physicsworld--2020-07-17--New metasurface lens banishes chromatic aberration - Physics World

A new type of metasurface lens developed by US researchers is far less susceptible to optical dispersion than previous designs – which means that it can focus a wider range of wavelengths more efficiently .
Boubacar Kanté of the University of California , Berkeley and colleagues believe their new lens could find a range applications including hi-tech medical imaging , energy harvesting and virtual reality .
Optical dispersion occurs when the refractive index of a medium varies with the light ’ s wavelength .
One of its most visible manifestations is chromatic aberration in a lens : the lens has @ @ @ @ @ @ @ which its refractive index is higher , resulting in a blurred image .
Since dispersion was first explained by Isaac Newton in 1660 , people have developed ways to mitigate it .
One involves achromatic doublet lenses , comprising two lenses with different refractive indices stuck together such that the dispersion of one roughly compensates the dispersion of the other .
Today , however , optical technology is moving away from traditional lenses and towards flat optical metasurfaces .
These are thinner and lighter and offer functionalities such as reconfigurability and variation of @ @ @ @ @ @ @ to achieve with traditional lenses .
However , there are difficulties associated with metasurfaces – and among the most prominent are increased chromatic aberration and other performance variations with wavelength .
The principal cause of these problems is that , whereas bulk lenses control light through cumulative effects on the waves passing through , metasurfaces use optical elements to interact with the wavefronts directly and tailor their shape and phase .
To achieve this interaction , these optical elements comprise structures on the scale of the wavelength of the light they control .
@ @ @ @ @ @ @ this interaction .
Moreover , many of the most efficient metasurface designs are based on resonators , which have a sharp peak at one wavelength : “ If you want to make a laser , you want one colour , so a resonant cavity is perfect , ” explains Kanté , “ But if you want to make a lens , one colour is not good enough !
” In the new work , Kanté and colleagues took a different approach .
Instead of using resonators , they used a “ fishnet ” @ @ @ @ @ @ @ nm titanium dioxide grids spaced 370 nm apart .
Each element behaves as a waveguide : “ You need to make those little waveguides as broadband as possible , ” explains Kanté .
Waveguide-based metasurfaces have been designed before , but they have invariably had efficiencies well below those of the current design .
However , the researchers had another , subtler trick up their sleeves .
The phase of each waveguide must be carefully selected to produce a surface with maximum possible efficiency .
Previously , researchers have selected the phase of @ @ @ @ @ @ @ to be part of a lattice of identical waveguides .
“ When I make my lens , the waveguide next to it is different , ” explains Kanté , “ but I assume that it ’ s not that different , so the error that I get by assuming that it ’ s the same is not that big.
” In 2017 , however , Kanté and colleagues showed that this is simply inadequate .
They also presented a method for calculating the correct phase .
In their latest research , they used @ @ @ @ @ @ @ pillar in the lattice .
The resulting lens focused at least 70 % of incident light in the wavelength range 640-1200 nm to the same point .
The researchers believe that , if a scalable production process can be developed , their design could perform a range of tasks , such as producing virtual reality images and focusing light in solar cells – a process that helps harvest energy more efficiently .
“ If you are now comparable in efficiency [ with traditional lenses ] the next question becomes ‘ how large scale @ @ @ @ @ @ @ much do they cost ?
’ ” says Kanté .
Even without large-scale production , however , Kanté believes the lenses could contribute to techniques such as fluorescence imaging , which is a Nobel-prize winning super-resolution microscopy technique now widely used in research and medicine : “ You pump the molecules with one colour and they emit at another , ” explains Kanté , “ Now that our lenses are broadband , you could actually pump and collect with the same ultrathin lens.
” Francesco Monticone of Cornell University is impressed “ While @ @ @ @ @ @ @ variety of design methods to realize broadband achromatic metasurfaces – with some impressive results…the experimental demonstration and measurements presented [ by Kanté ’ s team ] are outstanding.
” Monticone ’ s group recently published fundamental limits on the bandwidth of optical metalenses : “ The fabricated metalenses [ made by Kanté ’ s team ] represent an important step toward reaching these physical bounds , extending the current state of the art of metalenses and their potential for many applications requiring broad bandwidth and high efficiency , ” he says .
The @ @ @ @ @ @ @

Not an aberration: schematic drawing of the metalens (left), which is made of tiny titanium waveguides. The drawing on the right is of a single waveguide. (Courtesy Boubacar Kanté)
A new type of metasurface lens developed by US researchers is far less susceptible to optical dispersion than previous designs – which means that it can focus a wider range of wavelengths more efficiently. Boubacar Kanté of the University of California, Berkeley and colleagues believe their new lens could find a range applications including hi-tech medical imaging, energy harvesting and virtual reality.
Optical dispersion occurs when the refractive index of a medium varies with the light’s wavelength. One of its most visible manifestations is chromatic aberration in a lens: the lens has a shorter focal length for wavelengths for which its refractive index is higher, resulting in a blurred image. Since dispersion was first explained by Isaac Newton in 1660, people have developed ways to mitigate it. One involves achromatic doublet lenses, comprising two lenses with different refractive indices stuck together such that the dispersion of one roughly compensates the dispersion of the other.
Today, however, optical technology is moving away from traditional lenses and towards flat optical metasurfaces. These are thinner and lighter and offer functionalities such as reconfigurability and variation of refractive index with polarization that are impossible to achieve with traditional lenses. However, there are difficulties associated with metasurfaces – and among the most prominent are increased chromatic aberration and other performance variations with wavelength.
Wavelength independence needed
The principal cause of these problems is that, whereas bulk lenses control light through cumulative effects on the waves passing through, metasurfaces use optical elements to interact with the wavefronts directly and tailor their shape and phase. To achieve this interaction, these optical elements comprise structures on the scale of the wavelength of the light they control. Variations in the wavelength therefore significantly affect this interaction. Moreover, many of the most efficient metasurface designs are based on resonators, which have a sharp peak at one wavelength: “If you want to make a laser, you want one colour, so a resonant cavity is perfect,” explains Kanté, “But if you want to make a lens, one colour is not good enough!”
In the new work, Kanté and colleagues took a different approach. Instead of using resonators, they used a “fishnet” structure – a lattice of interconnected 350 nm titanium dioxide grids spaced 370 nm apart. Each element behaves as a waveguide: “You need to make those little waveguides as broadband as possible,” explains Kanté. Waveguide-based metasurfaces have been designed before, but they have invariably had efficiencies well below those of the current design. However, the researchers had another, subtler trick up their sleeves.
The phase of each waveguide must be carefully selected to produce a surface with maximum possible efficiency. Previously, researchers have selected the phase of each waveguide independently, by assuming it to be part of a lattice of identical waveguides. “When I make my lens, the waveguide next to it is different,” explains Kanté, “but I assume that it’s not that different, so the error that I get by assuming that it’s the same is not that big.” In 2017, however, Kanté and colleagues showed that this is simply inadequate. They also presented a method for calculating the correct phase. In their latest research, they used this to select the orientation of each pillar in the lattice. The resulting lens focused at least 70% of incident light in the wavelength range 640-1200 nm to the same point.
Fluorescence imaging
The researchers believe that, if a scalable production process can be developed, their design could perform a range of tasks, such as producing virtual reality images and focusing light in solar cells – a process that helps harvest energy more efficiently. “If you are now comparable in efficiency [with traditional lenses] the next question becomes ‘how large scale can you make these things and how much do they cost?’” says Kanté. Even without large-scale production, however, Kanté believes the lenses could contribute to techniques such as fluorescence imaging, which is a Nobel-prize winning super-resolution microscopy technique now widely used in research and medicine: “You pump the molecules with one colour and they emit at another,” explains Kanté, “Now that our lenses are broadband, you could actually pump and collect with the same ultrathin lens.”
Francesco Monticone of Cornell University is impressed “While several recent papers have proposed a large variety of design methods to realize broadband achromatic metasurfaces – with some impressive results…the experimental demonstration and measurements presented [by Kanté’s team] are outstanding.” Monticone’s group recently published fundamental limits on the bandwidth of optical metalenses: “The fabricated metalenses [made by Kanté’s team] represent an important step toward reaching these physical bounds, extending the current state of the art of metalenses and their potential for many applications requiring broad bandwidth and high efficiency,” he says.
The metalenses are described in Nature Communications.


physicsworld--2020-07-16--How a longhorn beetle could help keep you cool, the pros and cons of online conferences - Physics Wo

How a longhorn beetle could help keep you cool, the pros and cons of online conferences - Physics World

Nature in all its glorious diversity has come up with some very clever solutions to difficult problems .
In this @ @ @ @ @ Weekly podcast the science writer Michael Allen talks about a longhorn beetle from south-east Asia @ @ @ @ @ sizzling temperatures has inspired the creation of a highly reflective material that could soon be @ @ @ @ @ COVID-19 pandemic has caused profound changes in the ways that physicists meet to exchange ideas @ @ @ @ @ week , Physics World ’ s Tami Freeman attended her first virtual conference – the @ @ @ @ @ Association of Physicists in Medicine and the Canadian Organization of Medical Physicists ( AAPM/COMP ) @ @ @ @ @ pros and cons of online meetings .

