing and when the patient was sampled in the course of the illness, so there needs to be more data to confirm this.)
Finally, the genetic changes in the UK variant mirror changes in the South African variant, which has also been associated with rising case numbers. That makes a plausible link: that this particular genetic change may be behind the increased transmissibility in both variants.
However, this is still short of definitive confirmation that the new variant is more transmissible.
According to Slaoui, figuring this out for certain would require laboratory animal testing to see how easily the virus can spread from one organism to another. But this testing can take several weeks.
In the face of that uncertainty, many urge caution.
Again, there’s still no evidence this new variant causes more severe disease. The evidence points only to increased transmissibility. But a more transmissible virus is still a concern. “In general, the more people get infected, the number of hospitalizations and deaths rise accordingly as a proportion of that number,” Hodcroft says. “So more cases is also bad news.”
What does the mutation ... do?
The UK variant of SARS-CoV-2 actually contains 23 mutations in the genome of the virus. “We don’t really know what they do,” Rasmussen says. Individually, many of these mutations have already been seen in other strains of the virus around the world. But the combination of these changes in a single virus could be making the new variant more likely to spread.
However, scientists do think that some mutations may be more important than others, and there are several mechanisms by which mutations could make the virus more infectious. Those include:
1. The virus could end up with changes to its spike protein that allow it to enter cells more easily.
2. The virus could develop a mechanism to replicate more quickly inside a body, which would lead “to people becoming infectious faster, or contagious faster than they would with another variant,” Rasmussen explains.
3. The virus could theoretically have evolved an ability to counteract the cell’s innate immune defenses, making it easier to infect that cell.
One of the pathways scientists suspect may be at work stems from the N501Y mutation, where the amino acid asparagine is replaced by the amino acid tyrosine in the 501st position of the viral protein sequence. It’s one of several mutations in the virus’s spike protein in the UK variant, but N501Y is in the part of the spike that actually comes into direct contact with human cells. The same mutation has been found in the South African variant of SARS-CoV-2 that’s also quickly spreading.
Since the virus attaching to a host cell is critical to the virus’s reproduction, the virus’s spike protein is especially important — and delicate.
“If you were just making random changes in the lab, almost any change you make in that area would result in just a dead virus that can no longer get into the cell,” said Benjamin Neuman, a virologist at Texas A&M University Texarkana. “That fact that this thing is able to spread at all tells you that it’s at least as good as the original version. The fact that it’s spreading faster may indicate that it’s a little bit better at grabbing on to host cells, which is the first step of the entry process.”
But this particular N501Y mutation has already been detected in strains that have risen and fallen in other parts of the world over the course of the pandemic. So it may be that the other mutations coupled with N501Y are having some sort of compounding effect. And scientists still need to do more work to determine if this is actually what’s causing the rise of the new SARS-CoV-2 variant in the UK. Finding out the answer could help researchers come up with ways to counter this variety of the coronavirus.
How did these coronavirus mutations happen?
Scientists don’t know exactly how the UK variant came to be. But there may be a clue. Hodcroft is struck by the sheer number of mutations in the UK variant — 23 in all — which makes her suspect it’s possible this variant arose in an immunocompromised person. “It’s an above-average number of mutations,” she says.
In most people, she explains, the immune system mounts a full-on assault on the virus, eliminating it in a matter of a couple of weeks. “In people that have compromised immune systems, though, there’s a very different dynamic,” she says. “So, for one thing, the virus could be in them for months instead of weeks.” That gives the virus more time to evolve, to accumulate mutations that might make it easier to thwart the immune system.
“It’s one scenario,” she says. “We may never know exactly what happened here.”
The basic truth: The more this virus spreads, the more chances there are for dangerous new variants to emerge. In any person — or animal, for that matter — the chance for a dangerous new variant to arise is rare. But rare things can happen when there are so many cases: more than 80 million confirmed cases worldwide.
Since viruses like SARS-CoV-2 are mutating and since Covid-19 has spread in so many people, it’s theoretically only a matter of time before a certain set of mutations align in a way to give the virus a boost.
What can we do about Covid-19 mutants?
To stop mutations, quite simply, we need to stop the spread of SARS-CoV-2 in general. For one, that helps us deal with the pandemic overall. But “that’s also conveniently how we get fewer emerging variants,” Rasmussen says. “If the virus isn’t replicating, it can’t mutate. And if it can’t mutate, the new variants can’t emerge.”
