greenmedinfo--2020-06-11--Korean red ginseng is an excellent skin whitening and anti-aging product.

Background : is a marvelous herbal remedy for all ailments of body .
That may be why it is called Panax , which means '' cure for all '' .
Melanin is a pigment that gives color to our skin ; however , increased melanin production can lead to tumor formation .
Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming .
Consequently , a phenomenon called photoaging has been observed for all skin colors and types .
As a result of this phenomenon , a set of enzymes called matrix @ @ @ @ @ @ @ for extracellular matrix proteins , mainly collagen , is increased , causing depletion of collagen and resulting in early wrinkle formation .
Methods : Therefore , in our study , we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng ( KRG ) extractand HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG .
We prepared a 3 % red ginseng extract cream and evaluated its effects on human skin .
Results : Our results demonstrated that KRG induced potent @ @ @ @ @ @ @ in B16/F10 cells ; moreover , it reduced the transcription and translation of components involved in the melanin production pathway .
In theexperiments , KRG potently suppressed the expression of matrix metalloproteinases , reduced wrinkle formation , and inhibited collagen degradation .
On human skin , ginseng cream increased skin resilience and skin moisture and enhanced skin tone .
Conclusion : Therefore , we conclude that KRG is an excellent skin whitening and antiaging product .

Background: is a marvelous herbal remedy for all ailments of body. That may be why it is called Panax, which means"cure for all". Melanin is a pigment that gives color to our skin; however, increased melanin production can lead to tumor formation. Human exposure to ultraviolet B radiation has increased extensively owing to the increased sunlight due to global warming. Consequently, a phenomenon called photoaging has been observed for all skin colors and types. As a result of this phenomenon, a set of enzymes called matrix metalloproteinases, which serve as degradation enzymes for extracellular matrix proteins, mainly collagen, is increased, causing depletion of collagen and resulting in early wrinkle formation.
Methods: Therefore, in our study, we used the murine melanoma cell line B16/F10 to study the inhibition of melanogenesis by Korean Red Ginseng (KRG) extractand HRM-2 hairless mice exposed to artificial ultraviolet B to examine the efficacy of KRG. We prepared a 3% red ginseng extract cream and evaluated its effects on human skin.
Results: Our results demonstrated that KRG induced potent suppression of tyrosinase activity and melanin production in B16/F10 cells; moreover, it reduced the transcription and translation of components involved in the melanin production pathway. In theexperiments, KRG potently suppressed the expression of matrix metalloproteinases, reduced wrinkle formation, and inhibited collagen degradation. On human skin, ginseng cream increased skin resilience and skin moisture and enhanced skin tone.
Conclusion: Therefore, we conclude that KRG is an excellent skin whitening and antiaging product.


greenmedinfo--2020-06-11--Twenty-four week administration of Korean red ginseng in diabetes patients resulted in a significant

Twenty-four week administration of Korean red ginseng in diabetes patients resulted in a significant improvement in follistatin and SHBG levels.

BACKGROUND : The elderly population is growing rapidly worldwide and sarcopenia , which is considered as a new geriatric syndrome has become an important issue .
In particular , diabetes is known to be an important risk factor for sarcopenia .
In this study , we investigated the effects of Korean Red Ginseng ( KRG ) on biomarkers of sarcopenia in middle and old age diabetes patients .
PATIENTS AND METHODS : This study was a randomized , double-blind , placebo-controlled trial .
Participants were randomly allocated to either the placebo or KRG group and took corresponding tablets for 24 @ @ @ @ @ @ @ in sarcopenia biomarkers at week 24 .
Secondary outcomes were changes in inflammatory and antioxidant markers and lean body mass at week 24 .
RESULTS : Fifty-nine patients completed the study .
Follistatin and sex hormone binding globulin ( SHBG ) were significantly improved in KRG group .
In the subgroup analysis , female postmenopausal patients over the age of 55 showed a significant improvement in serum SHBG , follistatin , and growth differentiation factor 15 ( GDF-15 ) and an attenuated reduction in Troponin T ( TNT ) after the administration of @ @ @ @ @ @ @ of KRG in diabetes patients resulted in a significant improvement in follistatin and SHBG levels , especially in old postmenopausal women .
A further , larger population study with a longer follow-up period is warranted to verify and understand the effects of KRG on sarcopenia .

BACKGROUND: The elderly population is growing rapidly worldwide and sarcopenia, which is considered as a new geriatric syndrome has become an important issue. In particular, diabetes is known to be an important risk factor for sarcopenia. In this study, we investigated the effects of Korean Red Ginseng (KRG) on biomarkers of sarcopenia in middle and old age diabetes patients.
PATIENTS AND METHODS: This study was a randomized, double-blind, placebo-controlled trial. Participants were randomly allocated to either the placebo or KRG group and took corresponding tablets for 24 weeks. The primary outcomes were changes in sarcopenia biomarkers at week 24. Secondary outcomes were changes in inflammatory and antioxidant markers and lean body mass at week 24.
RESULTS: Fifty-nine patients completed the study. Follistatin and sex hormone binding globulin (SHBG) were significantly improved in KRG group. In the subgroup analysis, female postmenopausal patients over the age of 55 showed a significant improvement in serum SHBG, follistatin, and growth differentiation factor 15 (GDF-15) and an attenuated reduction in Troponin T (TNT) after the administration of KRG.
CONCLUSION: Twenty-four week administration of KRG in diabetes patients resulted in a significant improvement in follistatin and SHBG levels, especially in old postmenopausal women. A further, larger population study with a longer follow-up period is warranted to verify and understand the effects of KRG on sarcopenia.


greenmedinfo--2020-06-11--A systematic review and meta-analysis on the survival of cancer patients treated with a fermented vi

A systematic review and meta-analysis on the survival of cancer patients treated with a fermented viscum album L. extract.

PURPOSE : We aimed at updating the evidence found in controlled studies addressing general and event-free survival of cancer patients treated with the fermented mistletoe extract Iscador .
METHODS : The databases Embase , PubMed , CAMbase , Scopus , AMED and Cochrane were searched for clinical studies on cancer patients treated with Iscador .
Quality of studies and risk of bias were evaluated according to the Cochrane guidelines and the Newcastle Ottawa Scale .
Outcome data were expressed as hazard ratios ( HR ) and the respective 95 % confidence intervals ( CI ) .
Meta-analysis was carried out @ @ @ @ @ @ @ Eighty-two controlled studies met the inclusion criteria , of which 32 with 55 strata provided data for extracting HR and CI .
The overall HR was 0.59 ( 95 % CI : [ 0.53 ; 0.65 ] , p < 0.0001 ) in favour of Iscador treatment .
Heterogeneity of study results was moderate ( I2 = 50.9 % ; p < 0.0001 , τ2 = 0.053 ) .
Meta-regression did not reveal significant effects of sample size or study design .
However , significant differences were found between cancer entities ( p @ @ @ @ @ @ @ effects in cervical ( HR = 0.43 ) and less pronounced effects in lung cancer ( HR = 0.84 ) .
CONCLUSIONS : We found almost identical effects on cancer survival based on a broader database of higher quality .
However , none of the studies was blinded and , therefore , there might be risk of performance bias .
Implications for cancer survivors are as follows : findings indicate that adjuvant treatment of cancer patients with Iscador can be associated with a better survival .

PURPOSE: We aimed at updating the evidence found in controlled studies addressing general and event-free survival of cancer patients treated with the fermented mistletoe extract Iscador.
METHODS: The databases Embase, PubMed, CAMbase, Scopus, AMED and Cochrane were searched for clinical studies on cancer patients treated with Iscador. Quality of studies and risk of bias were evaluated according to the Cochrane guidelines and the Newcastle Ottawa Scale. Outcome data were expressed as hazard ratios (HR) and the respective 95% confidence intervals (CI). Meta-analysis was carried out using a random-effects model.
RESULTS: Eighty-two controlled studies met the inclusion criteria, of which 32 with 55 strata provided data for extracting HR and CI. The overall HR was 0.59 (95% CI: [0.53; 0.65], p<0.0001) in favour of Iscador treatment. Heterogeneity of study results was moderate (I2 = 50.9%; p<0.0001,τ2 = 0.053). Meta-regression did not reveal significant effects of sample size or study design. However, significant differences were found between cancer entities (p<0.01), with most pronounced effects in cervical (HR = 0.43) and less pronounced effects in lung cancer (HR = 0.84).
CONCLUSIONS: We found almost identical effects on cancer survival based on a broader database of higher quality. However, none of the studies was blinded and, therefore, there might be risk of performance bias. Implications for cancer survivors are as follows: findings indicate that adjuvant treatment of cancer patients with Iscador can be associated with a better survival.


greenmedinfo--2020-06-11--Anticancer effects of herbal medicine compounds and novel formulations: a literature review.

INTRODUCTION : Many agents disrupt the cell cycle and its signaling circuits leading to cancer progress .
Cancer therapy is performed by surgery , radiation , and chemical drugs remaining some side effects .
OBJECTIVE : To evaluate the anticancer traits of herbal medicines .
METHODS : We collected previously published data in searching engines ( Web of Science , PubMed , Medline , and SCOPUS ) by searching key words '' herbal medicine , '' '' anticancer effect , '' '' compounds , '' and '' fractions . ''
RESULTS : Herbal medicines have unraveled anticancer effects mostly through @ @ @ @ @ @ @ by curcumin and terpenoides ; CD95 signaling and enhancement of CD95L expression by resveratrol ; and inhibiting tyrosine kinas , angiogenesis , and cell cycle arrest in G2/M phase by β-lapachone-genistein and cytochrome-c release into the cytosol and caspase-9 activation by biocalein and quercetin .
Additionally , impeding cell cycle in the G1 phase in ovarian cancer cells by 7-hydroxystaurosporine , immune cells enrichment ( neutrophils and NK cells activation by Viscum album L. , T cells and NK cells activation and cytokines such as tumor necrosis factor release by Ganoderma lucidum andmicroRNAs @ @ @ @ @ @ @ Oleaeuropaea , curcumin and ginseng ) .
These effects have implications for proper cancer cells elimination .
It has been revealed that cytotoxic effects of herbal compounds ( mostly those secondary metabolites ) have exerted anticancer properties against several cancer cell lines .
In addition , targeting microRNAs , nanoparticle-assisted herbal synergism , and novel drug delivery systems and combination chemotherapies have also emerged exerting higher efficacies for specific cell targeting as novel cancer therapy approaches .
CONCLUSION : Considering side effects , toxicity , and higher costs of common cancer therapy approaches @ @ @ @ @ @ @ will confer promising insights for health outcomes .

