principiascientificinternational--2020-11-11--Woman sheds coronavirus for 70 days without symptoms

A woman with COVID-19 in Washington state shed infectious virus particles for 70 days , meaning she was contagious during that entire time , despite never showing symptoms of the disease , according to a new report .
The 71-year-old woman had a type of , or cancer of the white blood cells , and so her was weakened and less able to clear her body of the new coronavirus , known as SARS-CoV-2 .
Although researchers have suspected that people with weakened immune systems may shed the virus for longer than typical , there was little evidence of this @ @ @ @ @ @ @ contradict guidelines from the ( CDC ) , which say that immunocompromised people with COVID-19 are likely not infectious after 20 days .
The new findings suggest “ long-term shedding of infectious virus may be a concern in certain immunocompromised patients , ” the authors wrote in their paper , published Wednesday ( Nov. 4 ) in the journal .
“ As this virus continues to spread , more people with a range of immunosuppressing disorders will become infected , and it ’ s important to understand how SARS-CoV-2 behaves in these populations @ @ @ @ @ @ @ , a virologist at the National Institute of Allergy and Infectious Diseases , .
The woman was infected in late February during the country ’ s first reported COVID-19 outbreak , which occurred at the Life Care Center rehabilitation facility in Kirkland , Washington , where she was a patient .
She was hospitalized for anemia related to her cancer on Feb. 25 , and doctors screened her for COVID-19 because she came from the center with the outbreak .
She tested positive on March 2 .
Over the next 15 weeks , @ @ @ @ @ @ @ more than a dozen times .
The virus was detected in her upper respiratory tract for 105 days ; and infectious virus particles — meaning they were capable of spreading the disease — were detected for at least 70 days .
Specifically , the researchers were able to isolate the virus from the patient ’ s samples , and grow it in a lab .
They were even able to capture images of the virus using scanning and transmission electron microscopy .
Typically , people with COVID-19 are contagious for about eight days @ @ @ @ @ @ @ .
Previously , the longest duration of infectious virus shedding in a COVID-19 patient was reported to be 20 days .
The woman was likely contagious for so long because her body didn ’ t mount a proper immune response .
Indeed , the woman ’ s blood samples did not appear to contain against the virus .
The woman was treated with two rounds of , or blood from recovered COVID-19 patients that contains antibodies against the disease .
She cleared the infection after her second treatment , though there ’ s @ @ @ @ @ @ @ plasma helped , as the woman still had low concentrations of antibodies after the transfusion .
The authors also performed genetic sequencing of SARS-CoV-2 over the course of the woman ’ s infection , and saw that the virus developed several mutations over time .
However , the mutations did not affect how fast the virus replicated .
In addition , the authors did not see evidence that any of these mutations gave the virus a survival advantage , because none of the mutated variants became dominant over the course of the infection @ @ @ @ @ @ @ virus is unknown and is something that should be examined in future research involving patients with weakened immune systems , the authors said .
In addition , the researchers don ’ t know why the woman never experienced despite being immunocompromised , which puts her at higher risk of severe disease , according to the CDC .
“ You would indeed think that the immunocompromised status would allow the virus to spread from the upper ( more common cold scenario ) to the lower respiratory tract ( pneumonia ) , ” Munster told @ @ @ @ @ @ @ Even though the patient was at least infected for 105 days , this clearly didn ’ t happen , and this remains a mystery to us.
” The authors note that their study involved only a single case , and so the findings may not necessarily apply to all patients with conditions that suppress the immune system .
An estimated 3 million people in the U.S. have an immunocompromising condition , including people with , as well as those who have received stem-cell transplants , organ transplants and chemotherapy , the authors said @ @ @ @ @ @ @ persistence and eventual clearance [ in immunocompromised patients ] will be essential to providing appropriate treatment and preventing transmission of SARS-CoV-2 , ” the authors concluded .
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Woman sheds coronavirus for 70 days without symptoms
Written by Rachael Rettner
A woman with COVID-19 in Washington state shed infectious virus particles for 70 days, meaning she was contagious during that entire time, despite never showing symptoms of the disease, according to a new report.
The 71-year-old woman had a type of leukemia , or cancer of the white blood cells, and so her immune system was weakened and less able to clear her body of the new coronavirus, known as SARS-CoV-2. Although researchers have suspected that people with weakened immune systems may shed the virus for longer than typical, there was little evidence of this happening, until now.
The findings contradict guidelines from the Centers for Disease Control and Prevention (CDC), which say that immunocompromised people with COVID-19 are likely not infectious after 20 days.
The new findings suggest “long-term shedding of infectious virus may be a concern in certain immunocompromised patients,” the authors wrote in their paper, published Wednesday (Nov. 4) in the journal Cell .
“As this virus continues to spread, more people with a range of immunosuppressing disorders will become infected, and it’s important to understand how SARS-CoV-2 behaves in these populations,” study senior author Vincent Munster, a virologist at the National Institute of Allergy and Infectious Diseases, said in a statement .
The woman was infected in late February during the country’s first reported COVID-19 outbreak, which occurred at the Life Care Center rehabilitation facility in Kirkland, Washington, where she was a patient.
She was hospitalized for anemia related to her cancer on Feb. 25, and doctors screened her for COVID-19 because she came from the center with the outbreak. She tested positive on March 2.
Over the next 15 weeks, the woman would be tested for COVID-19 more than a dozen times. The virus was detected in her upper respiratory tract for 105 days; and infectious virus particles — meaning they were capable of spreading the disease — were detected for at least 70 days. Specifically, the researchers were able to isolate the virus from the patient’s samples, and grow it in a lab. They were even able to capture images of the virus using scanning and transmission electron microscopy.
Typically, people with COVID-19 are contagious for about eight days after infection, according to the report. Previously, the longest duration of infectious virus shedding in a COVID-19 patient was reported to be 20 days.
The woman was likely contagious for so long because her body didn’t mount a proper immune response. Indeed, the woman’s blood samples did not appear to contain antibodies against the virus.
