greenmedinfo--2020-08-01--12 Top Natural Remedies That Actually Work

When it comes to traditional remedies , do n't mistake `` old '' for obsolete .
In the case of these 12 natural remedies that actually work , they may be old , but they really are tried and true In the modern digital age , information that has stood the test of time is increasingly drowned out by the latest crazes .
Health trends and fad diets hawked by fitness gurus offer you endless ways to get fitter and be better than you were yesterday , but how much of their advice will actually `` stick '' and become @ @ @ @ @ @ @ to learn a dozen best-practices for your health that are `` Grandma approved , '' read on and discover 12 natural remedies that were passed down through the ages because they actually work .
A neti pot is a traditional remedy used to cleanse the sinus passages of mucus , dust and irritants , in much the same way that we bathe our bodies .
Popular in the Far East , the tradition of the neti pot has not been widely adopted in the U.S .
However , natural health enthusiasts have kept @ @ @ @ @ @ @ allergies and most drug stores and pharmacies have them in stock .
A warm saline solution is prepared in the neti pot using distilled water .
The spout is placed against each nostril , and with your head slightly tilted , the water is poured into each nostril while breathing through your mouth .
The water flows out the opposite nostril , carrying debris and pollen that lodge in your sinus cavities and cause irritation .
The warm water soothes and relaxes the delicate sinus tissues and breathing can return to normal .
@ @ @ @ @ @ @ used regularly to adjust to the routine and keep pollens at bay during allergy season .
Some important neti pot tips : • Use saline packets or make your own using 16 ounces of distilled water to 1 teaspoon mineral ( not iodized ) salt Tea is one of the oldest healing potions in the modern world .
With more than 124 beneficial pharmacological actions in our GreenMedInfo.com database , there are hundreds of reasons to drink tea .
And here 's one more : it can help you get over a cold @ @ @ @ @ @ @ known to possess antiviral components and has demonstrated in trials to be inversely associated with influenza infection .
[ i ] These benefits are not limited to green tea .
The herbal tea Echinacea Plus was found in a clinical trial to shorten cold and flu symptoms compared to placebo .
[ ii ] Why not add some honey to your cup ?
During cold and flu season , honey is a great way to enhance your tea 's taste and healing properties .
Honey not only increases flavor , it can boost @ @ @ @ @ @ @ have some , add a squeeze of lemon juice for extra vitamin C and anti-inflammatory effects .
One of the most therapeutic substances on Earth is a flowering plant known as curcuma longa .
You may not recognize the plant 's name , but its use is unmistakable -- a bright orange culinary spice that is a key ingredient in many popular Asian dishes .
Turmeric , the exotic spice produced by grinding the curcuma longa plant 's roots into a fine powder , has been studied in thousands of scientific trials , @ @ @ @ @ @ @ for the herb 's near-limitless healing properties .
For millennia , scientists and herbalists have been exploring the therapeutic properties in this magical herb .
Widely used by athletes and active adults , turmeric and its isolated active ingredient , curcumin , have been shown to reduce joint pain and inflammation in ways that outperform many modern drugs .
In fact , a 2012 study showed that curcumin outperformed diclofenac , a standard arthritis treatment , and ibuprofen on arthritis pain and quality-of-life indicators with no negative side effects .
[ iv ] @ @ @ @ @ @ @ key to effectiveness .
That 's not hard to do with turmeric .
You can add it to your diet in delicious curries and exotic dishes or take it in supplement form .
Golden milk tea , also called the turmeric latte , is another delicious way to benefit from the anti-inflammatory properties -- and delicious taste -- of this priceless plant .
Spa bathing has been used to soothe the body and spirit for thousands of years .
Ancient Romans used intricate plumbing systems to pipe and heat the healing mineral waters @ @ @ @ @ @ @ so they could physically rejuvenate and relax from the stressors of life .
Whether it 's occasional body pain from strain or overwork , or a chronic condition such as back pain or fibromyalgia , soaking , steaming and showering can be the remedy to set you on your feet again .
The best part ?
You do n't need to travel to a health spa to enjoy the benefits of hydrotherapy .
Turn your bathroom into a healing oasis with three simple things : hot water , cold water and magnesium chloride @ @ @ @ @ @ @ The next time you 're feeling strained , draw a warm bath and add at least 2 cups of Epsom salts .
Thermal mineral water contains important minerals , including calcium , magnesium , sodium and potassium , and a 20-minute soak soothes inflammatory pathways that are linked to pain response .
A 2019 study found that daily mineral soaks provided clear therapeutic benefit for several musculoskeletal diseases .
[ v ] For an extra therapeutic boost , try finishing off your hot bath with a cold shower .
It may seem like @ @ @ @ @ @ @ just two minutes under a cold stream of water increases blood flow and lymphatic circulation and boosts your immunity , among other health benefits .
Some minor injuries , such as a pulled muscle or a mild impact that causes swelling , can be effectively treated at home by applying an ice pack to the affected area .
But how do you know if your injury should be treated by soaking in a hot bath or applying a cold pack ?
Cold and heat are the most commonly applied at-home pain remedies .
@ @ @ @ @ @ @ mineral bath , are for relaxing stiff , aching muscles and increasing blood flow to the area .
Ice is generally used for recent acute injuries where swelling is present .
Ice packs can help reduce swelling and pain from twisted ankles and strained elbows and slow any bleeding into the tissues that causes bruising .
[ vi ] The key to this remedy 's effectiveness lies in elevating and resting the swollen area and applying the ice pack right away .
Do not place ice directly on the skin ; use a @ @ @ @ @ @ @ You can use a bag of frozen vegetables or place ice into a tea towel , just watch the area for signs of ice burn ( when the skin turns pink ) and do not ice for more than 30 minutes at a time .
You may already know about the therapeutic properties of black seed , aka nigella sativa .
A traditional remedy that is said to cure `` everything but death , '' black seed is taken as a dietary supplement by natural health advocates the world-over .
One of the @ @ @ @ @ @ @ for is gastritis , or inflammation of the stomach lining , a problem that affects everyone on occasion .
The use of oral medications , consuming too much alcohol or rich food , or simply experiencing a stress-filled day wherein proper nutrition is neglected can all ignite a bout of gastritis or upset stomach , symptoms of which include stomach pain , cramps , nausea and sometimes vomiting .
Another common trigger for gastritis is Helicobacter pylori , also known as H. pylori , a bacterium found in half the world 's population @ @ @ @ @ @ @ stomach ulcers if left untreated .
[ vii ] To combat gastritis and calm inflamed stomach tissues , research has shown that a spoonful of ground black seed and honey paste , taken three times a day after meals , can significantly reduce symptoms and even eradicate the presence of H. pylori bacteria .
[ viii ] Making black seed a regular addition to your diet can have added benefits , as well .
Multiple studies have shown the lipid-lowering effects of black seed on hypercholesterolemia , for example .
While it 's @ @ @ @ @ @ @ body , the need for trusted social bonds is equally necessary for a vital , healthy life .
Intimate relationships , be they physical , emotional , or both , are proven to be critical to your happiness and overall quality of life .
In a longitudinal study of young adults over 40 years that measured their happiness during college and again 35 years later , the happiest participants were the ones who said they valued and enjoyed their close relationships .
[ ix ] It was n't critical to keep the same @ @ @ @ @ @ @ a high value on developing close bonds were the happiest across time .
In terms of intimacy versus isolation , intimacy is the remedy when isolation creates disease of the spirit .
If you are partnered , make the effort to strengthen and sustain closeness by cuddling , eye-gazing and sharing and listening with empathy .
If you 're single , consider the many health benefits of dancing with a partner .
Age is not a barrier to entry , nor to receiving the positive effects .
A 2009 study of patients in @ @ @ @ @ @ @ of patients who danced with staff members experienced a significant reduction in agitation , uplifted mood , increased social bonding and improvement in overall quality of life .
[ x ] Added bonus -- it 's a great way to stay fit .
Another old remedy that really works was reportedly used by Hippocrates , the father of modern medicine , as far back as 400 B.C .