INTRODUCTION: Many agents disrupt the cell cycle and its signaling circuits leading to cancer progress. Cancer therapy is performed by surgery, radiation, and chemical drugs remaining some side effects.
OBJECTIVE: To evaluate the anticancer traits of herbal medicines.
METHODS: We collected previously published data in searching engines (Web of Science, PubMed, Medline, and SCOPUS) by searching key words"herbal medicine,""anticancer effect,""compounds,"and"fractions."
RESULTS: Herbal medicines have unraveled anticancer effects mostly through cancer cells apoptosis via blocking NF-κB pathway by curcumin and terpenoides; CD95 signaling and enhancement of CD95L expression by resveratrol; and inhibiting tyrosine kinas, angiogenesis, and cell cycle arrest in G2/M phase by β-lapachone-genistein and cytochrome-c release into the cytosol and caspase-9 activation by biocalein and quercetin. Additionally, impeding cell cycle in the G1 phase in ovarian cancer cells by 7-hydroxystaurosporine, immune cells enrichment (neutrophils and NK cells activation by Viscum album L., T cells and NK cells activation and cytokines such as tumor necrosis factor release by Ganoderma lucidum andmicroRNAs regulation (by Sinomeniumacutum, shikonin, Oleaeuropaea, curcumin and ginseng). These effects have implications for proper cancer cells elimination. It has been revealed that cytotoxic effects of herbal compounds (mostly those secondary metabolites) have exerted anticancer properties against several cancer cell lines. In addition, targeting microRNAs, nanoparticle-assisted herbal synergism, and novel drug delivery systems and combination chemotherapies have also emerged exerting higher efficacies for specific cell targeting as novel cancer therapy approaches.
CONCLUSION: Considering side effects, toxicity, and higher costs of common cancer therapy approaches, application of novel herbal medicine-based therapies will confer promising insights for health outcomes.


greenmedinfo--2020-06-11--Cost-effectiveness of real-world administration of concomitant Viscum album L. therapy for the treat

Cost-effectiveness of real-world administration of concomitant Viscum album L. therapy for the treatment of stage IV pancreatic cancer.

Background : For patients receiving add-onL .
( VA ) treatments for late-stage pancreatic cancer , an improved overall survival ( OS ) was observed .
Only limited information regarding cost-effectiveness ( CE ) for comparisons between standard of care and standard of care plus add-on VA in stage IV pancreatic cancer treatment is available .
The present study assessed the costs and cost-effectiveness of standard of care plus VA ( V ) compared to standard of care alone ( C ) for a hospital in Germany .
Methods : An observational study was conducted using data from the Network @ @ @ @ @ @ @ stage IV pancreatic cancer at diagnosis and receivedortreatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( CEA ) including the analysis of the incremental cost-effectiveness ratios ( ICER ) were performed from the hospital 's perspective based on routine data from the financial controlling department and observed data on OS .
The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis .
Results : 88 patients ( or = 34 ; treatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( @ @ @ @ @ @ @ incremental cost-effectiveness ratios ( ICER ) were performed from the hospital 's perspective based on routine data from the financial controlling department and observed data on OS .
The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis .
= 34 ; ortreatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( CEA ) including the analysis of the incremental cost-effectiveness ratios ( ICER ) were performed from the hospital 's perspective based on routine data from the financial controlling department and observed data on @ @ @ @ @ @ @ analysis was tested for robustness in a bootstrap-based sensitivity analysis.treatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( CEA ) including the analysis of the incremental cost-effectiveness ratios ( ICER ) were performed from the hospital 's perspective based on routine data from the financial controlling department and observed data on OS .
The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.ortreatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( CEA ) including the analysis of the incremental cost-effectiveness @ @ @ @ @ @ @ the hospital 's perspective based on routine data from the financial controlling department and observed data on OS .
The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.ortreatment in a certified German Cancer Center .
Cost and cost-effectiveness analyses ( CEA ) including the analysis of the incremental cost-effectiveness ratios ( ICER ) were performed from the hospital 's perspective based on routine data from the financial controlling department and observed data on OS .
The primary result of the analysis was tested for robustness in a @ @ @ @ @ @ @ on this CEA analysis , from the hospital 's point of view , the costs per mean month of OS and per mean hospital stay were lower for patients under combinational standard of care plus VA compared to patients receiving standard of care alone for the treatment of stage IV pancreatic cancer .
Further prospective cost-effectiveness studies are mandatory to reevaluate our findings .

Background: For patients receiving add-onL. (VA) treatments for late-stage pancreatic cancer, an improved overall survival (OS) was observed. Only limited information regarding cost-effectiveness (CE) for comparisons between standard of care and standard of care plus add-on VA in stage IV pancreatic cancer treatment is available. The present study assessed the costs and cost-effectiveness of standard of care plus VA (V) compared to standard of care alone (C) for a hospital in Germany.
Methods: An observational study was conducted using data from the Network Oncology clinical registry. Patients included had stage IV pancreatic cancer at diagnosis and receivedortreatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.
Results: 88 patients (or = 34;treatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis. = 34;ortreatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.treatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.ortreatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.ortreatment in a certified German Cancer Center. Cost and cost-effectiveness analyses (CEA) including the analysis of the incremental cost-effectiveness ratios (ICER) were performed from the hospital's perspective based on routine data from the financial controlling department and observed data on OS. The primary result of the analysis was tested for robustness in a bootstrap-based sensitivity analysis.or.
Conclusion: Based on this CEA analysis, from the hospital's point of view, the costs per mean month of OS and per mean hospital stay were lower for patients under combinational standard of care plus VA compared to patients receiving standard of care alone for the treatment of stage IV pancreatic cancer. Further prospective cost-effectiveness studies are mandatory to reevaluate our findings.


greenmedinfo--2020-06-11--After 12 years from the start of the trial, the patients in the Viscum arm continue to show a consid

After 12 years from the start of the trial, the patients in the Viscum arm continue to show a considerably longer PRDFS compared to oral etoposide.

Background : In relapsed osteosarcoma , the 5-yr postrelapse disease-free survival ( PRDFS ) rate after the second relapse is < 20 % .
In June 2007 , a randomized study was started comparing oral etoposide vsfermentatum Pini ( an extract derived from the parasitic plantL.
, European mistletoe ) as maintenance therapy in patients with metastatic osteosarcoma in complete surgical remission after the second relapse .
The primary endpoint was the PRDFS rate at 12 months ( compared to the historical control rate ) .
This is a long-term updated result.. 10 patients received oral etoposide 50 mg/mdaily for @ @ @ @ @ @ @ months , and 9 patients receivedfermentatum Pini 3 times/wk subcutaneously for 1 year .
The study closed early in July 2011 due to insufficient recruitment .
Lymphocyte subpopulations were analyzed at T0 , T3 , T6 , T9 , and T12 months .
Results : On 30 June 2019 , at a median follow-up ITT of 83 months ( range 3-144 ms ) , a median PRDFS of 106 ms ( 2-144 ) was observed in thearm with 5/9 patients who never relapse vs a PRDFS of 7 months ( 3-134 ) in @ @ @ @ @ @ @ the Etoposide arm relapsed ) ( hazard ratio HR = 0.287 , 95 % CI : 0.076-0.884 , =0.03 ) .
Model forecast 10-yr overall survival rates as 64 % in thearm and 33 % in the etoposide arm .
Lymphocyte subpopulation counts ( CD3 , CD4 , and CD56 ) showed an increase in the Viscum arm while a decrease was observed in the etoposide arm during treatment .
Conclusions : After 12 years from the start of the trial , the patients in thearm continue to show a considerably longer PRDFS @ @ @ @ @ @ @ trend for an advantage in OS is evident even if the number of treated patients is too small to draw conclusions.as maintenance treatment after complete surgical remission in relapsed osteosarcoma should be further investigated and compared with other drugs .

Background: In relapsed osteosarcoma, the 5-yr postrelapse disease-free survival (PRDFS) rate after the second relapse is<20%. In June 2007, a randomized study was started comparing oral etoposide vsfermentatum Pini (an extract derived from the parasitic plantL., European mistletoe) as maintenance therapy in patients with metastatic osteosarcoma in complete surgical remission after the second relapse. The primary endpoint was the PRDFS rate at 12 months (compared to the historical control rate). This is a long-term updated result.. 10 patients received oral etoposide 50 mg/mdaily for 21 days every 28 days for 6 months, and 9 patients receivedfermentatum Pini 3 times/wk subcutaneously for 1 year. The study closed early in July 2011 due to insufficient recruitment. Lymphocyte subpopulations were analyzed at T0, T3, T6, T9, and T12 months.
Results: On 30 June 2019, at a median follow-up ITT of 83 months (range 3-144 ms), a median PRDFS of 106 ms (2-144) was observed in thearm with 5/9 patients who never relapse vs a PRDFS of 7 months (3-134) in the etoposide arm (all patients in the Etoposide arm relapsed) (hazard ratio HR = 0.287, 95% CI: 0.076-0.884,=0.03). Model forecast 10-yr overall survival rates as 64% in thearm and 33% in the etoposide arm. Lymphocyte subpopulation counts (CD3, CD4, and CD56) showed an increase in the Viscum arm while a decrease was observed in the etoposide arm during treatment.
Conclusions: After 12 years from the start of the trial, the patients in thearm continue to show a considerably longer PRDFS compared to oral etoposide, and a trend for an advantage in OS is evident even if the number of treated patients is too small to draw conclusions.as maintenance treatment after complete surgical remission in relapsed osteosarcoma should be further investigated and compared with other drugs.


greenmedinfo--2020-06-11--Viscum album applications might be suited to alleviate symptom burden during anticancer therapy in b

Viscum album applications might be suited to alleviate symptom burden during anticancer therapy in breast cancer patients.

L extracts ( VA ) are frequently used in integrative oncology .
Aim of this study was to evaluate the impact of add-on VA applications on various patient-reported outcome measures.A longitudinal real-world study was conducted , using data from the Network Oncology clinical registry .
Primary , nonmetastasized breast cancer patients treated with oncological standard therapy partly combined with VA applications were included .
Internal Coherence Cancer-related Fatigue , and EORTC QLQ-C30 questionnaires were assessed at baseline and 6 , 12 , and 24 months later.A total of 319 patients received standard oncological therapy and 40 % of them additionally @ @ @ @ @ @ @ months for patients treated with chemotherapy ( Ctx ) only a significant decline of the thermo-coherence , and worsening of fatigue was observed .
For patients receiving VA applications but no Ctx , significant beneficial effects on thermo-coherence , fatigue , and seven EORTC QLQ-C30 scales were observed 24 months later .
Adjusted multivariable long-term subgroup ( = 106 ) regression analysis revealed that Ctx , immuno- , and endocrine therapies had a worsening of 17 , 17 , and 6 point changes , respectively , for EORTC QLQ-C30 fatigue ( = .0004 @ @ @ @ @ @ @ improvement of 12 point change .
A similar impact of improvement ( add-on VA ) and worsening ( standard oncological treatment regimens ) on EORTC QLQ-C30 insomnia ( = .009 ) and physical functioning ( = .005 ) were observed.In the present real-world study , add-on VA applications had a supportive effect on cancer-related fatigue , insomnia , physical functioning , and thermo-coherence .
Thus , VA applications might be suited to alleviate symptom burden during anticancer therapy in breast cancer patients .