Nature in all its glorious diversity has come up with some very clever solutions to difficult problems. In this episode of the Physics World Weekly podcast the science writer Michael Allen talks about a longhorn beetle from south-east Asia, whose ability to survive sizzling temperatures has inspired the creation of a highly reflective material that could soon be keeping you cool.
The COVID-19 pandemic has caused profound changes in the ways that physicists meet to exchange ideas about their research. This week, Physics World’s Tami Freeman attended her first virtual conference – the joint meeting of the American Association of Physicists in Medicine and the Canadian Organization of Medical Physicists (AAPM/COMP) – and chats about the pros and cons of online meetings.


physicsworld--2020-07-16--Biosensor platform promises fast, low-cost detection of water contamination - Physics World

With 80 % of the world ’ s population at risk of water insecurity , there ’ s a clear need for a fast , simple and reliable way to test water for a wide range of contaminants .
Julius Lucks and his team at Northwestern University believe they have the answer .
Its name is ROSALIND – RNA output sensors activated by ligand induction .
In their recent study , published in Nature Biotechnology , Lucks and his team didn ’ t invent a sophisticated new technique .
Instead , they took advantage of the elegant solutions that have @ @ @ @ @ @ @ the water ’ s contents .
This approach provides a straightforward positive or negative test for up to 17 different water contaminants , and it works in minutes .
Putting nature to a new use The researchers ’ approach is to take molecular machinery ( including DNA , RNA and proteins ) and reprogramme it for their own needs .
In this case , the machinery comes from bacterial cells and uses the components that normally copy the DNA ’ s genetic code into a messenger form to be turned into the cell @ @ @ @ @ @ @ the team re-engineered these molecular machines to work outside the cell for a new purpose .
Usually , DNA is copied when the code is needed by the cell .
For this testing platform , that control is instead used to trigger DNA copying only when specific water contaminants are present .
The water samples being tested are mixed in a tube pre-loaded with these molecular machines .
When contaminants are present , the machines copy out a messenger form that lights up in the tube – giving off a signal that ’ @ @ @ @ @ @ @ .
This allows ROSALIND to turn a contaminant we could never see into a light signal we can ’ t miss .
Importantly , the acronym ROSALIND also honours Rosalind Franklin , whose work was vital to the discovery of the DNA double-helix structure .
According to Lucks , “ her work essentially eventually enabled us to learn how to reprogram DNA to act in our technology ” .
Franklin ’ s 100th birthday would have been the same month that this research was published , he notes .
Taking technology where it @ @ @ @ @ @ @ water require significant expertise and equipment – making them expensive – ROSALIND is different , according to Lucks .
“ We ’ re offering a technology that enables anyone to directly test their own water and know if they have contamination within minutes , ” he explains .
“ It ’ s so simple to use that we can put it into the hands of the people who need it most.
” The researchers have tested their method in the field , where it successfully matched the results of a gold standard laboratory @ @ @ @ @ @ @ whilst being much quicker and more affordable .
Putting the technology into people ’ s hands doesn ’ t just mean making it cheaper , but also making it easier to use .
Using the molecular machines outside of the cell allows them to be freeze dried , which keeps all of the components stable until they are needed .
All the user needs to do is add a drop of water .
Not only is this process simple , but the whole system is highly flexible .
Currently , 17 different contaminants @ @ @ @ @ @ @ , antibiotics and additives to personal care products – and ROSALIND could be easily updated to add more relevant contaminants in future .
Having previously tried to test water in his own home , Lucks was frustrated to find it a difficult or impossible task .
“ To ensure access to safe and clean drinking water , we need technologies that will allow easy monitoring of water quality , ” he says .
As the researchers move from creating their concept in the lab to developing this platform via a start-up company , @ @ @ @ @ @ @ will soon bring water testing technology to the masses .

Samples of water being tested using ROSALIND glow to indicate the presence of different water contaminants. (Courtesy: Northwestern University)
With 80% of the world’s population at risk of water insecurity, there’s a clear need for a fast, simple and reliable way to test water for a wide range of contaminants. Julius Lucks and his team at Northwestern University believe they have the answer. Its name is ROSALIND – RNA output sensors activated by ligand induction.
In their recent study, published in Nature Biotechnology, Lucks and his team didn’t invent a sophisticated new technique. Instead, they took advantage of the elegant solutions that have evolved in nature to “taste” the water’s contents. This approach provides a straightforward positive or negative test for up to 17 different water contaminants, and it works in minutes.
Putting nature to a new use
The researchers’ approach is to take molecular machinery (including DNA, RNA and proteins) and reprogramme it for their own needs. In this case, the machinery comes from bacterial cells and uses the components that normally copy the DNA’s genetic code into a messenger form to be turned into the cell’s building blocks. Instead, the team re-engineered these molecular machines to work outside the cell for a new purpose.
Usually, DNA is copied when the code is needed by the cell. For this testing platform, that control is instead used to trigger DNA copying only when specific water contaminants are present. The water samples being tested are mixed in a tube pre-loaded with these molecular machines. When contaminants are present, the machines copy out a messenger form that lights up in the tube – giving off a signal that’s easily seen by the human eye. This allows ROSALIND to turn a contaminant we could never see into a light signal we can’t miss.
Importantly, the acronym ROSALIND also honours Rosalind Franklin, whose work was vital to the discovery of the DNA double-helix structure. According to Lucks, “her work essentially eventually enabled us to learn how to reprogram DNA to act in our technology”. Franklin’s 100th birthday would have been the same month that this research was published, he notes.
Taking technology where it is needed
Whilst current methods to test water require significant expertise and equipment – making them expensive – ROSALIND is different, according to Lucks. “We’re offering a technology that enables anyone to directly test their own water and know if they have contamination within minutes,” he explains. “It’s so simple to use that we can put it into the hands of the people who need it most.” The researchers have tested their method in the field, where it successfully matched the results of a gold standard laboratory test – flame atomic absorption spectroscopy – whilst being much quicker and more affordable.
Putting the technology into people’s hands doesn’t just mean making it cheaper, but also making it easier to use. Using the molecular machines outside of the cell allows them to be freeze dried, which keeps all of the components stable until they are needed. All the user needs to do is add a drop of water. Not only is this process simple, but the whole system is highly flexible. Currently, 17 different contaminants can be detected – including toxic metals, antibiotics and additives to personal care products – and ROSALIND could be easily updated to add more relevant contaminants in future.
Having previously tried to test water in his own home, Lucks was frustrated to find it a difficult or impossible task. “To ensure access to safe and clean drinking water, we need technologies that will allow easy monitoring of water quality,” he says. As the researchers move from creating their concept in the lab to developing this platform via a start-up company, Stemloop, Lucks is hoping that ROSALIND will soon bring water testing technology to the masses.