Apple cider vinegar , or ACV , has health benefits that have been known for millennia , thanks to powerful antifungal and antimicrobial properties .
@ @ @ @ @ @ @ apple cider vinegar makes a wonderful remedy for halitosis .
For an instant bad breath remedy , add 1/2 tablespoon of ACV to a cup of purified water and gargle the mixture in your mouth for 10 seconds at a time until the cup is empty .
Be sure to swish in the back of your cheeks and into your upper and lower gumline to eradicate any odor-causing bacteria .
ACV can help combat unpleasant body odors by adjusting your skin 's pH level , which eliminates odor-causing bacteria .
For armpit odor @ @ @ @ @ @ @ with undiluted apple cider vinegar on a cloth or cotton ball before applying a natural deodorant .
Be sure to avoid antiperspirants containing aluminum and other cancer-causing chemicals .
For foot odor , fill a pan with warm water and add 1/3 cup of ACV , then let your feet soak in this mixture for 15 minutes once per week .
Pomegranate may be without equal when it comes to healthy foods .
Eating the fruiting ovary of the pomegranate bush is so beneficial , it just might save your life .
And @ @ @ @ @ @ @ of pomegranate juice may also save your to-do list .
For a quick pick-me-up , 4 to 6 ounces of pomegranate juice is a great way to ward off fatigue by supplying vital nutrients , a mega-dose of antioxidants and helping maintain stable blood sugar levels .
Pomegranate juice has demonstrated in multiple trials to contribute to blood sugar homeostasis , [ xi ] making it useful in managing energy throughout the day .
Pomegranate juice can help regulate blood pressure , [ xii ] another factor that can contribute to fatigue .
@ @ @ @ @ @ @ in your mouth after eating the fruit or drinking its juice , and it may be key to pomegranate 's energizing superpowers .
When blood flow is impeded to the heart , energy levels dip , such as in cases of atherosclerosis , when arterial plaque builds up in the arteries .
In a three-year trial of patients with atherosclerosis who supplemented their diet with pomegranate juice , artery-clogging plaque was reduced by up to 30 % , effectively reversing the disease process by up to 39 % within one year .
[ @ @ @ @ @ @ @ % increase in patients ' antioxidant status .
[ xiv ] So , raise a glass of pomegranate juice and drink to your health and high energy .
Arnica montana is a perennial flower in the same family as sunflowers , dandelions and marigolds .
Sometimes called the `` mountain daisy , '' arnica is a natural ibuprofen alternative that can be useful to quell minor pain and bruising associated with superficial injuries .
Due to the highly addictive nature of opioids and arnica 's usefulness for both pain and bruising , arnica @ @ @ @ @ @ @ surgeries such as face lifts .
A study comparing the effects of topically applied compounds on bruise healing found that 20 % arnica reduced bruising more than .003 % white petrolatum , 1 % vitamin K and 3 % retinol creams .
[ xv ] Arnica is generally applied as an ointment or gel and can be purchased in homeopathic formulas and as a flower remedy .
Known for its invigorating fragrance , eucalyptus is revered for its ability to soothe irritated sinuses and make breathing easier when you have a stuffed-up nose @ @ @ @ @ @ @ contribute to this airway-clearing effect .
You can enjoy the therapeutic properties of eucalyptus by adding a few drops of essential oil to a humidifier , especially if you place it by your bed at night .
If your stuffy nose is acute , try adding fresh eucalyptus leaves or 10 to 12 drops of essential oil to a bowl of steaming water , then placing a towel over your head while you breathe in deeply .
This practice can also have a beneficial effect on your lungs , as evidenced by a @ @ @ @ @ @ @ that experienced lung repair after inhaling eucalyptus vapors 15 minutes a day for 60 days .
[ xvi ] Dark circles under your eyes can be the result of many causes , including genetics , dietary deficiencies , stress , sleep deprivation and smoking , among other factors .
No single remedy will work for everyone ; however , you can take a multi-pronged approach to reduce dark circles and restore a fresh-faced appearance .
Make sure you are well hydrated by consuming around 2 liters of purified water each day .
Next @ @ @ @ @ @ @ diverse diet of whole , organic foods .
Sleep is crucial to reducing dark circles , so do your best to get a full seven to nine hours of sleep each night , preferably in a cool room with fresh , circulating air .
If you 're currently using cigarettes , consider a smoking cessation program .
Radiation exposure from cigarettes is 36 times worse for your health than working at a nuclear reactor , [ xvii ] so you can bet it contributes to dark under-eye circles .
Finally , sunlight deficiency @ @ @ @ @ @ @ [ xviii ] so be sure to get at least 15 minutes of unfiltered sunlight through your irises daily to boost important vitamin D levels .
While some stress is unavoidable , do n't let life 's pressures deter you from adhering to these basic healthy habits .
By prioritizing self-care , you will remain stronger , healthier and more capable of managing life 's stressors in a balanced way .
[ i ] Mijong Park , Hiroshi Yamada , Kumi Matsushita , Shinya Kaji , Takahiro Goto , Yuko Okada , Kazuhiro @ @ @ @ @ @ @ Consumption Is Inversely Associated with the Incidence of Influenza Infection among Schoolchildren in a Tea Plantation Area of Japan .
J Nutr .
2011 Oct ; 141 ( 10 ) :1862-70 .
Epub 2011 Aug 10 .
PMID : 21832025 [ ii ] G F Lindenmuth , E B Lindenmuth .
The efficacy of echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms : a randomized , double-blind placebo-controlled study .
J Altern Complement Med .
2000 Aug ; 6 ( 4 ) :327-34 .
PMID @ @ @ @ @ @ @ , Ratika Rahmasari , Ayaka Matsunaga , Takahiro Haruyama , Nobuyuki Kobayashi .
Anti-influenza Viral Effects of Honey In Vitro : Potent High Activity of Manuka Honey .
Arch Med Res .
2014 May 28 .
Epub 2014 May 28 .
PMID : 24880005 [ iv ] Chandran B , Goel A .
A randomized , pilot study to assess the efficacy and safety of curcumin in patients with active rheumatoid arthritis .
Phytother Res .
2012 Mar 9 .
[ v ] Angioni , M. M. , Denotti , A. , Pinna @ @ @ @ @ @ @ Montisci , F. , Dessole , G. , … Cauli , A .
( 2019 ) .
Spa therapy induces clinical improvement and protein changes in patients with chronic back pain .
Reumatismo , 71 ( 3 ) , 119-131. doi:10.4081/reumatismo.2019.1200 [ vi ] Southern California Orthopedic Institute , Patient Education , Health Articles , Should You Ice or Heat an injury ?
https : //www.scoi.com/patient-resources/education/articles/should-you-ice-or-heat-injury [ vii ] UptoDate , Patient education : Helicobacter pylori infection and treatment ( Beyond the Basics ) , https : //www.uptodate.com/contents/helicobacter-pylori-infection-and-treatment-beyond-the-basics [ viii ] Hashem-Dabaghian F @ @ @ @ @ @ @ Ghobadi A .
Combination of Nigella sativa and Honey in Eradication of Gastric Helicobacter pylori Infection .
Iran Red Crescent Med J .
2016 ; 18 ( 11 ) : e23771 .
Published 2016 Jun 21. doi:10.5812/ircmj.23771 [ ix ] Sneed , J. R. , Whitbourne , S. , Schwartz , S. J. , & Huang , S. ( 2012 ) .
The relationship between identity , intimacy , and midlife well-being : Findings from the Rochester Adult Longitudinal Study .
Psychology and Aging , 27 , 318-323. doi:10.1037/a0026378 [ xi ] Hye @ @ @ @ @ @ @ Cho .
Inhibitory effect of pomegranate on intestinal sodium dependent glucose uptake .
Am J Chin Med .
2011 ; 39 ( 5 ) :1015-27 .
PMID : 21905289 [ xii ] Golbon Sohrab , Hanieh Roshan , Samira Ebrahimof , Omid Nikpayam , Giti Sotoudeh , Fereidoun Siasi .
Effects of pomegranate juice consumption on blood pressure and lipid profile in patients with type 2 diabetes : A single-blind randomized clinical trial .
Clin Nutr ESPEN .
2019 Feb ; 29:30-35 .
Epub 2018 Dec 20 .
PMID : 30661697 [ xiii @ @ @ @ @ @ @ Diana Gaitini , Samy Nitecki , Aaron Hoffman , Leslie Dornfeld , Nina Volkova , Dita Presser , Judith Attias , Harley Liker , Tony Hayek .
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness , blood pressure and LDL oxidation .
Clin Nutr .
2004 Jun ; 23 ( 3 ) :423-33 .
PMID : 15158307 [ xiv ] Michael Aviram , Mira Rosenblat , Diana Gaitini , Samy Nitecki , Aaron Hoffman , Leslie Dornfeld , Nina Volkova , Dita Presser , @ @ @ @ @ @ @ Hayek .
Pomegranate juice consumption for 3 years by patients with carotid artery stenosis reduces common carotid intima-media thickness , blood pressure and LDL oxidation .
Clin Nutr .
2004 Jun ; 23 ( 3 ) :423-33 .
PMID : 15158307 [ xvii ] Hvistendahl M. Coal Ash Is More Radioactive than Nuclear Waste .
Scientific American .
2007. https : //www.scientificamerican.com/article.cfm ?
id=coal-ash-is-more-radioactive-than-nuclear-waste [ xviii ] Lindqvist PG , Epstein E , Nielsen K , Landin-Olsson M , Ingvar C , Olsson H. Avoidance of sun exposure as a risk factor for @ @ @ @ @ @ @ risk analysis of the Melanoma in Southern Sweden cohort .
J Intern Med .
2016 ; 280 ( 4 ) :375‐387 .
doi:10.1111/joim.12496

