renegadetribune--2020-08-27--Natural Substances that Fight Malignant Melanoma

Conventional medicine offers little hope in the fight against deadly malignant melanoma , but there are multiple foods , botanicals , and vitamins with proven anti-melanoma activity within nature ’ s pharmacopeia Cutaneous malignant melanoma , one of the most aggressive types of tumors , accounts for 75 % of death due to cancer , and its incidence is on the rise worldwide ( 1 , 2 ) .
In North America , it has become the most prevalent form of cancer for the demographic aged 25 to 29 ( 3 ) .
When detected early , surgical excision of @ @ @ @ @ @ @ care .
However , metastatic melanoma , wherein the tumor cells detach from the primary growth and disseminate to distant organs , is notoriously resistant to conventional radiation , immunotherapy , and chemotherapy ( 3 ) .
Even after surgical removal , recurrence is a distinct possibility , and therapies employed by the biomedical paradigm have limited success ( 4 ) .
Commonly employed treatments include the DNA alkylating chemotherapeutic agent , dacarbazine , which have response rates of 10 to 26 % , most of which are partial , and are accompanied @ @ @ @ @ @ @ , neutropenia , and thrombocytopenia ( 5 ) .
More selective therapies such as BRAF inhibitors , targeted for the small percentage of advanced melanoma patients with a genetic BRAF V600 mutation , are associated with widespread resistance and the development of other cancers , including keratoacanthoma and squamous cell carcinoma , as side effects ( 6 ) .
For metastatic melanoma , the five-year survival rate is dismal at less than 25 % ( 6 ) .
However , there are evidence-based natural substances supported by the scientific literature for their anti-melanoma @ @ @ @ @ @ @ an adjunctive approached alongside other multi-pronged strategies .
Although regarded in modernity as a pesky garden weed , dandelion , or Taraxacum officinale , has long been a staple of traditional Chinese , Middle Eastern , and Native American folk medicine ( 3 , 7 , 8 ) .
It has been used by traditional medical systems for digestive , kidney , liver , and spleen disorders , as well as tumors of the lung , breast , and uterus ( 7 ) .
Dandelion is renowned in holistic medicine as a detoxifying @ @ @ @ @ @ @ anti-oxidant , anti-angiogenic ( prevents growth of blood vessels that supply tumors with nutrients ) , anti-nociceptive ( attenuates sensation of pain ) , and anti-cancer ( 3 ) .
Studies have demonstrated that dandelion transforms mouse melanoma cells from a proliferative phenotype , which epitomizes the profligate cell division of cancer growth , to a differentiated phenotype representative of restoration of a normal cell cycle ( 9 , Salem et al.
, 2004 ) .
Lupeol-a , the triterpene compound in dandelion found to elicit this effect , is cytostatic , meaning @ @ @ @ @ @ @ ( 9 ) .
Taraxacum japonicum , a species of dandelion native to Japan , has also been shown to suppress two stages of carcinogenesis , namely , tumor initiation and promotion ( 10 ) .
It was concluded that a triterpenoid compound called taxasterol within dandelion is a chemopreventative , meaning an agent that slows or prevents the development of cancer ( 10 ) .
In an in vitro study , researchers propose that dandelion root extract represents a novel chemotherapeutic agent , as it selectively induced apoptosis , or programmed cell @ @ @ @ @ @ @ while preserving noncancerous cells ( 3 ) .
Not only do healthy cells remain unaffected , but “ melanoma cells retain the signals to commit suicide long after DRE [ dandelion root extract ] has been removed from the system ” ( 3 ) .
According to researchers , various compounds in dandelion root , including triterpenes , sesquiterpenes , coumarins , and phenolic compounds likely work synergistically to invoke anti-cancer effects ( 3 ) .
They conclude , “ We believe that this nontoxic extract can undergo precipitous translation from bench top @ @ @ @ @ @ @ are already commercially available in the form of tea and supplements…as a chemotherapeutic against aggressive chemoresistant cancers ” ( 3 ) .
For those with ragweed allergies , however , caution may be warranted because dandelion can be cross-reactive since they both reside in the Asteraceae ( Compositae ) family .
UV-induced sunburn lesions , which represent a potent risk factor for melanoma , are inhibited by caffeine , which elicits a sunscreen-like effect in rodent studies ( 1 ) .
Not only does caffeine suppress growth of melanoma cells in vitro and @ @ @ @ @ @ @ cell suicide , also known as apoptosis , induced by UV exposure ( 1 ) .
This effectively enhances clearance of defective precancerous cells ( 1 ) .
One epidemiological study compiled data from 74,666 women in the Nurses ’ Health Study , 89,220 women in the Nurses ’ Health Study II , and 39,424 men in the Health Professionals Follow-up Study , comprising over 4 million person-years of follow-up ( 1 ) .
After adjusting for confounding variables , it was found that a high caffeine intake ( ≥ 393 mg/day ) @ @ @ @ @ @ @ cutaneous malignant melanoma than a low intake ( < 60 mg/day ) ( 1 ) .
This correlation was particularly prominent in women , where high caffeine intake decreased risk by 22 % relative to low intake ( 1 ) .
The inverse relationship between caffeine intake and melanoma risk was likewise more apparent for melanomas occurring on anatomic sites such as the head , neck , and extremities , which receive greater sun exposure , compared to sites on the trunk normally insulated from the sun ( 1 ) .
A staple @ @ @ @ @ @ @ , ashwagandha or Withania somnifera is an adaptogenic herb that increases non-specific resistance to chemical , biological , and physical insults , enhances survival during stress , and counteracts pathology ( 11 ) .
It has historically been used to augment energy and to treat musculoskeletal conditions such as arthritis and rheumatism ( 12 ) .
In addition to its anti-stress effects , ashwagandha is classified as an antioxidant , anti-parkinsonism , anti-ageing , antiulcerogenic , and anti-tumor agent ( Halder et al.
, 2015 ) .
In fact , it exhibits anti-tumor @ @ @ @ @ @ @ renal , pancreatic , fibrosarcoma , leukemia , and mouse lung adenoma cells ( 13 ) .
Notably , a crude water extract of ashwagandha reduced viability of human malignant melanoma cells in a dose- and time-dependent manner ( 13 ) .
Morphological changes in ashwagandha-treated cells appeared , such as formation of apoptotic bodies , nuclear blebbing , and DNA fragmentation , indicating that ashwagandha induced programmed cell death in melanoma cell lines ( 13 ) .
The authors conclude that the ashwagandha extract exhibited a potent chemotherapeutic effect , or cytotoxic @ @ @ @ @ @ @ ( 13 ) .
Not just limited to holiday romance , the festive plant mistletoe , a hemiparasitic evergreen shrub , is routinely used in complementary cancer therapy in Central Europe ( 14 ) .
Since ancient times , it has been perceived as a mystical plant and was used for ailments of the spleen and kidney in the middle ages ( 15 ) .
Mistletoe likewise demonstrates anti-hypertensive , anti-rheumatic , anti-diabetic , and antioxidant effects , but since the early twentieth century , it has been used as a cancer therapy @ @ @ @ @ @ @ are conflicting , in vivo and in vitro studies have highlighted anti-tumor effects of mistletoe against acute lymphoblastic leukemia , various carcinomas , and melanoma cells ( 15 , 16 , 17 ) .
In addition , mistletoe has prolonged survival in patients with pancreatic cancer as well as breast and gynecological cancers in human studies ( 18 ) .
One systematic review analyzed 23 controlled clinical trials of mistletoe in cancer , including cancers of the bladder , breast , colon , genital , head and neck , kidney , lung , @ @ @ @ @ @ @ and melanoma ( 19 ) .
Although results were mixed and heterogeneity of studies was identified , statistically significant increases in survival and quality of life were reported in eight and three trials , respectively ( 19 ) .
In another review , 22 of 26 randomized controlled trials ( RCTs ) and all 10 of 10 non-RCTs analyzed reported that mistletoe improved quality of life in patients with malignant disease ( 20 ) .
Mistletoe likewise reduces the side effects of conventional cytoreductive treatments ( 20 ) .
When used in concert @ @ @ @ @ @ @ “ coping , fatigue , sleep , exhaustion , energy , nausea , vomiting , appetite , depression , anxiety , ability to work , and emotional and functional well-being in general ” ( 20 , p.142 ) .
Especially relevant to cancer is the immunomodulatory effect of mistletoe extract , as mistletoe can enhance both humoral ( antibody-mediated ) and cellular immune responses when injected into cancer patients ( 21 ) , potentially increasing the ability of the immune system to eliminate cancer .
In fact , in a mouse melanoma model @ @ @ @ @ @ @ promoting secretion of a signaling molecule called interleukin-12 ( IL-12 ) , which causes immune cells in the spleen to proliferate ( 22 ) , up-regulating immune defenses against cancer .
Also , researchers state that , “ Polysaccharides present in the herb and in berries increased phagocytic activity of granulocytes and macrophages in in vitro experiments , ” which increases the ability of immune cells to eat and dispose of defective or neoplastic cells ( 15 , p. 378 ) It is hypothesized that water soluble mistletoe lectins are the active anti-cancer @ @ @ @ @ @ @ polysaccharides , phenolic compounds , and viscotoxins ( 14 , 23 ) .