physicsworld--2020-07-16--Mediator atoms help graphene self-heal - Physics World

Graphene and other carbon materials are known to change their structure and even self-heal defects , but the processes involved in these atomic rearrangements often have high energy barriers and so shouldn ’ t occur under normal conditions .
An international team of researchers in Korea , the UK , Japan , the US and France has now cleared up the mystery by showing that fast-moving carbon atoms catalyse many of the restructuring processes .
Graphene – a carbon sheet just one atomic layer thick – is an ideal system for studying defects because of its simple two-dimensional single-element structure @ @ @ @ @ @ @ the structural evolution of graphene defects via a mechanism known as a Stone-Thrower-Wales type bond rotation .
This mechanism involves a change in the connectivity of atoms within the lattice , but it has a relatively large activation energy , making it “ forbidden ” without some form of assistance .
Using some of the best transmission electron microscopes available , researchers led by Alex Robertson of Oxford University and Kazu Suenaga of AIST Tsukuba found that so-called “ mediator atoms ” – carbon atoms that do not fit properly into the graphene @ @ @ @ @ @ @ bonds break and form .
“ The importance of these rapid , unseen ‘ helpers ’ has been previously underestimated because they move so fast and have been next-to-impossible to observe , ” says co-team leader Christopher Ewels , a nanoscientist at the University of Nantes .
The breakthrough , Ewels says , came when they realized that these usually fast-moving atoms slow down when bound to existing defects in the lattice .
“ Our technique can be likened to those nature programmes on television in which cameramen often have a hard time @ @ @ @ @ @ @ can be shy , ” he explains .
“ They therefore sometimes set themselves up in hides next to a watering hole where they know the animals are sure to go , and that ’ s how they get their film footage .
“ In our case , the mediator atoms shoot around too fast for our cameras .
By instead imaging and watching pre-existing defects ( the watering holes ) that occasionally trap mediator atoms ( which can linger near the defects for seconds , minutes or even hours ) , we @ @ @ @ @ @ @ how they influence defect restructuring.
” Since the images were blurred because of the speed of the processes involved , detailed theoretical modelling calculations were required to interpret them .
These calculations were done at Seoul National University by Gun-Do Lee and his team and Ewels and his colleagues at the CNRS in Nantes .
The mediator atoms act as catalysts thanks to their reactive dangling bonds , Ewels explains .
By bonding to defective sites and lowering the activation energy of reactions , they trigger a variety of bond-breaking and bond-forming processes @ @ @ @ @ @ @ become incorporated into the lattice , kicking out atoms that were already there and causing the ejected atoms to mediate further rearrangements ( see image above ) .
“ These processes may occur in many other environments , from interstellar carbon chemistry to graphite moderators in nuclear reactors , ” Ewels tells Physics World .
The new work thus provides an important fundamental understanding of how graphene and related 2D materials structurally rearrange and repair themselves , he adds .
The researchers , who report their results in Science Advances , speculate that @ @ @ @ @ @ @ in other bulk materials .
They now plan to explore this idea further .
“ We suspect similar process may underlie mechanical deformation processes of many 2D and 3D materials , ” Ewels says .

Mediator atoms in graphene. (Courtesy: C Ewels)
Graphene and other carbon materials are known to change their structure and even self-heal defects, but the processes involved in these atomic rearrangements often have high energy barriers and so shouldn’t occur under normal conditions. An international team of researchers in Korea, the UK, Japan, the US and France has now cleared up the mystery by showing that fast-moving carbon atoms catalyse many of the restructuring processes.
Graphene – a carbon sheet just one atomic layer thick – is an ideal system for studying defects because of its simple two-dimensional single-element structure. Until now, researchers typically explained the structural evolution of graphene defects via a mechanism known as a Stone-Thrower-Wales type bond rotation. This mechanism involves a change in the connectivity of atoms within the lattice, but it has a relatively large activation energy, making it “forbidden” without some form of assistance.
Using some of the best transmission electron microscopes available, researchers led by Alex Robertson of Oxford University and Kazu Suenaga of AIST Tsukuba found that so-called “mediator atoms” – carbon atoms that do not fit properly into the graphene lattice – act as catalysts to help bonds break and form. “The importance of these rapid, unseen ‘helpers’ has been previously underestimated because they move so fast and have been next-to-impossible to observe,” says co-team leader Christopher Ewels, a nanoscientist at the University of Nantes.
The breakthrough, Ewels says, came when they realized that these usually fast-moving atoms slow down when bound to existing defects in the lattice. “Our technique can be likened to those nature programmes on television in which cameramen often have a hard time filming some of the animals, which can be shy,” he explains. “They therefore sometimes set themselves up in hides next to a watering hole where they know the animals are sure to go, and that’s how they get their film footage.
“In our case, the mediator atoms shoot around too fast for our cameras. By instead imaging and watching pre-existing defects (the watering holes) that occasionally trap mediator atoms (which can linger near the defects for seconds, minutes or even hours), we are able to image them and observe how they influence defect restructuring.”
Since the images were blurred because of the speed of the processes involved, detailed theoretical modelling calculations were required to interpret them. These calculations were done at Seoul National University by Gun-Do Lee and his team and Ewels and his colleagues at the CNRS in Nantes.
Active catalysts
The mediator atoms act as catalysts thanks to their reactive dangling bonds, Ewels explains. By bonding to defective sites and lowering the activation energy of reactions, they trigger a variety of bond-breaking and bond-forming processes. In some cases, the mediators become incorporated into the lattice, kicking out atoms that were already there and causing the ejected atoms to mediate further rearrangements (see image above). “These processes may occur in many other environments, from interstellar carbon chemistry to graphite moderators in nuclear reactors,” Ewels tells Physics World. The new work thus provides an important fundamental understanding of how graphene and related 2D materials structurally rearrange and repair themselves, he adds.
The researchers, who report their results in Science Advances, speculate that analogous mediator atom species may be present in other bulk materials. They now plan to explore this idea further. “We suspect similar process may underlie mechanical deformation processes of many 2D and 3D materials,” Ewels says.


physicsworld--2020-07-15--Impurities toughen tooth enamel, but could make teeth vulnerable to decay - Physics World

The fundamental building blocks of human tooth enamel contain characteristic impurities that could contribute to their toughness , but also make teeth more vulnerable to decay .
US researchers led by Derk Joester at Northwestern University made the discovery using two atomic-scale imaging techniques , which revealed distinctive distributions of impurities within the crystal structure of enamel .
Their findings could lead to new ways to improve the health of our enamel , and to repair the damage created by tooth decay .
Coating the entire crown of the human tooth , enamel is an extremely hard substance that is @ @ @ @ @ @ @ mechanical forces associated with chewing .
Yet in many people , the material is broken down through tooth decay – which is one of the most widespread chronic diseases .
So far , techniques for repairing and synthesizing new enamel have had limited success , largely due to limitations in our understanding of the material ’ s deeply hierarchical structure .
At the microscopic level , enamel is made up of rods composed of thousands of long , thin crystals with rectangular cross-sections – called crystallites .
The rods are arranged in complex @ @ @ @ @ @ @ wide , the crystallite building blocks are primarily composed of the mineral hydroxyl-apatite .
This has an orderly lattice containing calcium , phosphate , and hydroxyl ions .
However , the crystallites are also known to possess cross-sectional variations in chemical composition on atomic scales .
To explore these variations in more detail , Joester ’ s team first carried out scanning transmission electron microscopy ( STEM ) on thin , ultra-cold crystallite cross-sections .
The resulting images revealed that within the periodic lattice of hydroxyl-apatite , crystallites have central cores with slightly @ @ @ @ @ @ @ between two distinctive layers ( see figure ) .
Since these structures were damaged by STEM electron beams , Joester ’ s team also employed the technique of atom-probe tomography ( APT ) , which can locate individual atoms at sub-nanometre resolutions .
Within these images , they saw that crystallite cores contain high concentrations of sodium , fluoride , and carbonate ion impurities , and are flanked by two magnesium-rich layers .
Through simulations , combined with experiments involving X-ray diffraction , Joester and colleagues revealed that these chemical gradients create stress @ @ @ @ @ @ @ partly responsible for the materials ’ s high mechanical resilience .
However , the impurities could also increase the solubility of the material in acidic conditions , making it more vulnerable to decay .
The team ’ s findings could offer important new insights into the crystal growth that takes place during enamel formation , and how it could be controlled artificially .
If achieved , such techniques could lead to new treatments for people suffering from tooth decay , and to new ways of maintaining healthy enamel .
The study is described @ @ @