The woman was treated with two rounds of convalescent plasma , or blood from recovered COVID-19 patients that contains antibodies against the disease. She cleared the infection after her second treatment, though there’s no way to know if the convalescent plasma helped, as the woman still had low concentrations of antibodies after the transfusion.
The authors also performed genetic sequencing of SARS-CoV-2 over the course of the woman’s infection, and saw that the virus developed several mutations over time. However, the mutations did not affect how fast the virus replicated. In addition, the authors did not see evidence that any of these mutations gave the virus a survival advantage, because none of the mutated variants became dominant over the course of the infection.
Exactly how the woman cleared the virus is unknown and is something that should be examined in future research involving patients with weakened immune systems, the authors said.
In addition, the researchers don’t know why the woman never experienced symptoms of COVID-19 despite being immunocompromised, which puts her at higher risk of severe disease, according to the CDC .
“You would indeed think that the immunocompromised status would allow the virus to spread from the upper (more common cold scenario) to the lower respiratory tract (pneumonia),” Munster told Live Science in an email. “Even though the patient was at least infected for 105 days, this clearly didn’t happen, and this remains a mystery to us.”
The authors note that their study involved only a single case, and so the findings may not necessarily apply to all patients with conditions that suppress the immune system.
An estimated 3 million people in the U.S. have an immunocompromising condition, including people with HIV , as well as those who have received stem-cell transplants, organ transplants and chemotherapy, the authors said.
“Understanding the mechanism of virus persistence and eventual clearance [in immunocompromised patients] will be essential to providing appropriate treatment and preventing transmission of SARS-CoV-2,” the authors concluded.
Read more at www.livescience.com
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principiascientificinternational--2020-11-11--Claim to Finding Missing Part of Universe? Big Bang Baloney!

Scientists have long assumed that about 40 percent of the universe ’ s visible matter — the kind makes up everything we can see and touch — was missing , never having been detected .
Now , a team of researchers from France ’ s National Center of Scientific Research ( CNRS ) says it ’ s finally found it — hidden away in the diffuse filaments of the gigantic , galaxy-connecting cosmic web .
The research , published Friday in the journal Astronomy & Astrophysics , revealed the missing matter after scientists took a new look at a pile @ @ @ @ @ @ @ gas that make up the cosmic web are thought to connect networks of galaxies across vast voids of nothingness in the universe , according to a CNRS press release .
Sometimes they also serve as a source of fresh material for nearby galaxies or black holes , making the web itself even more threadbare and faint .
The French researchers suggest that it ’ s because these cosmic web filaments are so diffuse , and the signals they give off are so weak , that they went undetected for 20 years even though @ @ @ @ @ @ @ .
To find the 40 percent of all the visible matter in the universe that they contain , the CNRS researchers took a look at the filaments ’ x-ray emissions coupled with information on 15,000 filaments ’ physical arrangement .
Through that x-ray analysis , the team was able to confirm that the filaments contained vast amounts of previously-overlooked hot gases — a huge fraction of the universe ’ s matter hiding in plain sight .
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Claim to Finding Missing Part of Universe? Big Bang Baloney!
Written by Dan Robitszki
Scientists have long assumed that about 40 percent of the universe’s visible matter — the kind makes up everything we can see and touch — was missing, never having been detected.
Now, a team of researchers from France’s National Center of Scientific Research (CNRS) says it’s finally found it — hidden away in the diffuse filaments of the gigantic, galaxy-connecting cosmic web. The research, published Friday in the journal Astronomy & Astrophysics, revealed the missing matter after scientists took a new look at a pile of 20-year-old data.
Hidden Web
The filaments of gas that make up the cosmic web are thought to connect networks of galaxies across vast voids of nothingness in the universe, according to a CNRS press release. Sometimes they also serve as a source of fresh material for nearby galaxies or black holes, making the web itself even more threadbare and faint.
The French researchers suggest that it’s because these cosmic web filaments are so diffuse, and the signals they give off are so weak, that they went undetected for 20 years even though all the data was in plain sight.
Fresh Eyes
To find the 40 percent of all the visible matter in the universe that they contain, the CNRS researchers took a look at the filaments’ x-ray emissions coupled with information on 15,000 filaments’ physical arrangement.
Through that x-ray analysis, the team was able to confirm that the filaments contained vast amounts of previously-overlooked hot gases — a huge fraction of the universe’s matter hiding in plain sight.
Read more Big Bang Baloney at futurism.com
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principiascientificinternational--2020-11-11--Using PCR Tests to Diagnose COVID19 Is Bad Science & Fraudulent

Using PCR Tests to Diagnose COVID19 Is Bad Science & Fraudulent Positive RT-PCR test means being sick with COVID .
This assumption is misleading .
Very few people , including doctors , understand how a PCR test works .
RT-PCR means Real Time-Polymerase Chain Reaction .
( This article is in English & underneath are notes in French ) In French , it means : Réaction de Polymérisation en Chaîne en Temps Réel .
In medicine , we use this tool mainly to diagnose a viral infection .
Starting from a clinical situation with the presence or absence of particular @ @ @ @ @ @ @ different diagnoses based on tests .
In the case of certain infections , particularly viral infections , we use the RT-PCR technique to confirm a diagnostic hypothesis suggested by a clinical picture .
We do not routinely perform RT-PCR on any patient who is overheated , coughing or has an inflammatory syndrome !
It is a laboratory , molecular biology technique of gene amplification because it looks for gene traces ( DNA or RNA ) by amplifying them .
In addition to medicine , other fields of application are genetics , research , @ @ @ @ @ @ @ carried out in a specialized laboratory , it can not be done in any laboratory , even a hospital .
This entails a certain cost , and a delay sometimes of several days between the sample and the result .
Today , since the emergence of the new disease called COVID-19 ( COrona VIrus Disease-2019 ) , the RT-PCR diagnostic technique is used to define positive cases , confirmed as SARS-CoV-2 ( coronavirus responsible for the new acute respiratory distress syndrome called COVID-19 ) .
These positive cases are assimilated to COVID-19 cases @ @ @ @ @ @ @ even admitted to intensive care units .
Official postulate of our managers : positive RT-PCR cases = COVID-19 patients .