Lectins in particular induce programmed cell death , or apoptosis , in cancer cell lines , and exhibit direct cytotoxic ( cancer cell killing ) activity ( 15 ) .
Commercial methods of aqueous mistletoe purification are not able to extract water insoluble triterpenoids , which have anti-melanoma effects ( 24 ) .
However , one mouse study using a novel method to produce triterpenoid-enriched mistletoe extracts found that this variety amplified the anti-tumor effects of mistletoe ( 14 ) @ @ @ @ @ @ @ which had a dense network of blood vessels surrounding the tumor , the mistletoe extract and solubilized triterpenoids elicited anti-angiogenic effects , causing blood vessels around the tumor to collapse , preventing delivery of nutrients to the tumor ( 14 ) .
In this model , mistletoe extracts led to the significant suppression of tumor growth , which was further enhanced by combined treatment with triterpenoids ( 14 ) .
Sulforaphane is an isothiocyanate compound found in all cruciferous vegetables , such as arugula , broccoli , Brussel sprouts , cabbage , cauliflower @ @ @ @ @ @ @ , rutabaga , turnip , wasabi , and watercress .
However , it is particularly concentrated in broccoli sprouts , which contain 10 to 100 times the glucoraphanin content of the mature plants , which is a glucosinolate of sulforaphane ( 25 ) .
In vitro and in vivo models demonstrate that sulforaphane induces apoptosis , or cell suicide , in melanoma cells , as indicated by predictable morphological changes that occur with cell death , such as condensation and fragmentation of genetic material and a step in cellular disassembly called membrane blebbing @ @ @ @ @ @ @ model , when sulforaphane was administered simultaneously with melanoma development , “ There was 95.5 % inhibition of lung tumour nodule formation and 94.06 % increase in the life span of metastatic tumour bearing animals ” ( 27 ) .
At a mechanistic level , sulforaphane prevented invasion of melanoma cells to secondary sites by inhibiting the activation of matrix metalloproteinases ( MMPs ) , enzymes which hydrolyze , or degrade extracellular proteins such as collagens and elastin and allow for tumors to migrate ( 27 ) .
The researchers conclude , “ @ @ @ @ @ @ @ [ sulforaphane ] may be a promising candidate for molecular-targeting chemotherapy against melanoma ” ( 26 , p. 332 ) .
Gonzalez and colleagues ( 2012 ) proposed the revolutionary bioenergetic theory of carcinogenesis , which posits that cancer originates when cells revert to a more primitive phenotype favoring uncontrolled proliferation and cell immortalization ( 28 ) .
This occurs as an adaptive response to ensure survival in the harsh cellular milieu and toxic external environment that so drastically departs from the one in which we evolved ( 28 ) .
Cancer cells @ @ @ @ @ @ @ glycolysis instead of the mitochondrial-based , oxygen-dependent oxidative phosphorylation , which is the primary generator of energy currency in the body ( 29 ) .
One reason malignant cells switch to fermentation , or anaerobic ( oxygen-independent ) processes for energy production , is due to defective mitochondrial membrane potential , which can be corrected by vitamin C ( 29 ) .
In this respect , ascorbate , the water-soluble vitamin C , may be helpful by increasing electron flux through the mitochondria , restoring energy production such that apoptosis of cancer cells @ @ @ @ @ @ @ can occur ( 29 ) .
Vitamin C also optimizes cellular differentiation and intercellular communication , both of which are compromised in a cancerous state and perpetuate tumor growth ( 29 ) .
Further , vitamin C up-regulates the proliferation and activity of lymphocytes , or white blood cells , and prevents oxidative damage that would engender further mitochondrial dysfunction ( 30 , 31 ) .
In addition , vitamin C increases the anti-malignancy effects of lysosomes , the ‘ garbage disposal ’ organelles that reside within white blood cells , which control @ @ @ @ @ @ @ cells vulnerable to death pathways ( 32 , 33 ) .
Likewise , vitamin C promotes collagen formation , which can sequester tumors , inhibit their growth , and prevent tumor metastasis ( 30 ) .
Along the same lines , vitamin C interferes with the action of hyaluronidase , an enzyme which degrades connective tissue and allows tumors to spread , in order to wall off the tumor with ground substance ( 30 ) .
Remarkably , high concentrations of vitamin C are selectively toxic to tumors but not to normal tissues @ @ @ @ @ @ @ it elicits anti-cancer effects by facilitating the formation of hydrogen peroxide ( a reactive oxygen species ) in the extracellular space , which can produce other free radicals such as aldehydes and hydroxyl radicals that in turn jeopardize cell viability ( 34 ) .
Hydrogen peroxide not only generates double-stranded DNA breaks , which induces death of cancer cells , but it also recruits immune cells to the site of the tumor to eliminate cancer cells ( 35 , 36 ) .
Whereas normal cells have adequate levels of catalase , an enzyme @ @ @ @ @ @ @ damage , malignant cells are deficient in this antioxidant enzyme , harboring 10 to 100 fold less catalase content than healthy cells ( 37 ) .
In the 1970s , Nobel Prize winner Linus Pauling conducted experiments demonstrating that high dose vitamin C therapy elongated survival of cancer patients by four times compared to controls ( 38 ) .
In another study , “ all melanoma cell lines were susceptible to ascorbate-mediated cytotoxicity , ” and “ pharmacologic ascorbate was superior or equivalent to dacarbazine as an anti tumor agent ” ( 6 @ @ @ @ @ @ @ melanoma cells , ascorbic acid induced apoptosis by acting as a pro-oxidant and increasing intracellular levels of reactive oxygen species , which disrupted membrane potential and lead to cell death ( 39 ) .
Researchers state , “ While AA [ ascorbic acid ] alone may not be enough of an intervention in the treatment of most active cancers , it appears to improve quality of life and extend survival and it should be considered as part of the treatment protocol for all patients with cancer ” ( 29 , p. 31 ) @ @ @ @ @ @ @ as oral supplementation is unlikely to generate plasma concentrations required to kill tumor cells ( 37 ) .
The combination of vitamin C with other mitochondrial support such as B vitamins , magnesium , coenzyme Q10 ( CoQ10 ) , acetyl L-carnitine , alpha lipoic acid , pyrroloquinoline quinone ( PQQ ) , D-ribose , creatine , and phospholipids , would be ideal for reversing the metabolic derangements observed in cancer ( 38 , 40 ) .
Polyphenols , which represent secondary metabolites of plants that evolved as defense mechanisms against pests and @ @ @ @ @ @ @ disease , diabetes , osteoporosis , neurodegenerative disorders , and cancers ( 41 ) .
Catechin , a polyphenol in green tea , has been elucidated to render collagen resistant to degradation by the mammalian enzyme collagenase ( 42 ) .
Therefore , researchers tested various polyphenols to see if they could inhibit the basement membrane degradation that is essential to melanoma metastasis to the lungs ( 43 ) .
For metastasis to take place , tumor cells must be liberated from the primary tumor into circulation , adhere to the extracellular matrix @ @ @ @ @ @ @ the proteolytic cleavage of the basement membrane , or the fibrous layer of connective tissue that divides epithelial cells from the underlying lamina propria ( 43 ) .
Finally , the malignant cells attach to the secondary site and tumor growth resumes ( 43 ) .
However , metastasis could be arrested if any one of the steps in this sequential process were prevented ( 43 ) .
In this experiment , curcumin , from the spice turmeric , and ellagic acid , which is abundant in red grapes , were directly toxic @ @ @ @ @ @ @ , indicating their anticarcinogen potential ( 43 ) .
Further , many of the polyphenols significantly reduced melanoma metastasis to the lungs , with curcumin , catechin , rutin ( from figs , apples , and tea ) , epicatechin ( from dark chocolate ) , and naringin and naringenin ( from grapefruit ) reducing lung tumor colonies by 89.28 % , 82.2 % , 71.2 % , 61 % , 27.2 % , and 26.1 % , respectively ( 43 ) .
In order of appearance , these polyphenols increased lifespan of @ @ @ @ @ @ @ , 63.59 % , 55.29 % , 26.6 % , and 27.18 % ( 43 ) .
The best strategy would be to obtain polyphenolic compounds from whole foods sources in order to obtain the synergistic effects of other active constituents .
As a general rule , the deeper pigmented the fruit or vegetable , the higher the polyphenolic content .
Polyphenols inhibit cancer through pleiotropic mechanisms , including “ estrogenic/antiestrogenic activity , antiproliferation , induction of cell cycle arrest or apoptosis , prevention of oxidation , induction of detoxification enzymes , regulation @ @ @ @ @ @ @ activity and changes in cellular signaling ” ( 41 ) .
For those with a family history of melanoma interested in prevention , sun exposure is a contentious topic .
According to researchers , “ It has been documented that the role of sunlight in melanoma differs according to anatomic site , which is supportive of the hypothesis that melanomas may arise through divergent etiologic pathways ” ( 1 ) .