L extracts (VA) are frequently used in integrative oncology. Aim of this study was to evaluate the impact of add-on VA applications on various patient-reported outcome measures.A longitudinal real-world study was conducted, using data from the Network Oncology clinical registry. Primary, nonmetastasized breast cancer patients treated with oncological standard therapy partly combined with VA applications were included. Internal Coherence Cancer-related Fatigue, and EORTC QLQ-C30 questionnaires were assessed at baseline and 6, 12, and 24 months later.A total of 319 patients received standard oncological therapy and 40% of them additionally VA applications. After 6 and 12 months for patients treated with chemotherapy (Ctx) only a significant decline of the thermo-coherence, and worsening of fatigue was observed. For patients receiving VA applications but no Ctx, significant beneficial effects on thermo-coherence, fatigue, and seven EORTC QLQ-C30 scales were observed 24 months later. Adjusted multivariable long-term subgroup (= 106) regression analysis revealed that Ctx, immuno-, and endocrine therapies had a worsening of 17, 17, and 6 point changes, respectively, for EORTC QLQ-C30 fatigue (= .0004), while VA applications showed an improvement of 12 point change. A similar impact of improvement (add-on VA) and worsening (standard oncological treatment regimens) on EORTC QLQ-C30 insomnia (= .009) and physical functioning (= .005) were observed.In the present real-world study, add-on VA applications had a supportive effect on cancer-related fatigue, insomnia, physical functioning, and thermo-coherence. Thus, VA applications might be suited to alleviate symptom burden during anticancer therapy in breast cancer patients.


greenmedinfo--2020-06-11--A case report of recurrent gastric cancer successfully treated with a combination of docetaxel monot

A case report of recurrent gastric cancer successfully treated with a combination of docetaxel monotherapy and long-term mistletoe extract treatment.

Recurrent gastric cancer with peritoneal seeding is associated with poor overall survival .
A 71-year-old man with advanced gastric cancer @ @ @ @ @ stage IIIb , T4b N1 M0 ) .
Abdomino-pelvic computed tomography performed 7 months after @ @ @ @ @ enhanced peritoneal thickening .
He was diagnosed with peritoneal seeding and received second-line chemotherapy ( @ @ @ @ @ he refused chemotherapy due to the side effects ( general weakness , nausea , and @ @ @ @ @ .
He started receiving alternative therapy withextract ( VAE ) ( mistletoe ) instead of @ @ @ @ @ decreased after mistletoe therapy .
So we started third-line chemotherapy ( docetaxel ) with VAE @ @ @ @ @ health with complete response postoperatively 32 months after combination treatment and survived over 60 months @ @ @ @ @ .
We report a case of recurrent gastric cancer that was successfully treated with a @ @ @ @ @ long-term mistletoe extract treatment .

Recurrent gastric cancer with peritoneal seeding is associated with poor overall survival. A 71-year-old man with advanced gastric cancer underwent radical total gastrectomy (stage IIIb, T4b N1 M0). Abdomino-pelvic computed tomography performed 7 months after surgery revealed increased ascites with enhanced peritoneal thickening. He was diagnosed with peritoneal seeding and received second-line chemotherapy (irinotecan). However, he refused chemotherapy due to the side effects (general weakness, nausea, and vomiting) after 1 cycle. He started receiving alternative therapy withextract (VAE) (mistletoe) instead of chemotherapy. Malignant ascites gradually decreased after mistletoe therapy. So we started third-line chemotherapy (docetaxel) with VAE. The patient achieved good health with complete response postoperatively 32 months after combination treatment and survived over 60 months after surgery without disease progression. We report a case of recurrent gastric cancer that was successfully treated with a combination of docetaxel monotherapy and long-term mistletoe extract treatment.


greenmedinfo--2020-06-11--How Google is Manipulating COVID Related Search Results

Visit our Re-post guidelines This article is copyrighted by GreenMedInfo LLC , 2020 Amazingly , most users of Google still @ @ @ @ @ spell that the Search Engine Manipulation Effect ( SEME ) holds over their minds and @ @ @ @ @ to COVID , it 's no less egregious , and it 's more important now @ @ @ @ @ : https : //questioningcovid.com/ Get my book Regenerate : Unlocking Your Body 's Radical Resilience @ @ @ @ @ Edition https : //www.amazon.com/Regenerate-Biological-Reverse-Chronic-Disease/dp/1401956386

Visit our Re-post guidelines This article is copyrighted by GreenMedInfo LLC, 2020
Amazingly, most users of Google still don't understand the powerful spell that the Search Engine Manipulation Effect (SEME) holds over their minds and behavior. When it comes to COVID, it's no less egregious, and it's more important now than ever to question everything: https://questioningcovid.com/
Referenced material:
https://www.greenmedinfo.com/blog/google-just-obliterated-natural-and-health-freedom-websites-its-search-results-wh
https://www.greenmedinfo.com/blog/how-google-uses-mind-control-tactics-promote-pro-vaccine-industry-propaganda https://www.greenmedinfo.com/blog/did-googles-manipulation-sway-vaccine-legislation
https://trends.google.com/trends/explore?q=covid%20is%20a%20scam,covid%20is%20almost%20over
https://www.blog.google/products/search/how-google-autocomplete-works-search/
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greenmedinfo--2020-06-12--The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-ric

Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease .
The aim of this three-arm , crossover , randomized , double-blind , placebo-controlled intervention study was to examine the impact ofjuice ( AMJ ) , high-polyphenol ( AMJ treatment , 1.17 g/100 mL polyphenols ) and low-polyphenol ( dAMJ treatment , 0.29 g/100 mL polyphenols ) dose , on the transcriptome in peripheral blood mononuclear cells ( PBMC ) of 19 subjects at cardiovascular risk .
Transcriptome data were obtained by microarray .
Bioinformatic functional annotation analysis was performed on both the whole transcriptome @ @ @ @ @ @ @ DEGs ) .
Expression of selected DEGs was validated by RT-qPCR .
Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles , with the most pronounced and specific effect noticed for AMJ in the last treatment period ( TP3 ) of the trial .
Between the high-dose and low-dose treatments in TP3 , there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways , which primarily included immunomodulation and regulation of cell proliferation/death .
Increased expression of , , @ @ @ @ @ @ @ by RT-qPCR .
The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk .

Foods and food products that contain polyphenols are proposed to modulate risk of cardiovascular disease. The aim of this three-arm, crossover, randomized, double-blind, placebo-controlled intervention study was to examine the impact ofjuice (AMJ), high-polyphenol (AMJ treatment, 1.17 g/100 mL polyphenols) and low-polyphenol (dAMJ treatment, 0.29 g/100 mL polyphenols) dose, on the transcriptome in peripheral blood mononuclear cells (PBMC) of 19 subjects at cardiovascular risk. Transcriptome data were obtained by microarray. Bioinformatic functional annotation analysis was performed on both the whole transcriptome datasets and the differentially expressed genes (DEGs). Expression of selected DEGs was validated by RT-qPCR. Administration of AMJ and dAMJ treatments during the two consecutive four-week treatment periods had additive effects on PBMC transcriptome profiles, with the most pronounced and specific effect noticed for AMJ in the last treatment period (TP3) of the trial. Between the high-dose and low-dose treatments in TP3, there was a multitude of overlapping DEGs and DEG-enriched biological processes and pathways, which primarily included immunomodulation and regulation of cell proliferation/death. Increased expression of,,,,, andin TP3 was confirmed by RT-qPCR. The results suggest the immunomodulatory effects of prolonged habitual consumption of polyphenol-rich aronia juice in individuals at cardiovascular risk.


greenmedinfo--2020-06-12--A. melanocarpa extract has therapeutic potential to treat prostate enlargement and benign prostatic

A. melanocarpa extract has therapeutic potential to treat prostate enlargement and benign prostatic hyperplasia.

This study aimed to investigate the beneficial effects ofon testosterone propionate ( TP ) -induced benign prostatic hyperplasia ( BPH ) in Wistar rats .
Moreover , the bioactive constituents in the extract were determined using LC/MS and HPLC analyses .
The dried fruits ofwere extracted using accelerated solvent extraction ( ASE ) under different extract conditions ( temperature , 30 C or 100 C ; extract solvent , 60 % or 100 % ethanol ) to yield four extracts ( T1~T4 ) .
Of the fourextracts , T1 extracted under the condition of 100 % ethanol/low temperature ( 30 @ @ @ @ @ @ @ on TP-induced prostatic hyperplasia in rats .
The administration of T1 ( 100 mg/kg body weight , p.o . )
for six weeks attenuated TP-induced prostate enlargement and reduced the levels of dihydrotestosterone ( DHT ) and 5α-reductase in both serum and prostate tissue .
The suppression of PCNA mRNA expression in prostate tissue was remarkable in T1-treated rats .
In LC/MS analysis , the levels of main anthocyanins and phenolics were significantly higher in T1 than in the other extracts .
Furthermore , the quantitative study showed that the contents of cyanidin-3-glucose @ @ @ @ @ @ @ 1.10~1.26 folds higher compared to those in the other extracts .
These findings demonstrated thatextract containing anthocyanins as bioactive constituents attenuated the development of testosterone-induced prostatic hyperplasia , and suggested that this extract has therapeutic potential to treat prostate enlargement and BPH .

This study aimed to investigate the beneficial effects ofon testosterone propionate (TP)-induced benign prostatic hyperplasia (BPH) in Wistar rats. Moreover, the bioactive constituents in the extract were determined using LC/MS and HPLC analyses. The dried fruits ofwere extracted using accelerated solvent extraction (ASE) under different extract conditions (temperature, 30 C or 100 C; extract solvent, 60% or 100% ethanol) to yield four extracts (T1~T4). Of the fourextracts, T1 extracted under the condition of 100% ethanol/low temperature (30 C) exhibited the greatest inhibitory activity on TP-induced prostatic hyperplasia in rats. The administration of T1 (100 mg/kg body weight, p.o.) for six weeks attenuated TP-induced prostate enlargement and reduced the levels of dihydrotestosterone (DHT) and 5α-reductase in both serum and prostate tissue. The suppression of PCNA mRNA expression in prostate tissue was remarkable in T1-treated rats. In LC/MS analysis, the levels of main anthocyanins and phenolics were significantly higher in T1 than in the other extracts. Furthermore, the quantitative study showed that the contents of cyanidin-3-glucose and cyanidin-3-xylose in T1 exhibited 1.27~1.67 and 1.10~1.26 folds higher compared to those in the other extracts. These findings demonstrated thatextract containing anthocyanins as bioactive constituents attenuated the development of testosterone-induced prostatic hyperplasia, and suggested that this extract has therapeutic potential to treat prostate enlargement and BPH.


greenmedinfo--2020-06-12--Aronia berry inhibits disruption of Caco-2 intestinal barrier function.