Visit our Re-post guidelines This article is copyrighted by GreenMedInfo LLC, 2023
When it comes to traditional remedies, don't mistake "old" for obsolete. In the case of these 12 natural remedies, they may be old, but they really are tried and true
In the modern digital age, information that has stood the test of time is increasingly drowned out by the latest crazes. Health trends and fad diets hawked by fitness gurus offer you endless ways to get fitter and be better than you were yesterday, but how much of their advice will actually "stick" and become multi-generational wisdom?
If you'd like to learn a dozen best-practices for your health that are "Grandma approved," read on and discover 12 natural remedies that were passed down through the ages because they actually work.
1. Neti Pot for Allergies
A neti pot is a traditional remedy used to cleanse the sinus passages of mucus, dust and irritants, in much the same way that we bathe our bodies. Popular in the Far East, the tradition of the neti pot has not been widely adopted in the U.S. However, natural health enthusiasts have kept the tradition alive to aid with seasonal allergies and most drug stores and pharmacies have them in stock.
A warm saline solution is prepared in the neti pot using distilled water. The spout is placed against each nostril, and with your head slightly tilted, the water is poured into each nostril while breathing through your mouth.
The water flows out the opposite nostril, carrying debris and pollen that lodge in your sinus cavities and cause irritation. The warm water soothes and relaxes the delicate sinus tissues and breathing can return to normal. Like bathing, neti pots must be used regularly to adjust to the routine and keep pollens at bay during allergy season. Some important neti pot tips:
Use distilled water only
Warm the water to 98.6 degrees F
Use saline packets or make your own using 16 ounces of distilled water to 1 teaspoon mineral (not iodized) salt
2. Hot Tea for Cold and Flu
Tea is one of the oldest healing potions in the modern world. With more than 124 beneficial pharmacological actions in our GreenMedInfo.com database, there are hundreds of reasons to drink tea. And here's one more: it can help you get over a cold or flu faster.
Green tea is known to possess antiviral components and has demonstrated in trials to be inversely associated with influenza infection.[i] These benefits are not limited to green tea. The herbal tea Echinacea Plus was found in a clinical trial to shorten cold and flu symptoms compared to placebo.[ii]
Why not add some honey to your cup? During cold and flu season, honey is a great way to enhance your tea's taste and healing properties. Honey not only increases flavor, it can boost your immunity to influenza . [iii] And if you have some, add a squeeze of lemon juice for extra vitamin C and anti-inflammatory effects.
3. Turmeric for Joint Pain
One of the most therapeutic substances on Earth is a flowering plant known as curcuma longa. You may not recognize the plant's name, but its use is unmistakable -- a bright orange culinary spice that is a key ingredient in many popular Asian dishes. Turmeric, the exotic spice produced by grinding the curcuma longa plant's roots into a fine powder, has been studied in thousands of scientific trials, not for the enticing flavor, but for the herb's near-limitless healing properties.
For millennia, scientists and herbalists have been exploring the therapeutic properties in this magical herb. Widely used by athletes and active adults, turmeric and its isolated active ingredient, curcumin, have been shown to reduce joint pain and inflammation in ways that outperform many modern drugs.
In fact, a 2012 study showed that curcumin outperformed diclofenac, a standard arthritis treatment, and ibuprofen on arthritis pain and quality-of-life indicators with no negative side effects.[iv]
Like most herbs, consistent supplementation is key to effectiveness. That's not hard to do with turmeric. You can add it to your diet in delicious curries and exotic dishes or take it in supplement form. Golden milk tea, also called the turmeric latte, is another delicious way to benefit from the anti-inflammatory properties -- and delicious taste -- of this priceless plant.
4. Hydrotherapy for Muscle Strain
Spa bathing has been used to soothe the body and spirit for thousands of years. Ancient Romans used intricate plumbing systems to pipe and heat the healing mineral waters of places like Bath, England, so they could physically rejuvenate and relax from the stressors of life.
Whether it's occasional body pain from strain or overwork, or a chronic condition such as back pain or fibromyalgia, soaking, steaming and showering can be the remedy to set you on your feet again. The best part? You don't need to travel to a health spa to enjoy the benefits of hydrotherapy. Turn your bathroom into a healing oasis with three simple things: hot water, cold water and magnesium chloride.
The next time you're feeling strained, draw a warm bath and add at least 2 cups of Epsom salts. Thermal mineral water contains important minerals, including calcium, magnesium, sodium and potassium, and a 20-minute soak soothes inflammatory pathways that are linked to pain response. A 2019 study found that daily mineral soaks provided clear therapeutic benefit for several musculoskeletal diseases.[v]
For an extra therapeutic boost, try finishing off your hot bath with a cold shower. It may seem like an abrupt way to finish, but just two minutes under a cold stream of water increases blood flow and lymphatic circulation and boosts your immunity, among other health benefits.
5. Ice Packs for Swelling
Some minor injuries, such as a pulled muscle or a mild impact that causes swelling, can be effectively treated at home by applying an ice pack to the affected area. But how do you know if your injury should be treated by soaking in a hot bath or applying a cold pack?
Cold and heat are the most commonly applied at-home pain remedies. Heat therapies, such as a thermal mineral bath, are for relaxing stiff, aching muscles and increasing blood flow to the area. Ice is generally used for recent acute injuries where swelling is present. Ice packs can help reduce swelling and pain from twisted ankles and strained elbows and slow any bleeding into the tissues that causes bruising.[vi]
The key to this remedy's effectiveness lies in elevating and resting the swollen area and applying the ice pack right away. Do not place ice directly on the skin; use a towel or cloth as a barrier. You can use a bag of frozen vegetables or place ice into a tea towel, just watch the area for signs of ice burn (when the skin turns pink) and do not ice for more than 30 minutes at a time.
6. Black Seed for Stomachache
You may already know about the therapeutic properties of black seed, aka nigella sativa. A traditional remedy that is said to cure "everything but death," black seed is taken as a dietary supplement by natural health advocates the world-over. One of the ailments that black seed has proven useful for is gastritis, or inflammation of the stomach lining, a problem that affects everyone on occasion.
The use of oral medications, consuming too much alcohol or rich food, or simply experiencing a stress-filled day wherein proper nutrition is neglected can all ignite a bout of gastritis or upset stomach, symptoms of which include stomach pain, cramps, nausea and sometimes vomiting. Another common trigger for gastritis is Helicobacter pylori, also known as H. pylori, a bacterium found in half the world's population that can lead to the development of stomach ulcers if left untreated.[vii]
To combat gastritis and calm inflamed stomach tissues, research has shown that a spoonful of ground black seed and honey paste, taken three times a day after meals, can significantly reduce symptoms and even eradicate the presence of H. pylori bacteria.[viii]
Making black seed a regular addition to your diet can have added benefits, as well. Multiple studies have shown the lipid-lowering effects of black seed on hypercholesterolemia, for example.
7. Intimacy for Depression
While it's important to take care of the physical body, the need for trusted social bonds is equally necessary for a vital, healthy life. Intimate relationships, be they physical, emotional, or both, are proven to be critical to your happiness and overall quality of life.
In a longitudinal study of young adults over 40 years that measured their happiness during college and again 35 years later, the happiest participants were the ones who said they valued and enjoyed their close relationships.[ix] It wasn't critical to keep the same partners to benefit; those who placed a high value on developing close bonds were the happiest across time.
In terms of intimacy versus isolation, intimacy is the remedy when isolation creates disease of the spirit. If you are partnered, make the effort to strengthen and sustain closeness by cuddling, eye-gazing and sharing and listening with empathy.
If you're single, consider the many health benefits of dancing with a partner. Age is not a barrier to entry, nor to receiving the positive effects. A 2009 study of patients in a dementia care unit showed 67% of patients who danced with staff members experienced a significant reduction in agitation, uplifted mood, increased social bonding and improvement in overall quality of life.[x] Added bonus -- it's a great way to stay fit.
8. Apple Cider Vinegar for Odor
Another old remedy that really works was reportedly used by Hippocrates, the father of modern medicine, as far back as 400 B.C. Apple cider vinegar, or ACV, has health benefits that have been known for millennia, thanks to powerful antifungal and antimicrobial properties.
Thanks to its high acid profile, apple cider vinegar makes a wonderful remedy for halitosis. For an instant bad breath remedy, add 1/2 tablespoon of ACV to a cup of purified water and gargle the mixture in your mouth for 10 seconds at a time until the cup is empty. Be sure to swish in the back of your cheeks and into your upper and lower gumline to eradicate any odor-causing bacteria.
ACV can help combat unpleasant body odors by adjusting your skin's pH level, which eliminates odor-causing bacteria. For armpit odor, wipe your underarm area each morning with undiluted apple cider vinegar on a cloth or cotton ball before applying a natural deodorant. Be sure to avoid antiperspirants containing aluminum and other cancer-causing chemicals. For foot odor, fill a pan with warm water and add 1/3 cup of ACV, then let your feet soak in this mixture for 15 minutes once per week.
9. Pomegranate Juice for Fatigue
Pomegranate may be without equal when it comes to healthy foods. Eating the fruiting ovary of the pomegranate bush is so beneficial, it just might save your life. And on those low-energy days, a shot of pomegranate juice may also save your to-do list.
For a quick pick-me-up, 4 to 6 ounces of pomegranate juice is a great way to ward off fatigue by supplying vital nutrients, a mega-dose of antioxidants and helping maintain stable blood sugar levels. Pomegranate juice has demonstrated in multiple trials to contribute to blood sugar homeostasis,[xi] making it useful in managing energy throughout the day.
Pomegranate juice can help regulate blood pressure,[xii] another factor that can contribute to fatigue. Pomegranate's remarkable astringency can be felt in your mouth after eating the fruit or drinking its juice, and it may be key to pomegranate's energizing superpowers.
When blood flow is impeded to the heart, energy levels dip, such as in cases of atherosclerosis, when arterial plaque builds up in the arteries. In a three-year trial of patients with atherosclerosis who supplemented their diet with pomegranate juice, artery-clogging plaque was reduced by up to 30%, effectively reversing the disease process by up to 39% within one year.[xiii]
Additional benefits included a 130% increase in patients' antioxidant status.[xiv] So, raise a glass of pomegranate juice and drink to your health and high energy.
10. Arnica for Bruising
Arnica montana is a perennial flower in the same family as sunflowers, dandelions and marigolds. Sometimes called the "mountain daisy," arnica is a natural ibuprofen alternative that can be useful to quell minor pain and bruising associated with superficial injuries.
Due to the highly addictive nature of opioids and arnica's usefulness for both pain and bruising, arnica has become a popular remedy after cosmetic surgeries such as face lifts. A study comparing the effects of topically applied compounds on bruise healing found that 20% arnica reduced bruising more than .003% white petrolatum, 1% vitamin K and 3% retinol creams.[xv]
Arnica is generally applied as an ointment or gel and can be purchased in homeopathic formulas and as a flower remedy.
11. Eucalyptus for Stuffy Nose
Known for its invigorating fragrance, eucalyptus is revered for its ability to soothe irritated sinuses and make breathing easier when you have a stuffed-up nose. Eucalyptus has anti-inflammatory properties that may contribute to this airway-clearing effect.
You can enjoy the therapeutic properties of eucalyptus by adding a few drops of essential oil to a humidifier, especially if you place it by your bed at night. If your stuffy nose is acute, try adding fresh eucalyptus leaves or 10 to 12 drops of essential oil to a bowl of steaming water, then placing a towel over your head while you breathe in deeply.
This practice can also have a beneficial effect on your lungs, as evidenced by a 2018 study on mice with induced emphysema that experienced lung repair after inhaling eucalyptus vapors 15 minutes a day for 60 days.[xvi]
12. Healthy Habits for Under-Eye Circles
Dark circles under your eyes can be the result of many causes, including genetics, dietary deficiencies, stress, sleep deprivation and smoking, among other factors. No single remedy will work for everyone; however, you can take a multi-pronged approach to reduce dark circles and restore a fresh-faced appearance.
Make sure you are well hydrated by consuming around 2 liters of purified water each day. Next, eliminate nutrient deficiencies by eating a diverse diet of whole, organic foods. Sleep is crucial to reducing dark circles, so do your best to get a full seven to nine hours of sleep each night, preferably in a cool room with fresh, circulating air.
If you're currently using cigarettes, consider a smoking cessation program. Radiation exposure from cigarettes is 36 times worse for your health than working at a nuclear reactor,[xvii] so you can bet it contributes to dark under-eye circles.
Finally, sunlight deficiency may be as deadly as smoking,[xviii] so be sure to get at least 15 minutes of unfiltered sunlight through your irises daily to boost important vitamin D levels.
While some stress is unavoidable, don't let life's pressures deter you from adhering to these basic healthy habits. By prioritizing self-care, you will remain stronger, healthier and more capable of managing life's stressors in a balanced way.
References
[i] Mijong Park, Hiroshi Yamada, Kumi Matsushita, Shinya Kaji, Takahiro Goto, Yuko Okada, Kazuhiro Kosuge, Toshiro Kitagawa. Green Tea Consumption Is Inversely Associated with the Incidence of Influenza Infection among Schoolchildren in a Tea Plantation Area of Japan. J Nutr. 2011 Oct ;141(10):1862-70. Epub 2011 Aug 10. PMID: 21832025
[ii] G F Lindenmuth, E B Lindenmuth. The efficacy of echinacea compound herbal tea preparation on the severity and duration of upper respiratory and flu symptoms: a randomized, double-blind placebo-controlled study. J Altern Complement Med. 2000 Aug;6(4):327-34. PMID: 10976979
[iii] Ken Watanabe, Ratika Rahmasari, Ayaka Matsunaga, Takahiro Haruyama, Nobuyuki Kobayashi. Anti-influenza Viral Effects of Honey In Vitro: Potent High Activity of Manuka Honey. Arch Med Res. 2014 May 28. Epub 2014 May 28. PMID: 24880005
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greenmedinfo--2020-08-03--Prenatal curcumin administration rescues neuromorphological and cognitive alterations in Ts65Dn down