Although frequency of ultraviolet ( UV ) radiation-induced sunburns represents one of the primary risk factors for ( 44 ) , the @ @ @ @ @ @ @ is convoluted .
A longitudinal study tracking 38,000 women for 15 years , in fact , found that chronic sun exposure was protective against malignant melanoma , whereas intermittent sun exposure elevated melanoma risk ( 45 ) .
Contrary to popular belief , sun exposure was found to be protective , as it was also correlated with significantly reductions in cardiovascular and all-cause mortality ( 45 ) .
Therefore , habitual insulation from the sun is clearly deleterious , but safe sunning practices should still be observed to avoid burning and potential detriment @ @ @ @ @ @ @ people with cancer now can not wait for research to be translated into clinical practice and adopted as standard of care .
Given the nontoxic nature of the aforementioned interventions , they can easily be incorporated into the arsenal of modalities used to reverse cancer as elements of a multi-faceted approach that addresses diet , exercise , sleep , stress , social support , latent infections , hormonal balance , detoxification , and mitochondrial dysfunction .
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Conventional medicine offers little hope in the fight against deadly malignant melanoma, but there are multiple foods, botanicals, and vitamins with proven anti-melanoma activity within nature’s pharmacopeia
Cutaneous malignant melanoma, one of the most aggressive types of tumors, accounts for 75% of death due to cancer, and its incidence is on the rise worldwide (1, 2). In North America, it has become the most prevalent form of cancer for the demographic aged 25 to 29 (3). When detected early, surgical excision of the primary site is the standard of care. However, metastatic melanoma, wherein the tumor cells detach from the primary growth and disseminate to distant organs, is notoriously resistant to conventional radiation, immunotherapy, and chemotherapy (3).
Even after surgical removal, recurrence is a distinct possibility, and therapies employed by the biomedical paradigm have limited success (4). Commonly employed treatments include the DNA alkylating chemotherapeutic agent, dacarbazine, which have response rates of 10 to 26%, most of which are partial, and are accompanied by side effects including anemia, nausea, neutropenia, and thrombocytopenia (5). More selective therapies such as BRAF inhibitors, targeted for the small percentage of advanced melanoma patients with a genetic BRAF V600 mutation, are associated with widespread resistance and the development of other cancers, including keratoacanthoma and squamous cell carcinoma, as side effects (6).
For metastatic melanoma, the five-year survival rate is dismal at less than 25% (6). However, there are evidence-based natural substances supported by the scientific literature for their anti-melanoma effects, which may be used as an adjunctive approached alongside other multi-pronged strategies.
Dandelion
Although regarded in modernity as a pesky garden weed, dandelion, or Taraxacum officinale, has long been a staple of traditional Chinese, Middle Eastern, and Native American folk medicine (3, 7, 8). It has been used by traditional medical systems for digestive, kidney, liver, and spleen disorders, as well as tumors of the lung, breast, and uterus (7). Dandelion is renowned in holistic medicine as a detoxifying agent, but is also anti-inflammatory, anti-oxidant, anti-angiogenic (prevents growth of blood vessels that supply tumors with nutrients), anti-nociceptive (attenuates sensation of pain), and anti-cancer (3).
Studies have demonstrated that dandelion transforms mouse melanoma cells from a proliferative phenotype, which epitomizes the profligate cell division of cancer growth, to a differentiated phenotype representative of restoration of a normal cell cycle (9, Salem et al., 2004). Lupeol-a, the triterpene compound in dandelion found to elicit this effect, is cytostatic, meaning that it inhibits cell growth and multiplication (9).
Taraxacum japonicum, a species of dandelion native to Japan, has also been shown to suppress two stages of carcinogenesis, namely, tumor initiation and promotion (10). It was concluded that a triterpenoid compound called taxasterol within dandelion is a chemopreventative, meaning an agent that slows or prevents the development of cancer (10). In an in vitro study, researchers propose that dandelion root extract represents a novel chemotherapeutic agent, as it selectively induced apoptosis, or programmed cell death, in human melanoma cells, while preserving noncancerous cells (3). Not only do healthy cells remain unaffected, but “melanoma cells retain the signals to commit suicide long after DRE [dandelion root extract] has been removed from the system” (3).
According to researchers, various compounds in dandelion root, including triterpenes, sesquiterpenes, coumarins, and phenolic compounds likely work synergistically to invoke anti-cancer effects (3). They conclude, “We believe that this nontoxic extract can undergo precipitous translation from bench top to bedside, with dandelion products that are already commercially available in the form of tea and supplements…as a chemotherapeutic against aggressive chemoresistant cancers” (3). For those with ragweed allergies, however, caution may be warranted because dandelion can be cross-reactive since they both reside in the Asteraceae (Compositae) family.
Coffee
UV-induced sunburn lesions, which represent a potent risk factor for melanoma, are inhibited by caffeine, which elicits a sunscreen-like effect in rodent studies (1). Not only does caffeine suppress growth of melanoma cells in vitro and in vivo, but it also up-regulates cell suicide, also known as apoptosis, induced by UV exposure (1). This effectively enhances clearance of defective precancerous cells (1).
One epidemiological study compiled data from 74,666 women in the Nurses’ Health Study, 89,220 women in the Nurses’ Health Study II, and 39,424 men in the Health Professionals Follow-up Study, comprising over 4 million person-years of follow-up (1). After adjusting for confounding variables, it was found that a high caffeine intake (≥ 393 mg/day) was associated with a lower risk of cutaneous malignant melanoma than a low intake (< 60 mg/day) (1). This correlation was particularly prominent in women, where high caffeine intake decreased risk by 22% relative to low intake (1).
The inverse relationship between caffeine intake and melanoma risk was likewise more apparent for melanomas occurring on anatomic sites such as the head, neck, and extremities, which receive greater sun exposure, compared to sites on the trunk normally insulated from the sun (1).
Ashwagandha
A staple in traditional Ayurvedic and Unani medical systems, ashwagandha or Withania somnifera is an adaptogenic herb that increases non-specific resistance to chemical, biological, and physical insults, enhances survival during stress, and counteracts pathology (11). It has historically been used to augment energy and to treat musculoskeletal conditions such as arthritis and rheumatism (12). In addition to its anti-stress effects, ashwagandha is classified as an antioxidant, anti-parkinsonism, anti-ageing, antiulcerogenic, and anti-tumor agent (Halder et al., 2015). In fact, it exhibits anti-tumor effects in human breast, prostate, renal, pancreatic, fibrosarcoma, leukemia, and mouse lung adenoma cells (13).
Notably, a crude water extract of ashwagandha reduced viability of human malignant melanoma cells in a dose- and time-dependent manner (13). Morphological changes in ashwagandha-treated cells appeared, such as formation of apoptotic bodies, nuclear blebbing, and DNA fragmentation, indicating that ashwagandha induced programmed cell death in melanoma cell lines (13). The authors conclude that the ashwagandha extract exhibited a potent chemotherapeutic effect, or cytotoxic effect, on human malignant melanoma cells (13).
Mistletoe
Not just limited to holiday romance, the festive plant mistletoe, a hemiparasitic evergreen shrub, is routinely used in complementary cancer therapy in Central Europe (14). Since ancient times, it has been perceived as a mystical plant and was used for ailments of the spleen and kidney in the middle ages (15). Mistletoe likewise demonstrates anti-hypertensive, anti-rheumatic, anti-diabetic, and antioxidant effects, but since the early twentieth century, it has been used as a cancer therapy (15).
Although human trials are conflicting, in vivo and in vitro studies have highlighted anti-tumor effects of mistletoe against acute lymphoblastic leukemia, various carcinomas, and melanoma cells (15, 16, 17). In addition, mistletoe has prolonged survival in patients with pancreatic cancer as well as breast and gynecological cancers in human studies (18). One systematic review analyzed 23 controlled clinical trials of mistletoe in cancer, including cancers of the bladder, breast, colon, genital, head and neck, kidney, lung, and stomach, as well as gliomas and melanoma (19). Although results were mixed and heterogeneity of studies was identified, statistically significant increases in survival and quality of life were reported in eight and three trials, respectively (19).