We fight the new variant as we would any variant of SARS-CoV-2: with masks, with social distancing, with good hand hygiene. “I don’t think people should be panicking,” Hodcroft says. “Lower case numbers, no matter what the variant, are better.”
It’s already been said but if we actually follow protocol and have policies that support those protocols a new variant that is more transmissible would be combatted just as an older variant. So like worry less about mutants and more about masking and distancing and vaccination. — K. Taylor, Ph.D., M.S. (@KYT_ThatsME) December 21, 2020
Scientists have one more tool, though: genetic tracking. At Nextstrain, Hodcroft and her colleagues receive viral genetic sequences from all over the world to try to paint a real-time picture of transmission chains and keep tabs on how the virus is changing. But not every place in the world is providing the same amount of data.
The UK does a lot of viral sequencing, for instance. It was able to pick up on the new viral strain quickly because of that. In other locations around the globe, that might not have happened so fast.
“In the US, it’s a really spotty picture,” Hodcroft says when it comes to sequencing. “Some states have really invested in sequencing; some states haven’t. So for some states, we probably have a fair idea of what’s going on. In other states, we really don’t have many sequences.”
Overall, the CDC reports that the US has sequenced only 51,000 of the more than 17 million cases reported in the country. That’s 0.07 percent. In comparison, the UK aims to sequence 10,000 virus samples per week, and plans to increase that capacity further. (In addition: The UK sequences the genomes faster than the US, according to infectious disease researcher Trevor Bedford.) That lack of viral genetic testing creates a big blind spot in the US. The UK variant could have already arrived here undetected “given the small fraction of US infections that have been sequenced,” the CDC states.
More sequencing, overall, would lead to the faster detection of new strains and faster means to contain them if they were deemed problematic.
Do mutations mean a Covid-19 vaccine won’t work anymore?
With new mutations, there is a concern that a new strain of SARS-CoV-2 could arise that would be different enough from previous versions such that prior exposures — whether through a vaccine or an infection — won’t offer protection. So, yes, it’s possible that the coronavirus could someday mutate in a way that would elude a vaccine or previous immunity.
Right now, though, scientists think this UK variant would still fall under the same umbrella of protection as earlier strains. If someone received a Covid-19 vaccine for an older generation of the virus, they would likely have protection against this one.
To explain why, it helps to understand how the immune system deals with viruses. When the human body detects a hostile foreign entity like a virus, it starts to produce antibodies (proteins that attach to the virus or to infected cells). Antibodies can then interfere with how the virus works. They can also flag the virus or virus-infected cells for destruction by other immune cells.
The specific places where the antibodies attach to the virus are called epitopes, and most Covid-19 vaccines target epitopes on the virus’s spike protein (which is what the virus uses to attach to human cells and enter them).
“The good thing with the vaccine is that it induces an immune response against several epitopes that have been mapped around the spike protein,” Slaoui said. “The chances that one set of mutations would alter all those epitopes, I think, are extremely very low. The expectation, scientifically, is that these kinds of variations are unlikely to escape fully the protective response by the vaccine.”
More good news: Scientists at the University of Texas Medical Branch have announced (via a tweet) preliminary evidence that antibodies that neutralize the more common strain of the virus also neutralize a strain with the N501Y mutation (the one that impacts the part of the virus that comes into direct contact with human cells, as mentioned above). That suggests that an immune system primed — by a natural infection, at least — to fight the old variant can also fight one with this specific mutation.
Some good news (and incredibly fast work) on one of the mutations scientists are worried about: N501Y.
In these lab experiments serum from recovered #covid19 patients was just as good at neutralizing virus with the mutation as without it. https://t.co/SIxfo2x3qp — Kai Kupferschmidt (@kakape) December 22, 2020
Texas A&M’s Neuman noted that there’s also evidence right now showing how well vaccines can protect against mutated forms of the virus in clinical trials. Many of the vaccines being administered were engineered to counter the earliest generations of SARS-CoV-2 but are still showing themselves to be highly effective against Covid-19 caused by more recent versions of the virus.
“All the tests are being done, all the papers being published, are being done with current strains, which have several mutations relative to [the first iterations of the virus], and it does still seem to be working,” Neuman said.