Prenatal curcumin administration rescues neuromorphological and cognitive alterations in Ts65Dn down syndrome mice.

BACKGROUND : The cognitive dysfunction in Down syndrome ( DS ) is partially caused by deficient neurogenesis during fetal stages .
Curcumin enhances neurogenesis and learning and memory .
OBJECTIVES : We aimed to test the ability of curcumin to rescue the neuromorphological and cognitive alterations of the Ts65Dn ( TS ) mouse model of DS when administered prenatally or during early postnatal stages , and to evaluate whether these effects were maintained several weeks after the treatment .
METHODS : To evaluate the effects of prenatal curcumin administration , 65 pregnant TS females were subcutaneously treated with curcumin ( @ @ @ @ @ @ @ ( Embryonic Day ) 10 to PD ( Postnatal Day ) 2 .
All the analyses were performed on their TS and Control ( CO ) male and female progeny .
At PD2 , the changes in neurogenesis , cellularity , and brain weight were analyzed in 30 TS and CO pups .
The long-term effects of prenatal curcumin were evaluated in another cohort of 44 TS and CO mice between PD30 and PD45 .
The neuromorphological effects of the early postnatal administration of curcumin were assessed on PD15 in 30 male and @ @ @ @ @ @ @ curcumin ( 300 mg/kg ) or vehicle from PD2 to PD15 .
The long-term neuromorphological and cognitive effects were assessed from PD60 to PD90 in 45 mice .
Data was compared by ANOVAs .
RESULTS : Prenatal administration of curcumin increased the brain weight ( +45 % , P < 0.001 ) , the density of BrdU ( bromodeoxyuridine ) - ( +150 % , P < 0.001 ) and DAPI ( 4',6-diamidino-2-phenylindole ) - ( +38 % , P = 0.005 ) positive cells , and produced a long-term improvement of cognition @ @ @ @ @ @ @ = 0.007 ) mice with respect to vehicle-treated mice .
Postnatal administration of curcumin did not rescue any of the short- or long-term altered phenotypes of TS mice .
CONCLUSION : The beneficial effects of prenatal curcumin administration to TS mice suggest that it could be a therapeutic strategy to treat DS cognitive disabilities .

BACKGROUND: The cognitive dysfunction in Down syndrome (DS) is partially caused by deficient neurogenesis during fetal stages. Curcumin enhances neurogenesis and learning and memory.
OBJECTIVES: We aimed to test the ability of curcumin to rescue the neuromorphological and cognitive alterations of the Ts65Dn (TS) mouse model of DS when administered prenatally or during early postnatal stages, and to evaluate whether these effects were maintained several weeks after the treatment.
METHODS: To evaluate the effects of prenatal curcumin administration, 65 pregnant TS females were subcutaneously treated with curcumin (300 mg/kg) or vehicle from ED (Embryonic Day) 10 to PD (Postnatal Day) 2. All the analyses were performed on their TS and Control (CO) male and female progeny. At PD2, the changes in neurogenesis, cellularity, and brain weight were analyzed in 30 TS and CO pups. The long-term effects of prenatal curcumin were evaluated in another cohort of 44 TS and CO mice between PD30 and PD45. The neuromorphological effects of the early postnatal administration of curcumin were assessed on PD15 in 30 male and female TS and CO pups treated with curcumin (300 mg/kg) or vehicle from PD2 to PD15. The long-term neuromorphological and cognitive effects were assessed from PD60 to PD90 in 45 mice. Data was compared by ANOVAs.
RESULTS: Prenatal administration of curcumin increased the brain weight (+45%, P <0.001), the density of BrdU (bromodeoxyuridine)- (+150%, P <0.001) and DAPI (4',6-diamidino-2-phenylindole)- (+38%, P = 0.005) positive cells, and produced a long-term improvement of cognition in TS (+35%, P = 0.007) mice with respect to vehicle-treated mice. Postnatal administration of curcumin did not rescue any of the short- or long-term altered phenotypes of TS mice.
CONCLUSION: The beneficial effects of prenatal curcumin administration to TS mice suggest that it could be a therapeutic strategy to treat DS cognitive disabilities.


greenmedinfo--2020-08-03--These findings support a long-term beneficial role of carotenoid consumption on cognitive function i

These findings support a long-term beneficial role of carotenoid consumption on cognitive function in women.

BACKGROUND : A protective association of dietary carotenoids with cognitive function has been suggested , but most studies have been relatively small with limited periods of follow-up .
OBJECTIVES : We examined prospectively long-term intakes of carotenoids in relation to subjective cognitive function ( SCF ) , a self-reported , validated indicator of cognitive dysfunction .
METHODS : Among 49,493 female registered nurses with a mean age of 48 y in 1984 , we used multinomial logistic regression to estimate the ORs and 95 % CIs relating intakes of carotenoids to self-reported SCF in 2012 and 2014 .
Mean intakes @ @ @ @ @ @ @ FFQs collected in 1984 , 1986 , and every 4 y afterwards until 2006 .
Self-reported SCF was assessed by a 7-item questionnaire on changes in memory and cognition ; validity was supported by strong associations with Apolipoprotein E ( APOE ) ε4 genotype and concurrent cognitive function and cognitive decline measured by telephone-based neuropsychological tests .
The mean values of scores assessed in 2012 and 2014 were categorized as '' good '' ( 0 points , 40.8 % ) , '' moderate '' ( 0.5-2.5 points , 46.9 % ) , and @ @ @ @ @ @ @ 12.3 % ) .
RESULTS : Higher intake of total carotenoids was associated with substantially lower odds of moderate or poor cognitive function after controlling for other dietary and nondietary risk factors and total energy intake .
Comparing the top with the bottom quintile of total carotenoids , the multivariable ORs were 0.86 ( 95 % CI : 0.80 , 0.93 ; P-trend CONCLUSIONS : Our findings support a long-term beneficial role of carotenoid consumption on cognitive function in women .

BACKGROUND: A protective association of dietary carotenoids with cognitive function has been suggested, but most studies have been relatively small with limited periods of follow-up.
OBJECTIVES: We examined prospectively long-term intakes of carotenoids in relation to subjective cognitive function (SCF), a self-reported, validated indicator of cognitive dysfunction.
METHODS: Among 49,493 female registered nurses with a mean age of 48 y in 1984, we used multinomial logistic regression to estimate the ORs and 95% CIs relating intakes of carotenoids to self-reported SCF in 2012 and 2014. Mean intakes of carotenoids were calculated from 7 repeated FFQs collected in 1984, 1986, and every 4 y afterwards until 2006. Self-reported SCF was assessed by a 7-item questionnaire on changes in memory and cognition; validity was supported by strong associations with Apolipoprotein E (APOE)ε4 genotype and concurrent cognitive function and cognitive decline measured by telephone-based neuropsychological tests. The mean values of scores assessed in 2012 and 2014 were categorized as"good"(0 points, 40.8%),"moderate"(0.5-2.5 points, 46.9%), and"poor"(3-7 points, 12.3%).
RESULTS: Higher intake of total carotenoids was associated with substantially lower odds of moderate or poor cognitive function after controlling for other dietary and nondietary risk factors and total energy intake. Comparing the top with the bottom quintile of total carotenoids, the multivariable ORs were 0.86 (95% CI: 0.80, 0.93; P-trend < 0.001) for moderate SCF and 0.67 (95% CI: 0.60, 0.75; P-trend < 0.001) for poor SCF. This lower OR was also seen for carotenoids consumed 28 y before SCF assessment. Similar associations were found for total β-carotene, dietary β-carotene, α-carotene, lycopene, lutein + zeaxanthin, and β-cryptoxanthin. The significant associations for β-cryptoxanthin, lycopene, and lutein + zeaxanthin persisted after mutual adjustment for each other.
CONCLUSIONS: Our findings support a long-term beneficial role of carotenoid consumption on cognitive function in women.


greenmedinfo--2020-08-03--Beta-cryptoxanthin alleviates myocardial ischaemia/reperfusion injury.

The present study aimed to explore the function and molecular mechanism ofβ-cryptoxanthin on myocardial ischaemia-reperfusion injury ( MIRI ) .
@ @ @ @ @ ligation with reperfusion was utilised to establish a MIRI rat model .
The results indicated @ @ @ @ @ and ameliorates signs of pathological histology in MIRI .
TNF-α , IL-1β , and IL-6 @ @ @ @ @ attenuated in response to β-cryptoxanthin treatment , serum LDH and CK-MB activities were also decreased @ @ @ @ @ blot results suggested that p65 was translocated to the nucleus in the I/R injury rat @ @ @ @ @ the β-cryptoxanthin administration group , p65 expression and activity in the nucleus were decreased in @ @ @ @ @ , p-p38 MAPK levels in response to β-cryptoxanthin were decreased , indicating that MAPK is @ @ @ @ @ regulation .
In conclusion , β-cryptoxanthin alleviates myocardial ischaemia/reperfusion injury by inhibiting NF-κB-mediated inflammatory signalling @ @ @

The present study aimed to explore the function and molecular mechanism ofβ-cryptoxanthin on myocardial ischaemia-reperfusion injury (MIRI). Left anterior descending coronary artery ligation with reperfusion was utilised to establish a MIRI rat model. The results indicated that β-cryptoxanthin decreases infarct size and ameliorates signs of pathological histology in MIRI. TNF-α, IL-1β, and IL-6 levels in the serum were attenuated in response to β-cryptoxanthin treatment, serum LDH and CK-MB activities were also decreased. Immunohistochemical analysis and western blot results suggested that p65 was translocated to the nucleus in the I/R injury rat model. However, in the β-cryptoxanthin administration group, p65 expression and activity in the nucleus were decreased in a dose-dependent manner. Furthermore, p-p38 MAPK levels in response to β-cryptoxanthin were decreased, indicating that MAPK is involved in NF-κB signalling pathway regulation. In conclusion, β-cryptoxanthin alleviates myocardial ischaemia/reperfusion injury by inhibiting NF-κB-mediated inflammatory signalling in rats.


greenmedinfo--2020-08-03--These results show that carotenoids have a variety of anti-inflammatory and antiatherosclerosis acti

These results show that carotenoids have a variety of anti-inflammatory and antiatherosclerosis activities.