Magnesium-rich: an atomic-resolution scanning transmission electron microscopy image of an enamel crystallite looking down the long axis of the crystal. The dark areas show magnesium ions forming two layers on either side of the core. (Courtesy: Northwestern University)
The fundamental building blocks of human tooth enamel contain characteristic impurities that could contribute to their toughness, but also make teeth more vulnerable to decay. US researchers led by Derk Joester at Northwestern University made the discovery using two atomic-scale imaging techniques, which revealed distinctive distributions of impurities within the crystal structure of enamel. Their findings could lead to new ways to improve the health of our enamel, and to repair the damage created by tooth decay.
Coating the entire crown of the human tooth, enamel is an extremely hard substance that is well adapted to withstanding the wear and mechanical forces associated with chewing. Yet in many people, the material is broken down through tooth decay – which is one of the most widespread chronic diseases. So far, techniques for repairing and synthesizing new enamel have had limited success, largely due to limitations in our understanding of the material’s deeply hierarchical structure.
At the microscopic level, enamel is made up of rods composed of thousands of long, thin crystals with rectangular cross-sections – called crystallites. The rods are arranged in complex meshess. No more than 170 nm wide, the crystallite building blocks are primarily composed of the mineral hydroxyl-apatite. This has an orderly lattice containing calcium, phosphate, and hydroxyl ions. However, the crystallites are also known to possess cross-sectional variations in chemical composition on atomic scales.
Atom-probe tomography
To explore these variations in more detail, Joester’s team first carried out scanning transmission electron microscopy (STEM) on thin, ultra-cold crystallite cross-sections. The resulting images revealed that within the periodic lattice of hydroxyl-apatite, crystallites have central cores with slightly different compositions. These cores are sandwiched between two distinctive layers (see figure). Since these structures were damaged by STEM electron beams, Joester’s team also employed the technique of atom-probe tomography (APT), which can locate individual atoms at sub-nanometre resolutions. Within these images, they saw that crystallite cores contain high concentrations of sodium, fluoride, and carbonate ion impurities, and are flanked by two magnesium-rich layers.
Through simulations, combined with experiments involving X-ray diffraction, Joester and colleagues revealed that these chemical gradients create stress patterns in enamel, which could be partly responsible for the materials’s high mechanical resilience. However, the impurities could also increase the solubility of the material in acidic conditions, making it more vulnerable to decay. The team’s findings could offer important new insights into the crystal growth that takes place during enamel formation, and how it could be controlled artificially. If achieved, such techniques could lead to new treatments for people suffering from tooth decay, and to new ways of maintaining healthy enamel.
The study is described in Nature.


physicsworld--2020-07-15--GPS for cancer cells: PET tracks real-time migration of single radiolabelled cells - Physics World

The ability to accurately track the movement of cancer cells as they metastasize to other locations in the body could allow oncologists to better target therapies and start treatments earlier .
To achieve this , researchers at Stanford University School of Medicine have developed CellGPS , an extremely sensitive and accurate method of single cell tracking using positron emission tomography ( PET ) .
They describe the technique and its feasibility to track single cell migration in laboratory mice in Nature Biomedical Engineering .
Applications for single cancer cell tracking using CellGPS include modelling and investigating the earliest stages of @ @ @ @ @ @ @ tumour cell clusters in the blood , and the role of haemodynamic forces , cell adhesion , blood flow and biomechanical interactions .
CellGPS could also be used to non-invasively measure the routes and kinetics of immune-cell mobilization in response to injury .
The CellGPS technique uses mesoporous silica nanoparticles ( MSNs ) to efficiently transfer radionuclides into cells for real-time cell tracking .
The researchers labelled the nanoparticles with gallium 68 ( 68Ga ) , a radiometal with a 67-min half-life that ’ s commonly used for PET imaging of neuroendocrine tumours @ @ @ @ @ @ @ cell loading , they coated the nanoparticles with a lipid bilayer .
MSNs with a diameter of 200 nm and a pore size of 4 nm carried 68Ga into live MDA-MB-231 breast cancer cells ( a common model of breast cancer metastasis to the lungs ) , achieving a radioactivity level of nearly 100 Bq per cell .
The researchers initially assessed the metabolic activity of the cells after radiolabelling , noting that there was a small ( 5–15 % ) decrease in overall metabolic activity within 24 hours .
They verified that @ @ @ @ @ @ @ , did not result in significant biological differences in apoptosis , proliferation and migration .
After determining the optimal settings for acquiring PET images and data , the researchers injected approximately 100 breast cancer cells labelled with 68Ga-MSNs intravenously into mice .
They used PET to confirm that the cancer cells arrested in the lungs .
When they subsequently reduced the number of injected cells to just one , PET-CT showed a single focus of radiotracer accumulation in their lungs , appearing as a hot spot of approximately 1.7 mm diameter .
The @ @ @ @ @ @ @ track the position of a moving cell in vivo .
Using the list-mode data from the scanner , they computed the 3D position of a single cell injected into a tail vein through a butterfly catheter .
The cell , traveling at a velocity of up to 50 mm/s , was tracked to the lungs within 3 s of intravenous injection .
Its location matched the focal signal seen on conventional PET-CT imaging .
To demonstrate that single cells can be imaged beyond the 67 min half-life of 68Ga , the researchers also @ @ @ @ @ @ @ 89Zr , a positron-emitting radionuclide with a half-life of 78 hr ) .
They intravenously injected single cells labelled with 89Zr-MSNs into two mice and imaged them over multiple days using PET .
A single focus of uptake could be detected in the lungs for up to 48 hr and remained stable .
Principal investigator Guillem Pratx and colleagues state that the two most important findings of their research are that PET is sufficiently sensitive to image static single cells labelled with more than 20 Bq per cell of 68Ga , and that @ @ @ @ @ @ @ directly from list-mode PET data .
“ The CellGPS methodology could be extended to enable tracking of multiple cells simultaneously in the same individual , ” they explain .
“ In the case of cellular therapies in which millions of cells are injected , it will be possible to label and track a small subset of cells using the CellGPS methodology.
” “ We plan to push the technology to enable tracking of multiple single cells at the same time in the same individual by multiplexing the PET signals , ” Pratx tells @ @ @ @ @ @ @ to investigate new applications where cell migration is key , primarily in the area of immune cell tracking for cancer immunotherapy applications , stem cell regenerative medicine , and more advanced models of cancer metastasis .
”

The CellGPS workflow: nanoparticles are used to concentrate 68Ga and then loaded into cells; isolated single cells are administered into mice; emitted gamma rays are captured using a small-animal PET scanner and processed to estimate the location of the moving cell in real time. (Courtesy: Nat. Biomed. Eng. 10.1038/s41551-020-0570-5)
The ability to accurately track the movement of cancer cells as they metastasize to other locations in the body could allow oncologists to better target therapies and start treatments earlier. To achieve this, researchers at Stanford University School of Medicine have developed CellGPS, an extremely sensitive and accurate method of single cell tracking using positron emission tomography (PET). They describe the technique and its feasibility to track single cell migration in laboratory mice in Nature Biomedical Engineering.
Applications for single cancer cell tracking using CellGPS include modelling and investigating the earliest stages of metastatic migration, including the circulation of tumour cell clusters in the blood, and the role of haemodynamic forces, cell adhesion, blood flow and biomechanical interactions. CellGPS could also be used to non-invasively measure the routes and kinetics of immune-cell mobilization in response to injury.
The CellGPS technique uses mesoporous silica nanoparticles (MSNs) to efficiently transfer radionuclides into cells for real-time cell tracking. The researchers labelled the nanoparticles with gallium 68 (68Ga), a radiometal with a 67-min half-life that’s commonly used for PET imaging of neuroendocrine tumours and metastatic prostate cancer. To enhance cell loading, they coated the nanoparticles with a lipid bilayer. MSNs with a diameter of 200 nm and a pore size of 4 nm carried 68Ga into live MDA-MB-231 breast cancer cells (a common model of breast cancer metastasis to the lungs), achieving a radioactivity level of nearly 100 Bq per cell.
The researchers initially assessed the metabolic activity of the cells after radiolabelling, noting that there was a small (5–15%) decrease in overall metabolic activity within 24 hours. They verified that DNA damage in cells, although detectable, did not result in significant biological differences in apoptosis, proliferation and migration.
After determining the optimal settings for acquiring PET images and data, the researchers injected approximately 100 breast cancer cells labelled with 68Ga-MSNs intravenously into mice. They used PET to confirm that the cancer cells arrested in the lungs. When they subsequently reduced the number of injected cells to just one, PET-CT showed a single focus of radiotracer accumulation in their lungs, appearing as a hot spot of approximately 1.7 mm diameter.
The researchers also used PET data to dynamically track the position of a moving cell in vivo. Using the list-mode data from the scanner, they computed the 3D position of a single cell injected into a tail vein through a butterfly catheter. The cell, traveling at a velocity of up to 50 mm/s, was tracked to the lungs within 3 s of intravenous injection. Its location matched the focal signal seen on conventional PET-CT imaging.
Dynamic tracking of a single cell in vivo at three time points. The blue lines represent detected coincidence events, the red dot is the estimated cell location, the yellow line is the reconstructed trajectory. Bottom-right: reconstructed trajectory with respect to the bony anatomy. (Courtesy: Nat. Biomed. Eng. 10.1038/s41551-020-0570-5)
To demonstrate that single cells can be imaged beyond the 67 min half-life of 68Ga, the researchers also tested the CellGPS workflow using zirconium-89 (89Zr, a positron-emitting radionuclide with a half-life of 78 hr). They intravenously injected single cells labelled with 89Zr-MSNs into two mice and imaged them over multiple days using PET. A single focus of uptake could be detected in the lungs for up to 48 hr and remained stable.
Guillem Pratx.
Principal investigator Guillem Pratx and colleagues state that the two most important findings of their research are that PET is sufficiently sensitive to image static single cells labelled with more than 20 Bq per cell of 68Ga, and that single migrating cells can be tracked dynamically directly from list-mode PET data.
“The CellGPS methodology could be extended to enable tracking of multiple cells simultaneously in the same individual,” they explain. “In the case of cellular therapies in which millions of cells are injected, it will be possible to label and track a small subset of cells using the CellGPS methodology.”
“We plan to push the technology to enable tracking of multiple single cells at the same time in the same individual by multiplexing the PET signals,” Pratx tells Physics World. “We also plan to investigate new applications where cell migration is key, primarily in the area of immune cell tracking for cancer immunotherapy applications, stem cell regenerative medicine, and more advanced models of cancer metastasis.”