Covid-19 vaccine developers say they are keeping a close eye on these changes and testing to make sure their vaccines are still effective. “In terms of the new variant, Pfizer and BioNTech are monitoring SARS-CoV-2 sequence changes and the companies are working to generate data on how well serum from people immunized with [the Pfizer/BioNTech vaccine] may be able to neutralize the new strain,” said a Pfizer spokesperson via email.
And the new Covid-19 vaccines are well equipped to adapt. The two that have received emergency use authorizations from the Food and Drug Administration — the Pfizer/BioNTech vaccine and the Moderna vaccine — both use mRNA as their platform. These vaccines deliver the instructions for making the spike protein of SARS-CoV-2 to human cells. Those human cells then manufacture the component themselves, allowing the immune system to use it to prepare for an infection. One huge advantage of this approach is that the mRNA sequence can be altered quickly; the first such vaccines for Covid-19 were developed within days after the genetic sequence of the virus was posted online.
Could manufacturers like Moderna or Pfizer/BioNTech then retool their vaccines to target the new variants without going through the whole tedious clinical trial process again?
Possibly, according to Jesse Goodman, a former chief scientist at the FDA and a professor of medicine at Georgetown University. He told Vox that vaccines for new variants of the influenza virus are approved every year without large-scale trials. New versions of a Covid-19 vaccine to accommodate mutations similarly might not need another round of study in tens of thousands of people, but may require some testing to figure out dosing and immune response. With such a new virus and brand new vaccines, the regulations for these situations have not yet been laid out.
Should we expect more mutations in the future?
Short answer: yes.
The UK and South African variants are unlikely to be the last to make headlines. Coronavirus is constantly evolving. We should expect it to keep changing slightly.
“There will be new variants that emerge,” Rasmussen says. The thing is, with each new significant strain, scientists will have to do careful work to determine whether it’s more dangerous.
And there are some mutations we can perhaps even expect — if not in the coming weeks, over the next several years.
Recently, virology researchers at the Fred Hutch Cancer Research Center published a preprint (i.e., not yet peer-reviewed) study, looking at how a coronavirus that causes the common cold evolved from the 1980s onward. To accomplish that, they got old blood samples, which included antibodies that cling to this particular virus. They also reconstructed pieces of the cold virus from other eras. Basically, they wanted to see if older blood could still neutralize newer virus. If it couldn’t, that would indicate the virus has evolved over time to evade the immune system.
Here’s what the researchers found: “This other human coronavirus does indeed evolve over the course of multiple years to gradually escape human immunity,” Jesse Bloom, a virologist who co-authored the study, says. “So we think this suggests that there’s the potential for SARS-CoV-2 to do the same thing.” But Bloom stresses that this process takes years. It’s enough time to prepare, to monitor, and to potentially tweak vaccine formulations to keep up with the virus’s evolution.
It’s not like the virus can evolve into an entirely different beast. “It can mutate to maybe escape antibodies,” Rachel Eguia, the study’s lead author, says. But it can’t change so much that it alters its ability to enter cells.
Scientists are also keeping their eyes out for a rapid, major mutation event known as recombination. That’s where an individual is infected with two different strains of the virus at the same time, allowing the virus strains to swap parts. These new viruses could then evade the antibodies that targeted their predecessors. Some researchers think that recombination might be how SARS-CoV-2 originated in the first place.
“This is all hypothetical in this particular virus, but it happens in other viruses all the time,” Neuman said.
Faced with these looming challenges, reducing the transmission of the coronavirus in general is still the best way to protect the fragile progress made in the Covid-19 pandemic so far. Reducing transmissions is also one of the best ways to make sure powerful tools like vaccines remain potent for as long as possible. The fact that multiple Covid-19 vaccines are coming out is not a cause for complacency, and these new variants of SARS-CoV-2 highlight how important it is to remain vigilant.
Correction: An earlier version of this article misstated how Nextstrain gathers data.


vox--2020-12-30--The US is getting an official women’s history museum

It has gotten less attention than expanded unemployment insurance or the battle over stimulus checks , but tucked into the year-end legislation passed by Congress last week was a provision that could change the way the United States commemorates its history .
The legislation included the Smithsonian Women ’ s History Act , the culmination of a years-long effort to establish a women ’ s history museum in Washington , DC .