Objective : This research is aimed at determining the vascular health characteristics of carotenoids by evaluating their effect on excessive inflammatory response in endothelial and monocyte cells , the main factors of atherosclerosis .
Methods : Human umbilical vein endothelial cells ( HUVECs ) or U937 monocytes were treated with escalating concentrations ( 0.1 , 0.5 , and 1 M ) of five most common carotenoids in human plasma , i.e.
, -carotene , -carotene , -cryptoxanthin , lutein , and lycopene prior to stimulation with 2 mM fructose .
We examined the monocyte adhesion to endothelial cells ( ECs @ @ @ @ @ @ @ Chemokine and proinflammatory cytokine production as well as intracellular oxidative stress were also assessed in fructose-stimulated ECs and monocytes .
Results : Carotenoids repressed monocyte adhesion to fructose-stimulated ECs dose dependently via decreasing primarily the expression of endothelial VCAM-1 .
In ECs and monocytes , three carotenoids , i.e.
, -cryptoxanthin , lutein , and lycopene , suppressed the fructose-induced expression of chemokines MCP-1 , M-CSF , and CXCL-10 and inflammatory cytokines TNF-and IL-1 , with CXCL-10 being the most repressed inflammatory mediator.-Cryptoxanthin , lutein , and lycopene dramatically downregulated the fructose-induced CXCL-10 @ @ @ @ @ @ @ in the inflammatory response was associated with a slight but significant decrease of intracellular oxidative stress .
Conclusions : Our results show that carotenoids have a variety of anti-inflammatory and antiatherosclerosis activities , which can help prevent or reduce fructose-induced inflammatory vascular diseases .

Objective: This research is aimed at determining the vascular health characteristics of carotenoids by evaluating their effect on excessive inflammatory response in endothelial and monocyte cells, the main factors of atherosclerosis.
Methods: Human umbilical vein endothelial cells (HUVECs) or U937 monocytes were treated with escalating concentrations (0.1, 0.5, and 1 M) of five most common carotenoids in human plasma, i.e.,-carotene,-carotene,-cryptoxanthin, lutein, and lycopene prior to stimulation with 2 mM fructose. We examined the monocyte adhesion to endothelial cells (ECs) and relevant endothelial adhesion molecules. Chemokine and proinflammatory cytokine production as well as intracellular oxidative stress were also assessed in fructose-stimulated ECs and monocytes.
Results: Carotenoids repressed monocyte adhesion to fructose-stimulated ECs dose dependently via decreasing primarily the expression of endothelial VCAM-1. In ECs and monocytes, three carotenoids, i.e.,-cryptoxanthin, lutein, and lycopene, suppressed the fructose-induced expression of chemokines MCP-1, M-CSF, and CXCL-10 and inflammatory cytokines TNF-and IL-1, with CXCL-10 being the most repressed inflammatory mediator.-Cryptoxanthin, lutein, and lycopene dramatically downregulated the fructose-induced CXCL-10 expression in vascular cells. The reduction in the inflammatory response was associated with a slight but significant decrease of intracellular oxidative stress.
Conclusions: Our results show that carotenoids have a variety of anti-inflammatory and antiatherosclerosis activities, which can help prevent or reduce fructose-induced inflammatory vascular diseases.


greenmedinfo--2020-08-03--Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor d

Higher maternal plasma β-cryptoxanthin concentration is associated with better cognitive and motor development in offspring at 2 years of age.

PURPOSE : Current literature on the roles ofα- , β-carotene and β-cryptoxanthin in neurocognitive function has largely focused on preventing cognitive decline in older people , and less on neuro-development in children .
We examined the relations of maternal plasma carotenoids concentrations with offspring cognitive development up to age 4.5 years in the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort study .
METHODS : Maternal plasmaα- , β-carotene and β-cryptoxanthin concentrations at delivery were determined by ultra-performance liquid chromatography .
Children 's cognition was assessed at ages 2 ( Bayley Scales of Infant and Toddler Development ) and @ @ @ @ @ @ @ years .
Associations were examined in 419 mother-offspring pairs using linear regressions adjusting for key confounders .
RESULTS : Median and interquartile range of maternal plasma concentrations ( mg/L ) were : α-carotene 0.052 ( 0.032 , 0.081 ) , β-carotene 0.189 ( 0.134 , 0.286 ) , and β-cryptoxanthin 0.199 ( 0.123 , 0.304 ) .
In 2 years old children , higher maternal carotenoids [ per standard deviation ( SD ) log-concentration ] were positively associated with neurocognitive functions : β-cryptoxanthin with higherscores in cognitive [ β = 0.18 , ( @ @ @ @ @ @ @ receptive language [ β = 0.17 ( 0.07 , 0.27 ) SD ] , fine motor [ β = 0.16 ( 0.05 , 0.26 ) SD ] , and gross motor [ β = 0.16 ( 0.06 , 0.27 ) SD ] scales ; β-carotene with higher cognitive score [ β = 0.17 ( 0.05 , 0.29 ) SD ] .
No significant associations were observed with neurocognitive functions at age 4.5 years .
CONCLUSION : Our study provides novel data suggesting a potential role of prenatal carotenoids , particularlyβ-cryptoxanthin , on early @ @ @ @ @ @ @ the prenatal influences sustain beyond early childhood requires further investigation in longer term studies .

PURPOSE: Current literature on the roles ofα-, β-carotene and β-cryptoxanthin in neurocognitive function has largely focused on preventing cognitive decline in older people, and less on neuro-development in children. We examined the relations of maternal plasma carotenoids concentrations with offspring cognitive development up to age 4.5 years in the Growing Up in Singapore Towards healthy Outcomes mother-offspring cohort study.
METHODS: Maternal plasmaα-, β-carotene and β-cryptoxanthin concentrations at delivery were determined by ultra-performance liquid chromatography. Children's cognition was assessed at ages 2 (Bayley Scales of Infant and Toddler Development) and 4.5 (Kaufman Brief Intelligence Test) years. Associations were examined in 419 mother-offspring pairs using linear regressions adjusting for key confounders.
RESULTS: Median and interquartile range of maternal plasma concentrations (mg/L) were:α-carotene 0.052 (0.032, 0.081), β-carotene 0.189 (0.134, 0.286), and β-cryptoxanthin 0.199 (0.123, 0.304). In 2 years old children, higher maternal carotenoids [per standard deviation (SD) log-concentration] were positively associated with neurocognitive functions: β-cryptoxanthin with higherscores in cognitive [β = 0.18, (0.08, 0.28) SD], receptive language [β = 0.17 (0.07, 0.27) SD], fine motor [β = 0.16 (0.05, 0.26) SD], and gross motor [β = 0.16 (0.06, 0.27) SD] scales; β-carotene with higher cognitive score [β = 0.17 (0.05, 0.29) SD]. No significant associations were observed with neurocognitive functions at age 4.5 years.
CONCLUSION: Our study provides novel data suggesting a potential role of prenatal carotenoids, particularlyβ-cryptoxanthin, on early offspring cognitive and motor development. Whether the prenatal influences sustain beyond early childhood requires further investigation in longer term studies.


greenmedinfo--2020-08-03--Moringa Oleifera: a review of its occurrence, pharmacological importance and oxidative stress.

Oxidative / nitrosative stress can be caused by excessive production of ROS and RNS with metabolic reactions that change balance in favor of oxidants in cases where oxidants increase and antioxidants decrease in organisms using oxygen .
ROS and RNS react with several biological macromolecules in cell , such as carbohydrates , nucleic acids , lipids , and proteins , and alter their functions .
Some natural antioxidants are constantly being researched for their benefits in terms of human health , which can strengthen the body 's antioxidant defense system and have the potential to scavenger free radicals .
It @ @ @ @ @ @ @ prevent and / or treat diseases due to the consumption of more suitable fruits , herbs , spices and vegetables and the presence of bioactive antioxidant compounds .
Moringa oleifera , a new and important one of these plants , has a wide range of bioactive compounds that can be obtained in different herbal structures such as leaves , seeds , stems and shells .
It consists of bioactive molecules such as phenolic compounds , fats , fatty acids , carbohydrates , proteins , functional peptides , vitamins , minerals and essential amino @ @ @ @ @ @ @ glycosides and have great potential for use in various formulations in various health and food products .
This review highlights the formation of MO , its importance in natural medicine , its pharmacological value , and its role as a possible anti-proliferative agent against cancer and its use in some diseases .

Oxidative / nitrosative stress can be caused by excessive production of ROS and RNS with metabolic reactions that change balance in favor of oxidants in cases where oxidants increase and antioxidants decrease in organisms using oxygen. ROS and RNS react with several biological macromolecules in cell, such as carbohydrates, nucleic acids, lipids, and proteins, and alter their functions. Some natural antioxidants are constantly being researched for their benefits in terms of human health, which can strengthen the body's antioxidant defense system and have the potential to scavenger free radicals. It is a well-known and practical strategy to prevent and / or treat diseases due to the consumption of more suitable fruits, herbs, spices and vegetables and the presence of bioactive antioxidant compounds. Moringa oleifera, a new and important one of these plants, has a wide range of bioactive compounds that can be obtained in different herbal structures such as leaves, seeds, stems and shells. It consists of bioactive molecules such as phenolic compounds, fats, fatty acids, carbohydrates, proteins, functional peptides, vitamins, minerals and essential amino acids as well as a number of glycosides and have great potential for use in various formulations in various health and food products. This review highlights the formation of MO, its importance in natural medicine, its pharmacological value, and its role as a possible anti-proliferative agent against cancer and its use in some diseases.


greenmedinfo--2020-08-03--These findings of this study support the potential of Moringa oleifera-supplemented diets in cancer

These findings of this study support the potential of Moringa oleifera-supplemented diets in cancer treatment and care.

Previous studies in a mouse model have indicated the anticancer potential of boiledpod ( bMO ) -supplemented diets ; however , its molecular mechanisms are still unclear .
Therefore , the present study aimed to explore the protein expression profiles responsible for the suppressive effect of bMO supplementation on azoxymethane ( AOM ) /dextran sodium sulfate ( DSS ) -induced mouse colon carcinogenesis .
Analysis by gel electrophoresis and liquid chromatography-tandem mass spectrophotometry demonstrated that there were 125 proteins that were differentially expressed in mouse colon tissues between 14 experimental groups of mice .
The differentially expressed proteins are involved @ @ @ @ @ @ @ signal transduction , metabolism , transcription and translation .
Venn diagram analysis of the differentially expressed proteins was performed in six selected mouse groups , including negative control , positive control mice induced by AOM/DSS , the AOM/DSS groups receiving preventive or therapeutic bMO diets and their bMO-supplemented control groups .
This analysis identified 7 proteins ; 60S acidic ribosomal protein P1 ( Rplp1 ) , fragile X mental retardation , cystatin 9 , round spermatids protein , zinc finger protein 638 , protein phosphatase 2C ( Ppm1g ) and unnamed protein product @ @ @ @ @ @ @ and therapeutic effects of bMO in AOM/DSS-induced mouse colon cancer .
Analysis based on the search tool for interactions of chemicals ( STITCH ) database predicted that Rplp1 interacted with the apoptotic and inflammatory pathways , whereas Ppm1g was associated only with inflammatory networks .
This proteomic analysis revealed candidate proteins that are responsible for the effects of bMO supplementation , potentially by regulating apoptotic and inflammatory signaling networks in colorectal cancer prevention and therapy .