[ 1 ] This is the starting postulate , the premise of all official propaganda , which justifies all restrictive government measures : isolation , confinement , quarantine , mandatory masks , color codes by country and travel bans , tracking , social distances in companies , stores and even , even more importantly , in schools [ 2 ] .
This misuse of RT-PCR technique is used as a relentless and intentional @ @ @ @ @ @ @ scientific safety councils and by the dominant media , to justify excessive measures such as the violation of a large number of constitutional rights , the destruction of the economy with the bankruptcy of entire active sectors of society , the degradation of living conditions for a large number of ordinary citizens , under the pretext of a pandemic based on a number of positive RT-PCR tests , and not on a real number of patients .
Technical aspects : to better understand and not be manipulated The PCR technique was developed by @ @ @ @ @ @ @ Kary Mullis was awarded the Nobel Prize in Chemistry in 1993 .
Although this is disputed [ 3 ] , Kary Mullis himself is said to have criticized the interest of PCR as a diagnostic tool for an infection , especially a viral one .
He stated that if PCR was a good tool for research , it was a very bad tool in medicine , in the clinic [ 4 ] .
Mullis was referring to the AIDS virus ( HIV retrovirus or HIV ) [ 5 ] , before the COVID-19 @ @ @ @ @ @ @ limitation of the technique in viral infections [ 6 ] , by its creator , can not be dismissed out of hand ; it must be taken into account !
As the analysis can be performed in real time , continuously , it becomes RT ( Real-Time ) – PCR , even more efficient .
It can be done from any molecule , including those of the living , the nucleic acids that make up the genes : Viruses are not considered as “ living ” beings , they are packets of information @ @ @ @ @ @ @ genome .
It is by an amplification technique ( multiplication ) that the molecule sought is highlighted and this point is very important .
If there is DNA or RNA of the desired element in a sample , it is not identifiable as such .
This DNA or RNA must be amplified ( multiplied ) a certain number of times , sometimes a very large number of times , before it can be detected .
From a minute trace , up to billions of copies of a specific sample can be obtained , @ @ @ @ @ @ @ is all that amount in the organism being tested .
In the case of COVID-19 , the element sought by RT-PCR is SARS-CoV-2 , an RNA virus [ 8 ] .
There are DNA viruses such as Herpes and Varicella viruses .
The most well known RNA viruses , in addition to coronaviruses , are Influenza , Measles , EBOLA , ZIKA viruses .
In the case of SARS-CoV-2 , RNA virus , an additional specific step is required , a transcription of RNA into DNA by means of an enzyme , Reverse @ @ @ @ @ @ @ phase .
It is not the whole virus that is identified , but sequences of its viral genome .
This does not mean that this gene sequence , a fragment of the virus , is not specific to the virus being sought , but it is an important nuance nonetheless : RT-PCR does not reveal any virus , but only parts , specific gene sequences of the virus .
At the beginning of the year , the SARS-CoV-2 genome was sequenced .
It consists of about 30,000 base pairs .
The nucleic acid @ @ @ @ @ @ @ the genes , is a sequence of bases .
In comparison , the human genome has more than 3 billion base pairs .
Teams are continuously monitoring the evolution of the SARS-CoV-2 viral genome as it evolves [ 9-10-11 ] , through the mutations it undergoes .
Today , there are many variants [ 12 ] .
By taking a few specific genes from the SARS-CoV-2 genome , it is possible to initiate RT-PCR on a sample from the respiratory tract .
For COVID-19 disease , which has a nasopharyngeal ( nose ) @ @ @ @ @ @ @ , the sample should be taken from the upper respiratory tract as deeply as possible in order to avoid contamination by saliva in particular .
All the people tested said that it is very painful [ 13 ] .
The Gold Standard ( preferred site for sampling ) is the nasopharyngeal ( nasal ) approach , the most painful route .
If there is a contraindication to the nasal approach , or preferably to the individual being tested , depending on the official organs , the oropharyngeal approach ( through the mouth ) @ @ @ @ @ @ @ trigger a nausea/vomiting reflex in the individual being tested .
Normally , for the result of an RT-PCR test to be considered reliable , amplification from 3 different genes ( primers ) of the virus under investigation is required .
The essential notion of Cycle Time or Cycle Threshold or Ct positivity threshold [ 16 ] .
An RT-PCR test is negative ( no traces of the desired element ) or positive ( presence of traces of the desired element ) .
However , even if the desired element is present in a @ @ @ @ @ @ @ of RT-PCR is to be able to finally highlight it by continuing the amplification cycles as much as necessary .
RT-PCR can push up to 60 amplification cycles , or even more !
Here is how it works : Etc exponentially up to 40 to 60 cycles !
When we say that the Ct ( Cycle Time or Cycle Threshold or RT-PCR positivity threshold ) is equal to 40 , it means that the laboratory has used 40 amplification cycles , i.e .
obtained 240 copies .
This is what underlies the sensitivity @ @ @ @ @ @ @ is true that in medicine we like to have high specificity and sensitivity of the tests to avoid false positives and false negatives , in the case of COVID-19 disease , this hypersensitivity of the RT-PCR test caused by the number of amplification cycles used has backfired .
This over-sensitivity of the RT-PCR test is deleterious and misleading !
It detaches us from the medical reality which must remain based on the real clinical state of the person : is the person ill , does he or she have symptoms ?
That is @ @ @ @ @ @ @ said at the beginning of the article , in medicine we always start from the person : we examine him/her , we collect his/her symptoms ( complaints-anamnesis ) and objective clinical signs ( examination ) and on the basis of a clinical reflection in which scientific knowledge and experience intervene , we make diagnostic hypotheses .
Only then do we prescribe the most appropriate tests , based on this clinical reflection .
We constantly compare the test results with the patient ’ s clinical condition ( symptoms and signs ) , which takes @ @ @ @ @ @ @ to our decisions and treatments .
Today , our governments , supported by their scientific safety advice , are making us do the opposite and put the test first , followed by a clinical reflection necessarily influenced by this prior test , whose weaknesses we have just seen , particularly its hypersensitivity .
None of my clinical colleagues can contradict me .