The objective of this work was to determine how aronia berry polyphenols and its microbial catabolites improve intestinal barrier function .
Caco-2 cells were cultured on transwell plates and allowed differentiate to form a model intestinal barrier , having baseline transepithelial electrical resistance ( TEER ) ≥ 300 Ω cm .
Barrier function of differentiated Caco-2 cells was compromised by the addition of an inflammatory cocktail ( IC : TNF-α , IL-1β , and IFN-γ to the basolateral media and lipopolysaccharide to the apical media ) .
Polyphenol-rich aronia berry powder or individual polyphenols representative of parent compounds or catabolites @ @ @ @ @ @ @ with IC .
TEER was determined subsequently by chopstick electrode or continuous analysis .
Permeability was determined by application of 4 kDa FITC-dextran or Lucifer yellow .
Expression of tight junction proteins was assessed by qRT-PCR analysis .
Application of the ICto differentiated Caco-2 cells routinely reduced TEER by ~40 % within 24 h. Individual polyphenols representative of parent compounds or phenolic microbial catabolites at 100 μM did not inhibit IC reduction of TEER in Caco-2 cells .
Whole aronia berry powder inhibited loss of TEER by ~50 % at 24 h after @ @ @ @ @ @ @ mg/mL of aronia berry powder prevented an IC-induced barrier permeability of FITC-dextran and Lucifer yellow .
After 12 h of IC treatment , Caco-2 cells had increased claudin 1 ( CLDN1 ) relative to the untreated control .
Application of aronia berry powderinhibited CLDN1 and also increased expression of zonula ocludens-1 ( ZO-1 ) after 12 h. In summary , aronia berry , but not its microbiota-derived catabolites improved intestinal barrier function in a cellular model of chronic colonic inflammation .
In this case , improved barrier function was associated with modulation of @ @ @ @

The objective of this work was to determine how aronia berry polyphenols and its microbial catabolites improve intestinal barrier function. Caco-2 cells were cultured on transwell plates and allowed differentiate to form a model intestinal barrier, having baseline transepithelial electrical resistance (TEER) ≥ 300 Ω cm. Barrier function of differentiated Caco-2 cells was compromised by the addition of an inflammatory cocktail (IC: TNF-α, IL-1β, and IFN-γ to the basolateral media and lipopolysaccharide to the apical media). Polyphenol-rich aronia berry powder or individual polyphenols representative of parent compounds or catabolites were applied to the basolateral media concurrently with IC. TEER was determined subsequently by chopstick electrode or continuous analysis. Permeability was determined by application of 4 kDa FITC-dextran or Lucifer yellow. Expression of tight junction proteins was assessed by qRT-PCR analysis. Application of the ICto differentiated Caco-2 cells routinely reduced TEER by ~40% within 24 h. Individual polyphenols representative of parent compounds or phenolic microbial catabolites at 100 μM did not inhibit IC reduction of TEER in Caco-2 cells. Whole aronia berry powder inhibited loss of TEER by ~50% at 24 h after application of the IC. Furthermore 5 mg/mL of aronia berry powder prevented an IC-induced barrier permeability of FITC-dextran and Lucifer yellow. After 12 h of IC treatment, Caco-2 cells had increased claudin 1 (CLDN1) relative to the untreated control. Application of aronia berry powderinhibited CLDN1 and also increased expression of zonula ocludens-1 (ZO-1) after 12 h. In summary, aronia berry, but not its microbiota-derived catabolites improved intestinal barrier function in a cellular model of chronic colonic inflammation. In this case, improved barrier function was associated with modulation of tight junction expression.


greenmedinfo--2020-06-12--Black raspberries and protocatechuic acid mitigate DNFB-induced contact hypersensitivity.

Contact hypersensitivity ( CHS ) is the most common occupational dermatological disease .
Dendritic cells ( DCs ) mediate the sensitization stage of CHS , while T-cells facilitate the effector mechanisms that drive CHS .
Black raspberry ( , BRB ) and BRB phytochemicals possess immunomodulatory properties , but their dietary effects on CHS are unknown .
We examined the effects of diets containing BRB and protocatechuic acid ( PCA , a constituent of BRB and an anthocyanin metabolite produced largely by gut microbes ) , on CHS , using a model induced by 2,4-dinitrofluorobenze ( DNFB ) .
Mice @ @ @ @ @ @ @ with BRB or PCA .
In vitro bone-marrow derived DCs and RAW264.7 macrophages were treated with BRB extract and PCA .
Mice fed BRB or PCA supplemented diets displayed decreased DNFB-induced ear swelling , marked by decreased splenic DC accumulation .
BRB extract diminished DC maturation associated with reducedexpression and Interleukin ( IL ) -12 secretion , and PCA reduced IL-12 .
Dietary supplementation with BRB and PCA induced differential decreases in IL-12-driven CHS mediators , including Interferon ( IFN ) -γ and IL-17 production by T-cells .
BRB extracts and PCA directly @ @ @ @ @ @ @ oxide and IL-12 .
Our results demonstrate that BRB and PCA mitigate CHS pathology , providing a rationale for CHS alleviation via dietary supplementation with BRB or BRB derived anthocyanins .

Contact hypersensitivity (CHS) is the most common occupational dermatological disease. Dendritic cells (DCs) mediate the sensitization stage of CHS, while T-cells facilitate the effector mechanisms that drive CHS. Black raspberry (, BRB) and BRB phytochemicals possess immunomodulatory properties, but their dietary effects on CHS are unknown. We examined the effects of diets containing BRB and protocatechuic acid (PCA, a constituent of BRB and an anthocyanin metabolite produced largely by gut microbes), on CHS, using a model induced by 2,4-dinitrofluorobenze (DNFB). Mice were fed control diet or diets supplemented with BRB or PCA. In vitro bone-marrow derived DCs and RAW264.7 macrophages were treated with BRB extract and PCA. Mice fed BRB or PCA supplemented diets displayed decreased DNFB-induced ear swelling, marked by decreased splenic DC accumulation. BRB extract diminished DC maturation associated with reducedexpression and Interleukin (IL)-12 secretion, and PCA reduced IL-12. Dietary supplementation with BRB and PCA induced differential decreases in IL-12-driven CHS mediators, including Interferon (IFN)-γ and IL-17 production by T-cells. BRB extracts and PCA directly attenuated CHS-promoting macrophage activity mediated by nitric oxide and IL-12. Our results demonstrate that BRB and PCA mitigate CHS pathology, providing a rationale for CHS alleviation via dietary supplementation with BRB or BRB derived anthocyanins.


greenmedinfo--2020-06-12--Recent evidence of the beneficial effects associated with glucuronic acid contained in Kombucha beve

Recent evidence of the beneficial effects associated with glucuronic acid contained in Kombucha beverages.

PURPOSE OF THE REVIEW : Glucuronic acid is contained naturally in kombucha beverages due to the associations between bacteria and @ @ @ @ @ The purpose of this review is to describe the literature related to the hepatoprotective effect @ @ @ @ @ in different kombucha beverages .
RECENT FINDINGS : Although previous research supports beneficial hepatoprotective effects @ @ @ @ @ kombucha , these effects are mainly attributed to the tea phytochemicals .
However , there @ @ @ @ @ deficiencies in some in vivo studies that should be considered .
There is no sufficient @ @ @ @ @ effects of kombucha consumption .
Consumption of kombucha could be considered a safe practice in @ @ @ @ @ hepatoprotective effects .
The content of the beneficial or toxic components is very variable because @ @ @ @ @ process .
In persons with side sickness , other conditions such as pregnancy , and @ @ @ @ @ , a restriction in its consumption must be advisable .

PURPOSE OF THE REVIEW: Glucuronic acid is contained naturally in kombucha beverages due to the associations between bacteria and yeasts during its fermentation. The purpose of this review is to describe the literature related to the hepatoprotective effect associated with glucuronic acid present in different kombucha beverages.
RECENT FINDINGS: Although previous research supports beneficial hepatoprotective effects of glucuronic acid consumption from kombucha, these effects are mainly attributed to the tea phytochemicals. However, there are some improvements in methodological deficiencies in some in vivo studies that should be considered. There is no sufficient evidence to generalize the adverse effects of kombucha consumption. Consumption of kombucha could be considered a safe practice in healthy populations due to its hepatoprotective effects. The content of the beneficial or toxic components is very variable because it depends on its manufacturing process. In persons with side sickness, other conditions such as pregnancy, and hypersensitivity to some kombucha components, a restriction in its consumption must be advisable.


greenmedinfo--2020-06-12--Blueberry anthocyanin extract significantly delayed the progression of diabetic cataracts.

PURPOSE : To investigate the mechanism of the protective effects of blueberry anthocyanin extract ( BAE ) against oxidative stress and the roles of SIRT1 and NF-B in the pathogenesis of diabetic cataracts .
METHODS : Male SD rats were randomly divided into a control group ( group A ) and an experimental group .
The rats in the experimental group were intraperitoneally injected with streptozotocin ( STZ ) ( 60 mg/kg ) .
Rats with blood glucose levels≥16.7 mmol/L were considered to have DM .
The rats in the experimental group were subdivided into group B ( distilled water @ @ @ @ @ @ @ , group C ( 5 % blueberry anthocyanin extract by oral gavage : 10 ml/kg/day ) , and group D ( 15 % blueberry anthocyanin extract by oral gavage : 10 ml/kg/day ) , with 15 rats in each group .
At the end of 8 weeks , some biochemical parameters , including the expression of SIRT1 and NF-B by qRT-PCR and western blotting and the activity of SOD and GSH , were measured in lens epithelial cells ( LECs ) .
RESULTS : The lenses of the rats in the control group @ @ @ @ @ @ @ .
Four weeks following STZ injection , cataracts gradually progressed in the experimental rats .
SIRT1 expression was upregulated in groups B , C and D compared to the control group .
However , the expression of NF-κB decreased in the experimental groups with increasing doses of BAE ( p < 0.05 ) .
Our study also showed that the activity of the SOD enzyme and GSH in the LECs of the rats in the experimental group increased with higher doses of BAE .
CONCLUSIONS : The results indicated that BAE significantly delayed @ @ @ @ @ @ @ .
These effects may be due to the dose-dependent antioxidant activity of BAE , which is mediated by enhanced SOD and GSH activities , SIRT1 expression and reduced NF-κB expression .