Previous studies in a mouse model have indicated the anticancer potential of boiledpod (bMO)-supplemented diets; however, its molecular mechanisms are still unclear. Therefore, the present study aimed to explore the protein expression profiles responsible for the suppressive effect of bMO supplementation on azoxymethane (AOM)/dextran sodium sulfate (DSS)-induced mouse colon carcinogenesis. Analysis by gel electrophoresis and liquid chromatography-tandem mass spectrophotometry demonstrated that there were 125 proteins that were differentially expressed in mouse colon tissues between 14 experimental groups of mice. The differentially expressed proteins are involved in various biological processes, such as signal transduction, metabolism, transcription and translation. Venn diagram analysis of the differentially expressed proteins was performed in six selected mouse groups, including negative control, positive control mice induced by AOM/DSS, the AOM/DSS groups receiving preventive or therapeutic bMO diets and their bMO-supplemented control groups. This analysis identified 7 proteins; 60S acidic ribosomal protein P1 (Rplp1), fragile X mental retardation, cystatin 9, round spermatids protein, zinc finger protein 638, protein phosphatase 2C (Ppm1g) and unnamed protein product as being potentially associated with the preventive and therapeutic effects of bMO in AOM/DSS-induced mouse colon cancer. Analysis based on the search tool for interactions of chemicals (STITCH) database predicted that Rplp1 interacted with the apoptotic and inflammatory pathways, whereas Ppm1g was associated only with inflammatory networks. This proteomic analysis revealed candidate proteins that are responsible for the effects of bMO supplementation, potentially by regulating apoptotic and inflammatory signaling networks in colorectal cancer prevention and therapy.


greenmedinfo--2020-08-03--Preparation and characterization of polymeric microparticles loaded with Moringa oleifera leaf extra

Preparation and characterization of polymeric microparticles loaded with Moringa oleifera leaf extract for exuding wound treatment.

The aim of this study was to develop an innovative formulation , particularly useful for the treatment of exuding wounds .
An extract from Moringa oleifera leaves ( MOE ) , prepared by an eco-friendly method , was used as active ingredient .
Its preliminary characterization showed that MOE is rich in quercetin-O-glucoside and quercetin-O-malonyl glucoside , responsible for the antioxidant , radical scavenging and antibacterial activities ( toward Staphylococcus aureus , S. epidermidis , S. faecalis and S. pyogenes ) .
Moreover , MOE showed the ability to stimulate keratinocytes growth .
Thus , bioadhesive biocompatible polymeric microparticles loaded @ @ @ @ @ @ @ in order to treat exuding wounds .
The microparticles , obtained by spray drying , using chitosan as polymer , showed good swelling ability .
This is useful to obtain the transition from microparticles to a continuous gel covering the wound , after deposition on it .
This has the double function to protect the damage area and to promote the healing .
The in vitro release study showed that the formed gel is able to release immediately MOE , in the first minutes after application , and to promote a sustained release @ @ @ @ @ @ @ against the most sensitive bacterial strains .
These findings suggest that the developed microparticles represent an interesting tool for exuding wounds treatment .
Keywords : Moringa oleifera extract ; antioxidant ; antimicrobial ; microparticles ; exuding wounds ; wound healing .

The aim of this study was to develop an innovative formulation, particularly useful for the treatment of exuding wounds. An extract from Moringa oleifera leaves (MOE), prepared by an eco-friendly method, was used as active ingredient. Its preliminary characterization showed that MOE is rich in quercetin-O-glucoside and quercetin-O-malonyl glucoside, responsible for the antioxidant, radical scavenging and antibacterial activities (toward Staphylococcus aureus, S. epidermidis, S. faecalis and S. pyogenes). Moreover, MOE showed the ability to stimulate keratinocytes growth. Thus, bioadhesive biocompatible polymeric microparticles loaded with such extract were developed and prepared in order to treat exuding wounds. The microparticles, obtained by spray drying, using chitosan as polymer, showed good swelling ability. This is useful to obtain the transition from microparticles to a continuous gel covering the wound, after deposition on it. This has the double function to protect the damage area and to promote the healing. The in vitro release study showed that the formed gel is able to release immediately MOE, in the first minutes after application, and to promote a sustained release within 24 h reaching an efficacious concentration against the most sensitive bacterial strains. These findings suggest that the developed microparticles represent an interesting tool for exuding wounds treatment. Keywords:Moringa oleifera extract; antioxidant; antimicrobial; microparticles; exuding wounds; wound healing.


greenmedinfo--2020-08-03--The pro-neurogenic effects of cannabidiol and its potential therapeutic implications in psychiatric

The pro-neurogenic effects of cannabidiol and its potential therapeutic implications in psychiatric disorders.

During the last decades , researchers have investigated the functional relevance of adult hippocampal neurogenesis in normal brain function as well as in the pathogenesis of diverse psychiatric conditions .
Although the underlying mechanisms of newborn neuron differentiation and circuit integration have yet to be fully elucidated , considerable evidence suggests that the endocannabinoid system plays a pivotal role throughout the processes of adult neurogenesis .
Thus , synthetic , and natural cannabinoid compounds targeting the endocannabinoid system have been utilized to modulate the proliferation and survival of neural progenitor cells and immature neurons .
Cannabidiol ( CBD ) , @ @ @ @ @ @ @ the endocannabinoid system by inhibiting fatty acid amide hydrolase ( FAAH ) activity ( the rate-limiting enzyme for anandamide hydrolysis ) , allosterically modulating CB1 and CB2 receptors , and activating components of the '' extended endocannabinoid system .
`` Congruently , CBD has shown prominent pro-neurogenic effects , and , unlikeΔ-tetrahydrocannabinol , it has the advantage of being devoid of psychotomimetic effects .
Here , we first review pre-clinical studies supporting the facilitating effects of CBD on adult hippocampal neurogenesis and available data disclosing cannabinoid mechanisms by which CBD can induce neural @ @ @ @ @ @ @ the respective implications for its neuroprotective , anxiolytic , anti-depressant , and anti-reward actions .
In conclusion , accumulating evidence reveals that , in rodents , adult neurogenesis is key to understand the behavioral manifestation of symptomatology related to different mental disorders .
Hence , understanding how CBD promotes adult neurogenesis in rodents could shed light upon translational therapeutic strategies aimed to ameliorate psychiatric symptomatology dependent on hippocampal function in humans .

During the last decades, researchers have investigated the functional relevance of adult hippocampal neurogenesis in normal brain function as well as in the pathogenesis of diverse psychiatric conditions. Although the underlying mechanisms of newborn neuron differentiation and circuit integration have yet to be fully elucidated, considerable evidence suggests that the endocannabinoid system plays a pivotal role throughout the processes of adult neurogenesis. Thus, synthetic, and natural cannabinoid compounds targeting the endocannabinoid system have been utilized to modulate the proliferation and survival of neural progenitor cells and immature neurons. Cannabidiol (CBD), a constituent of theplant, interacts with the endocannabinoid system by inhibiting fatty acid amide hydrolase (FAAH) activity (the rate-limiting enzyme for anandamide hydrolysis), allosterically modulating CB1 and CB2 receptors, and activating components of the"extended endocannabinoid system."Congruently, CBD has shown prominent pro-neurogenic effects, and, unlikeΔ-tetrahydrocannabinol, it has the advantage of being devoid of psychotomimetic effects. Here, we first review pre-clinical studies supporting the facilitating effects of CBD on adult hippocampal neurogenesis and available data disclosing cannabinoid mechanisms by which CBD can induce neural proliferation and differentiation. We then review the respective implications for its neuroprotective, anxiolytic, anti-depressant, and anti-reward actions. In conclusion, accumulating evidence reveals that, in rodents, adult neurogenesis is key to understand the behavioral manifestation of symptomatology related to different mental disorders. Hence, understanding how CBD promotes adult neurogenesis in rodents could shed light upon translational therapeutic strategies aimed to ameliorate psychiatric symptomatology dependent on hippocampal function in humans.


greenmedinfo--2020-08-03--Enhancing ovarian cancer conventional chemotherapy through the combination with cannabidiol loaded m

Enhancing ovarian cancer conventional chemotherapy through the combination with cannabidiol loaded microparticles.

In this work , we evaluated , for the first time , the antitumor effect of cannabidiol ( CBD ) as monotherapy and in combination with conventional chemotherapeutics in ovarian cancer and developed PLGA-microparticles as CBD carriers to optimize its anticancer activity .
Spherical microparticles , with a mean particle size around 25µm and high entrapment efficiency were obtained .
Microparticles elaborated with a CBD : polymer ratio of 10:100 were selected due to the most suitable release profile with a zero-order CBD release ( 14.13±0.17 μg/day/10 mg Mps ) for 40 days .
The single administration of this formulation @ @ @ @ @ @ @ at least 10 days and an in ovo antitumor efficacy comparable to that of CBD in solution after daily topical administration ( ≈1.5-fold reduction in tumor growth vs control ) .
The use of CBD in combination with paclitaxel ( PTX ) was really effective .
The best treatment schedule was the pre+co-administration of CBD ( 10µM ) with PTX .
Using this protocol , the single administration of microparticles was even more effective than the daily administration of CBD in solution , achieving a ≈10- and 8- fold reduction in PTX ICrespectively @ @ @ @ @ @ @ ovo .
While PTX conducted to a 1.5-fold tumor growth inhibition , its combination with both CBD in solution ( daily administered ) and 10-Mps ( single administration ) showed a 2-fold decrease .
These results show the promising potential of CBD-Mps administered in combination with PTX for ovarian cancer treatment , since it would allow to reduce the administered dose of this antineoplastic drug maintaining the same efficacy and , as a consequence , reducing PTX adverse effects .

In this work, we evaluated, for the first time, the antitumor effect of cannabidiol (CBD) as monotherapy and in combination with conventional chemotherapeutics in ovarian cancer and developed PLGA-microparticles as CBD carriers to optimize its anticancer activity. Spherical microparticles, with a mean particle size around 25µm and high entrapment efficiency were obtained. Microparticles elaborated with a CBD:polymer ratio of 10:100 were selected due to the most suitable release profile with a zero-order CBD release (14.13±0.17 μg/day/10 mg Mps) for 40 days. The single administration of this formulation showed an invitro extended antitumor activity for at least 10 days and an in ovo antitumor efficacy comparable to that of CBD in solution after daily topical administration (≈1.5-fold reduction in tumor growth vs control). The use of CBD in combination with paclitaxel (PTX) was really effective. The best treatment schedule was the pre+co-administration of CBD (10µM) with PTX. Using this protocol, the single administration of microparticles was even more effective than the daily administration of CBD in solution, achieving a ≈10- and 8- fold reduction in PTX ICrespectively. This protocol was also effective in ovo. While PTX conducted to a 1.5-fold tumor growth inhibition, its combination with both CBD in solution (daily administered) and 10-Mps (single administration) showed a 2-fold decrease. These results show the promising potential of CBD-Mps administered in combination with PTX for ovarian cancer treatment, since it would allow to reduce the administered dose of this antineoplastic drug maintaining the same efficacy and, as a consequence, reducing PTX adverse effects.


greenmedinfo--2020-08-03--Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures we

Report of a 6-month-old Asian infant with early infantile epileptic encephalopathy whose seizures were eliminated by cannabidiol.