Backed by Democrats like Rep. Carolyn Maloney of New York and Republicans like Sen. Susan Collins of Maine , the act authorizes the creation of the museum on @ @ @ @ @ @ @ combination of federal and private money .
“ For too long , women ’ s stories have been left out of the telling of our nation ’ s history , but with this vote , we begin to rectify that , ” Maloney said in a statement last week .
The omnibus legislation also included a provision to establish a National Museum of the American Latino , which will focus on “ Latino contributions to life , art , history , and culture in the United States.
” Both will be located on @ @ @ @ @ @ @ an exact location to be specified within two years , according to CNN .
The bills establishing the museums were blocked earlier this month by Utah Republican Sen. Mike Lee , who argued that they were divisive .
“ At this moment in the history of our diverse nation , we need our federal government and the Smithsonian Institution itself to pull us closer together and not further apart , ” he said .
But many say that , on the contrary , the museums are long overdue .
“ Having a museum @ @ @ @ @ @ @ US history should not be a controversial undertaking by any stretch of the imagination , ” Kali Nicole Gross , a professor at Emory University and Rutgers University and co-author of A Black Women ’ s History of the United States , told Vox .
“ The fact that it is shows that we have a long way to go still.
” The legislation is the culmination of a years-long process The idea of a national women ’ s history museum first came before Congress in 2003 , when Collins and others introduced @ @ @ @ @ @ @ to CNBC .
It didn ’ t pass , but in 2014 , a congressional commission recommended the building of a museum .
Then , in February 2020 , the House passed the Smithsonian Women ’ s History Act to establish the museum .
But passage of both this bill and legislation to establish the Museum of the American Latino was blocked in the Senate by Lee , who said the US does not need “ separate but equal museums , ” according to CNN .
The Smithsonian “ should not have an @ @ @ @ @ @ @ a museum of women ’ s history or museum of American men ’ s history or Mormon history or Asian American history or Catholic history .
American history is an inclusive story that should unite us , ” he added .
But many disagreed , and both proposals ended up included in the omnibus legislation passed last week that included $ 600 stimulus checks and other Covid-19 relief .
Lawmakers have applauded the plans for both museums , expressing hope that they will tell the stories of Americans too often left out of @ @ @ @ @ @ @ this vote , Latinos and Latinas across our nation will finally have their stories , struggles , and impact on our country validated by the United States Congress , ” Sen. Bob Menendez ( D-NJ ) said in a statement after the legislation ’ s passage .
And Maloney said in a statement that it was “ fitting ” that the bill establishing the women ’ s history museum was passed “ as we mark the centennial of the 19th Amendment and in the year in which we elected our first woman vice @ @ @ @ @ @ @ of work left to be done The museums will likely take years to build .
The National Museum of African American History , the most recent addition to the Smithsonian , was authorized by Congress in 2003 and opened in 2016 , CNN notes .
And in the planning process , the key will be an “ expansive view ” of women ’ s history , Gross said , including women of different abilities , trans and queer communities , and the experiences of women from all walks of life : “ women @ @ @ @ @ @ @ writers , women who were seamstresses , women who were farmers , women who were domestics , ” she explained .
“ I want it all.
” Such an expansive view could also extend to more experiential ways of teaching history , Gross said , including the history of street harassment in the US .
“ From the first women starting to work and having to navigate public streets , there were all kinds of perils , ” she explained , especially for Black women .
“ They carried hatpins ; they learned @ @ @ @ @ @ @ defensively to protect themselves.
” It will be interesting to see if the museum could find a way to recreate or use “ that embodied experience ” to teach about the misogyny that has been a major part of American history , Gross said .
Neither the women ’ s history museum nor the Museum of the American Latino will start from zero .
According to the Washington Post , they will build on the work of the American Women ’ s History Initiative , established in 2018 , and the Smithsonian Latino @ @ @ @ @ @ @ Women ’ s History Initiative has launched several exhibitions and has continued to produce virtual events during the pandemic , including forthcoming programs on female spies during World War II and sexism in science .
Officials at the Smithsonian say their work on such programs will help make the new museums a success .
“ The Smithsonian has unparalleled experience building national museums , and is already doing significant work to tell the stories of American Women and Latinos , ” the institution said in a statement to CNN .
“ We look @ @ @ @ @ @ @ further amplify these stories and help our country learn more about the impact that women and Latinos have had on the fabric of our nation.