PURPOSE: To investigate the mechanism of the protective effects of blueberry anthocyanin extract (BAE) against oxidative stress and the roles of SIRT1 and NF-B in the pathogenesis of diabetic cataracts.
METHODS: Male SD rats were randomly divided into a control group (group A) and an experimental group. The rats in the experimental group were intraperitoneally injected with streptozotocin (STZ) (60 mg/kg). Rats with blood glucose levels≥16.7 mmol/L were considered to have DM. The rats in the experimental group were subdivided into group B (distilled water by oral gavage: 10 ml/kg/day), group C (5% blueberry anthocyanin extract by oral gavage: 10 ml/kg/day), and group D (15% blueberry anthocyanin extract by oral gavage: 10 ml/kg/day), with 15 rats in each group. At the end of 8 weeks, some biochemical parameters, including the expression of SIRT1 and NF-B by qRT-PCR and western blotting and the activity of SOD and GSH, were measured in lens epithelial cells (LECs).
RESULTS: The lenses of the rats in the control group appeared transparent during the entire 8-week period. Four weeks following STZ injection, cataracts gradually progressed in the experimental rats. SIRT1 expression was upregulated in groups B, C and D compared to the control group. However, the expression of NF-κB decreased in the experimental groups with increasing doses of BAE (p<0.05). Our study also showed that the activity of the SOD enzyme and GSH in the LECs of the rats in the experimental group increased with higher doses of BAE.
CONCLUSIONS: The results indicated that BAE significantly delayed the progression of diabetic cataracts in rats. These effects may be due to the dose-dependent antioxidant activity of BAE, which is mediated by enhanced SOD and GSH activities, SIRT1 expression and reduced NF-κB expression.


greenmedinfo--2020-06-12--Anthocyanins in blueberries grown in hot climate exert strong antioxidant activity and may be effect

Anthocyanins in blueberries grown in hot climate exert strong antioxidant activity and may be effective against urinary tract bacteria.

Anthocyanins are extensively studied for their health-related properties , including antibacterial activity against urinary tract infections ( UTI ) .
Among common fruits , blueberries , with their remarkable antioxidant capacity , are one of the richest sources .
Anthocyanin-rich extracts were obtained from four varieties : Snowchaser , Star , Stella Blue and Cristina Blue , grown in the hot climate of Southern Spain .
Their total anthocyanins contents ( TAC ) were determined spectrophotometrically , and the anthocyanin profile by ultra high performance liquid chromatography - tandem mass spectrometer ( UHPLC-MS/MS ) .
Their antioxidant activity was assessed @ @ @ @ @ @ @ ) assay , while antibacterial activity against strains isolated from UTI patients was assessed in vitro , helping to select the varieties with the highest bioactive potential .
Star showed the highest TAC and antioxidant activity ( 1663± 159 mg of cyanidin-3 -- glucoside ( cy-3 -- glu ) equivalents/100 g fresh weight ( FW ) , 6345± 601 μmol Trolox equivalents ( TE ) /100 g FW , respectively ) , followed by Cristina Blue , Stella Blue and Snowchaser .
As far as we know , this is the first time @ @ @ @ @ @ @ .
The extracts inhibited all the tested strains , MICs ranging from 0.4 mg/mL ( for Stella Blue extract against UTI ) to 9.5 mg/mL ( for all extracts against UTIssp. )
.
This is the first study that assessed in vitro the antibacterial activity of blueberries against , andspp .
strains isolated from UTI .

Anthocyanins are extensively studied for their health-related properties, including antibacterial activity against urinary tract infections (UTI). Among common fruits, blueberries, with their remarkable antioxidant capacity, are one of the richest sources. Anthocyanin-rich extracts were obtained from four varieties: Snowchaser, Star, Stella Blue and Cristina Blue, grown in the hot climate of Southern Spain. Their total anthocyanins contents (TAC) were determined spectrophotometrically, and the anthocyanin profile by ultra high performance liquid chromatography - tandem mass spectrometer (UHPLC-MS/MS). Their antioxidant activity was assessed by oxygen radical absorbance capacity (ORAC) assay, while antibacterial activity against strains isolated from UTI patients was assessed in vitro, helping to select the varieties with the highest bioactive potential. Star showed the highest TAC and antioxidant activity (1663± 159 mg of cyanidin-3--glucoside (cy-3--glu) equivalents/100 g fresh weight (FW), 6345± 601 μmol Trolox equivalents (TE)/100 g FW, respectively), followed by Cristina Blue, Stella Blue and Snowchaser. As far as we know, this is the first time that cyanidin-3-rutinoside has been identified in blueberries. The extracts inhibited all the tested strains, MICs ranging from 0.4 mg/mL (for Stella Blue extract against UTI) to 9.5 mg/mL (for all extracts against UTIssp.). This is the first study that assessed in vitro the antibacterial activity of blueberries against,andspp. strains isolated from UTI.


greenmedinfo--2020-06-12--Top Five Best and Worst Anti-Aging Substances

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By providing the information contained herein we are not diagnosing , treating @ @ @ @ @ or preventing any type of disease or medical condition .
Before beginning any type of @ @ @ @ @ treatment regimen , it is advisable to seek the advice of a licensed healthcare professional @

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greenmedinfo--2020-06-11--Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress i

Glycosyl flavones from Humulus japonicus suppress MMP-1 production via decreasing oxidative stress in UVB irradiated human dermal fibroblasts.

Exposure to Ultraviolet ( UV ) light induces photoaging of skin , leading to wrinkles and sunburn .
The perennial herb Humulus japonicus , widely distributed in Asia , is known to have anti-inflammatory , antimicrobial , and antioxidant effects .
However , the physiological activities of isolated compounds from H. japonicus have rarely been investigated .
This study focused on the isolation of active compounds from H. japonicus and the evaluation of their effects on photoaging in UVB-irradiated human fibroblast ( Hs68 ) cells .
When the extract and four fractions of H. japonicus were treated respectively in UVB-irradiated @ @ @ @ @ @ @ the ethyl acetate ( EtOAc ) fraction showed the strongest inhibitory effect on MMP-1 secretion .
From EtOAc fraction , we isolated luteolin-8-C-glucoside ( 1 ) , apigenin-8-C-glucoside ( 2 ) , and luteolin-7-O-glucoside ( 3 ) .
These compounds suppressed UVB-induced MMP-1 production by inhibiting the phosphorylation of the mitogen-activated protein kinases ( MAPKs ) and activator protein-1 ( AP-1 ) .
When the antioxidant activity of the compounds were estimated by conducting western blot , calculating the bond dissociation energies of the O-H bond ( BDE ) at different grade , @ @ @ @ @ @ @ found luteolin-8-C-glucoside ( 1 ) showed the strongest activity on the suppression of UVB-induced photoaging .
These results demonstrate the inhibitory effect of three flavone glycosides derived from H. japonicus on MMP-1 production , MAPK and AP-1 signaling , and oxidative stress ; this could prove useful in suppressing UVB induced photoaging .

Exposure to Ultraviolet (UV) light induces photoaging of skin, leading to wrinkles and sunburn. The perennial herb Humulus japonicus, widely distributed in Asia, is known to have anti-inflammatory, antimicrobial, and antioxidant effects. However, the physiological activities of isolated compounds from H. japonicus have rarely been investigated. This study focused on the isolation of active compounds from H. japonicus and the evaluation of their effects on photoaging in UVB-irradiated human fibroblast (Hs68) cells. When the extract and four fractions of H. japonicus were treated respectively in UVB-irradiated Hs68 cells to investigate anti-photoaging effects, the ethyl acetate (EtOAc) fraction showed the strongest inhibitory effect on MMP-1 secretion. From EtOAc fraction, we isolated luteolin-8-C-glucoside (1), apigenin-8-C-glucoside (2), and luteolin-7-O-glucoside (3). These compounds suppressed UVB-induced MMP-1 production by inhibiting the phosphorylation of the mitogen-activated protein kinases (MAPKs) and activator protein-1 (AP-1). When the antioxidant activity of the compounds were estimated by conducting western blot, calculating the bond dissociation energies of the O-H bond (BDE) at different grade, and measuring radical scavenging activity, we found luteolin-8-C-glucoside (1) showed the strongest activity on the suppression of UVB-induced photoaging. These results demonstrate the inhibitory effect of three flavone glycosides derived from H. japonicus on MMP-1 production, MAPK and AP-1 signaling, and oxidative stress; this could prove useful in suppressing UVB induced photoaging.


greenmedinfo--2020-06-11--These results suggest that naturally-derived polyphenols exert antidepressant-like effects in matern

These results suggest that naturally-derived polyphenols exert antidepressant-like effects in maternal separation.

There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of host behaviour and as therapeutic target for neuropsychiatric disorders .
In addition , accumulating evidence suggests that early-life stress can exert long-lasting changes on the brain and microbiota , and this early adversity is associated with increased risk for developing depression in later life .
The maternal separation ( MS ) model in rats is a robust paradigm to study the effects of early-life stress on the microbiota-gut-brain axis .
Recently , we have shown that polyphenols , naturally occurring compounds associated with several health @ @ @ @ @ @ @ vitro models .
In this study , we assess the therapeutic potential of a variety of both flavonoid and non-flavonoid polyphenols in reversing the impact of MS on behaviour and the microbiota-gut-brain axis .
Rats underwent a dietary intervention with the naturally-derived polyphenols xanthohumol and quercetin , as well as with a phlorotannin extract for 8 weeks .
Treatment with polyphenols prevented the depressive- and anxiety-like behaviours induced by MS , where xanthohumol effects were correlated with rescue of BDNF plasma levels .
In addition , MS resulted in altered brain levels of @ @ @ @ @ @ @ , accompanied by abnormal elevation of plasma corticosterone .
Although polyphenols did not reverse neurotransmitter imbalance , xanthohumol normalised corticosterone levels in MS rats .
Finally , we explored the impact of MS and polyphenolic diets on the gut microbiota .
We observed profound changes in microbial composition and diversity produced by MS condition and by xanthohumol treatment .
Moreover , functional prediction analysis revealed that MS results in altered enrichment of pathways associated with microbiota-brain interactions that are significantly reversed by xanthohumol treatment .
These results suggest that naturally-derived polyphenols exert antidepressant-like @ @ @ @ @ @ @ could be potentially mediated by HPA regulation , BDNF levels rescue and modulation of the microbiota-gut-brain axis .