We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy , eliminating his intractable tonic seizures .
The infant began suffering clusters of brief tonic seizures from birth at 39 weeks gestation .
EEG showed burst-suppression and seizures could not be controlled by trials of phenobarbital , zonisamide , vitamin B6 , clobazam , levetiracetam , topiramate , phenytoin , valproate , high-dose phenobarbital , and ACTH therapy .
The boy was discharged from hospital at 130 days of age still averaging tonic seizures 20-30 times per day .
We started @ @ @ @ @ @ @ 207 , increasing the dosage to 18 mg/kg/d on day 219 .
His seizures reduced in frequency and completely disappeared by day 234 .
These effects were maintained , with improved EEG background , even afterhis other medications were discontinued .
Cannabidiol 's effectiveness in treating drug-resistant epilepsy has been confirmed in large-scale clinical trials in Europe and the United States ; however , no such trials have been run in Asia .
In addition , no reports to date have documented its efficacy in an infant as young as six months of @ @ @ @ @ @ @ high-dose artisanal cannabidiol may effectively treat drug-resistant epilepsy in patients without access to pharmaceutical-grade CBD .

We observed that cannabidiol supplements were highly effective in treating an infant boy with drug-resistant early infantile epileptic encephalopathy, eliminating his intractable tonic seizures. The infant began suffering clusters of brief tonic seizures from birth at 39 weeks gestation. EEG showed burst-suppression and seizures could not be controlled by trials of phenobarbital, zonisamide, vitamin B6, clobazam, levetiracetam, topiramate, phenytoin, valproate, high-dose phenobarbital, and ACTH therapy. The boy was discharged from hospital at 130 days of age still averaging tonic seizures 20-30 times per day. We started him on a cannabidiol supplement on day 207, increasing the dosage to 18 mg/kg/d on day 219. His seizures reduced in frequency and completely disappeared by day 234. These effects were maintained, with improved EEG background, even afterhis other medications were discontinued. Cannabidiol's effectiveness in treating drug-resistant epilepsy has been confirmed in large-scale clinical trials in Europe and the United States; however, no such trials have been run in Asia. In addition, no reports to date have documented its efficacy in an infant as young as six months of age. This important case suggests that high-dose artisanal cannabidiol may effectively treat drug-resistant epilepsy in patients without access to pharmaceutical-grade CBD.


greenmedinfo--2020-08-03--Fermentation improves calcium bioavailability in Moringa oleifera leaves and prevents bone loss in c

Fermentation improves calcium bioavailability in Moringa oleifera leaves and prevents bone loss in calcium-deficient rats.

Nowadays , there is an increasing demand of healthier plant calcium supplements.leaves ( MOL ) are rich in calcium and thus are promising candidates for developing efficient calcium supplements .
Here , using fermentation-based approaches , we developed aleaf ferment ( MOLF ) , which contents higher levels of calcium .
The therapeutic potential of the MOLF was also examined both in vitro and in vivo .
Nine lactic acid bacteria and four yeasts were tested for better fermentation of MOL .
Calcium-deficient rats were used for evaluating the therapeutic effects of MOLF .
The results of liquid fermentation showed @ @ @ @ @ @ @ MOL calcium most strikingly , with the content of calcium increased nearly 2.4-fold ( from 2.08 % to 4.90 % ) .
The resulting MOLF was then subjected to cell experiments and animal experiments .
The results showed that calcium absorption in Caco-2 cells in MOLF group was higher than that in CaClgroup significantly .
Interestingly , in calcium-deficient rats , MOLF treatment significantly increased the thickness of cortical bone , rat body weight , wet weight of the femur , and the femur bone density , whereas it decreased osteoclast numbers .
@ @ @ @ @ @ @ calcium bioavailability of MOL , promote the growth and development of calcium-deficient rats , bone calcium deposition , and bone growth ; enhance bone strength ; reduce bone resorption ; and prevent calcium deficiency .

Nowadays, there is an increasing demand of healthier plant calcium supplements.leaves (MOL) are rich in calcium and thus are promising candidates for developing efficient calcium supplements. Here, using fermentation-based approaches, we developed aleaf ferment (MOLF), which contents higher levels of calcium. The therapeutic potential of the MOLF was also examined both in vitro and in vivo. Nine lactic acid bacteria and four yeasts were tested for better fermentation of MOL. Calcium-deficient rats were used for evaluating the therapeutic effects of MOLF. The results of liquid fermentation showed that the mixture ofandelevated the content of MOL calcium most strikingly, with the content of calcium increased nearly 2.4-fold (from 2.08% to 4.90%). The resulting MOLF was then subjected to cell experiments and animal experiments. The results showed that calcium absorption in Caco-2 cells in MOLF group was higher than that in CaClgroup significantly. Interestingly, in calcium-deficient rats, MOLF treatment significantly increased the thickness of cortical bone, rat body weight, wet weight of the femur, and the femur bone density, whereas it decreased osteoclast numbers. These results indicate that microbial fermentation increased calcium bioavailability of MOL, promote the growth and development of calcium-deficient rats, bone calcium deposition, and bone growth; enhance bone strength; reduce bone resorption; and prevent calcium deficiency.


greenmedinfo--2020-08-04--This study has shown that ascorbic acid and alpha-tocopherol are beneficial in the therapy of polycy

This study has shown that ascorbic acid and alpha-tocopherol are beneficial in the therapy of polycystic ovary syndrome.

Polycystic ovary syndrome ( PCOS ) affects up to 10 % of women within reproductive ages and has been a cause of infertility and poor quality of life .
Alteration in the oxidant-antioxidant profile occurs in PCOS .
This study , therefore , investigates the contribution of ascorbic acid ( AA ) and alpha-tocopherol ( ATE ) on different PCOS parameters .
The mifepristone and letrozole models were used , and young mature female mice were randomly assigned to groups of six per group .
On PCOS induction with either mifepristone or letrozole , mice were administered AA and ATE @ @ @ @ @ @ @ mg/kg in the respective models .
Vaginal cytology , body weights , and temperature , as well as blood glucose , testosterone , and insulin levels , were measured .
Total antioxidant capacity and malondialdehyde levels were analyzed .
Determination of gene expression of some reactive oxygen species and histomorphological analysis on the ovaries and uteri were performed .
At the end of the experiments , AA and ATE restored reproductive cycling , with AA being more effective .
AA and ATE increased fasting blood glucose but had no significant effect on serum @ @ @ @ @ @ @ , but ATE caused slight increases .
AA and ATE both increased total antioxidant capacity and decreased malondialdehyde levels .
AA and ATE also slightly upregulated the mRNA expressions of catalase , superoxide dismutase , and heme oxygenase 1 mainly .
AA and ATE also decreased ovarian weight and mostly resolved cysts in the ovaries and congestion in the uterus .
This study has shown that AA and ATE are beneficial in the therapy of PCOS .

Polycystic ovary syndrome (PCOS) affects up to 10% of women within reproductive ages and has been a cause of infertility and poor quality of life. Alteration in the oxidant-antioxidant profile occurs in PCOS. This study, therefore, investigates the contribution of ascorbic acid (AA) and alpha-tocopherol(ATE) on different PCOS parameters. The mifepristone and letrozole models were used, and young mature female mice were randomly assigned to groups of six per group. On PCOS induction with either mifepristone or letrozole, mice were administered AA and ATE at doses ranging from 10-1000mg/kg to 0.1-1000 mg/kg in the respective models. Vaginal cytology, body weights, and temperature, as well as blood glucose, testosterone, and insulin levels, were measured. Total antioxidant capacity and malondialdehyde levels were analyzed. Determination of gene expression of some reactive oxygen species and histomorphological analysis on the ovaries and uteri were performed. At the end of the experiments, AA and ATE restored reproductive cycling, with AA being more effective. AA and ATE increased fasting blood glucose but had no significant effect on serum insulin levels. AA decreased testosterone levels,but ATE caused slight increases. AA and ATE both increased total antioxidant capacity and decreased malondialdehyde levels. AA and ATE also slightly upregulated the mRNA expressions of catalase, superoxide dismutase, and heme oxygenase 1 mainly. AA and ATE also decreased ovarian weight and mostly resolved cysts in the ovaries and congestion in the uterus. This study has shown that AA and ATE are beneficial in the therapy of PCOS.


greenmedinfo--2020-08-04--This study indicates that higher serum carotenoid levels might be inversely associated with non-Hodg

This study indicates that higher serum carotenoid levels might be inversely associated with non-Hodgkin lymphoma risk.

Limited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma ( NHL ) and the findings have been inconclusive .
This study aims to assess the association between serum total or specific carotenoid levels and NHL risk .
This 1:1 matched , hospital-based case-control study enrolled 512 newly diagnosed ( within 1 month ) NHL patients and 512 healthy controls who were matched by age ( ±5 years ) and sex in Urumqi , China .
Serum carotenoid levels were measured by high-pressure liquid chromatography .
Conditional logistic regression showed that higher serum total carotenoid @ @ @ @ @ @ @ α-carotene , β-carotene , β-cryptoxanthin , and lycopene ) were dose-dependently associated with decreased NHL risk .
The multivariable-adjusted odds ratios ( ORs ) and their 95 % confidence intervals ( CIs ) for NHL risk for quartile 4 ( vs. quartile 1 ) were 0.31 ( 0.22 , 0.48 ; P for trend : < 0.001 ) for total carotenoids , 0.52 ( 0.33 , 0.79 ; P for trend : 0.003 ) forα-carotene , 0.63 ( 0.42 , 0.94 ; P for trend : 0.031 ) for β-carotene , 0.73 ( @ @ @ @ @ @ @ : 0.034 ) for β-cryptoxanthin , and 0.51 ( 0.34 , 0.75 ; P for trend : 0.001 ) for lycopene .
A null association was observed between serum lutein+zeaxanthin and NHL risk ( OR : 0.89 , 95 % CI : 0.57 , 1.38 ; P for trend : 0.556 ) .
Significant interactions were observed after stratifying according to smoking status , and inverse associations were more evident among current smokers than past or never smokers for total carotenoids , α-carotene , and lycopene ( P for heterogeneity : 0.047 , @ @ @ @ @ @ @ study indicates that higher serum carotenoid levels might be inversely associated with NHL risk , especially among current smokers .