physicsworld--2020-07-15--Superhydrophobic surfaces toughen up - Physics World

A micron-scale “ armour ” that protects highly water-repellent nanostructures from damage has been developed by researchers in China and Finland .
The new extra-durable coating could make it possible to employ these “ superhydrophobic ” surfaces on devices such as solar panels and vehicle windscreens that experience tough environmental conditions .
As their name suggests , superhydrophobic materials repel water extremely well .
They owe this impressive ability to a thin layer of air that develops around nanometre-scale structures on their surface .
By ensuring that droplets barely touch the solid part of the surface at all , the @ @ @ @ @ @ @ , allowing water droplets to roll off with near-zero friction .
These nanostructured surfaces are , however , mechanically fragile and can easily be wiped away .
To address this drawback , a research team led by Xu Deng of the University of Electronic Science and Technology of China in Chengdu and Robin Ras of Finland ’ s Aalto University created a superhydrophobic surface containing structures at two different length scales : a nanoscale structure that is water repellent and a microscale one that provides durability .
The microstructure consists of an interconnected @ @ @ @ @ @ @ inverted pyramids .
Within these pyramids are the highly water-repellent and mechanically fragile nanostructures .
The frame thus acts as a shield , preventing the nanostructure coating from being removed by abradants larger than the frame .
“ A finger , screwdriver or even sandpaper glides over these microstructures , leaving the nanostructures untouched , thereby preserving the surface ’ s attractive water-repellent feature , ” Ras says .
Ras goes on to explain that the microscale armour could be made from almost any material .
“ It ’ s the interconnecting structure @ @ @ @ @ @ @ strong and rigid , ” he says .
“ We made ours with pockets of different sizes , shapes and materials , including silicon , ceramics , metals and transparent glass .
The beauty of this approach is that it is a generic concept that works for numerous materials , giving us the flexibility to design a wide range of durable waterproof surfaces.
” In one of their experiments , Ras , Deng and colleagues constructed a superhydrophobic surface from transparent glass and used it as a cover for solar cells .
“ @ @ @ @ @ @ @ when they are on rooftops or other difficult-to-reach places , they become gradually contaminated with sand and dust , which results in poorer efficiency over time , ” Ras says .
“ For maintaining the high efficiency of current-generation solar panels , regular cleaning is needed , especially in places where there is a lot of dust in the air .
Our durable water-repellent coating means that they get cleaned automatically by rain or dew.
” Other applications for the superhydrophobic surfaces include anti-icing and anti-fogging surfaces , he adds , or machines @ @ @ @ @ @ @ .
The surfaces may even have antimicrobial properties since bacteria , viruses and pathogens can not cling to the nanostructures .
To prove that their surfaces could withstand difficult working environments , the researchers put them through a battery of tests : baking them at 100°C for several weeks ; immersing them in highly corrosive liquids for hours ; blasting them with high-pressure water jets ; and exposing them to extreme humidity while bending them .
They even rubbed them with sandpaper and cut them with a sharp steel blade .
None of @ @ @ @ @ @ @ and they continued to repel liquids as effectively as before .
The team members , who report their work in Nature , say they now plan to commercialize their coatings .
“ The benefits for the user are that they can keep surfaces spotless and clean , function in otherwise challenging conditions and reduce downtime by doing away with the need for constant cleaning , ” Ras tells Physics World .

A schematic representation of how the surface looks, and how the structure repels water. (Courtesy: Aalto University)
A micron-scale “armour” that protects highly water-repellent nanostructures from damage has been developed by researchers in China and Finland. The new extra-durable coating could make it possible to employ these “superhydrophobic” surfaces on devices such as solar panels and vehicle windscreens that experience tough environmental conditions.
As their name suggests, superhydrophobic materials repel water extremely well. They owe this impressive ability to a thin layer of air that develops around nanometre-scale structures on their surface. By ensuring that droplets barely touch the solid part of the surface at all, the air layer effectively acts as a lubricant, allowing water droplets to roll off with near-zero friction.
These nanostructured surfaces are, however, mechanically fragile and can easily be wiped away. To address this drawback, a research team led by Xu Deng of the University of Electronic Science and Technology of China in Chengdu and Robin Ras of Finland’s Aalto University created a superhydrophobic surface containing structures at two different length scales: a nanoscale structure that is water repellent and a microscale one that provides durability.
The microstructure consists of an interconnected frame containing “pockets” of tiny inverted pyramids. Within these pyramids are the highly water-repellent and mechanically fragile nanostructures. The frame thus acts as a shield, preventing the nanostructure coating from being removed by abradants larger than the frame. “A finger, screwdriver or even sandpaper glides over these microstructures, leaving the nanostructures untouched, thereby preserving the surface’s attractive water-repellent feature,” Ras says.
A generic concept
Ras goes on to explain that the microscale armour could be made from almost any material. “It’s the interconnecting structure of the surface frame that makes it strong and rigid,” he says. “We made ours with pockets of different sizes, shapes and materials, including silicon, ceramics, metals and transparent glass. The beauty of this approach is that it is a generic concept that works for numerous materials, giving us the flexibility to design a wide range of durable waterproof surfaces.”
In one of their experiments, Ras, Deng and colleagues constructed a superhydrophobic surface from transparent glass and used it as a cover for solar cells. “One problem with solar cells is that when they are on rooftops or other difficult-to-reach places, they become gradually contaminated with sand and dust, which results in poorer efficiency over time,” Ras says. “For maintaining the high efficiency of current-generation solar panels, regular cleaning is needed, especially in places where there is a lot of dust in the air. Our durable water-repellent coating means that they get cleaned automatically by rain or dew.”
Withstanding difficult working environments
Other applications for the superhydrophobic surfaces include anti-icing and anti-fogging surfaces, he adds, or machines and vehicles that operate in harsh conditions. The surfaces may even have antimicrobial properties since bacteria, viruses and pathogens cannot cling to the nanostructures.
To prove that their surfaces could withstand difficult working environments, the researchers put them through a battery of tests: baking them at 100°C for several weeks; immersing them in highly corrosive liquids for hours; blasting them with high-pressure water jets; and exposing them to extreme humidity while bending them. They even rubbed them with sandpaper and cut them with a sharp steel blade. None of these treatments appeared to affect the surfaces and they continued to repel liquids as effectively as before.
The team members, who report their work in Nature, say they now plan to commercialize their coatings. “The benefits for the user are that they can keep surfaces spotless and clean, function in otherwise challenging conditions and reduce downtime by doing away with the need for constant cleaning,” Ras tells Physics World.