There is a growing emphasis on the role of the microbiota-gut-brain axis as modulator of host behaviour and as therapeutic target for neuropsychiatric disorders. In addition, accumulating evidence suggests that early-life stress can exert long-lasting changes on the brain and microbiota, and this early adversity is associated with increased risk for developing depression in later life. The maternal separation (MS) model in rats is a robust paradigm to study the effects of early-life stress on the microbiota-gut-brain axis. Recently, we have shown that polyphenols, naturally occurring compounds associated with several health benefits, have anti-stress effects in in vitro models. In this study, we assess the therapeutic potential of a variety of both flavonoid and non-flavonoid polyphenols in reversing the impact of MS on behaviour and the microbiota-gut-brain axis. Rats underwent a dietary intervention with the naturally-derived polyphenols xanthohumol and quercetin, as well as with a phlorotannin extract for 8 weeks. Treatment with polyphenols prevented the depressive- and anxiety-like behaviours induced by MS, where xanthohumol effects were correlated with rescue of BDNF plasma levels. In addition, MS resulted in altered brain levels of 5-hydroxyindoleacetic acid (5-HIAA) and dopamine, accompanied by abnormal elevation of plasma corticosterone. Although polyphenols did not reverse neurotransmitter imbalance, xanthohumol normalised corticosterone levels in MS rats. Finally, we explored the impact of MS and polyphenolic diets on the gut microbiota. We observed profound changes in microbial composition and diversity produced by MS condition and by xanthohumol treatment. Moreover, functional prediction analysis revealed that MS results in altered enrichment of pathways associated with microbiota-brain interactions that are significantly reversed by xanthohumol treatment. These results suggest that naturally-derived polyphenols exert antidepressant-like effects in MS rats, which mechanisms could be potentially mediated by HPA regulation, BDNF levels rescue and modulation of the microbiota-gut-brain axis.


greenmedinfo--2020-06-11--Hop bioactive compounds in prevention of nutrition-related noncommunicable diseases.

Nutrition-related noncommunicable diseases ( NR-NCDs ) such as cardiovascular disease and type 2 diabetes both negatively impact the quality of @ @ @ @ @ generate a substantial burden on society , demonstrating a need for intervention .
Phytochemicals are @ @ @ @ @ for combating NR-NCDs , and those found in hops have gained increased attention in recent @ @ @ @ @ strobile of the plant , are grown primarily for the brewing industry as they confer @ @ @ @ @ The bitter acids represent the main compounds of interest for improving beer quality .
Additionally @ @ @ @ @ as the prenylated chalcone xanthohumol , exhibit a wide range of health beneficial properties .
@ @ @ @ @ effects of bitter acids and xanthohumol on NR-NCDs , including inflammatory and immune diseases , @ @ @ @ @ as well as cancer prevention .

Nutrition-related noncommunicable diseases (NR-NCDs) such as cardiovascular disease and type 2 diabetes both negatively impact the quality of life of many individuals and generate a substantial burden on society, demonstrating a need for intervention. Phytochemicals are investigated as a potential approach for combating NR-NCDs, and those found in hops have gained increased attention in recent decades. Hops, the strobile of the plant, are grown primarily for the brewing industry as they confer taste and increased shelf-life. The bitter acids represent the main compounds of interest for improving beer quality. Additionally, bitter acids as well as the prenylated chalcone xanthohumol, exhibit a wide range of health beneficial properties. This review summarizes those beneficial effects of bitter acids and xanthohumol on NR-NCDs, including inflammatory and immune diseases, obesity and metabolic disorders, as well as cancer prevention.


greenmedinfo--2020-06-11--Hepatoprotective effect of raspberry ketone and white tea against acrylamide.

The current investigation was accomplished to evaluate the hepatoprotective effect of White tea and Raspberry Ketone against toxicity induced by @ @ @ @ @ adult male rats were divided randomly into group ( I ) control ; group ( @ @ @ @ @ with dose ( 6 mg/kg/day ) ; Group III : rats received 5 ml of @ @ @ @ @ rats received AA ( 5 mg/kg/day ) ; Group V : rats administrated with both @ @ @ @ @ and RK ( 6 mg/kg/day ) and Group VI : rats administrated AA ( 5 @ @ @ @ @ of WT extract/kg/day .
The biochemical assaysexhibited a significant increase in serum levels of Adiponectin @ @ @ @ @ ALP of the group treated with acrylamide if compared to the control group and an @ @ @ @ @ groups V and VI .
The histopathological and immunohistochemical findings confirm the biochemical observations .
@ @ @ @ @ proved that the supplementation of WT and RK enhanced the liver histology , immunohistochemistry and @ @ @ @ @ induced by acrylamide .

The current investigation was accomplished to evaluate the hepatoprotective effect of White tea and Raspberry Ketone against toxicity induced by acrylamide in rats. Sixty adult male rats were divided randomly into group (I) control; group (II) rats received RK with dose (6 mg/kg/day); Group III: rats received 5 ml of WT extract/kg/day; Group IV rats received AA (5 mg/kg/day); Group V: rats administrated with both AA (5 mg/kg/day) and RK (6 mg/kg/day) and Group VI: rats administrated AA (5 mg/kg/day) and 5 ml of WT extract/kg/day. The biochemical assaysexhibited a significant increase in serum levels of Adiponectin, AST, ALT, ALP of the group treated with acrylamide if compared to the control group and an improvement in their levels of groups V and VI. The histopathological and immunohistochemical findings confirm the biochemical observations. Inconclusion, the present investigation proved that the supplementation of WT and RK enhanced the liver histology, immunohistochemistry and biochemistry against the oxidative stress induced by acrylamide.


greenmedinfo--2020-06-11--Chemical profile and antioxidant activity of the Kombucha beverage derived from white, green, black

Chemical profile and antioxidant activity of the Kombucha beverage derived from white, green, black and red tea.

Kombucha is a fermented tea beverage prepared as a result of the symbiotic nature of bacterial cultures and yeast , @ @ @ @ @ .
Kombucha is characterised by rich chemical content and healthy properties .
It includes organic @ @ @ @ @ originating mainly from tea , amino acids , and biologically active compounds-polyphenols in particular .
@ @ @ @ @ the form of black tea , but other tea types are increasingly often used as @ @ @ @ @ impact its content and health benefits .
This work shows that the type of tea @ @ @ @ @ the parameters associated with the antioxidant potential , pH , as well as the content @ @ @ @ @ or sugar .
Red tea and green tea on the 1st and 14th day of @ @ @ @ @ source of antioxidants , especially polyphenols , including flavonoids .
Therefore , the choice of @ @ @ @ @ traditionally used black tea and the subjection of these tea types to fermentation seems to @ @ @ @ @ the healthy properties of kombucha .

Kombucha is a fermented tea beverage prepared as a result of the symbiotic nature of bacterial cultures and yeast, the so-called SCOBY (). Kombucha is characterised by rich chemical content and healthy properties. It includes organic acids, minerals and vitamins originating mainly from tea, amino acids, and biologically active compounds-polyphenols in particular. Kombucha is prepared mainly in the form of black tea, but other tea types are increasingly often used as well, which can significantly impact its content and health benefits. This work shows that the type of tea has a significant influence on the parameters associated with the antioxidant potential, pH, as well as the content of acetic acid, alcohol or sugar. Red tea and green tea on the 1st and 14th day of fermentation are a particularly prominent source of antioxidants, especially polyphenols, including flavonoids. Therefore, the choice of other tea types than the traditionally used black tea and the subjection of these tea types to fermentation seems to be beneficial in terms of the healthy properties of kombucha.


greenmedinfo--2020-06-12--Three Strategies to Prevent Osteoporosis and Build Strong Bones


greenmedinfo--2020-06-12--The effects of Allium sativum on immunity within the scope of COVID-19 infection.

The severity of coronavirus disease 2019 ( COVID-19 ) infection is quite variable and the manifestations varies from asymptomatic disease to severe acute respiratory infection .
Fever , dry cough , dyspnea , myalgia , fatigue , loss of appetite , olfactory and gustatory dysfunctions are the most prevalent general symptoms .
Decreased immune system cells such as suppressed regulatory T cells , cytotoxic and helper T cells , natural killer cells , monocytes/macrophages and increased proinflammatory cytokines are the characteristic features .
Compounds derived from Allium sativum ( garlic ) have the potential to decrease the expression of proinflammatory @ @ @ @ @ @ @ to more acceptable levels .
Allium sativum is suggested as a beneficial preventive measure before being infected with SARS-CoV-2 virus .
Allium sativum is a functional food well-known for its immunomodulatory , antimicrobial , antiinflammatory , antimutagenic , antitumor properties .
Its antiviral efficiency was also demonstrated .
Some constituents of this plant were found to be active against protozoan parasites .
Within this context , it appears to reverse most immune system dysfunctions observed in patients with COVID-19 infection .
The relations among immune system parameters , leptin , leptin receptor , @ @ @ @ @ @ @ proliferator activated receptor-gamma have also been interpreted .
Leptin 's role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection .
In conclusion , Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature .

The severity of coronavirus disease 2019 (COVID-19) infection is quite variable and the manifestations varies from asymptomatic disease to severe acute respiratory infection. Fever, dry cough, dyspnea, myalgia, fatigue, loss of appetite, olfactory and gustatory dysfunctions are the most prevalent general symptoms. Decreased immune system cells such as suppressed regulatory T cells, cytotoxic and helper T cells, natural killer cells, monocytes/macrophages and increased proinflammatory cytokines are the characteristic features. Compounds derived from Allium sativum (garlic) have the potential to decrease the expression of proinflammatory cytokines and to reverse the immunological abnormalities to more acceptable levels. Allium sativum is suggested as a beneficial preventive measure before being infected with SARS-CoV-2 virus. Allium sativum is a functional food well-known for its immunomodulatory, antimicrobial, antiinflammatory, antimutagenic, antitumor properties. Its antiviral efficiency was also demonstrated. Some constituents of this plant were found to be active against protozoan parasites. Within this context, it appears to reverse most immune system dysfunctions observed in patients with COVID-19 infection. The relations among immune system parameters, leptin, leptin receptor, adenosin mono phosphate-activated protein kinase, peroxisome proliferator activated receptor-gamma have also been interpreted. Leptin's role in boosting proinflammatory cytokines and in appetite decreasing suggest the possible beneficial effect of decreasing the concentration of this proinflammatory adipose tissue hormone in relieving some symptoms detected during COVID-19 infection. In conclusion, Allium sativum may be an acceptable preventive measure against COVID-19 infection to boost immune system cells and to repress the production and secretion of proinflammatory cytokines as well as an adipose tissue derived hormone leptin having the proinflammatory nature.


greenmedinfo--2020-06-12--The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in

The effect of dried Ziziphus vulgaris on glycemic control, lipid profile, apo-proteins and hs-CRP in patients with type 2 diabetes mellitus.