In another review, 22 of 26 randomized controlled trials (RCTs) and all 10 of 10 non-RCTs analyzed reported that mistletoe improved quality of life in patients with malignant disease (20). Mistletoe likewise reduces the side effects of conventional cytoreductive treatments (20). When used in concert with conventional treatments, mistletoe consistently improved “coping, fatigue, sleep, exhaustion, energy, nausea, vomiting, appetite, depression, anxiety, ability to work, and emotional and functional well-being in general” (20, p.142).
Especially relevant to cancer is the immunomodulatory effect of mistletoe extract, as mistletoe can enhance both humoral (antibody-mediated) and cellular immune responses when injected into cancer patients (21), potentially increasing the ability of the immune system to eliminate cancer. In fact, in a mouse melanoma model, mistletoe exerted its anti-cancer effects by promoting secretion of a signaling molecule called interleukin-12 (IL-12), which causes immune cells in the spleen to proliferate (22), up-regulating immune defenses against cancer. Also, researchers state that, “Polysaccharides present in the herb and in berries increased phagocytic activity of granulocytes and macrophages in in vitro experiments,” which increases the ability of immune cells to eat and dispose of defective or neoplastic cells (15, p. 378)
It is hypothesized that water soluble mistletoe lectins are the active anti-cancer constituents in the plant, along with polysaccharides, phenolic compounds, and viscotoxins (14, 23). Lectins in particular induce programmed cell death, or apoptosis, in cancer cell lines, and exhibit direct cytotoxic (cancer cell killing) activity (15). Commercial methods of aqueous mistletoe purification are not able to extract water insoluble triterpenoids, which have anti-melanoma effects (24).
However, one mouse study using a novel method to produce triterpenoid-enriched mistletoe extracts found that this variety amplified the anti-tumor effects of mistletoe (14). Compared to the control group, which had a dense network of blood vessels surrounding the tumor, the mistletoe extract and solubilized triterpenoids elicited anti-angiogenic effects, causing blood vessels around the tumor to collapse, preventing delivery of nutrients to the tumor (14). In this model, mistletoe extracts led to the significant suppression of tumor growth, which was further enhanced by combined treatment with triterpenoids (14).
Broccoli Sprouts
Sulforaphane is an isothiocyanate compound found in all cruciferous vegetables, such as arugula, broccoli, Brussel sprouts, cabbage, cauliflower, chard, collard greens, radish, rutabaga, turnip, wasabi, and watercress. However, it is particularly concentrated in broccoli sprouts, which contain 10 to 100 times the glucoraphanin content of the mature plants, which is a glucosinolate of sulforaphane (25). In vitro and in vivo models demonstrate that sulforaphane induces apoptosis, or cell suicide, in melanoma cells, as indicated by predictable morphological changes that occur with cell death, such as condensation and fragmentation of genetic material and a step in cellular disassembly called membrane blebbing (26).
In an animal model, when sulforaphane was administered simultaneously with melanoma development, “There was 95.5% inhibition of lung tumour nodule formation and 94.06% increase in the life span of metastatic tumour bearing animals” (27). At a mechanistic level, sulforaphane prevented invasion of melanoma cells to secondary sites by inhibiting the activation of matrix metalloproteinases (MMPs), enzymes which hydrolyze, or degrade extracellular proteins such as collagens and elastin and allow for tumors to migrate (27).
The researchers conclude, “These results raise the possibility that SFN [sulforaphane] may be a promising candidate for molecular-targeting chemotherapy against melanoma” (26, p. 332).
Vitamin C
Gonzalez and colleagues (2012) proposed the revolutionary bioenergetic theory of carcinogenesis, which posits that cancer originates when cells revert to a more primitive phenotype favoring uncontrolled proliferation and cell immortalization (28). This occurs as an adaptive response to ensure survival in the harsh cellular milieu and toxic external environment that so drastically departs from the one in which we evolved (28).
Cancer cells resort to inefficient energy production via cytosol-based glycolysis instead of the mitochondrial-based, oxygen-dependent oxidative phosphorylation, which is the primary generator of energy currency in the body (29). One reason malignant cells switch to fermentation, or anaerobic (oxygen-independent) processes for energy production, is due to defective mitochondrial membrane potential, which can be corrected by vitamin C (29).
In this respect, ascorbate, the water-soluble vitamin C, may be helpful by increasing electron flux through the mitochondria, restoring energy production such that apoptosis of cancer cells, which is an energy-intensive process, can occur (29). Vitamin C also optimizes cellular differentiation and intercellular communication, both of which are compromised in a cancerous state and perpetuate tumor growth (29).
Further, vitamin C up-regulates the proliferation and activity of lymphocytes, or white blood cells, and prevents oxidative damage that would engender further mitochondrial dysfunction (30, 31). In addition, vitamin C increases the anti-malignancy effects of lysosomes, the ‘garbage disposal’ organelles that reside within white blood cells, which control cell death and survival and render cancer cells vulnerable to death pathways (32, 33).
Likewise, vitamin C promotes collagen formation, which can sequester tumors, inhibit their growth, and prevent tumor metastasis (30). Along the same lines, vitamin C interferes with the action of hyaluronidase, an enzyme which degrades connective tissue and allows tumors to spread, in order to wall off the tumor with ground substance (30).
Remarkably, high concentrations of vitamin C are selectively toxic to tumors but not to normal tissues (6). In particular, it elicits anti-cancer effects by facilitating the formation of hydrogen peroxide (a reactive oxygen species) in the extracellular space, which can produce other free radicals such as aldehydes and hydroxyl radicals that in turn jeopardize cell viability (34). Hydrogen peroxide not only generates double-stranded DNA breaks, which induces death of cancer cells, but it also recruits immune cells to the site of the tumor to eliminate cancer cells (35, 36). Whereas normal cells have adequate levels of catalase, an enzyme to detoxify hydrogen peroxide and prevent cellular damage, malignant cells are deficient in this antioxidant enzyme, harboring 10 to 100 fold less catalase content than healthy cells (37).
In the 1970s, Nobel Prize winner Linus Pauling conducted experiments demonstrating that high dose vitamin C therapy elongated survival of cancer patients by four times compared to controls (38). In another study, “all melanoma cell lines were susceptible to ascorbate-mediated cytotoxicity,” and “pharmacologic ascorbate was superior or equivalent to dacarbazine as an anti tumor agent” (6, p. 193). In mouse melanoma cells, ascorbic acid induced apoptosis by acting as a pro-oxidant and increasing intracellular levels of reactive oxygen species, which disrupted membrane potential and lead to cell death (39).
Researchers state, “While AA [ascorbic acid] alone may not be enough of an intervention in the treatment of most active cancers, it appears to improve quality of life and extend survival and it should be considered as part of the treatment protocol for all patients with cancer” (29, p. 31). Intravenous vitamin C is optimal, as oral supplementation is unlikely to generate plasma concentrations required to kill tumor cells (37). The combination of vitamin C with other mitochondrial support such as B vitamins, magnesium, coenzyme Q10 (CoQ10), acetyl L-carnitine, alpha lipoic acid, pyrroloquinoline quinone (PQQ), D-ribose, creatine, and phospholipids, would be ideal for reversing the metabolic derangements observed in cancer (38, 40).
Polyphenols
Polyphenols, which represent secondary metabolites of plants that evolved as defense mechanisms against pests and ultraviolet radiation, confer protection from cardiovascular disease, diabetes, osteoporosis, neurodegenerative disorders, and cancers (41). Catechin, a polyphenol in green tea, has been elucidated to render collagen resistant to degradation by the mammalian enzyme collagenase (42). Therefore, researchers tested various polyphenols to see if they could inhibit the basement membrane degradation that is essential to melanoma metastasis to the lungs (43).
For metastasis to take place, tumor cells must be liberated from the primary tumor into circulation, adhere to the extracellular matrix, and invade a secondary site via the proteolytic cleavage of the basement membrane, or the fibrous layer of connective tissue that divides epithelial cells from the underlying lamina propria (43). Finally, the malignant cells attach to the secondary site and tumor growth resumes (43). However, metastasis could be arrested if any one of the steps in this sequential process were prevented (43).