Apart from very special cases such as genetic screening for certain categories of populations ( age groups , sex ) and certain cancers or family genetic diseases , we always work @ @ @ @ @ @ @ ( symptoms , signs ) to the appropriate tests , never the other way around .
This is the conclusion of an article in the Swiss Medical Journal ( RMS ) published in 2007 , written by doctors Katia Jaton and Gilbert Greub microbiologists from the University of Lausanne : PCR in microbiology : from DNA amplification to result interpretation : It would be indefensible to give everyone an electrocardiogram to screen everyone who might have a heart attack one day .
On the other hand , in certain clinical contexts or on @ @ @ @ @ @ @ there , yes , an electrocardiogram can be beneficial .
Back to RT-PCR and Ct ( Cycle Time or Cycle Threshold ) .
In the case of an infectious disease , especially a viral one , the notion of contagiousness is another important element .
Since some scientific circles consider that an asymptomatic person can transmit the virus , they believe it is important to test for the presence of virus , even if the person is asymptomatic , thus extending the indication of RT-PCR to everyone .
This question brings us back @ @ @ @ @ @ @ therefore Ct .
The relationship between contagiousness and viral load is disputed by some people [ 18 ] and no formal proof , to date , allows us to make a decision .
However , common sense gives obvious credence to the notion that the more virus a person has inside him or her , especially in the upper airways ( oropharynx and nasopharynx ) , with symptoms such as coughing and sneezing , the higher the risk of contagiousness , proportional to the viral load and the importance of the person ’ @ @ @ @ @ @ @ sense , and although modern medicine has benefited greatly from the contribution of science through statistics and Evidence-Based Medicine ( EBM ) , it is still based primarily on common sense , experience and empiricism .
Medicine is the art of healing .
No test measures the amount of virus in the sample !
RT-PCR is qualitative : positive ( presence of the virus ) or negative ( absence of the virus ) .
This notion of quantity , therefore of viral load , can be estimated indirectly by the number of amplification @ @ @ @ @ @ @ the virus sought .
The lower the Ct used to detect the virus fragment , the higher the viral load is considered to be ( high ) .
The higher the Ct used to detect the virus fragment , the lower the viral load is considered to be ( low ) .
Thus , the French National Reference Centre ( CNR ) , in the acute phase of the pandemic , estimated that the peak of viral shedding occurred at the onset of symptoms , with an amount of virus corresponding to approximately @ @ @ @ @ @ @ SARS-CoV-2 viral RNA on average ( French COVID-19 cohort data ) with a variable duration of shedding in the upper airways ( from 5 days to more than 5 weeks ) [ 19 ] .
This number of 108 ( 100 million ) copies/μl corresponds to a very low Ct. A Ct of 35 corresponds to about 1 copy/μl .
Above Ct 35 , it becomes impossible to isolate a complete virus sequence and culture it !
In France and in most countries , Ct levels above 35 , even 40 , are @ @ @ @ @ @ @ Society of Microbiology ( SFM ) issued an opinion on September 25 , 2020 in which it does not recommend quantitative results , and it recommends to make positive up to a Ct of 37 for a single gene [ 20 ] !
With 1 copy/μl of a sample ( Ct 35 ) , without cough , without symptoms , one can understand why all these doctors and scientists say that a positive RT-PCR test means nothing , nothing at all in terms of medicine and clinic !
Positive RT-PCR tests , without @ @ @ @ @ @ @ to the presence or absence of symptoms , are used as is by our governments as the exclusive argument to apply and justify their policy of severity , austerity , isolation and aggression of our freedoms , with the impossibility to travel , to meet , to live normally !
There is no medical justification for these decisions , for these governmental choices !
In an article published on the website of the New York Times ( NYT ) on Saturday , August 29 , American experts from Harvard University are surprised that @ @ @ @ @ @ @ tests of contagiousness , even more so as evidence of pandemic progression in the case of SARS-CoV-2 infection [ 21 ] .
According to them , the threshold ( Ct ) considered results in positive diagnoses in people who do not represent any risk of transmitting the virus !
The binary “ yes/no ” answer is not enough , according to this epidemiologist from the Harvard University School of Public Health .
The amount of virus ( viral load ) ; but also and above all the clinical state , symptomatic or not @ @ @ @ @ @ @ question the use of the binary result of this RT-PCR test to determine whether a person is contagious and must follow strict isolation measures .
These questions are being raised by many physicians around the world , not only in the United States but also in France , Belgium ( Belgium Health Experts Demand Investigation Of WHO For Faking Coronavirus Pandemic ) , France , Germany , Italy , the United Kingdom , the United States and the United Kingdom .
in Germany , Spain… According to them : “ We are going @ @ @ @ @ @ @ in confinement , in isolation , for nothing .
» [ 22 ] .
22 ] And inflict suffering , anguish , economic and psychological dramas by the thousands !
Most RT-PCR tests set the Ct at 40 , according to the NYT .
Some set it at 37 .
“ Tests with such high thresholds ( Ct ) may not only detect live virus but also gene fragments , remnants of an old infection that do not represent any particular danger , ” the experts said .
A virologist at the University @ @ @ @ @ @ @ with a Ct greater than 35 is too sensitive .
“ A more reasonable threshold would be between 30 and 35 , ” she adds .
Almost no laboratory specifies the Ct ( number of amplification cycles performed ) or the number of copies of viral RNA per sample μl .
Here is an example of a laboratory result ( approved by Sciensano , the Belgian national reference center ) in an RT-PCR negative patient : In the NYT , experts compiled three datasets with officials from the states of Massachusetts , New @ @ @ @ @ @ @ “ Up to 90 % of the people who tested positive did not carry a virus .
» The Wadworth Center , a New York State laboratory , analyzed the results of its July tests at the request of the NYT : 794 positive tests with a Ct of 40 .
“ With a Ct threshold of 35 , approximately half of these PCR tests would no longer be considered positive , ” said the NYT .
“ And about 70 % would no longer be considered positive with a Ct of 30 @ @ @ @ @ @ @ and 90 % of people who tested positive in July with a Ct of 40 would have been considered negative with a Ct of 30 , adds the NYT .