We aimed to evaluate the effect of dried Ziziphus vulgaris [ Z. vulgaris ] consumption on liver enzymes , blood pressure , inflammatory status , glycemic control , and lipid concentrations in type 2 diabetes patients .
Seventy-six diabetic participants ( aged 20-65 years ) randomly assigned to intervention ( n = 38 ) and placebo ( n = 38 ) groups .
The intervention group received 30 g/day dried Z. vulgaris for 12 weeks .
At the end of the study , there was a significant reduction in the percentage change of weight , body mass index [ BMI @ @ @ @ @ @ @ resistance [ HOMA-IR ] , Apoprotein B100 [ ApoB100 ] , and high-sensitive c-reactive protein [ hs-CRP ] in the intervention group compared to the controls .
Also , increased values of quantitative insulin check index [ QUICKI ] and Apoprotein A-I [ ApoA-I ] in Z. vulgaris group compared tothe controls were observed .
In conclusion , consumption of dried Z. vulgaris fruit could have beneficial effects on improving the glycemic control and reducing the cardiovascular risk factors in the diabetic patients .
PRACTICAL APPLICATIONS : In the present study we found @ @ @ @ @ @ @ vulgaris fruit in patients with type 2 diabetes for 12 weeks has beneficial anti-inflammatory , anti-hyperglycemic , and anti-hyperlipidemic effects on type 2 diabetes mellitus [ T2DM ] patients compared to the control group .
Thus , it seems reasonable to design a large-scale clinical trial to determine the potential adverse effects of higher doses of this fruit and identify the therapeutic doses for the complementary treatment in T2DM medication .
The medication with this popular fruit as an ingredient could be easily accepted by diabetic patients and may reduce the dependency and @ @ @ @ @ @ @ medications which often have some adverse side effects .

We aimed to evaluate the effect of dried Ziziphus vulgaris [Z. vulgaris] consumption on liver enzymes, blood pressure, inflammatory status, glycemic control, and lipid concentrations in type 2 diabetes patients. Seventy-six diabetic participants (aged 20-65 years) randomly assigned to intervention (n = 38) and placebo (n = 38) groups. The intervention group received 30 g/day dried Z. vulgaris for 12 weeks. At the end of the study, there was a significant reduction in the percentage change of weight, body mass index [BMI], insulin, homeostasis model assessment-insulin resistance [HOMA-IR], Apoprotein B100 [ApoB100], and high-sensitive c-reactive protein [hs-CRP] in the intervention group compared to the controls. Also, increased values of quantitative insulin check index [QUICKI] and Apoprotein A-I [ApoA-I] in Z. vulgaris group compared tothe controls were observed. In conclusion, consumption of dried Z. vulgaris fruit could have beneficial effects on improving the glycemic control and reducing the cardiovascular risk factors in the diabetic patients. PRACTICAL APPLICATIONS: In the present study we found that consumption of 30 g/day dried Z. vulgaris fruit in patients with type 2 diabetes for 12 weeks has beneficial anti-inflammatory, anti-hyperglycemic, and anti-hyperlipidemic effects on type 2 diabetes mellitus [T2DM] patients compared to the control group. Thus, it seems reasonable to design a large-scale clinical trial to determine the potential adverse effects of higher doses of this fruit and identify the therapeutic doses for the complementary treatment in T2DM medication. The medication with this popular fruit as an ingredient could be easily accepted by diabetic patients and may reduce the dependency and dosage of some of the routine diabetes medications which often have some adverse side effects.


greenmedinfo--2020-06-12--Bioactive compounds, antioxidant and antimicrobial activities of extracts from different plant parts

Bioactive compounds, antioxidant and antimicrobial activities of extracts from different plant parts of two Ziziphus Mill. species

Ziziphus lotus L .
( Lam . )
and Z. mauritiana Lam.
, as a widespread species in Tunisia , @ @ @ @ @ medicinal and food uses .
The aim of the present study was to screen the @ @ @ @ @ flavonoids , and condensed tannins together with the radical scavenging capacity and the antimicrobial activity @ @ @ @ @ seeds extracts of Z. lotus and Z. mauritiana from different localities .
Results showed that @ @ @ @ @ phenolic compounds content for both species .
Furthermore , LC-ESI-MS analysis allowed the identification of @ @ @ @ @ species and organs , with the predominance of quinic acid and rutin .
Leaves extract @ @ @ @ @ highest total antioxidant capacity .
The antimicrobial tests showed that leaves extracts of Z. mauritiana @ @ @ @ @ Esseder exhibited the highest activity against four bacterial strains ( Staphylococcus aureus , Listeria monocytogenes @ @ @ @ @ coli ) .
The main results showed that the studied species of Ziziphus genus are @ @ @ @ @ bioactive molecules that could be an interesting material for industrial and food purposes .

Ziziphus lotus L. (Lam.) and Z. mauritiana Lam., as a widespread species in Tunisia, are well known for their medicinal and food uses. The aim of the present study was to screen the content of total polyphenols, flavonoids, and condensed tannins together with the radical scavenging capacity and the antimicrobial activity of leaves, fruits and seeds extracts of Z. lotus and Z. mauritiana from different localities. Results showed that leaves extracts presented the highest phenolic compounds content for both species. Furthermore, LC-ESI-MS analysis allowed the identification of 28 bioactive compounds regardless of species and organs, with the predominance of quinic acid and rutin. Leaves extract of Z. mauritiana possessed the highest total antioxidant capacity. The antimicrobial tests showed that leaves extracts of Z. mauritiana and Z. lotus from Oued Esseder exhibited the highest activity against four bacterial strains (Staphylococcus aureus, Listeria monocytogenes, Salmonella typhimurium and Escherichia coli). The main results showed that the studied species of Ziziphus genus are an excellent source of natural bioactive molecules that could be an interesting material for industrial and food purposes.


greenmedinfo--2020-06-12--Sage tea consumption may influence the oxidative status and reduce the blood glucose and atherogenic

Sage tea consumption may influence the oxidative status and reduce the blood glucose and atherogenic index in PCOS women.

Objective : Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome ( PCOS ) patients .
There are various reports about hypoglycemic and antioxidant effects ofL .
( common sage ) .
This study evaluated the possible medicinal effects of sage tea drinking on oxidative status , lipid profile , and insulin resistance in rats with testosterone-induced PCOS .
Materials and Methods : Eighteen immature female Wistar rats ( 21-day old ) were divided into 3 groups : 1 ) The Control group ( n=6 ) that received no treatment .
2 ) The PCOS group ( @ @ @ @ @ @ @ mg/kg BW for 35 days subcutaneously .
( 3 ) The PCOS -sage tea group ( n=6 ) to which after induction of PCOS by injection of testosterone enanthate , the sage tea was administered as a replacement of water for 14 days .
The beverages were refreshed every day .
The serum levels of total antioxidant capacity ( TAC ) , malondialdehyde ( MDA ) , glucose , insulin , HDL-C , total cholesterol , LDL-C , VLDL-C , total triglycerides , and atherogenic index were measured .
Results : Sage tea @ @ @ @ @ @ @ HDL-C , glucose , total cholesterol , LDL-C , and atherogenic index levels but it did not change the levels of MDA , insulin , total triglycerides , and VLDL-C .
Conclusion : Results suggested that sage tea consumption may influence the oxidative status and reduce the blood glucose and atherogenic index and may have cardiovascular protective effects in PCOS women .

Objective: Oxidative stress conditions and metabolic complications are common among polycystic ovary syndrome (PCOS) patients. There are various reports about hypoglycemic and antioxidant effects ofL. (common sage). This study evaluated the possible medicinal effects of sage tea drinking on oxidative status, lipid profile, and insulin resistance in rats with testosterone-induced PCOS.
Materials and Methods: Eighteen immature female Wistar rats (21-day old) were divided into 3 groups: 1) The Control group (n=6) that received no treatment. 2) The PCOS group (n=6) that received testosterone enanthate 10 mg/kg BW for 35 days subcutaneously. (3) The PCOS -sage tea group (n=6) to which after induction of PCOS by injection of testosterone enanthate, the sage tea was administered as a replacement of water for 14 days. The beverages were refreshed every day. The serum levels of total antioxidant capacity (TAC), malondialdehyde (MDA), glucose, insulin, HDL-C, total cholesterol, LDL-C, VLDL-C, total triglycerides, and atherogenic index were measured.
Results: Sage tea consumption increased serum TAC and decreased serum HDL-C, glucose, total cholesterol, LDL-C, and atherogenic index levels but it did not change the levels of MDA, insulin, total triglycerides, and VLDL-C.
Conclusion: Results suggested that sage tea consumption may influence the oxidative status and reduce the blood glucose and atherogenic index and may have cardiovascular protective effects in PCOS women.


greenmedinfo--2020-06-12--Jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin

Jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging.

Objective : Oxidative stress and ultraviolet B ( UVB ) irradiation are known as principal inducers of DNA damage and modulators of gene expression in aging process and skin photoaging , which are associated with upregulation of matrix metalloproteinases ( MMPs ) .
Because of the antioxidant capacity of jujube and green tea , we decided to determine their protective effects of human fibroblast cells against UVB-induced photo-damage and reduction of MMP-2 and MMP-9 expression .
Materials and Methods : We exposed human fibroblast cells to different doses of UVB ( 0-20 mJ/cm ) with or without different concentrations of @ @ @ @ @ @ @ viability was assessed using MTT assay .
Total antioxidant capacity and free radical scavenging activity of cell supernatant were assessed using FRAP and DPPH methods , respectively .
The concentrations of MMP-2 and MMP-9 in the samples were determined by ELISA kits .
Results : Fibroblast cells viability , 24 hr after UVB irradiation , reduced about 70 % compared to the controls .
Pre-treatment of the cells with jujube extract ( 8 mg/ml ) increased the cell viability by almost 85 % while green tea ( 0.5 mg/ml ) protected the irradiated @ @ @ @ @ @ @ MMP-2 and MMP-9 content decreased in a concentration-dependent manner in the cells pre-treated with jujube and green tea extracts .
Conclusion : These data suggest that jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging and can be suggested as a potential candidate for the development of new anti-UVB medicines and cosmetic products .