” And however they approach the task ahead , the goal should be to make sure “ that any woman can walk into that museum and learn about something that they can relate to , ” Gross said .

It has gotten less attention than expanded unemployment insurance or the battle over stimulus checks, but tucked into the year-end legislation passed by Congress last week was a provision that could change the way the United States commemorates its history.
The legislation included the Smithsonian Women’s History Act, the culmination of a years-long effort to establish a women’s history museum in Washington, DC. Backed by Democrats like Rep. Carolyn Maloney of New York and Republicans like Sen. Susan Collins of Maine, the act authorizes the creation of the museum on the National Mall, funded by a combination of federal and private money.
“For too long, women’s stories have been left out of the telling of our nation’s history, but with this vote, we begin to rectify that,” Maloney said in a statement last week.
The omnibus legislation also included a provision to establish a National Museum of the American Latino, which will focus on “Latino contributions to life, art, history, and culture in the United States.” Both will be located on or around the National Mall, with an exact location to be specified within two years, according to CNN.
The bills establishing the museums were blocked earlier this month by Utah Republican Sen. Mike Lee, who argued that they were divisive. “At this moment in the history of our diverse nation, we need our federal government and the Smithsonian Institution itself to pull us closer together and not further apart,” he said.
But many say that, on the contrary, the museums are long overdue. “Having a museum that features women’s experiences in US history should not be a controversial undertaking by any stretch of the imagination,” Kali Nicole Gross, a professor at Emory University and Rutgers University and co-author of A Black Women’s History of the United States, told Vox. “The fact that it is shows that we have a long way to go still.”
The legislation is the culmination of a years-long process
The idea of a women’s history museum has been before Congress since at least 1998, when Maloney introduced legislation to study the issue. It didn’t pass then, but a congressional commission on the matter was created in 2014, according to CNBC.
Then, in February 2020, the House passed the Smithsonian Women’s History Act to establish the museum. But passage of both this bill and legislation to establish the Museum of the American Latino was blocked in the Senate by Lee, who said the US does not need “separate but equal museums,” according to CNN.
The Smithsonian “should not have an exclusive museum of American Latino history or a museum of women’s history or museum of American men’s history or Mormon history or Asian American history or Catholic history. American history is an inclusive story that should unite us,” he added.
But many disagreed, and both proposals ended up included in the omnibus legislation passed last week that included $600 stimulus checks and other Covid-19 relief.
Lawmakers have applauded the plans for both museums, expressing hope that they will tell the stories of Americans too often left out of history classes and textbooks.
“With this vote, Latinos and Latinas across our nation will finally have their stories, struggles, and impact on our country validated by the United States Congress,” Sen. Bob Menendez (D-NJ) said in a statement after the legislation’s passage.
And Maloney said in a statement that it was “fitting” that the bill establishing the women’s history museum was passed “as we mark the centennial of the 19th Amendment and in the year in which we elected our first woman vice president.”
There’s a lot of work left to be done
The museums will likely take years to build. The National Museum of African American History, the most recent addition to the Smithsonian, was authorized by Congress in 2003 and opened in 2016, CNN notes.
And in the planning process, the key will be an “expansive view” of women’s history, Gross said, including women of different abilities, trans and queer communities, and the experiences of women from all walks of life: “women who were performers, women who were writers, women who were seamstresses, women who were farmers, women who were domestics,” she explained. “I want it all.”
Such an expansive view could also extend to more experiential ways of teaching history, Gross said, including the history of street harassment in the US. “From the first women starting to work and having to navigate public streets, there were all kinds of perils,” she explained, especially for Black women. “They carried hatpins; they learned how to use their purses and bags defensively to protect themselves.”
It will be interesting to see if the museum could find a way to recreate or use “that embodied experience” to teach about the misogyny that has been a major part of American history, Gross said.
Neither the women’s history museum nor the Museum of the American Latino will start from zero. According to the Washington Post, they will build on the work of the American Women’s History Initiative, established in 2018, and the Smithsonian Latino Center, founded in 1997. The Women’s History Initiative has launched several exhibitions and has continued to produce virtual events during the pandemic, including forthcoming programs on female spies during World War II and sexism in science.
Officials at the Smithsonian say their work on such programs will help make the new museums a success. “The Smithsonian has unparalleled experience building national museums, and is already doing significant work to tell the stories of American Women and Latinos,” the institution said in a statement to CNN. “We look forward to building two world-class museums to further amplify these stories and help our country learn more about the impact that women and Latinos have had on the fabric of our nation.”