In this experiment, curcumin, from the spice turmeric, and ellagic acid, which is abundant in red grapes, were directly toxic towards melanoma cells even at low concentrations, indicating their anticarcinogen potential (43). Further, many of the polyphenols significantly reduced melanoma metastasis to the lungs, with curcumin, catechin, rutin (from figs, apples, and tea), epicatechin (from dark chocolate), and naringin and naringenin (from grapefruit) reducing lung tumor colonies by 89.28%, 82.2%, 71.2%, 61%, 27.2%, and 26.1%, respectively (43). In order of appearance, these polyphenols increased lifespan of animals by 142.85%, 80.81%, 63.59%, 55.29%, 26.6%, and 27.18% (43).
The best strategy would be to obtain polyphenolic compounds from whole foods sources in order to obtain the synergistic effects of other active constituents. As a general rule, the deeper pigmented the fruit or vegetable, the higher the polyphenolic content. Polyphenols inhibit cancer through pleiotropic mechanisms, including “estrogenic/antiestrogenic activity, antiproliferation, induction of cell cycle arrest or apoptosis, prevention of oxidation, induction of detoxification enzymes, regulation of the host immune system, anti-inflammatory activity and changes in cellular signaling” (41).
Sun Exposure
For those with a family history of melanoma interested in prevention, sun exposure is a contentious topic. According to researchers, “It has been documented that the role of sunlight in melanoma differs according to anatomic site, which is supportive of the hypothesis that melanomas may arise through divergent etiologic pathways” (1).
Although frequency of ultraviolet (UV) radiation-induced sunburns represents one of the primary risk factors for (44), the relationship between sun exposure and melanoma risk is convoluted. A longitudinal study tracking 38,000 women for 15 years, in fact, found that chronic sun exposure was protective against malignant melanoma, whereas intermittent sun exposure elevated melanoma risk (45). Contrary to popular belief, sun exposure was found to be protective, as it was also correlated with significantly reductions in cardiovascular and all-cause mortality (45). Therefore, habitual insulation from the sun is clearly deleterious, but safe sunning practices should still be observed to avoid burning and potential detriment.
Although human trials are deficient, people with cancer now cannot wait for research to be translated into clinical practice and adopted as standard of care. Given the nontoxic nature of the aforementioned interventions, they can easily be incorporated into the arsenal of modalities used to reverse cancer as elements of a multi-faceted approach that addresses diet, exercise, sleep, stress, social support, latent infections, hormonal balance, detoxification, and mitochondrial dysfunction.
References
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2. Jerant, A.F., Johnson, J.T., & Caffrey, T.J. (2000). Early detection and treatment of skin cancer. American Family Physician, 62, 357-368. https://dx.doi.org/10.1080/14786419.2015.1022776
3. Chatterjee, S.J. et al. (2010). The effect of dandelion root extract in inducing apoptosis in drug-resistant melanoma cells. Evidence Based Complementary and Alternative Medicine. doi: 10.1155/2011/129045
4. Soengas, M.S., & Lowe, S.W. (2003). Apoptosis and melanoma chemoresistance. Oncogene, 22(20), 3138-3151.
5. Chapman, P.B. et al. (1999). Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. Journal of Clinical Oncology, 17, 2745-2751.
6. Serrano, O.K. et al. (2015). Antitumor effect of pharmacologic ascorbate in the B16 murine melanoma model. Free Radical Biology Medicine, 86, 193-203. doi: 10.1016/j.freeradbiomed.2015.06.032.
7. Sigstedt, S.C. et al. (2008). Evaluation of aqueous extracts of Taraxacum officinale on growth and invasion of breast and prostate cancer cells. International Journal of Oncology, 32(5), 1085-1090.
8. Sweeney, B. et al. (2005). Evidence-based systematic review of dandelion (Taraxacum officinale) by natural standard research collaboration. Journal of Herbal Pharmcology, 5(1), 79-93.
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13. Halder, B., Singh, S., & Thakur, S.S. (2015). Withania somnifera Root Extract Has Potent Cytotoxic Effect against Human Malignant Melanoma Cells. PLoS One, 10(9), e0137498.
14. Strüh, C.M. et al. (2013). Triterpenoids Amplify Anti-Tumoral Effects of Mistletoe Extracts on Murine B16.F10 Melanoma In Vivo. PLoS One, 8(4), e621688. doi: 10.1371/journal.pone.0062168
15. Nazaruk, J., & Orlikowski, P. (2016). Phytochemical profile and therapeutic potential of Viscum album L. Natural Product Resaerch, 30(4), 373-385.
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17. Thies, A. et al. (2008). Low-dose mistletoe lectin-I reduces melanoma growth and spread in a scid mouse xenograft model. British Journal of Cancer, 98, 106–112.
18. Kienle, G.S. et al. (2009). Viscum album L. extracts in breast and gynaecological cancers: a systematic review of clinical and preclinical research. Journal of Experimental Clinical Cancer Research, 28(1), 79. doi:10.1186/1756-9966-28-79.
19. Kienle, G.S. et al. (2003). Mistletoe in cancer – a systematic review on controlled clinical trials. European Journal of Medical Research, 8(3), 109-119.
20. Kienle, G.S., & Kiene, H. (2010). Review article: Influence of Viscum album L (European mistletoe) extracts on quality of life in cancer patients: a systematic review of controlled clinical studies. Integrateve Cancer Therapies, 9(2), 142-157. doi: 10.1177/1534735410369673.
21. Gardin, N.E. (2009). Immunological response to mistletoe (Viscum album L.) in cancer patients: a four-case series. Physiotherapy Research, 23(3), 407-411. doi: 10.1002/ptr.2643
22. Duong Van Huyen, J-P. et al. (2006). Interleukin-12 is associated with the in vivo anti-tumor effect of mistletoe extracts in B16 mouse melanoma. Cancer Letters, 243(1), 32-37. doi: 10.1016/j.canlet.2005.11.016
23. Beuth, J. (1997). Clinical relevance of immunoactive mistletoe lectin-I. Anticancer Drugs, 8(Suppl 1), S53-S55.
24. Jäger, S. et al. (2007). Solubility studies of oleanolic acid and betulinic acid in aqueous solutions and plant extracts of Viscum album L. Planta Medicine, 73, 157-162.
25. Fahey, J.W., Zhang, Y., & Talalay, P. (1997). Broccoli sprouts: an exceptionally rich source of inducers of enzymes that protect against chemical carcinogens. Proceedings of the National Academy of Sciences (USA), 94, 10367-10372.
26. Hamsa, P. T., Thejass, P., & Kuttan, G. (2011). Induction of apoptosis by sulforaphane in highly metastatic B16F-10 melanoma cells. Drug Chemistry and Toxicology, 34(3), 332-340.
27. Thejass, P., & Kuttan, G. (2006). Antimetastatic activity of sulforaphane. Breast Cancer Research Treatment, 99(3), 333-340.
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29. Gonzalez, M.J. et al. (2010). Mitochondria, energy and cancer: The relationship with Asocrbic acid. Journal of Orthomolecular Medicine, 25, 29-38.
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31. Dumitrescu, C., Belgun, M., & Olinescu, R. (1993). Effect of vitamin administration on the ratio between the pro- and antioxidative factors. Romanian Journal of Endocrinology, 21, 81-84.
32. Kirkegaard, T., & Jäättelä, M. (2009). Lysosomal involvement in cell death and cancer. Biochimica et Biophysica Acta (BBA) – Molecular Cell Research, 1793(4), 746-754.
33. Sakagami, H., & Satoh, K. (1997). Modulating factors of radical intensity and cytotoxic activity of ascorbate (review). Anticancer Research, 17, 3513-3520.
34. Benade, L., Howard, T., & Burke, D. (1969). Synergistic killing of Ehlrich ascites carcinoma cells by ascorbate and amino 1,2,4-triazole. Oncology, 23, 33-43.
35. Frankenberg-Schwager, M. et al. (2008). The role of non homologous DNA end joining, conservative homologous recombination, and single-strand annealing in the cell cycle-dependent repair of DNA double-strand breaks induced by H(2)O(2) in mammalian cells. Radiation Research, 170, 784-793.
36. Hara-Chikuma, M. et al. (2012). Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake. Journal of Experimental Medicine, 209, 1743-1752.
37. Riordan, N.H. et al. (1995). Intravenous ascorbate as a tumor cytotoxic chemotherapeutic agent. Medical Hypotheses, 44, 207-213.
38. Zeviar, D.D., et al. (2014). The role of mitochondria in cancer and other chronic diseases. Journal of Orthomolecular Medicine, 29(4), 157-166.
39. Kang, J.S. et al. (2003). L-ascorbic acid (vitamin C) induces the apoptosis of B16 murine melanoma cells via a caspase-8-independent pathway. Cancer Immunology and Immunotherapies, 52, 693-698.
40. Parikh, S. et al. (2009). A modern approach to the treatment of mitochondrial disease, 11(6), 414-430.
41. Pandey, K.B., & Rizvi, S.I. (2009). Plant polyphenols as dietary antioxidants in human health and disease. Oxidative Medicine and Cell Longevity, 2(5), 270-278.
42. Kuttan, R., Donnelly, P.V., & Di Ferrante, N. (1981). Collagen treated with (+)-catechin becomes resistant to the action of mammalian collagenase. Experientia, 37, 221-223.
43. Menon, L.G., Kuttan, R., & Kuttan, G. (1995). Inhibition of lung metastasis in mice induced by B16F10 melanoma cells by polyphenolic compounds. Cancer Letters, 221-225.
44. Cho, E. et al. (2005). Risk factors and individual probabilities of melanoma for whites. Journal of Clinical Oncology, 23, 2669-2675.
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renegadetribune--2020-08-27--Congressional Candidate Laura Loomer: “They’re Just Jealous Because I Got Big Tits & An Ashkenazi IQ