physicsworld--2020-07-15--Net entanglement - Physics World

Net entanglement - Physics World

The Internet – our latest innovation in the history of written communication , which itself began in the fourth millennium BC – is now half a century old .
It dates from the moment in October 1969 when a computer at the University of California , Los Angeles , accessed a computer at the Stanford Research Institute in Menlo Park .
It spread slowly , funded by the US Department of Defense ’ s Advanced Research Projects Agency , as a project known as ARPANET .
In 1970 it connected about 10 computers , and by 1977 there were around @ @ @ @ @ @ @ number reach 1000 .
From then , the numbers grew exponentially : from 10,000 by 1987 , to 100,000 by 1990 , to 1000,000 by 1993 , following the invention of the World Wide Web by Tim Berners-Lee at CERN in 1989 .
Today , about half of the world ’ s population has access to the Internet , and the total number of Internet-connected devices is estimated at around 25–30 billion – that is , four devices for each person on the planet .
Thus , the Internet went from being “ @ @ @ @ @ @ @ and academic researchers , to a fringe community of nerds , to the bright shining hope of capitalism , to suddenly being critical infrastructure ” , writes author and journalist James Ball .
“ And all of that happened with few of us paying attention and fewer still thinking even one step ahead.
” His latest book , The System : Who Owns the Internet , and How It Owns Us , is a compelling historical analysis .
But it also serves as a clarion call to attention and action before the Internet @ @ @ @ @ @ @ instead of its earlier source of unity – more like the profit-driven website Facebook than the non-profit Wikipedia , so to speak .
“ The joy and the wonder of the Internet is that everything is connected .
Clearly , for anyone trying to look at how to fix its problems , the fact that everything is connected makes everything a lot harder , too.
” Ball is well qualified to write on this subject .
He was a self-proclaimed teenage Internet nerd .
Then , after graduating from a UK university in @ @ @ @ @ @ @ , who has now spent more than a decade reporting on the Internet .
In 2014 he was a member of the Guardian US team awarded a Pulitzer Prize for its coverage of US National Security Agency online surveillance , arising from the whistleblowing of Edward Snowden .
The System begins at the beginning in 1969 with a section , “ The mechanics ” , on the structure and operation of the Internet , divided into three chapters .
“ The architects ” discusses the engineers and academics who invented the system .
@ @ @ @ @ @ @ less glamorous fibre-optic companies that provide the physical links .
“ The custodians ” profiles those who supervise its operation , notably ICANN , the Internet Corporation for Assigned Names and Numbers : until 2016 a US government agency , but now an international body that makes its income by taking a portion of the fees paid by people buying online addresses .
The second section of the book , “ The money ” , deals with the venture capitalists and chief executives responsible for starting and promoting Internet companies – some of @ @ @ @ @ @ @ invasively inquisitive system of online advertising that earns these vast profits .
The third and final section , “ The melee ” , picks up on earlier discussions , covering topics such as government intelligence agencies and anonymous hackers ( “ The cyber warriors ” ) , and the US Federal Communications Commission ( “ The rulemakers ” ) .
The final chapter , “ The resistance ” , focuses on activist groups , such as the San Francisco-based Electronic Frontier Foundation , trying to hold the Internet ’ s power in check @ @ @ @ @ @ @ many significant interviews with pioneers in the field , including Steve Crocker , a software engineer present at the first log-in in 1969 ; Gorän Marby , a Swedish regulator who took over the helm of ICANN in 2016 ; Brian O ’ Kelley , the former chief executive of huge online advertising company AppNexus ; Cindy Cohn , a lawyer who directs the Electronic Frontier Foundation , and Wikipedia founder Jimmy Wales .
But certain key players do not feature in interviews , notably the founders of Amazon , Facebook and Google @ @ @ @ @ @ @ chief in charge of the National Security Agency at the time of the Snowden revelations .
In discussing the need for future regulation of the Internet , Ball makes an illuminating historical comparison .
The four best-known Internet companies – Amazon , Apple , Facebook and Google ( now formally called Alphabet ) – are “ engines running along the railway lines set out by the Internet ’ s very structure ” .
And “ just as railways could be used to create new monopolies in other industries – by charging different rates @ @ @ @ @ @ @ ” – so too can the Internet , when its structure has been harnessed by the big players .
Following Tim Wu , a Columbia Law School professor and author of The Curse of Bigness : Antitrust in the New Gilded Age ( 2018 ) , Ball argues that hard-fought competition laws introduced to regulate railway monopolies in the early decades of the 20th century , must now be reinvented to control the Internet for the good of the world , rather than just a group of billionaires .
As Wu concludes : @ @ @ @ @ @ @ ripe for the reinvigoration of the big case tradition , I don ’ t know it.
” Otherwise , the major Internet companies will continue to follow the example of Facebook ’ s 2014 purchase of WhatsApp for $ 19bn , as well as an analytics app that had allowed Facebook to spot and quash potential rivals .
As Ball comments , “ no-one was there to stop it , or even to question it .
No-one ever is ” – until now that is .
Maybe , he speculates in conclusion , @ @ @ @ @ @ @ will be the current rise of authoritarian China ’ s technology giants and the consequent ebbing of the US dominance of the Internet after half a century .
If so , ironically , a world-changing innovation originally triggered by military research may once again benefit from military considerations .

Physics World. Members of the Institute of Physics can enjoy the full issue Taken from the July 2020 issue of. Members of the Institute of Physics can enjoy the full issue via the Physics World app
Andrew Robinson reviews The System: Who Owns the Internet, and How It Owns Us by James Ball
Seat of power James Ball’s new book argues that the Internet needs to be regulated because Facebook and the other “big four” Internet companies hold too much power. (Courtesy: iStock/Jason Doly)
The Internet – our latest innovation in the history of written communication, which itself began in the fourth millennium BC – is now half a century old. It dates from the moment in October 1969 when a computer at the University of California, Los Angeles, accessed a computer at the Stanford Research Institute in Menlo Park. It spread slowly, funded by the US Department of Defense’s Advanced Research Projects Agency, as a project known as ARPANET. In 1970 it connected about 10 computers, and by 1977 there were around 100. Not until 1985 did the number reach 1000. From then, the numbers grew exponentially: from 10,000 by 1987, to 100,000 by 1990, to 1000,000 by 1993, following the invention of the World Wide Web by Tim Berners-Lee at CERN in 1989. Today, about half of the world’s population has access to the Internet, and the total number of Internet-connected devices is estimated at around 25–30 billion – that is, four devices for each person on the planet.
Thus, the Internet went from being “a closed community of US government staff and academic researchers, to a fringe community of nerds, to the bright shining hope of capitalism, to suddenly being critical infrastructure”, writes author and journalist James Ball. “And all of that happened with few of us paying attention and fewer still thinking even one step ahead.” His latest book, The System: Who Owns the Internet, and How It Owns Us, is a compelling historical analysis.
But it also serves as a clarion call to attention and action before the Internet degrades and becomes a source of division instead of its earlier source of unity – more like the profit-driven website Facebook than the non-profit Wikipedia, so to speak. “The joy and the wonder of the Internet is that everything is connected. Clearly, for anyone trying to look at how to fix its problems, the fact that everything is connected makes everything a lot harder, too.”
Ball is well qualified to write on this subject. He was a self-proclaimed teenage Internet nerd. Then, after graduating from a UK university in 2008, he became an investigative journalist, who has now spent more than a decade reporting on the Internet. In 2014 he was a member of the Guardian US team awarded a Pulitzer Prize for its coverage of US National Security Agency online surveillance, arising from the whistleblowing of Edward Snowden.
The System begins at the beginning in 1969 with a section, “The mechanics”, on the structure and operation of the Internet, divided into three chapters. “The architects” discusses the engineers and academics who invented the system. “The cable guys” covers the less glamorous fibre-optic companies that provide the physical links. “The custodians” profiles those who supervise its operation, notably ICANN, the Internet Corporation for Assigned Names and Numbers: until 2016 a US government agency, but now an international body that makes its income by taking a portion of the fees paid by people buying online addresses.
The second section of the book, “The money”, deals with the venture capitalists and chief executives responsible for starting and promoting Internet companies – some of whom have become billionaires – and the invasively inquisitive system of online advertising that earns these vast profits.
The third and final section, “The melee”, picks up on earlier discussions, covering topics such as government intelligence agencies and anonymous hackers (“The cyber warriors”), and the US Federal Communications Commission (“The rulemakers”). The final chapter, “The resistance”, focuses on activist groups, such as the San Francisco-based Electronic Frontier Foundation, trying to hold the Internet’s power in check.
Along the way, Ball includes many significant interviews with pioneers in the field, including Steve Crocker, a software engineer present at the first log-in in 1969; Gorän Marby, a Swedish regulator who took over the helm of ICANN in 2016; Brian O’Kelley, the former chief executive of huge online advertising company AppNexus; Cindy Cohn, a lawyer who directs the Electronic Frontier Foundation, and Wikipedia founder Jimmy Wales. But certain key players do not feature in interviews, notably the founders of Amazon, Facebook and Google, or, unsurprisingly, the intelligence chief in charge of the National Security Agency at the time of the Snowden revelations.
In discussing the need for future regulation of the Internet, Ball makes an illuminating historical comparison. The four best-known Internet companies – Amazon, Apple, Facebook and Google (now formally called Alphabet) – are “engines running along the railway lines set out by the Internet’s very structure”. And “just as railways could be used to create new monopolies in other industries – by charging different rates to different companies, or playing favourites” – so too can the Internet, when its structure has been harnessed by the big players.
Hard-fought competition laws introduced to regulate railway monopolies in the early decades of the 20th century, must now be reinvented to control the Internet for the good of the world, rather than just a group of billionaires
Following Tim Wu, a Columbia Law School professor and author of The Curse of Bigness: Antitrust in the New Gilded Age (2018), Ball argues that hard-fought competition laws introduced to regulate railway monopolies in the early decades of the 20th century, must now be reinvented to control the Internet for the good of the world, rather than just a group of billionaires. As Wu concludes: “If there is a sector more ripe for the reinvigoration of the big case tradition, I don’t know it.” Otherwise, the major Internet companies will continue to follow the example of Facebook’s 2014 purchase of WhatsApp for $19bn, as well as an analytics app that had allowed Facebook to spot and quash potential rivals. As Ball comments, “no-one was there to stop it, or even to question it. No-one ever is” – until now that is.
Maybe, he speculates in conclusion, the spur to democratic reform and regulation will be the current rise of authoritarian China’s technology giants and the consequent ebbing of the US dominance of the Internet after half a century. If so, ironically, a world-changing innovation originally triggered by military research may once again benefit from military considerations.
2020 Bloomsbury £20.00hb 288pp