And yet , all these people had to isolate themselves , with all the dramatic psychological and economic consequences , while they were not sick and probably not contagious at all .
In France , the Centre National de Référence ( CNR ) , the French Society of Microbiology ( SFM ) continue to push Ct to 37 and recommend to laboratories to @ @ @ @ @ @ @ as a primer .
I remind you that from Ct 32 onwards , it becomes very difficult to culture the virus or to extract a complete sequence , which shows the completely artificial nature of this positivity of the test , with such high Ct levels , above 30 .
Similar results were reported by researchers from the UK Public Health Agency in an article published on August 13 in Eurosurveillance : “ The probability of culturing the virus drops to 8 % in samples with Ct levels above 35.
” [ 23 @ @ @ @ @ @ @ National Reference Center in France only evaluates the sensitivity of commercially available reagent kits , not their specificity : serious doubts persist about the possibility of cross-reactivity with viruses other than SARS-CoV-2 , such as other benign cold coronaviruses .
[ 20 ] It is potentially the same situation in other countries , including Belgium .
Similarly , mutations in the virus may have invalidated certain primers ( genes ) used to detect SARS-CoV-2 : the manufacturers give no guarantees on this , and if the AFP fast-checking journalists tell you otherwise , @ @ @ @ @ @ @ these guarantees , these proofs .
If they have nothing to hide and if what I say is false , this guarantee will be provided to you and will prove their good faith .
• We must demand that the RT-PCR results be returned mentioning the Ct used because beyond Ct 30 , a positive RT-PCR test means nothing .
• We must listen to the scientists and doctors , specialists , virologists who recommend the use of adapted Ct , lower , at 30 .
An alternative is to obtain the number @ @ @ @ @ @ @ sample .
[ 23 ] • We need to go back to the patient , to the person , to his or her clinical condition ( presence or absence of symptoms ) and from there to judge the appropriateness of testing and the best way to interpret the result .
Until there is a better rationale for PCR screening , with a known and appropriate Ct threshold , an asymptomatic person should not be tested in any way .
Even a symptomatic person should not automatically be tested , as long as they @ @ @ @ @ @ @ days .
Let ’ s stop this debauchery of RT-PCR testing at too high Ct levels and return to clinical , quality medicine .
Once we understand how RT-PCR testing works , it becomes impossible to let the current government routine screening strategy , inexplicably supported by the virologists in the safety councils , continue .
My hope is that , finally , properly informed , more and more people will demand that this strategy be stopped , because it is all of us , enlightened , guided by real benevolence and common @ @ @ @ @ @ @ and individual destinies .
No one else should do it for us , especially when we realize that those who decide are no longer reasonable or rational .
• The RT-PCR test is a laboratory diagnostic technique that is not well suited to clinical medicine .
• It is a binary , qualitative diagnostic technique that confirms ( positive test ) or not ( negative test ) the presence of an element in the medium being analyzed .
In the case of SARS-CoV-2 , the element is a fragment of the viral genome @ @ @ @ @ @ @ In medicine , even in an epidemic or pandemic situation , it is dangerous to place tests , examinations , techniques above clinical evaluation ( symptoms , signs ) .
It is the opposite that guarantees quality medicine .
• The main limitation ( weakness ) of the RT-PCR test , in the current pandemic situation , is its extreme sensitivity ( false positive ) if a suitable threshold of positivity ( Ct ) is not chosen .
Today , experts recommend using a maximum Ct threshold of 30 .
• This Ct @ @ @ @ @ @ @ RT-PCR result so that the physician knows how to interpret this positive result , especially in an asymptomatic person , in order to avoid unnecessary isolation , quarantine , psychological trauma .
• In addition to mentioning the Ct used , laboratories must continue to ensure the specificity of their detection kits for SARS-CoV-2 , taking into account its most recent mutations , and must continue to use three genes from the viral genome being studied as primers or , if not , mention it .
Is the obstinacy of governments to use @ @ @ @ @ @ @ by RT-PCR , due to ignorance ?
Is it due to stupidity ?
To a kind of cognitive trap trapping their ego ?
In any case , we should be able to question them , and if among the readers of this article there are still honest journalists , or naive politicians , or people who have the possibility to question our rulers , then do so , using these clear and scientific arguments .
It is all the more incomprehensible that our rulers have surrounded themselves with some of the most experienced @ @ @ @ @ @ @ have been able to gather this information myself , shared , I remind you , by competent people above all suspicion of conspiracy , such as Hélène Banoun , Pierre Sonigo , Jean-François Toussaint , Christophe De Brouwer , whose intelligence , intellectual honesty and legitimacy can not be questioned , then the Belgian , French and Quebec scientific advisors , etc.
, know all this as well .
Why continue in this distorted direction , obstinately making mistakes ?
It is not insignificant to reimpose confinements , curfews , quarantines , reduced @ @ @ @ @ @ @ our shaky economies , to plunge entire families into precariousness , to sow so much fear and anxiety generating a real state of post-traumatic stress worldwide , to reduce access to care for other pathologies that nevertheless reduce life expectancy much more than COVID-19 !
[ 24 ] Is there intent to harm ?
Is there an intention to use the alibi of a pandemic to move humanity towards an outcome it would otherwise never have accepted ?
In any case , not like that !
Would this hypothesis , which modern censors @ @ @ @ @ @ @ , be the most valid explanation for all this ?
Indeed , if we draw a straight line from the present events , if they are maintained , we could find ourselves once again confined with hundreds , thousands of human beings forced to remain inactive , which , for the professions of catering , entertainment , sales , fairgrounds , itinerants , canvassers , risks being catastrophic with bankruptcies , unemployment , depression , suicides by the hundreds of thousands .
[ 25-26-27-28 ] The impact on education , on our children @ @ @ @ @ @ @ long planned care , operations , treatments to be cancelled , postponed , will be profound and destructive .
“ We risk a looming food crisis if action is not taken quickly.
” [ 29 ] .
It is time for everyone to come out of this negative trance , this collective hysteria , because famine , poverty , massive unemployment will kill , mow down many more people than SARS-CoV-2 !