And however they approach the task ahead, the goal should be to make sure “that any woman can walk into that museum and learn about something that they can relate to,” Gross said.


vox--2020-12-30--The UK approved the Oxford/AstraZeneca Covid-19 vaccine. The US might not get it until April.

The United Kingdom on Wednesday authorized its second Covid-19 vaccine for distribution .
Developed by the University of Oxford and AstraZeneca , the newly approved vaccine costs less and is easier to store than the Pfizer/BioNTech vaccine that received similar approval in the UK on December 2 .
Officials said the advantages of the Oxford/AstraZeneca vaccine could accelerate the vaccination effort as the UK contends with a new , more transmissible variant of SARS-CoV-2 , the virus that causes Covid-19 .
“ This approval means more people can be protected against this virus and will help save lives , ” @ @ @ @ @ @ @ UK ’ s health regulator , the Medicines and Healthcare products Regulatory Agency , said in a statement .
The UK aims to vaccinate 1 million people per week and is shifting to a more aggressive vaccination schedule , according to the New York Times .
The country will administer the first vaccine dose to “ as many people as possible , ” rather than try to keep supplies in reserve to ensure everyone receives a second dose , as other countries , including the United States , have done so far .
@ @ @ @ @ @ @ and low cost could also be a boon to less wealthy nations .
If its efficacy is high — and if the vaccine is distributed quickly — it could save countless lives .
However , some lingering questions about the results of clinical trials for this vaccine are holding it back from approval in the US , which is conducting its own trials of the vaccine ’ s effectiveness .
Why the Oxford/AstraZeneca Covid-19 vaccine is different from those developed by Pfizer/BioNTech and Moderna In the UK , the Oxford/AstraZeneca vaccine is approved @ @ @ @ @ @ @ and will normally be administered as two doses spaced four to 12 weeks apart .
It costs $ 3 to $ 4 a dose and can be stored in regular refrigerators .
By comparison , the Moderna and Pfizer/BioNTech vaccines that have received emergency use authorizations in the US cost between $ 15 and $ 25 per dose and require freezers .
The Pfizer/BioNTech vaccine in particular needs cold storage at minus 70 degrees Celsius ( minus 94 degrees Fahrenheit ) or lower .
The Oxford/AstraZeneca vaccine also uses a different technology from @ @ @ @ @ @ @ The Pfizer/BioNTech and Moderna vaccines harness a molecule called mRNA as their platform to deliver the instructions for making a part of the SARS-CoV-2 virus .
Oxford and AstraZeneca used a different innovative method , reprogramming another virus to transmit DNA instructions for making parts of the SARS-CoV-2 virus .
Using another virus to package and deliver genetic material helps the Oxford/AstraZeneca vaccine remain stable even at higher temperatures .
However , Oxford and AstraZeneca encountered some problems in their clinical trials , including a dosage mistake that led to one group receiving @ @ @ @ @ @ @ initial shot .
So far , its efficacy seems to be less than that of the Moderna and Pfizer/BioNTech vaccines , though well above the 50 percent threshold the Food and Drug Administration and the European Medicines Agency set for vaccine approval .
But the actual efficacy value remains unclear , ranging between 70 percent and 90 percent efficacy in preventing Covid-19 .
And Oxford and AstraZeneca have been cagey about certain details surrounding their research .
One reason the Oxford/AstraZeneca vaccine has been approved in the UK but not in the US @ @ @ @ @ @ @ data on a rolling basis .
The FDA prefers to have more complete trial data .
In the US , phase 3 clinical trials of the Oxford/AstraZeneca vaccine are still being conducted .
During a press call on December 30 , Moncef Slaoui , the scientific lead for the US government ’ s Operation Warp Speed , said it might be months before the US gives this vaccine the green light .
“ We project , if everything goes well , that the readout and emergency use authorization may be granted somewhere early @ @ @ @ @ @ @ Slaoui said .
But as in the UK , having another vaccine available in the US , particularly one that ’ s cheaper and easier to store , would help control the spread of Covid-19 .
The US government has already invested $ 1.2 billion in the Oxford/AstraZeneca vaccine and has committed to purchasing 300 million doses .