Objective: Oxidative stress and ultraviolet B (UVB) irradiation are known as principal inducers of DNA damage and modulators of gene expression in aging process and skin photoaging, which are associated with upregulation of matrix metalloproteinases (MMPs). Because of the antioxidant capacity of jujube and green tea, we decided to determine their protective effects of human fibroblast cells against UVB-induced photo-damage and reduction of MMP-2 and MMP-9 expression.
Materials and Methods: We exposed human fibroblast cells to different doses of UVB (0-20 mJ/cm) with or without different concentrations of jujube and green tea extracts. Cell viability was assessed using MTT assay. Total antioxidant capacity and free radical scavenging activity of cell supernatant were assessed using FRAP and DPPH methods, respectively. The concentrations of MMP-2 and MMP-9 in the samples were determined by ELISA kits.
Results: Fibroblast cells viability, 24 hr after UVB irradiation, reduced about 70% compared to the controls. Pre-treatment of the cells with jujube extract (8 mg/ml) increased the cell viability by almost 85% while green tea (0.5 mg/ml) protected the irradiated cells by 71%. Also, MMP-2 and MMP-9 content decreased in a concentration-dependent manner in the cells pre-treated with jujube and green tea extracts.
Conclusion: These data suggest that jujube and green tea could be useful to attenuate solar UVB light-induced oxidative stress and skin photoaging and can be suggested as a potential candidate for the development of new anti-UVB medicines and cosmetic products.


greenmedinfo--2020-06-12--Agathisflavone inhibits influenza virus neuraminidase.

BACKGROUND : Neuraminidase inhibitors ( NAIs ) are the only class of antivirals in clinical use against influenza virus approved worldwide .
However , approximately 1-3 % of circulating strains present resistance mutations to oseltamivir ( OST ) , the most used NAI .
Therefore , it is important to catalogue new molecules to inhibit influenza virus , especially OST-resistant strains .
Natural products from tropical plants used for human consumption represent a worthy class of substances .
Their use could be stimulated in resource-limited setting where the access to expensive antiviral therapies is restricted .
METHODS : We evaluated @ @ @ @ @ @ @ from Anacardium occidentale L. RESULTS : The neuraminidase ( NA ) activity of wild-type and OST-resistant influenza virus was inhibited by agathisflavone , with IC50 values ranging from 20 to 2.0µM , respectively .
Agathisflavone inhibited influenza virus replication with EC50 of 1.3 µM .
Sequential passages of the virus in the presence of agathisflavone revealed the emergence of mutation R249S , A250S and R253Q in the NA gene .
These changes are outside the OST binding region , meaning that agathisflavone targets this viral enzyme at a region different than conventional NAIs @ @ @ @ @ @ @ that agathisflavone has a promising chemical structure for the development of anti-influenza drugs .

BACKGROUND: Neuraminidase inhibitors (NAIs) are the only class of antivirals in clinical use against influenza virus approved worldwide. However, approximately 1-3% of circulating strains present resistance mutations to oseltamivir (OST), the most used NAI. Therefore, it is important to catalogue new molecules to inhibit influenza virus, especially OST-resistant strains. Natural products from tropical plants used for human consumption represent a worthy class of substances. Their use could be stimulated in resource-limited setting where the access to expensive antiviral therapies is restricted.
METHODS: We evaluated the anti-influenza virus activity of agathisflavone derived from Anacardium occidentale L.
RESULTS: The neuraminidase (NA) activity of wild-type and OST-resistant influenza virus was inhibited by agathisflavone, with IC50 values ranging from 20 to 2.0µM, respectively. Agathisflavone inhibited influenza virus replication with EC50 of 1.3 µM. Sequential passages of the virus in the presence of agathisflavone revealed the emergence of mutation R249S, A250S and R253Q in the NA gene. These changes are outside the OST binding region, meaning that agathisflavone targets this viral enzyme at a region different than conventional NAIs.
CONCLUSION: Altogether our data suggest that agathisflavone has a promising chemical structure for the development of anti-influenza drugs.


greenmedinfo--2020-06-12--Anacardic acid mitigates liver fat accumulation and impaired glucose tolerance in mice fed a high‐fa

Anacardic acid mitigates liver fat accumulation and impaired glucose tolerance in mice fed a high‐fat and high‐sucrose diet

In this study , we evaluated the effects of anacardic acid ( AA ) , a phenolic lipid found in @ @ @ @ @ on metabolic disorders related to obesity , fatty liver disease , and diabetes using both @ @ @ @ @ models .
The application of AA led to a reduction in lipid accumulation in 3T3-L1 @ @ @ @ @ Results from Western blot analysis revealed that AA treatment also led to decreased expression of @ @ @ @ @ proliferator-activated receptor gamma .
In vivo studies were performed to evaluate the effects of AA @ @ @ @ @ and diabetes .
Mice fed a high-fat and high-sucrose diet had significantly higher body and @ @ @ @ @ levels of liver fat , cholesterol , fasting glucose , and homeostasis model assessment of @ @ @ @ @ .
However , 12 weeks of oral treatment with 500 μg/kg BW AA slowed down @ @ @ @ @ liver and mitigated insulin resistance in these mice .
Thus , AA may reduce lipid @ @ @ @ @ effect .

In this study, we evaluated the effects of anacardic acid (AA), a phenolic lipid found in cashew nuts (), on metabolic disorders related to obesity, fatty liver disease, and diabetes using both in vitro and in vivo models. The application of AA led to a reduction in lipid accumulation in 3T3-L1 cells without observable cytotoxicity. Results from Western blot analysis revealed that AA treatment also led to decreased expression of fatty acid synthase and peroxisome proliferator-activated receptor gamma. In vivo studies were performed to evaluate the effects of AA treatment on fatty liver disease and diabetes. Mice fed a high-fat and high-sucrose diet had significantly higher body and liver weights, and higher levels of liver fat, cholesterol, fasting glucose, and homeostasis model assessment of insulin resistance (HOMA-IR). However, 12 weeks of oral treatment with 500 μg/kg BW AA slowed down lipid accumulation rates in the liver and mitigated insulin resistance in these mice. Thus, AA may reduce lipid levels and have an antidiabetic effect.


greenmedinfo--2020-06-12--Anti-proliferative profile of Anacardium occidentale polysaccharide.

This paper explores the application of cashew gum ( CG ) as an in vitro antiproliferative , firstly by isolating @ @ @ @ @ elemental analysis , gel-permeation chromatography , nuclear magnetic resonance ( NMR ) and atomic force @ @ @ @ @ The molar mass of isolated CG was in the order of 10-10 g/mol , with @ @ @ @ @ Polymer characterization by NMR identified key signals correlating to galactose , glucose , rhamnose and @ @ @ @ @ conformational stages were observed by AFM .
The impact of CG on cell morphology and @ @ @ @ @ non-tumor cell lines was studied by AFM and 3- ( 4,5-dimethyl-2-thiazole ) -2,5-diphenyl-2-H-tetrazolium bromide ( @ @ @ @ @ Antiproliferative activity was confirmed for HCT116 ( colorectal carcinoma ) , B16F10 ( melanoma ) @ @ @ @ @ ) cancer cell lines .
A change in cell morphology was demonstrated as an increased @ @ @ @ @ Considering that a CG does not exhibit cytotoxicity to non-tumor lines , it can be @ @ @ @ @ selectivity for tumor cells and can be a promising biomaterial for future studies .

This paper explores the application of cashew gum (CG) as an in vitro antiproliferative, firstly by isolating and characterizing the gum using elemental analysis, gel-permeation chromatography, nuclear magnetic resonance (NMR) and atomic force microscopy (AFM). The molar mass of isolated CG was in the order of 10-10 g/mol, with small protein traces present. Polymer characterization by NMR identified key signals correlating to galactose, glucose, rhamnose and acid-related groups. Three distinct conformational stages were observed by AFM. The impact of CG on cell morphology and viability with both tumor and non-tumor cell lines was studied by AFM and 3-(4,5-dimethyl-2-thiazole)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay respectively. Antiproliferative activity was confirmed for HCT116 (colorectal carcinoma), B16F10 (melanoma) and HL60 (promyelocytic leukemia) cancer cell lines. A change in cell morphology was demonstrated as an increased surface roughness for HL60. Considering that a CG does not exhibit cytotoxicity to non-tumor lines, it can be seen that the CG shows selectivity for tumor cells and can be a promising biomaterial for future studies.


greenmedinfo--2020-06-12--Consumption of cashew nuts may be beneficial for the management of colitis.

BACKGROUND : L. is a tropical plant used for the treatment of inflammatory diseases .
The goal of the present work was to investigate the anti-inflammatory and anti-oxidant potential of oral administration of cashew nuts ( fromL . )
in a mouse model of colitis .
METHODS : Induction of colitis was performed by intrarectally injection of dinitrobenzene sulfonic acid ( DNBS ) .
Cashew nuts were administered daily orally ( 100 mg/kg ) in DNBS-injected mice .
RESULTS : Four days after DNBS , histological and macroscopic colon alterations as well as marked clinical signs and increased cytokine production @ @ @ @ @ @ @ by myeloperoxidase ( MPO ) positive immunostaining , was correlated with up-regulation of adhesion molecules ICAM-1 and P-selectin in colons .
Oxidative stress was detected with increased malondialdehyde ( MDA ) levels , nitrotyrosine , and poly ADP-ribose polymerase ( PARP ) positive staining in inflamed colons .
Oral treatment with cashew nuts reduced histological , macroscopic damage , neutrophil infiltration , pro-inflammatory cytokines and MDA levels , as well as nitrotyrosine , PARP and ICAM-1 , and P-selectin expressions .
Colon inflammation could be related to nuclear factor ( NF ) -kB @ @ @ @ @ @ @ ( MnSOD ) antioxidant activity .
Cashew nuts administration inhibited NF-kB and increased MnSOD antioxidant expressions .
CONCLUSIONS : The results suggested that oral assumption of cashew nuts may be beneficial for the management of colitis .

BACKGROUND: L. is a tropical plant used for the treatment of inflammatory diseases. The goal of the present work was to investigate the anti-inflammatory and anti-oxidant potential of oral administration of cashew nuts (fromL.) in a mouse model of colitis.
METHODS: Induction of colitis was performed by intrarectally injection of dinitrobenzene sulfonic acid (DNBS). Cashew nuts were administered daily orally (100 mg/kg) in DNBS-injected mice.
RESULTS: Four days after DNBS, histological and macroscopic colon alterations as well as marked clinical signs and increased cytokine production were observed. Neutrophil infiltration, measured by myeloperoxidase (MPO) positive immunostaining, was correlated with up-regulation of adhesion molecules ICAM-1 and P-selectin in colons. Oxidative stress was detected with increased malondialdehyde (MDA) levels, nitrotyrosine, and poly ADP-ribose polymerase (PARP) positive staining in inflamed colons. Oral treatment with cashew nuts reduced histological, macroscopic damage, neutrophil infiltration, pro-inflammatory cytokines and MDA levels, as well as nitrotyrosine, PARP and ICAM-1, and P-selectin expressions. Colon inflammation could be related to nuclear factor (NF)-kB pathway activation and reduced manganese superoxide dismutase (MnSOD) antioxidant activity. Cashew nuts administration inhibited NF-kB and increased MnSOD antioxidant expressions.
CONCLUSIONS: The results suggested that oral assumption of cashew nuts may be beneficial for the management of colitis.