Does all this make sense in the face of a disease that is declining , over-diagnosed and misinterpreted by this misuse @ @ @ @ @ @ @ For many , the continuous wearing of the mask seems to have become a new norm .
Even if it is constantly downplayed by some health professionals and fact-checking journalists , other doctors warn of the harmful consequences , both medical and psychological , of this hygienic obsession which , maintained permanently , is in fact an abnormality !
What a hindrance to social relations , which are the true foundation of a physically and psychologically healthy humanity !
Some dare to find all this normal , or a lesser price to pay @ @ @ @ @ @ @ positive PCR tests .
Isolation , distancing , masking of the face , impoverishment of emotional communication , fear of touching and kissing even within families , communities , between relatives… Spontaneous gestures of daily life hindered and replaced by mechanical and controlled gestures … Terrified children , kept in permanent fear and guilt… All this will have a deep , lasting and negative impact on human organisms , in their physical , mental , emotional and representation of the world and society .
This is not normal !
We can not let @ @ @ @ @ @ @ organize our collective suicide any longer .
Dr Pascal Sacré is a physician specialized in critical care , author and renowned public health analyst , Charleroi , Belgium .
He is a Research Associate of the entre for Research on Globalization ( CRG ) Professionals whose references and comments are the basis of this article in its scientific aspect ( especially and mainly on RT-PCR ) : Former intern at the Paris Hospitals Participated in 1985 in the sequencing of the AIDS virus .
Honorary Professor at the School of Public Health at @ @ @ @ @ @ @ Physiology at the University of Paris-Descartes Director of IRMES , Institute for BioMedical Research and Sports Epidemiology Former member of the High Council of Public Health [ 6 ] « The Truth about PCR Test Kit from the Inventor and Other Experts » [ 10 ] https : //www.mediterranee-infection.com/wp-content/uploads/2020/04/FD_Raoult_SARS-CoV-2_EID_Sep2020_vL2.pdf , Article IHU-Méditerranée , Professeur D. Raoult , Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille , 7 septembre 2020 Dans l ’ ensemble , comme l ’ ont récemment souligné Tomaszewski et @ @ @ @ @ @ @ décrit pour les génomes viraux disponibles jusqu ’ en mai 2020 un déplacement mutationnel sur la spike et le complexe de réplication vers des gènes codant pour d ’ autres protéines non structurelles qui interagissent avec les voies de défense de l ’ hôte , il semble que le taux de mutation du SARS-CoV-2 s ’ accélère depuis mai , impliquant principalement des mutations C vers U. L ’ augmentation du taux de mutation du SRAS-CoV-2 génère des génotypes viraux plus éloignés de la souche Wuhan initiale que ceux observés de mars à @ @ @ @ @ @ @ de durée limitée , du moins pour le premier nouveau génotype que nous avons identifié , et est associé à une gravité globalement moindre à ce stade du développement de cette nouvelle épidémie .
Mutations observed in these seven different viral genotypes are located in most SARS- CoV-2 genes including structural and non-structural genes among which nsp2 , nsp3 ( predicted phosphoesterase ) , nsp5 ( membrane glycoprotein ) , nsp12 ( RNA-dependent RNA polymerase ) , S ( Spike glycoprotein ) , ORF3a , E ( membrane glycoprotein ) , M ( @ @ @ @ @ @ @ ( Nucleocapsid phosphoprotein ) .
[ 11 ] https : //www.researchgate.net/profile/Helene_Banoun Evolution of SARS-CoV-2 : Review of mutations , role of the host immune system , octobre 2020 , mise à jour par Hélène Banoun , [ 12 ] https : //nextstrain.org/ , We are incorporating SARS-CoV-2 genomes as soon as they are shared and providing analyses and situation reports .
In addition we have developed a number of resources and tools , and are facilitating independent groups to run their own analysis .
Please see the main SARS-CoV-2 page for more .
@ @ @ @ @ @ @ Institute for Health and Medical Research ) Cette spectaculaire sensibilité n ’ est pas sans inconvénient et nécessite des précautions particulières .
En effet , un échantillon positif amplifié un million de fois contient une très haute concentration de cible et le risque qu ’ il contamine ( carry over ) d ’ autres échantillons est particulièrement élevé .
La saturation des laboratoires peut encore accroître ce risque et générer des faux positifs accidentels .
Dans ces conditions , il est important que les résultats positifs soient confirmés par un second test , @ @ @ @ @ @ @ test positif présente des conséquences significatives , qu ’ elles soient médicales , professionnelles ou liées à l ’ obligation d ’ isolement .
Par rapport à cette question , il est important de raisonner quantitativement .
La virologie , ce n ’ est pas du tout ou rien .
De manière générale , au cours des infections virales aiguës , le risque de contagion et la gravité de l ’ infection varient en fonction de la quantité de virus présents dans l ’ organisme et de leur excrétion dans le milieu extérieur @ @ @ @ @ @ @ les sinus n ’ ont pas la dangerosité d ’ un million projetés par la toux .
Un sujet asymptomatique produit moins de virus qu ’ un sujet symptomatique et les sécrète moins vers l ’ extérieur .
La quantité de virus produite et donc le risque de contagion sont corrélés à la gravité des symptômes .
Même si elle n ’ est pas de zéro , le risque de transmission est donc vraisemblablement faible pour un sujet asymptomatique .
Malheureusement , répéter sans cesse que la contagion venant d ’ un sujet @ @ @ @ @ @ @ sur le niveau de risque pousse à prendre des mesures disproportionnées avec le risque .
De même , la stratégie « dépister-isoler » n ’ est pas réaliste lorsque le dépistage n ’ est pas suffisamment fiable et surtout lorsque le virus est déjà largement répandu dans la population .
Il est bien trop tard pour appliquer une méthode conçue pour bloquer une épidémie à sa naissance .
Comme pour une invasion de coccinelles ou de frelons , on ne peut stopper un virus qui est déjà partout avec une passoire trouée à @ @ @ @ @ @ @ L ’ échec de la stratégie actuelle est plutôt lié à sa conception naïve et inapplicable qu ’ aux mauvais comportements des citoyens .