physicsworld--2020-07-14--Physics in the pandemic: ‘Surviving the virus really aligns your perspective’ - Physics World

Between March and May , France went through a two-month period of strict confinement .
During this time , we were only allowed to leave our homes for essentials such as grocery shopping , and we needed to fill in a form every time explaining why we were out .
Once home working became the default at my institute , I joined my partner ( who is also an academic ) in the south of France , as I did not want to be on my own for such a long period .
Working from home was doable , although @ @ @ @ @ @ @ challenges ; for example , we had to share the kitchen table for our work and co-ordinate all our virtual meetings and talks so they wouldn ’ t interfere with each other .
Then , in early April , just before Easter , my partner came down with a heavy cough and fever .
We immediately suspected COVID-19 and entered an even stricter quarantine , during which we did not set foot outside our apartment .
At first , I had no symptoms , but within two days I was also not feeling @ @ @ @ @ @ @ we were both severely ill .
I am a young and healthy person , someone who runs marathons and has not a single medical condition or risk factor , yet COVID really wiped me out .
It was scary how little energy we had left once the virus took over .
We could not even find the energy to eat – a problem made worse by the fact that we entirely lost our senses of smell and taste .
After a week of symptoms , I began to improve .
However , although @ @ @ @ @ @ @ I was still severely weakened .
It took me five or six weeks to get back to normal energy levels .
Meanwhile , my partner continued to battle a fever and other severe symptoms for more than two weeks .
This was a challenge , as it meant that I needed to nurse him back to health while I myself was far from well .
Worse still , after an initial recovery , he developed a serious secondary bacterial infection and was hospitalized .
This was an extremely hard time , as no @ @ @ @ @ @ @ all I could do was hope he would get better .
Luckily , he eventually did – albeit only after an ordeal that spanned more than two months .
Now that our health permits it , we are back to working from home , and have been for more than a month .
The Strasbourg Observatory has also implemented a limited in-person return to the office , as the number of active coronavirus cases in France has been low since May .
Even so , there are many precautions .
We are only @ @ @ @ @ @ @ office at a time , and we organize this by filling in online sheets specifying the times when we are present .
Upon entering the buildings , we are greeted with a hand-sanitizing station and provided with masks .
As astronomers , we don ’ t have labs , which makes social distancing easier .
However , all our typical social gatherings and seminars are still prohibited .
I think the return to in-person work has been managed very well , as it is possible to keep our distance from each other and @ @ @ @ @ @ @ home can do so .
I think it is important to let individuals decide what they are comfortable with , depending on their own situation and risk assessment .
My biggest professional concern is how the crisis is going to impact my future in academia .
I am in my second postdoc and I need to find a more permanent position soon .
However , I lost several months of productivity to the virus and I am only on a two-year contract .
I also had a busy March–May period planned , including @ @ @ @ @ @ @ invited conference talk .
Obviously , none of that happened .
It is really hard to showcase your science without conferences , especially in the critical early stage of your career .
Although I have antibodies now and should be protected from the virus for a while , I do not plan to travel in the next few months or attend in-person meetings and conferences .
Even later this year , organizing in-person events would put attendees at risk , especially since very few will have antibodies .
Another problem that is severely @ @ @ @ @ @ @ at most telescopes , as support staff can not get to and from the facilities .
This means that anyone who was granted observing time during this period has not been able to do their observations – something that has impacted me personally .
Because my partner is also an academic , my prospects in academia were already pretty bleak due to the “ two-body problem ” , and my impression is that COVID has worsened the outlook on all fronts .
Many other junior scientists are in similar positions , and with @ @ @ @ @ @ @ hiring freezes , I assume the pressure on the job market will only increase .
An even bigger concern , though , is that members of my family or other loved ones will get the virus , especially if there is a second wave in the autumn .
When I see what it did to two healthy and fit people in their early 30s , I do not even want to imagine what it would do to people with medical conditions or other risk factors .
So I urge everyone to be very @ @ @ @ @ @ @ building had the virus a bit earlier than we did , and it is likely that we caught it from them just by passing through the same hallway , as we never met them in person during that time .
We observed all the strict confinement rules and took no risks , yet we were not able to avoid it – which shows that one can never be too careful .
But after surviving the virus , the silver lining is that it really aligns your perspective .
In academia we can become @ @ @ @ @ @ @ to squeeze the maximum productivity out of our days .
However , an experience like this teaches you that no matter what ’ s on your CV , all that really matters is that you and your loved ones are healthy and safe .
My partner and I are alive , and now fully healthy , and so are all our family and friends .
I have a newfound appreciation for that very simple fact .