Congressional Candidate Laura Loomer: “They’re Just Jealous Because I Got Big Tits & An Ashkenazi IQ”

The pro-Trump MAGApedes are super excited that BASED Laura Loomer is out-raising her Democrat opponent in her Florida Congressional district @ @ @ @ @ t like her is probably just jealous .
FYI this is from a few years @ @ @ @ @ this way AFTER lots of plastic surgery .

The pro-Trump MAGApedes are super excited that BASED Laura Loomer is out-raising her Democrat opponent in her Florida Congressional district. Anyone who doesn’t like her is probably just jealous. FYI this is from a few years ago, and she looks this way AFTER lots of plastic surgery.
Bitchute link
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Author: Thanks for being a reader of this site. Your contributions make this all possible. You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA . CashApp: Thanks for being a reader of this site. Your contributions make this all possible. You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA . CashApp: https://cash.app/$thekylehunt


renegadetribune--2020-08-27--BASED! Rabbi Spero’s Opening Prayer for the RNC

I love how we live in a country where supposedly 2 % of our population is jewish , but yet @ @ @ @ @ ( and rule us everywhere else too ) .

I love how we live in a country where supposedly 2% of our population is jewish, but yet they are our spiritual leaders (and rule us everywhere else too).


renegadetribune--2020-08-27--Karl Marx and Friedrich Engels Were Not Too Fond of “Niggers” – So Why Is BLM Run by Marxists?

Just to be clear , I am not implying that Karl Marx or Friedrich Engels were “ based ” for their commentary on Blacks , but just showing the hypocrisy of modern day Marxists .
Most social justice warriors and other assorted “ leftists ” today think very highly of Marxism , but they do not have a good understanding of Karl Marx or his comrade Friedrich Engels .
While Marxists want to see a utopia where everyone is equal , Marx and Engels were not very fond of “ niggers.
” He even claimed one of his fellow jews @ @ @ @ @ @ @ his phrenology , phenotype , and personality .
The Jewish Nigger , Lassalle… It is now quite plain to me — as the shape of his head and the way his hair grows also testify — that he is descended from the negroes who accompanied Moses ’ flight from Egypt ( unless his mother or paternal grandmother interbred with a nigger ) .
Now , this blend of Jewishness and Germanness , on the one hand , and basic negroid stock , on the other , must inevitably give rise to a peculiar @ @ @ @ @ @ @ is also nigger-like.
” ~ Marx to Engels in Manchester ( 30 July 1862 ) Rather than evolving , Negroes actually degenerated from a higher form ?
Wow !
In 1887 Marx ’ s son-in-law , Paul Lafargue , was a candidate for a Paris council seat in a district that contained a zoo .
Engels said that Lafargue had “ one-eighth or one-twelfth nigger blood , ” and told Lafargue ’ s wife in a letter that : What do the “ trained Marxists ” who started BLM have to say about @ @ @ @ @ @ @ were also not too fond of Mexicans , although some Mexicans are quite fond of Marxists .
After the United States took California from Mexico in the Mexican War , Marx sarcastically asked : Engels agreed with Marx that Mexicans are incapable of ruling their land .
He said : Marx and Engels also made comments that could be deemed “ racist ” about Indians , Muscovites , Turks , and even his own tribe of jews .
Yet the leading “ anti-racists ” all seem to be Marxists .
Cognitive dissonance is @ @ @ @ @ @

Just to be clear, I am not implying that Karl Marx or Friedrich Engels were “based” for their commentary on Blacks, but just showing the hypocrisy of modern day Marxists.
Most social justice warriors and other assorted “leftists” today think very highly of Marxism, but they do not have a good understanding of Karl Marx or his comrade Friedrich Engels. While Marxists want to see a utopia where everyone is equal, Marx and Engels were not very fond of “niggers.” He even claimed one of his fellow jews was part “nigger” because of his phrenology, phenotype, and personality.
The Jewish Nigger, Lassalle… It is now quite plain to me — as the shape of his head and the way his hair grows also testify — that he is descended from the negroes who accompanied Moses’ flight from Egypt (unless his mother or paternal grandmother interbred with a nigger). Now, this blend of Jewishness and Germanness, on the one hand, and basic negroid stock, on the other, must inevitably give rise to a peculiar product. The fellow’s importunity is also nigger-like.” ~ Marx to Engels in Manchester (30 July 1862)
Marx also said:
[Tremaux] proved that the common Negro type is the degenerate form of a much higher one … a very significant advance over Darwin.” ~ Karl Marx, letter to Friedrich Engels (7 August 1866)
Rather than evolving, Negroes actually degenerated from a higher form? Wow!
In 1887 Marx’s son-in-law, Paul Lafargue, was a candidate for a Paris council seat in a district that contained a zoo. Engels said that Lafargue had “one-eighth or one-twelfth nigger blood,” and told Lafargue’s wife in a letter that:
being in his quality as a nigger, a degree nearer to the rest of the animal kingdom than the rest of us, he is undoubtedly the most appropriate representative of that district.”
What do the “trained Marxists” who started BLM have to say about the above quotes?
http://www.renegadetribune.com/blm-founders-wikipedia-page-scrubbed-self-proclaimed-marxist-removed-jewish-father-changed/
http://www.renegadetribune.com/black-lives-matter-co-founder-admits-to-leaders-being-trained-marxists/
Marx and Engels were also not too fond of Mexicans, although some Mexicans are quite fond of Marxists.
After the United States took California from Mexico in the Mexican War, Marx sarcastically asked:
Is it a misfortune that magnificent California was seized from the lazy Mexicans who did not know what to do with it?”
Engels agreed with Marx that Mexicans are incapable of ruling their land. He said:
In America we have witnessed the conquest of Mexico and have rejoiced at it. It is to the interest of its own development that Mexico will be placed under the tutelage of the United States.”
Marx and Engels also made comments that could be deemed “racist” about Indians, Muscovites, Turks, and even his own tribe of jews. Yet the leading “anti-racists” all seem to be Marxists. Cognitive dissonance is a hell of a drug.
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Author: Thanks for being a reader of this site. Your contributions make this all possible. You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA . CashApp: Thanks for being a reader of this site. Your contributions make this all possible. You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA . CashApp: https://cash.app/$thekylehunt


renegadetribune--2020-08-26--Jerry Falwell, Jr Finished at Liberty University Over His Cuckold Fetish

Christians sure are an interesting bunch .
They often put on a front of being holier than thou , while behind closed doors they are some of the biggest freaks you could imagine .
I tend to think that their strict religious views on sex actually causes some of their weird fetishes .
Jerry Falwell , Jr. followed in his father ’ s footsteps , bringing the light of Yahweh to the young students of the world .
He was president of Liberty University , which his obscenely rich father started with a $ 2 billion grant .
However , @ @ @ @ @ @ @ scandals and has now decided to resign .
It all started with him posting a picture of himself having a drink with his arm around a woman who works at Liberty University , both with their pants unzipped .
Jerry put out the photo and then proceeded to remove it after getting some negative responses .
They were living it up during the “ pandemic , ” having a party with Liberty University employees on a big yacht .
They even put together a video of their shenanigans in the style of “ @ @ @ @ @ @ @ also deleted .
This all apparently got some people to start digging into the personal life of Jerry Falwell , and what they turned up did not paint Jerry or his wife Becki in a very good light .
It appears Jerry ’ s wife was having an affair with the pool boy and that Jerry knew he was being cuckolded .
If that was not bad enough , the pool boy alleges that Jerry would watch while being scantily clad .
Granda , 29 , claims he met the Falwells at a @ @ @ @ @ @ @ engaged in a years-long sexual affair with Becki , 53 , some of which Granda alleged Falwell Jr watched while wearing a speedo .
He also alleged that Jerry , 58 , would watch the pair having sex and enjoyed listening in on their phone calls – with audio released on Monday showing how Jerry asked Granda not to make his wife “ jealous ” by discussing dates with other women .
( The Sun ) This is the straw that broke the camel ’ s back and cause Jerry to resign , @ @ @ @ @ @ @ of his wife and the pool boy .
He told the AP : Falwell is a big Trump supporter and some people are saying that this expose is politically motivated .
For example , Andrew Anglin is very upset that a good Christian man “ on the right ” is being taken down for his personal affairs .
If the right-wing had any integrity at all , any slight ability to defend themselves , we would simply stop allowing our public figures to be destroyed by the media in this way .
We @ @ @ @ @ @ @ it is tearing us down completely .
The private and the public should be considered separate realities , and a right-wing public figure should only ever be judged by what he does publicly , as long as what he does in private doesn ’ t relate directly to his duties .
What this really goes to show is that we have been right in calling these insane religious deviants “ Christcucks ” for years .

Christians sure are an interesting bunch. They often put on a front of being holier than thou, while behind closed doors they are some of the biggest freaks you could imagine. I tend to think that their strict religious views on sex actually causes some of their weird fetishes.
Jerry Falwell, Jr. followed in his father’s footsteps, bringing the light of Yahweh to the young students of the world. He was president of Liberty University, which his obscenely rich father started with a $2 billion grant. However, Falwell has been hit with a few scandals and has now decided to resign.
It all started with him posting a picture of himself having a drink with his arm around a woman who works at Liberty University, both with their pants unzipped. Jerry put out the photo and then proceeded to remove it after getting some negative responses.
They were living it up during the “pandemic,” having a party with Liberty University employees on a big yacht. They even put together a video of their shenanigans in the style of “Trailer Park Boys,” which Jerry also deleted.
https://vimeo.com/444300274
This all apparently got some people to start digging into the personal life of Jerry Falwell, and what they turned up did not paint Jerry or his wife Becki in a very good light.
It appears Jerry’s wife was having an affair with the pool boy and that Jerry knew he was being cuckolded. If that was not bad enough, the pool boy alleges that Jerry would watch while being scantily clad.
Granda, 29, claims he met the Falwells at a Miami hotel when he was 20 and engaged in a years-long sexual affair with Becki, 53, some of which Granda alleged Falwell Jr watched while wearing a speedo. He also alleged that Jerry, 58, would watch the pair having sex and enjoyed listening in on their phone calls – with audio released on Monday showing how Jerry asked Granda not to make his wife “jealous” by discussing dates with other women. (The Sun)
This is the straw that broke the camel’s back and cause Jerry to resign, though he denies watching the sinful acts of his wife and the pool boy. He told the AP:
That’s the only reason I resigned: because I don’t want something my wife did to harm the school I’ve spent my whole life building.”
Falwell is a big Trump supporter and some people are saying that this expose is politically motivated. For example, Andrew Anglin is very upset that a good Christian man “on the right” is being taken down for his personal affairs.
If the right-wing had any integrity at all, any slight ability to defend themselves, we would simply stop allowing our public figures to be destroyed by the media in this way. We do not benefit from it, and it is tearing us down completely. The private and the public should be considered separate realities, and a right-wing public figure should only ever be judged by what he does publicly, as long as what he does in private doesn’t relate directly to his duties.
What this really goes to show is that we have been right in calling these insane religious deviants “Christcucks” for years.
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Author: Kyle Hunt Kyle is the publisher of the Renegade Tribune and the founder of Kyle is the publisher of the Renegade Tribune and the founder of Renegade Broadcasting , where he hosts The Solar Storm . He also organized the 2014 White Man March and created the film adaptation of Hellstorm . You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA


renegadetribune--2020-08-26--Richard Spencer Endorses Joe Biden

Richard Spencer Endorses Joe Biden

Recently Richard Spencer , the trust fund Nazbol sodomite , took to Twitter to declare his support of Joe Biden @ @ @ @ @ will think he ’ s just “ trolling ” , common sense tells us otherwise @ @ @ @ @ Dugin translating “ wife ” ( not 100 % sure that creature is female ) @ @ @ @ @ satanist .
I don ’ t actually think Spencer was dating this woman as he @ @ @ @ @ , but nonetheless , he ’ s taking his mask off .
I got a @ @ @ @ @ this obvious fraud out years ago .
Here is a video I did from a @ @ @ @ @ is a clip of me calling into a radio show that Richard was a guest @ @ @ @ @ I address his promotion of sodomite psychos like Jack Donovan and ask him why he @ @ @ @ @ sick vermin talk to young impressionable males about what it means to be masculine .

Recently Richard Spencer, the trust fund Nazbol sodomite, took to Twitter to declare his support of Joe Biden.
Busy with personal stuff over the past two days. Writing up my full Biden endorsement. It’ll be out tomorrow. #RidinWithBidenHarris — Richard Spencer (@RichardBSpencer) August 26, 2020
While some gullible people will think he’s just “trolling”, common sense tells us otherwise. After he left his Dugin translating “wife” (not 100% sure that creature is female) he began dating a leftist satanist.
I don’t actually think Spencer was dating this woman as he is clearly a rabid sodomite, but nonetheless, he’s taking his mask off.
I got a lot of hate for calling this obvious fraud out years ago. Here is a video I did from a few years back. There is a clip of me calling into a radio show that Richard was a guest on. n this clip I address his promotion of sodomite psychos like Jack Donovan and ask him why he’s having these mentally sick vermin talk to young impressionable males about what it means to be masculine.
Bitchute link
https://twitter.com/almightygenie/status/1297763679392403456
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Author: Sinead is a musician, writer, and thinker. Sinead is a musician, writer, and thinker.


renegadetribune--2020-08-26--Civil War Spreading: Streets of Kenosha, Wisconsin Turn Into Battlefield

Kenosha , Wisconsin is a small city of about 100,000 people on Lake Michigan .
Apparently it really felt like small town America , where people knew their neighbors and there was a sense of tranquility .
One of the tourist attractions is a Civil War museum , which seems all the more relevant now that civil war is raging on the once peaceful streets .
The spark that ignited the flames was the police shooting of a violent criminal who was resisting arrest .
Of course if the criminal was a White man , nothing would have happened to @ @ @ @ @ @ @ was shot , the city had to burn .
The first night was bad enough , as was detailed here : Then the second night saw even more burning , looting , and violence .
For some reason , the “ trained Marxists ” of BLM took out a lot of their anger on cars .
They also torched a bunch of buildings , some of which apparently had people trapped inside .
This would not be the first time BLM murdered someone with their arson .
They torched a bunch of small @ @ @ @ @ @ @ of many residents .
Obviously some people got very upset with what was being allowed to take place .
Some people came out armed to stop the looting wherever possible , as the police was either unable or unwilling to do so .
Then on the third night a few people were supposedly shot by an armed White man who was chased down by a few men , one armed with a pistol and another with a skateboard , so he fired at them .
Three were shot and supposedly two died .
@ @ @ @ @ @ @ who was shot in the head .
Here is the man who was shot in his arm .
The guy who got his arm shot had been running at the armed guard with a pistol out .
Adding further confusion to the situation , the armed guard who shot his attackers was apparently there to protect not only private property , but BLM !
This all happened admist the chaos of a third night of rioting .
That Kenosha , Wisconsin could so quickly turn into a war zone should be troubling for @ @ @ @ @ @ @ your small town or city in the blink of an eye , simply because some violent black criminal was shot by the police while resisting arrest .
We have seen the same scenario play out time and again .
You must prepare yourself for the worst , and assume that law enforcement will not be there to keep you safe during the burning , looting , and shooting .
If you are White , you are wearing an enemy uniform and you will be targeted by the Communist terrorists .

Kenosha, Wisconsin is a small city of about 100,000 people on Lake Michigan. Apparently it really felt like small town America, where people knew their neighbors and there was a sense of tranquility. One of the tourist attractions is a Civil War museum, which seems all the more relevant now that civil war is raging on the once peaceful streets.
The spark that ignited the flames was the police shooting of a violent criminal who was resisting arrest. Of course if the criminal was a White man, nothing would have happened to Kenosha, but since a Black man was shot, the city had to burn.
New footage shows Jacob Blake brawling with cops before being shot. The #Kenosha man, who survived, has a criminal history that includes assaulting police, resisting arrest, domestic abuse, a felony sex crime & more. There is a warrant for his arrest. https://t.co/8542oCLUIU — Andy Ngô 🏳🌈 (@MrAndyNgo) August 25, 2020
The first night was bad enough, as was detailed here:
http://www.renegadetribune.com/blm-rioting-and-looting-breaks-out-in-wisconsin-after-felon-shot-while-resisting-arrest/
Then the second night saw even more burning, looting, and violence.
https://twitter.com/after_theaction/status/1298210964018429952?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298210964018429952%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61675
For some reason, the “trained Marxists” of BLM took out a lot of their anger on cars.
Masked BLM rioters are smashing up cars using bats in #Kenosha. pic.twitter.com/4pe01R938U — Andy Ngô 🏳🌈 (@MrAndyNgo) August 25, 2020
https://twitter.com/ShelbyTalcott/status/1298113217173037056?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298113217173037056%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61675
Wisconsin: The aftermath of a riot in Kenosha at a used car dealership. pic.twitter.com/4dKGLnRLZg — Kalen’s old account (@fromkalen_old) August 25, 2020
They also torched a bunch of buildings, some of which apparently had people trapped inside.
“There’s families trapped in those apartments.” Kenosha. https://t.co/vIRbtjmkLy — Ian Miles Cheong (@stillgray) August 25, 2020
This would not be the first time BLM murdered someone with their arson.
A charred body was found in the wreckage of a Minneapolis pawnshop nearly two months after the building was burned down during the Black Lives Matter riots. https://t.co/5cCdA18Hjz — Andy Ngô 🏳🌈 (@MrAndyNgo) July 21, 2020
They torched a bunch of small businesses in Kenosha, ruining the livelihoods of many residents.
https://twitter.com/ShelbyTalcott/status/1298108679162560512?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298108679162560512%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61675
https://twitter.com/ShelbyTalcott/status/1298109088451231744?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298109088451231744%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61675
Smoke-filled streets as the crowd ran rampant through this business district, breaking into almost every store & setting multiple buildings ablaze #Kenosha #KenoshaWisconsin #KenoshaRiots pic.twitter.com/4FIG5ErQQp — Brendan Gutenschwager (@BGOnTheScene) August 25, 2020
The Department of Corrections building in #Kenosha burned to the ground. pic.twitter.com/iMfEFiFnvW — Jorge Ventura Media (@VenturaReport) August 25, 2020
Mattresses looted from this store minutes before the building was burned to the ground #KenoshaRiots #Kenosha #KenoshaProtests pic.twitter.com/OD4gJhrQdo — Brendan Gutenschwager (@BGOnTheScene) August 25, 2020
This is B&L Office Furniture in Kenosha, Wisconsin before & after the #BLM riots on Monday night This is a small business a place where people work Sitting on a property somebody invested in This is real America All destroyed by heartless criminals pic.twitter.com/XCFhASw6it — E (@ElijahSchaffer) August 25, 2020
This place in Kenosha, WI re-opened on July 9 after having been closed since March due to COVID. Now closing permanently after catastrophic riots. Don't whine about large multinational corporations taking over all commerce if you turn a blind eye to this pic.twitter.com/8Ym7UpfhEl — Michael Tracey (@mtracey) August 25, 2020
Obviously some people got very upset with what was being allowed to take place.
https://twitter.com/ShelbyTalcott/status/1298110914663796736?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298110914663796736%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61675
"Total carnage, I just don't understand why something like this would happen" says Daniel Esposito, owner of 4 buildings that were vandalized and looted lastnight in #Kenosha pic.twitter.com/c9EfvN16ku — Jorge Ventura Media (@VenturaReport) August 25, 2020
I spoke with Scott and his mother Linda. Their furniture store was set on fire last night during the Kenosha riots. Linda cried at the sight of the wreckage. Scott had a response to people who would say it's just property and there's insurance. Full vid: https://t.co/y1F7QgigE6 pic.twitter.com/Zw1y6ayds6 — Julio Rosas (@Julio_Rosas11) August 25, 2020
Some people came out armed to stop the looting wherever possible, as the police was either unable or unwilling to do so.
"F*** you, you ain't with us" woman yells at armed man who is attempting to stop the mob from looting and vandalizing #Kenosha businesses pic.twitter.com/FkDlqz9w4N — Jorge Ventura Media (@VenturaReport) August 25, 2020
Then on the third night a few people were supposedly shot by an armed White man who was chased down by a few men, one armed with a pistol and another with a skateboard, so he fired at them. Three were shot and supposedly two died.
GRAPHIC: Rioters chase down a man with a semi-auto rifle. He shoots them. Video by @BGOnTheScene. #KenoshaRiots pic.twitter.com/yrYxgIFs96 — Andy Ngô 🏳🌈 (@MrAndyNgo) August 26, 2020
Here’s footage of the guy who was shot in the head.
BREAKING: RIOTER HAS BEEN SHOT IN THE HEAD pic.twitter.com/l1NYqUYpD3 — Drew Hernandez (@DrewHLive) August 26, 2020
Here is the man who was shot in his arm.
EXTREMELY GRAPHIC: @Julio_Rosas11 recorded up-close footage of one of the men who tried to attack a man who was on the ground but armed with a semi-auto rifle. Half of his upper arm was blown off. #KenoshaRiots pic.twitter.com/81bFbBl7Dw — Andy Ngô 🏳🌈 (@MrAndyNgo) August 26, 2020
The guy who got his arm shot had been running at the armed guard with a pistol out.
GRAPHIC: I missed this in the video. The man who had his arm shot ran in with a pistol. He was still holding it for some time after he was hit: pic.twitter.com/dHx37kaDTk — Andy Ngô 🏳🌈 (@MrAndyNgo) August 26, 2020
Adding further confusion to the situation, the armed guard who shot his attackers was apparently there to protect not only private property, but BLM!
GASLIGHTING: the shooter was a libertarian who said he was in support of the BLM movement Also said he supported their right to protest and target government property The group wasn’t even all white & openly said they were there to protect BLM VIDEO EVIDENCE DOESN’T LIE https://t.co/mRS9za94rJ pic.twitter.com/B1AwigZ4Fl — E (@ElijahSchaffer) August 26, 2020
This all happened admist the chaos of a third night of rioting.
This video was take a few yards away from the shooting where you can see the rioters destroying the vehicles pic.twitter.com/LXHMQoIMh4 — E (@ElijahSchaffer) August 26, 2020
That Kenosha, Wisconsin could so quickly turn into a war zone should be troubling for everyone. This could soon happen to your small town or city in the blink of an eye, simply because some violent black criminal was shot by the police while resisting arrest. We have seen the same scenario play out time and again. You must prepare yourself for the worst, and assume that law enforcement will not be there to keep you safe during the burning, looting, and shooting. If you are White, you are wearing an enemy uniform and you will be targeted by the Communist terrorists.
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Author: Kyle Hunt Kyle is the publisher of the Renegade Tribune and the founder of Kyle is the publisher of the Renegade Tribune and the founder of Renegade Broadcasting , where he hosts The Solar Storm . He also organized the 2014 White Man March and created the film adaptation of Hellstorm . You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA


renegadetribune--2020-08-26--BLM Is Terrorizing White People Into Throwing Up Commie Fists

According to the FBI , terrorism is “ the unlawful use of force and violence against persons or property to intimidate or coerce a government , the civilian population , or any segment thereof , in furtherance of political or social objectives.
” Have you seen how the country is being burned to the ground by Black rioters and their assorted supporters ?
Have you watched as people have been punched , kicked , stomped , and killed for not supporting their movement ?
Does this not fit the definition of terrorism to a T ?
However , instead of @ @ @ @ @ @ @ , media mouthpieces , and political prostitutes have been bending over backward to show their support in whatever way possible .
One of the tactics currently being employed by these terrorists , who are called “ activists ” by our enemies , is to intimidate White people out in public into showing their support for BLM , with the unspoken threat of violence as a motivator .
A few months ago people were being told to kneel down in submission .
Now White people who are out dining are being accosted by BLM @ @ @ @ @ @ @ raise a “ Black power ” ( aka Commie ) fist to show solidarity with a group started by “ trained Marxists.
” It is funny how Black people whine when White people flee ( White flight ) from city areas after Black people move in and bring drugs , violence , and other crimes , and then they complain when White people move back into areas and start improving the living conditions .
If Blacks can complain about areas being gentrified , are we allowed to complain about areas that have been @ @ @ @ @ @ @ cities ?
I don ’ t even think the woman in the next clip is White , but just look at all the people who are surrounding the table , with violent Commie fists in the air and cameras filming .
If intimidating adults into submission was not bad enough , young children are also being targeted .
What do you think would happen if some pro-White activists accosted diners and tried intimidating them into throwing up a roman salute in solidarity ?
This Communist terrorism is being encouraged by the same tribe @ @ @ @ @ @ @ in Russia , supported ANC terrorism in South Africa , and started the NAACP in America .
Without jews inciting hatred against White people , this would not be taking place .
It is also a great diversion , while they roll out 5G , force us all to wear muzzles , and continue consolidating wealth while bankrupting the country .

According to the FBI, terrorism is “the unlawful use of force and violence against persons or property to intimidate or coerce a government, the civilian population, or any segment thereof, in furtherance of political or social objectives.”
Have you seen how the country is being burned to the ground by Black rioters and their assorted supporters? Have you watched as people have been punched, kicked, stomped, and killed for not supporting their movement? Does this not fit the definition of terrorism to a T?
However, instead of condemning the Communist terrorists, multinational corporations, media mouthpieces, and political prostitutes have been bending over backward to show their support in whatever way possible.
One of the tactics currently being employed by these terrorists, who are called “activists” by our enemies, is to intimidate White people out in public into showing their support for BLM, with the unspoken threat of violence as a motivator. A few months ago people were being told to kneel down in submission.
Now White people who are out dining are being accosted by BLM members, who are demanding that they raise a “Black power” (aka Commie) fist to show solidarity with a group started by “trained Marxists.”
BLM scumbags demand that diners at restaurant raise their fists for black power. Brave young couple retains dignity, refuses. Be that couple. Don’t be the embarrassing mustachioed coward to the right who has forfeited his dignity for all time. https://t.co/9wmyAm7yJl — Matt Walsh (@MattWalshBlog) August 25, 2020
BLM is supposedly targeting White people in “gentrified” areas
https://www.youtube.com/watch?v=euazPTReyLU
It is funny how Black people whine when White people flee (White flight) from city areas after Black people move in and bring drugs, violence, and other crimes, and then they complain when White people move back into areas and start improving the living conditions. If Blacks can complain about areas being gentrified, are we allowed to complain about areas that have been negrified, like Detroit and most major cities?
I don’t even think the woman in the next clip is White, but just look at all the people who are surrounding the table, with violent Commie fists in the air and cameras filming.
https://twitter.com/rawsmedia/status/1298078919527202816?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298078919527202816%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61674
If intimidating adults into submission was not bad enough, young children are also being targeted.
https://twitter.com/rawsmedia/status/1298079245718171648?ref_src=twsrc%5Etfw%7Ctwcamp%5Etweetembed%7Ctwterm%5E1298079245718171648%7Ctwgr%5E&ref_url=http%3A%2F%2Fwww.informationliberation.com%2F%3Fid%3D61674
What do you think would happen if some pro-White activists accosted diners and tried intimidating them into throwing up a roman salute in solidarity?
“Your complacency is the reason why we have to be out here. Your silence is participation”#DCProtests last Saturday. Another FTP March in DC tonite pic.twitter.com/QlYTvgrOaV — ChuckModi (@ChuckModi1) August 22, 2020
This Communist terrorism is being encouraged by the same tribe of people who led the bloody revolution in Russia, supported ANC terrorism in South Africa, and started the NAACP in America. Without jews inciting hatred against White people, this would not be taking place.
It is also a great diversion, while they roll out 5G, force us all to wear muzzles, and continue consolidating wealth while bankrupting the country.
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Author: Kyle Hunt Kyle is the publisher of the Renegade Tribune and the founder of Kyle is the publisher of the Renegade Tribune and the founder of Renegade Broadcasting , where he hosts The Solar Storm . He also organized the 2014 White Man March and created the film adaptation of Hellstorm . You can send support to: Kyle Hunt, PO Box 1052, Sorrento FL 32776. Bitcoin address: 1AfppjYZddJzc2C15PXKMsnyBPjPJQezwA