Cette question ne relève pas de la science .
Elle dépend des risques acceptables par un individu ou par un groupe .
Si on est dans la recherche du risque minimal , proche de zéro , parce que le risque n ’ a pas été quantifié , ou pour des raisons de responsabilité juridique , on doit prendre les précautions maximales .
Si on accepte un risque même faible @ @ @ @ @ @ @ protéger ceux qui en ont réellement besoin .
Les tests PCR permettent une détection extrêmement sensible de l ’ ARN viral .
Ils sont indispensables mais ne sont pas la solution ultime et unique qui permettra de contrôler l ’ épidémie et de gérer efficacement les risques de contagion .
Appliquée lorsque le virus est largement disséminé dans la population , la stratégie « dépister isoler » est vouée à l ’ échec .
Du fait de la sensibilité très élevée et des limites de leur spécificité , les tests PCR doivent être @ @ @ @ @ @ @ comme toujours en lien avec le contexte clinique et épidémiologique .
N ’ oublions pas qu ’ un sujet asymptomatique doit plutôt être considéré comme immunisé que comme malade .

Using PCR Tests to Diagnose COVID19 Is Bad Science & Fraudulent
Written by Dr. Pascal Sacré
Positive RT-PCR test means being sick with COVID. This assumption is misleading. Very few people, including doctors, understand how a PCR test works. RT-PCR means Real Time-Polymerase Chain Reaction. (This article is in English & underneath are notes in French)
In French, it means: Réaction de Polymérisation en Chaîne en Temps Réel. In medicine, we use this tool mainly to diagnose a viral infection.
Starting from a clinical situation with the presence or absence of particular symptoms in a patient, we consider different diagnoses based on tests. In the case of certain infections, particularly viral infections, we use the RT-PCR technique to confirm a diagnostic hypothesis suggested by a clinical picture.
We do not routinely perform RT-PCR on any patient who is overheated, coughing or has an inflammatory syndrome!
It is a laboratory, molecular biology technique of gene amplification because it looks for gene traces (DNA or RNA) by amplifying them.
In addition to medicine, other fields of application are genetics, research, industry and forensics.
The technique is carried out in a specialized laboratory, it cannot be done in any laboratory, even a hospital. This entails a certain cost, and a delay sometimes of several days between the sample and the result.
Today, since the emergence of the new disease called COVID-19 (COrona VIrus Disease-2019), the RT-PCR diagnostic technique is used to define positive cases, confirmed as SARS-CoV-2 (coronavirus responsible for the new acute respiratory distress syndrome called COVID-19).
These positive cases are assimilated to COVID-19 cases, some of whom are hospitalized or even admitted to intensive care units.
Official postulate of our managers: positive RT-PCR cases = COVID-19 patients. [1]
This is the starting postulate, the premise of all official propaganda, which justifies all restrictive government measures: isolation, confinement, quarantine, mandatory masks, color codes by country and travel bans, tracking, social distances in companies, stores and even, even more importantly, in schools [2].
This misuse of RT-PCR technique is used as a relentless and intentional strategy by some governments, supported by scientific safety councils and by the dominant media, to justify excessive measures such as the violation of a large number of constitutional rights, the destruction of the economy with the bankruptcy of entire active sectors of society, the degradation of living conditions for a large number of ordinary citizens, under the pretext of a pandemic based on a number of positive RT-PCR tests, and not on a real number of patients.
Technical aspects: to better understand and not be manipulated
The PCR technique was developed by chemist Kary B. Mullis in 1986. Kary Mullis was awarded the Nobel Prize in Chemistry in 1993.
Although this is disputed [3], Kary Mullis himself is said to have criticized the interest of PCR as a diagnostic tool for an infection, especially a viral one.
He stated that if PCR was a good tool for research, it was a very bad tool in medicine, in the clinic [4].
Mullis was referring to the AIDS virus (HIV retrovirus or HIV) [5], before the COVID-19 pandemic, but this opinion on the limitation of the technique in viral infections [6], by its creator, cannot be dismissed out of hand; it must be taken into account!
PCR was perfected in 1992.
As the analysis can be performed in real time, continuously, it becomes RT (Real-Time) – PCR, even more efficient.
It can be done from any molecule, including those of the living, the nucleic acids that make up the genes:
DNA (deoxyribonucleic acid)
RNA (Ribonucleic Acid)
Viruses are not considered as “living” beings, they are packets of information (DNA or RNA) forming a genome.
It is by an amplification technique (multiplication) that the molecule sought is highlighted and this point is very important.
RT-PCR is an amplification technique [7].
If there is DNA or RNA of the desired element in a sample, it is not identifiable as such.
This DNA or RNA must be amplified (multiplied) a certain number of times, sometimes a very large number of times, before it can be detected. From a minute trace, up to billions of copies of a specific sample can be obtained, but this does not mean that there is all that amount in the organism being tested.
In the case of COVID-19, the element sought by RT-PCR is SARS-CoV-2, an RNA virus [8].
There are DNA viruses such as Herpes and Varicella viruses.
The most well known RNA viruses, in addition to coronaviruses, are Influenza, Measles, EBOLA, ZIKA viruses.
In the case of SARS-CoV-2, RNA virus, an additional specific step is required, a transcription of RNA into DNA by means of an enzyme, Reverse Transcriptase.
This step precedes the amplification phase. It is not the whole virus that is identified, but sequences of its viral genome.
This does not mean that this gene sequence, a fragment of the virus, is not specific to the virus being sought, but it is an important nuance nonetheless:
RT-PCR does not reveal any virus, but only parts, specific gene sequences of the virus.
At the beginning of the year, the SARS-CoV-2 genome was sequenced.
It consists of about 30,000 base pairs. The nucleic acid (DNA-RNA), the component of the genes, is a sequence of bases. In comparison, the human genome has more than 3 billion base pairs.
Teams are continuously monitoring the evolution of the SARS-CoV-2 viral genome as it evolves [9-10-11], through the mutations it undergoes. Today, there are many variants [12].