The United Kingdom on Wednesday authorized its second Covid-19 vaccine for distribution. Developed by the University of Oxford and AstraZeneca, the newly approved vaccine costs less and is easier to store than the Pfizer/BioNTech vaccine that received similar approval in the UK on December 2.
Officials said the advantages of the Oxford/AstraZeneca vaccine could accelerate the vaccination effort as the UK contends with a new, more transmissible variant of SARS-CoV-2, the virus that causes Covid-19.
“This approval means more people can be protected against this virus and will help save lives,” June Raine, chief executive of the UK’s health regulator, the Medicines and Healthcare products Regulatory Agency, said in a statement.
The UK aims to vaccinate 1 million people per week and is shifting to a more aggressive vaccination schedule, according to the New York Times. The country will administer the first vaccine dose to “as many people as possible,” rather than try to keep supplies in reserve to ensure everyone receives a second dose, as other countries, including the United States, have done so far.
The Oxford/AstraZeneca vaccine’s high stability and low cost could also be a boon to less wealthy nations. If its efficacy is high — and if the vaccine is distributed quickly — it could save countless lives. However, some lingering questions about the results of clinical trials for this vaccine are holding it back from approval in the US, which is conducting its own trials of the vaccine’s effectiveness.
Why the Oxford/AstraZeneca Covid-19 vaccine is different from those developed by Pfizer/BioNTech and Moderna
In the UK, the Oxford/AstraZeneca vaccine is approved for people over the age of 18 and will normally be administered as two doses spaced four to 12 weeks apart. It costs $3 to $4 a dose and can be stored in regular refrigerators. By comparison, the Moderna and Pfizer/BioNTech vaccines that have received emergency use authorizations in the US cost between $15 and $25 per dose and require freezers. The Pfizer/BioNTech vaccine in particular needs cold storage at minus 70 degrees Celsius (minus 94 degrees Fahrenheit) or lower.
The Oxford/AstraZeneca vaccine also uses a different technology from the Covid-19 immunizations approved so far. The Pfizer/BioNTech and Moderna vaccines harness a molecule called mRNA as their platform to deliver the instructions for making a part of the SARS-CoV-2 virus. Oxford and AstraZeneca used a different innovative method, reprogramming another virus to transmit DNA instructions for making parts of the SARS-CoV-2 virus. Using another virus to package and deliver genetic material helps the Oxford/AstraZeneca vaccine remain stable even at higher temperatures.
However, Oxford and AstraZeneca encountered some problems in their clinical trials, including a dosage mistake that led to one group receiving less than a full dose for their initial shot. So far, its efficacy seems to be less than that of the Moderna and Pfizer/BioNTech vaccines, though well above the 50 percent threshold the Food and Drug Administration and the European Medicines Agency set for vaccine approval.
But the actual efficacy value remains unclear, ranging between 70 percent and 90 percent efficacy in preventing Covid-19. And Oxford and AstraZeneca have been cagey about certain details surrounding their research.
One reason the Oxford/AstraZeneca vaccine has been approved in the UK but not in the US is that UK regulators evaluate clinical trial data on a rolling basis. The FDA prefers to have more complete trial data. In the US, phase 3 clinical trials of the Oxford/AstraZeneca vaccine are still being conducted.
During a press call on December 30, Moncef Slaoui, the scientific lead for the US government’s Operation Warp Speed, said it might be months before the US gives this vaccine the green light. “We project, if everything goes well, that the readout and emergency use authorization may be granted somewhere early in the month of April,” Slaoui said.
But as in the UK, having another vaccine available in the US, particularly one that’s cheaper and easier to store, would help control the spread of Covid-19. The US government has already invested $1.2 billion in the Oxford/AstraZeneca vaccine and has committed to purchasing 300 million doses.


vox--2020-12-30--An ex-Facebook lawyer is Big Tech’s latest tie to the White House. Or is it?

President-elect Joe Biden ’ s selection of a former Facebook attorney to a senior role in his White House is serving as the latest flashpoint in the debate over how much influence the tech industry should have in Washington .
Biden on Wednesday named Jessica Hertz , until this year a lawyer focused on regulatory affairs in Facebook ’ s DC office , as his staff secretary , a quietly powerful White House role that determines , for instance , what paperwork the president sees .