Limited studies have investigated the effects of serum carotenoids on the risk of non-Hodgkin lymphoma (NHL) and the findings have been inconclusive. This study aims to assess the association between serum total or specific carotenoid levels and NHL risk. This 1:1 matched, hospital-based case-control study enrolled 512 newly diagnosed (within 1 month) NHL patients and 512 healthy controls who were matched by age (±5 years) and sex in Urumqi, China. Serum carotenoid levels were measured by high-pressure liquid chromatography. Conditional logistic regression showed that higher serum total carotenoid levels and their subtypes (e.g., α-carotene, β-carotene, β-cryptoxanthin, and lycopene) were dose-dependently associated with decreased NHL risk. The multivariable-adjusted odds ratios (ORs) and their 95% confidence intervals (CIs) for NHL risk for quartile 4 (vs. quartile 1) were 0.31 (0.22, 0.48; P for trend:<0.001) for total carotenoids, 0.52 (0.33, 0.79; P for trend: 0.003) forα-carotene, 0.63 (0.42, 0.94; P for trend: 0.031) for β-carotene, 0.73 (0.49, 1.05; P for trend: 0.034) for β-cryptoxanthin, and 0.51 (0.34, 0.75; P for trend: 0.001) for lycopene. A null association was observed between serum lutein+zeaxanthin and NHL risk (OR: 0.89, 95% CI: 0.57, 1.38; P for trend: 0.556). Significant interactions were observed after stratifying according to smoking status, and inverse associations were more evident among current smokers than past or never smokers for total carotenoids, α-carotene, and lycopene (P for heterogeneity: 0.047, 0.042, and 0.046). This study indicates that higher serum carotenoid levels might be inversely associated with NHL risk, especially among current smokers.


greenmedinfo--2020-08-04--A review of dietary carotenoids in cancer chemoprevention and chemotherapy.

In recent years , natural products have reemerged as biotherapeutic options , with several dietary carotenoids , viz .
astaxanthin @ @ @ @ @ β-cryptoxanthin , α-carotene , β-carotene , and lycopene , developing as potential candidates for chemoprevention @ @ @ @ @ colorectal , lung , and prostate cancers .
The potent cytotoxic and antiproliferative effects of @ @ @ @ @ are mediated by a wide range of molecular mechanisms modulating oxidative stress and redox balance @ @ @ @ @ MAPK ) and other cellular signaling proteins , transcription factors , caspase cascade pathways of @ @ @ @ @ and proliferation , angiogenesis , metastasis , gap junction intercellular communication ( GJIC ) , @ @ @ @ @ ) .
This review discusses recent evidence demonstrating the crucial roles of carotenoids in these @ @ @ @ @ cancer cell cytotoxicity .
In addition , recent case-control and cohort studies are discussed to @ @ @ @ @ carotenoids in cancer prevention and therapy .

In recent years, natural products have reemerged as biotherapeutic options, with several dietary carotenoids, viz. astaxanthin, fucoxanthin, siphonaxanthin,β-cryptoxanthin, α-carotene, β-carotene, and lycopene, developing as potential candidates for chemoprevention and chemotherapeutics of breast, colorectal, lung, and prostate cancers. The potent cytotoxic and antiproliferative effects of carotenoids against various cancer cells are mediated by a wide range of molecular mechanisms modulating oxidative stress and redox balance, mitogen-activated protein kinases (MAPK) and other cellular signaling proteins, transcription factors, caspase cascade pathways of apoptosis, cell cycle progression and proliferation, angiogenesis, metastasis, gap junction intercellular communication (GJIC), and multidrug resistance (MDR). This review discusses recent evidence demonstrating the crucial roles of carotenoids in these cellular and molecular events of cancer cell cytotoxicity. In addition, recent case-control and cohort studies are discussed to support the potential role of carotenoids in cancer prevention and therapy.


greenmedinfo--2020-08-04--The effect of dietary inorganic nitrate supplementation on cardiac function during submaximal exerci

The effect of dietary inorganic nitrate supplementation on cardiac function during submaximal exercise in men with heart failure.

Heart failure with reduced ejection fraction ( HFrEF ) is a common end point for patients with coronary artery disease and it is characterized by exercise intolerance due , in part , to a reduction in cardiac output .
Nitric oxide ( NO ) plays a vital role in cardiac function and patients with HFrEF have been identified as having reduced vascular NO .
This pilot study aimed to investigate if nitrate supplementation could improve cardiac measures during acute , submaximal exercise .
Five male participants ( 61± 3 years ) with HFrEF ( EF 32 ± 2.2 % ) @ @ @ @ @ @ @ supplemented with inorganic nitrate ( beetroot juice ) or a nitrate-depleted placebo for ~13 days prior to testing .
Participants completed a three-stage submaximal exercise protocol on a recumbent cycle ergometer withsimultaneous echocardiography for calculation of cardiac output ( Q ) , stroke volume ( SV ) , and total peripheral resistance ( TPR ) .
Heart rate and blood pressure were measured at rest and during each stage .
Both plasma nitrate ( mean = ~1028 % , = 0.004 ) and nitrite ( mean = ~109 % , = 0.01 ) @ @ @ @ @ @ @ differences between interventions at rest , but the percent change in SV and Q from rest to stage two and stage three of exercise was higher following nitrate supplementation ( all > 0.05 , ES > 0.8 ) .
Both interventions showed decreases in TPR during exercise , but the percent reduction TPR in stages two and three was greater following nitrate supplementation ( = 0.09 , ES = 0.98 and= 0.14 , ES = 0.82 , respectively ) .
There were clinically relevant increases in cardiac function during exercise following supplementation with @ @ @ @ @ @ @ study warrant further investigation in larger clinical trials .

Heart failure with reduced ejection fraction (HFrEF) is a common end point for patients with coronary artery disease and it is characterized by exercise intolerance due, in part, to a reduction in cardiac output. Nitric oxide (NO) plays a vital role in cardiac function and patients with HFrEF have been identified as having reduced vascular NO. This pilot study aimed to investigate if nitrate supplementation could improve cardiac measures during acute, submaximal exercise. Five male participants (61± 3 years) with HFrEF (EF 32 ± 2.2%) completed this pilot study. All participants supplemented with inorganic nitrate (beetroot juice) or a nitrate-depleted placebo for ~13 days prior to testing. Participants completed a three-stage submaximal exercise protocol on a recumbent cycle ergometer withsimultaneous echocardiography for calculation of cardiac output (Q), stroke volume (SV), and total peripheral resistance (TPR). Heart rate and blood pressure were measured at rest and during each stage. Both plasma nitrate (mean = ~1028%,= 0.004) and nitrite (mean = ~109%,= 0.01) increased following supplementation. There were no differences between interventions at rest, but the percent change in SV and Q from rest to stage two and stage three of exercise was higher following nitrate supplementation (all>0.05, ES>0.8). Both interventions showed decreases in TPR during exercise, but the percent reduction TPR in stages two and three was greater following nitrate supplementation (= 0.09, ES = 0.98 and= 0.14, ES = 0.82, respectively). There were clinically relevant increases in cardiac function during exercise following supplementation with nitrate. The findings from this pilot study warrant further investigation in larger clinical trials.


greenmedinfo--2020-08-04--From Lockdowns to "The Great Reset"

From Lockdowns to "The Great Reset"

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By providing the information contained herein we are not diagnosing , treating @ @ @ @ @ or preventing any type of disease or medical condition .
Before beginning any type of @ @ @ @ @ treatment regimen , it is advisable to seek the advice of a licensed healthcare professional @

This website is for information purposes only. By providing the information contained herein we are not diagnosing, treating, curing, mitigating, or preventing any type of disease or medical condition. Before beginning any type of natural, integrative or conventional treatment regimen, it is advisable to seek the advice of a licensed healthcare professional.
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greenmedinfo--2020-08-04--WHO Admits: No Direct Evidence Masks Prevent Viral Infection


greenmedinfo--2020-08-04--Leaves of white beetroot as a new source of antioxidant and anti-Inflammatory compounds.

The white beetroot cv.Śnieżna Kula is the first betanin-free beetroot registered in the European Union .
The aim of this study was to compare the phenolic acids profile and antioxidant capacity of leaves of white ( SK ) and red ( CC ) beetroots and red ( LC ) and white ( BL ) Swiss chard growing in Poland .
LC leaves were the richest source of total phenolics ( 16.55 mg GAE/g FW ) and phenolic acids ( 1.81 mg/g FW ) , while the highest content of flavonoids was determined in CC leaves ( 1.6 mg QE/g FW @ @ @ @ @ @ @ observed for LC , whereas CC extract exhibited the highest chelating power .
BL and CC leafextracts demonstrated high LOX inhibitory potential ( EC= 53.23 and 56.97 mg FW/mL , respectively ) .
An uncompetitive type of LOX inhibition was obtained for all extracts .
SK extracts demonstrated the highest XO inhibitory activity ( EC= 81.04 mg FW/mL ) .
A noncompetitive type of XO inhibition was obtained in both extracts from red leaves ( CC and LC ) , whereas an uncompetitive mode of inhibition was observed in the case of white @ @ @ @ @ @ @ .
Thus , it can be assumed that the presence of betanin influences the XO inhibition mechanism .

The white beetroot cv.Śnieżna Kula is the first betanin-free beetroot registered in the European Union. The aim of this study was to compare the phenolic acids profile and antioxidant capacity of leaves of white (SK) and red (CC) beetroots and red (LC) and white (BL) Swiss chard growing in Poland. LC leaves were the richest source of total phenolics (16.55 mg GAE/g FW) and phenolic acids (1.81 mg/g FW), while the highest content of flavonoids was determined in CC leaves (1.6 mg QE/g FW). The highest antiradical activity was observed for LC, whereas CC extract exhibited the highest chelating power. BL and CC leafextracts demonstrated high LOX inhibitory potential (EC= 53.23 and 56.97 mg FW/mL, respectively). An uncompetitive type of LOX inhibition was obtained for all extracts. SK extracts demonstrated the highest XO inhibitory activity (EC= 81.04 mg FW/mL). A noncompetitive type of XO inhibition was obtained in both extracts from red leaves (CC and LC), whereas an uncompetitive mode of inhibition was observed in the case of white leaf (SK and LC) extracts. Thus, it can be assumed that the presence of betanin influences the XO inhibition mechanism.