Karina Voggel is a postdoctoral fellow at the Observatoire Astronomique de Strasbourg, France. This post is part of a series on how the COVID-19 pandemic is affecting the personal and professional lives of physicists around the world. If you’d like to share your own perspective, please contact us at pwld@ioppublishing.org.
Blue skies, uncertain forecast: Karina Voggel at the Observatoire Astronomique de Strasbourg, France. (Courtesy: Karina Voggel)
Between March and May, France went through a two-month period of strict confinement. During this time, we were only allowed to leave our homes for essentials such as grocery shopping, and we needed to fill in a form every time explaining why we were out. Once home working became the default at my institute, I joined my partner (who is also an academic) in the south of France, as I did not want to be on my own for such a long period. Working from home was doable, although our small, open-plan apartment posed some challenges; for example, we had to share the kitchen table for our work and co-ordinate all our virtual meetings and talks so they wouldn’t interfere with each other.
Then, in early April, just before Easter, my partner came down with a heavy cough and fever. We immediately suspected COVID-19 and entered an even stricter quarantine, during which we did not set foot outside our apartment. At first, I had no symptoms, but within two days I was also not feeling well, and for the next week we were both severely ill. I am a young and healthy person, someone who runs marathons and has not a single medical condition or risk factor, yet COVID really wiped me out. It was scary how little energy we had left once the virus took over. We could not even find the energy to eat – a problem made worse by the fact that we entirely lost our senses of smell and taste.
After a week of symptoms, I began to improve. However, although I had cleared the acute illness, I was still severely weakened. It took me five or six weeks to get back to normal energy levels. Meanwhile, my partner continued to battle a fever and other severe symptoms for more than two weeks. This was a challenge, as it meant that I needed to nurse him back to health while I myself was far from well. Worse still, after an initial recovery, he developed a serious secondary bacterial infection and was hospitalized. This was an extremely hard time, as no visitors were allowed in the hospital and all I could do was hope he would get better. Luckily, he eventually did – albeit only after an ordeal that spanned more than two months.
Returning to a new normal
Now that our health permits it, we are back to working from home, and have been for more than a month. The Strasbourg Observatory has also implemented a limited in-person return to the office, as the number of active coronavirus cases in France has been low since May. Even so, there are many precautions. We are only allowed to have one person in an office at a time, and we organize this by filling in online sheets specifying the times when we are present. Upon entering the buildings, we are greeted with a hand-sanitizing station and provided with masks.
As astronomers, we don’t have labs, which makes social distancing easier. However, all our typical social gatherings and seminars are still prohibited. I think the return to in-person work has been managed very well, as it is possible to keep our distance from each other and people who want to continue working from home can do so. I think it is important to let individuals decide what they are comfortable with, depending on their own situation and risk assessment.
Lost opportunities
My biggest professional concern is how the crisis is going to impact my future in academia. I am in my second postdoc and I need to find a more permanent position soon. However, I lost several months of productivity to the virus and I am only on a two-year contract. I also had a busy March–May period planned, including several visits to the US and an invited conference talk. Obviously, none of that happened. It is really hard to showcase your science without conferences, especially in the critical early stage of your career. Although I have antibodies now and should be protected from the virus for a while, I do not plan to travel in the next few months or attend in-person meetings and conferences. Even later this year, organizing in-person events would put attendees at risk, especially since very few will have antibodies.
Another problem that is severely affecting astronomers is the cessation of operations at most telescopes, as support staff cannot get to and from the facilities. This means that anyone who was granted observing time during this period has not been able to do their observations – something that has impacted me personally. Because my partner is also an academic, my prospects in academia were already pretty bleak due to the “two-body problem”, and my impression is that COVID has worsened the outlook on all fronts. Many other junior scientists are in similar positions, and with universities in the US and UK issuing hiring freezes, I assume the pressure on the job market will only increase.
Words of caution
An even bigger concern, though, is that members of my family or other loved ones will get the virus, especially if there is a second wave in the autumn. When I see what it did to two healthy and fit people in their early 30s, I do not even want to imagine what it would do to people with medical conditions or other risk factors. So I urge everyone to be very careful. Someone else in our apartment building had the virus a bit earlier than we did, and it is likely that we caught it from them just by passing through the same hallway, as we never met them in person during that time. We observed all the strict confinement rules and took no risks, yet we were not able to avoid it – which shows that one can never be too careful.
But after surviving the virus, the silver lining is that it really aligns your perspective. In academia we can become obsessed with the workaholic mentality, trying to squeeze the maximum productivity out of our days. However, an experience like this teaches you that no matter what’s on your CV, all that really matters is that you and your loved ones are healthy and safe. My partner and I are alive, and now fully healthy, and so are all our family and friends. I have a newfound appreciation for that very simple fact.


physicsworld--2020-07-14--Photonic nanojet lenses are spun from spider silk - Physics World

Spider silk has been used by researchers in Taiwan to create tuneable lenses capable of focusing the shapes of incoming laser beams .
The work was done by a team led by Cheng-Yang Liu at National Yang-Ming University , who developed the lenses by treating freshly extracted silk with drips of resin , under tightly controlled conditions .
Their approach could offer significant improvements to existing biomedical imaging techniques .
Spider silk is well known for its useful mechanical properties including high values of elasticity , toughness and tensile strength .
Yet the material also has fascinating optical properties .
@ @ @ @ @ @ @ researchers have noted its potential for photonics applications such as light guiding , imaging and sensing .
In their study , Liu ’ s team focussed on creating photonic nanojets ( PNJs ) using spider silk draglines – the strong spokes that form the basic structures of many spiderwebs .
Typically , nanojets are formed when a transparent microscopic lens is illuminated on one side , creating an intense , focused point of light on the shadowed side through the effects of scattering , refraction , and diffraction .
To create the lenses @ @ @ @ @ @ @ dragline silk directly from long-legged cellar spiders .
They carefully controlled the temperature , humidity , and reeling speed to ensure the fibres were smooth and uniform .
They then dripped a resin onto the raw surface of the silk .
Due to the wetting properties of the material , this caused it to distort into domes , whose shapes varied depending on how long they were left under the drip .
Once the desired shapes were reached , the silk was placed in an ultraviolet oven for the resin to cure .
@ @ @ @ @ @ @ Liu ’ s team first explored their optical properties through numerical simulations .
These calculations revealed how the focal lengths , focusing sharpnesses , and peak focusing intensities of the beams each depended on the lens shapes .
The calculations also showed that these properties could be finely tuned by controlling the time the domes spent under the resin drip .
Through experiments , the researchers then showed that when visible laser beams were fired at their lenses , sharp PNJs could be focused far away from their flat , shadowed sides .
@ @ @ @ @ @ @ many advantages over the synthetic fibres currently used in tissue engineering .
For example , the material is biocompatible and can be easily absorbed by the body .
Because of this , Liu ’ s team believe the PNJs made possible with their lenses may lead to safe and reliable new ways to image biological tissues .
If achieved , this could enable researchers to create large-area , high-resolution images of samples , and to scan tissues to a range of different depths .
The research is described in the Journal of Applied @ @

Spider sense: a long-legged cellar spider used in the study (left) and the dome lens make using its dragline silk. (Courtesy: Cheng-Yang Liu)
Spider silk has been used by researchers in Taiwan to create tuneable lenses capable of focusing the shapes of incoming laser beams. The work was done by a team led by Cheng-Yang Liu at National Yang-Ming University, who developed the lenses by treating freshly extracted silk with drips of resin, under tightly controlled conditions. Their approach could offer significant improvements to existing biomedical imaging techniques.
Spider silk is well known for its useful mechanical properties including high values of elasticity, toughness and tensile strength. Yet the material also has fascinating optical properties. In recent studies, for example, researchers have noted its potential for photonics applications such as light guiding, imaging and sensing.
In their study, Liu’s team focussed on creating photonic nanojets (PNJs) using spider silk draglines – the strong spokes that form the basic structures of many spiderwebs. Typically, nanojets are formed when a transparent microscopic lens is illuminated on one side, creating an intense, focused point of light on the shadowed side through the effects of scattering, refraction, and diffraction.
Dripping resin
To create the lenses, the researchers first reeled stretches of dragline silk directly from long-legged cellar spiders. They carefully controlled the temperature, humidity, and reeling speed to ensure the fibres were smooth and uniform. They then dripped a resin onto the raw surface of the silk. Due to the wetting properties of the material, this caused it to distort into domes, whose shapes varied depending on how long they were left under the drip. Once the desired shapes were reached, the silk was placed in an ultraviolet oven for the resin to cure.
To produce PNJs from these lenses, Liu’s team first explored their optical properties through numerical simulations. These calculations revealed how the focal lengths, focusing sharpnesses, and peak focusing intensities of the beams each depended on the lens shapes. The calculations also showed that these properties could be finely tuned by controlling the time the domes spent under the resin drip. Through experiments, the researchers then showed that when visible laser beams were fired at their lenses, sharp PNJs could be focused far away from their flat, shadowed sides.
The mechanical properties of spider silk offer many advantages over the synthetic fibres currently used in tissue engineering. For example, the material is biocompatible and can be easily absorbed by the body. Because of this, Liu’s team believe the PNJs made possible with their lenses may lead to safe and reliable new ways to image biological tissues. If achieved, this could enable researchers to create large-area, high-resolution images of samples, and to scan tissues to a range of different depths.
The research is described in the Journal of Applied Physics.