Hertz is one of the highest-ranking aides serving Biden who recently was in the @ @ @ @ @ @ @ Her selection stirred anger from both the right , which wants to see the power of Big Tech curtailed , and activists on the far left , who have tried to argue that tech executives should be forbidden from administration positions .
But many — if not most — of the names from Big Tech companies that have been linked to possible appointments are also former aides to Biden at various points in his career , a fact that complicates the narrative that these appointees are first and foremost industry loyalists .
It @ @ @ @ @ @ @ the Obama-Biden administration to take well-paid jobs in the tech industry , which was not as politically toxic as it is today .
Taking a tech job then was , in fact , the safer option when compared to corporate gigs on Wall Street .
So a more Biden-friendly construct is that the president-elect is simply hiring people he used to work with and trusts rather than acceding to corporate influence .
Cynthia Hogan , for instance , a top adviser to Biden during the campaign , led Apple ’ s lobbying operation @ @ @ @ @ @ @ in two stints dating back to 1991 .
The same holds true for Hertz : She served as deputy counsel to Biden when he was vice president and is now returning to the Biden fold .
She only worked at Facebook for about two years .
Those two years , however , were more controversial than the tenures of former Biden aides who worked for Big Tech in earlier years .
Hertz joined Facebook just after the Cambridge Analytica scandal broke in 2018 — igniting a new round of public scrutiny for the @ @ @ @ @ @ @ focused on regulatory affairs , which culminated this month in an antitrust suit by the Federal Trade Commission .
Hertz left Facebook in June , according to her LinkedIn page ; in the fall , she was announced as the Biden transition team ’ s general counsel .
Facebook is the tech giant that appears most on the outs with Biden ’ s team .
His aides constantly battled with the company over disinformation and advertising policies during the campaign , and Biden has said he has “ never been a fan of @ @ @ @ @ @ @ a statement that it was the bosses ’ opinions who mattered : “ Members of the incoming Biden-Harris administration are committed to implementing the policy ideas presented by the Biden-Harris campaign and each individual has values that align with the President and Vice President-elect .
”

President-elect Joe Biden’s selection of a former Facebook attorney to a senior role in his White House is serving as the latest flashpoint in the debate over how much influence the tech industry should have in Washington.
Biden on Wednesday named Jessica Hertz, until this year a lawyer focused on regulatory affairs in Facebook’s DC office, as his staff secretary, a quietly powerful White House role that determines, for instance, what paperwork the president sees. Hertz is one of the highest-ranking aides serving Biden who recently was in the employ of a Big Tech company.
Her selection stirred anger from both the right, which wants to see the power of Big Tech curtailed, and activists on the far left, who have tried to argue that tech executives should be forbidden from administration positions.
But many — if not most — of the names from Big Tech companies that have been linked to possible appointments are also former aides to Biden at various points in his career, a fact that complicates the narrative that these appointees are first and foremost industry loyalists. It was not uncommon for departing aides from the Obama-Biden administration to take well-paid jobs in the tech industry, which was not as politically toxic as it is today. Taking a tech job then was, in fact, the safer option when compared to corporate gigs on Wall Street.
So a more Biden-friendly construct is that the president-elect is simply hiring people he used to work with and trusts rather than acceding to corporate influence. Cynthia Hogan, for instance, a top adviser to Biden during the campaign, led Apple’s lobbying operation, but she also worked for Biden in two stints dating back to 1991.
The same holds true for Hertz: She served as deputy counsel to Biden when he was vice president and is now returning to the Biden fold. She only worked at Facebook for about two years.
Those two years, however, were more controversial than the tenures of former Biden aides who worked for Big Tech in earlier years. Hertz joined Facebook just after the Cambridge Analytica scandal broke in 2018 — igniting a new round of public scrutiny for the tech giant — and her legal portfolio focused on regulatory affairs, which culminated this month in an antitrust suit by the Federal Trade Commission. Hertz left Facebook in June, according to her LinkedIn page; in the fall, she was announced as the Biden transition team’s general counsel.
Facebook is the tech giant that appears most on the outs with Biden’s team. His aides constantly battled with the company over disinformation and advertising policies during the campaign, and Biden has said he has “never been a fan of Facebook.”
A transition spokesman said in a statement that it was the bosses’ opinions who mattered: “Members of the incoming Biden-Harris administration are committed to implementing the policy ideas presented by the Biden-Harris campaign and each individual has values that align with the President and Vice President-elect.”