By taking a few specific genes from the SARS-CoV-2 genome, it is possible to initiate RT-PCR on a sample from the respiratory tract.
For COVID-19 disease, which has a nasopharyngeal (nose) and oropharyngeal (mouth) entry point, the sample should be taken from the upper respiratory tract as deeply as possible in order to avoid contamination by saliva in particular.
All the people tested said that it is very painful [13].
The Gold Standard (preferred site for sampling) is the nasopharyngeal (nasal) approach, the most painful route.
If there is a contraindication to the nasal approach, or preferably to the individual being tested, depending on the official organs, the oropharyngeal approach (through the mouth) is also acceptable. The test may trigger a nausea/vomiting reflex in the individual being tested.
Normally, for the result of an RT-PCR test to be considered reliable, amplification from 3 different genes (primers) of the virus under investigation is required.
“The primers are single-stranded DNA sequences specific to the virus. They guarantee the specificity of the amplification reaction. » [14] “The first test developed at La Charité in Berlin by Dr. Victor Corman and his associates in January 2020 allows to highlight the RNA sequences present in 3 genes of the virus called E, RdRp and N. To know if the sequences of these genes are present in the RNA samples collected, it is necessary to amplify the sequences of these 3 genes in order to obtain a signal sufficient for their detection and quantification. »[15].
The essential notion of Cycle Time or Cycle Threshold or Ct positivity threshold [16].
An RT-PCR test is negative (no traces of the desired element) or positive (presence of traces of the desired element).
However, even if the desired element is present in a minute, negligible quantity, the principle of RT-PCR is to be able to finally highlight it by continuing the amplification cycles as much as necessary.
RT-PCR can push up to 60 amplification cycles, or even more!
Here is how it works:
Cycle 1: target x 2 (2 copies)
Cycle 2: target x 4 (4 copies)
Cycle 3: target x 8 (8 copies)
Cycle 4: target x 16 (16 copies)
Cycle 5; target x 32 (32 copies)
Etc exponentially up to 40 to 60 cycles!
When we say that the Ct (Cycle Time or Cycle Threshold or RT-PCR positivity threshold) is equal to 40, it means that the laboratory has used 40 amplification cycles, i.e. obtained 240 copies.
This is what underlies the sensitivity of the RT-PCR assay.
While it is true that in medicine we like to have high specificity and sensitivity of the tests to avoid false positives and false negatives, in the case of COVID-19 disease, this hypersensitivity of the RT-PCR test caused by the number of amplification cycles used has backfired.
This over-sensitivity of the RT-PCR test is deleterious and misleading!
It detaches us from the medical reality which must remain based on the real clinical state of the person: is the person ill, does he or she have symptoms?
That is the most important thing!
As I said at the beginning of the article, in medicine we always start from the person: we examine him/her, we collect his/her symptoms (complaints-anamnesis) and objective clinical signs (examination) and on the basis of a clinical reflection in which scientific knowledge and experience intervene, we make diagnostic hypotheses.
Only then do we prescribe the most appropriate tests, based on this clinical reflection.
We constantly compare the test results with the patient’s clinical condition (symptoms and signs), which takes precedence over everything else when it comes to our decisions and treatments.
Today, our governments, supported by their scientific safety advice, are making us do the opposite and put the test first, followed by a clinical reflection necessarily influenced by this prior test, whose weaknesses we have just seen, particularly its hypersensitivity.
None of my clinical colleagues can contradict me.
Apart from very special cases such as genetic screening for certain categories of populations (age groups, sex) and certain cancers or family genetic diseases, we always work in this direction: from the person (symptoms, signs) to the appropriate tests, never the other way around.
This is the conclusion of an article in the Swiss Medical Journal (RMS) published in 2007, written by doctors Katia Jaton and Gilbert Greub microbiologists from the University of Lausanne :
PCR in microbiology: from DNA amplification to result interpretation:
“To interpret the result of a PCR, it is essential that clinicians and microbiologists share their experiences, so that the analytical and clinical levels of interpretation can be combined.”
It would be indefensible to give everyone an electrocardiogram to screen everyone who might have a heart attack one day.
On the other hand, in certain clinical contexts or on the basis of specific evocative symptoms, there, yes, an electrocardiogram can be beneficial.
Back to RT-PCR and Ct (Cycle Time or Cycle Threshold).
In the case of an infectious disease, especially a viral one, the notion of contagiousness is another important element.
Since some scientific circles consider that an asymptomatic person can transmit the virus, they believe it is important to test for the presence of virus, even if the person is asymptomatic, thus extending the indication of RT-PCR to everyone.
Are RT-PCR tests good tests for contagiousness? [17]
This question brings us back to the notion of viral load and therefore Ct.
The relationship between contagiousness and viral load is disputed by some people [18] and no formal proof, to date, allows us to make a decision.
However, common sense gives obvious credence to the notion that the more virus a person has inside him or her, especially in the upper airways (oropharynx and nasopharynx), with symptoms such as coughing and sneezing, the higher the risk of contagiousness, proportional to the viral load and the importance of the person’s symptoms.
This is called common sense, and although modern medicine has benefited greatly from the contribution of science through statistics and Evidence-Based Medicine (EBM), it is still based primarily on common sense, experience and empiricism.
Medicine is the art of healing.
No test measures the amount of virus in the sample!
RT-PCR is qualitative: positive (presence of the virus) or negative (absence of the virus).
This notion of quantity, therefore of viral load, can be estimated indirectly by the number of amplification cycles (Ct) used to highlight the virus sought.
The lower the Ct used to detect the virus fragment, the higher the viral load is considered to be (high).
The higher the Ct used to detect the virus fragment, the lower the viral load is considered to be (low).
Thus, the French National Reference Centre (CNR), in the acute phase of the pandemic, estimated that the peak of viral shedding occurred at the onset of symptoms, with an amount of virus corresponding to approximately 108 (100 million) copies of SARS-CoV-2 viral RNA on average (French COVID-19 cohort data) with a variable duration of shedding in the upper airways (from 5 days to more than 5 weeks) [19].
This number of 108 (100 million) copies/μl corresponds to a very low Ct.
A Ct of 32 corresponds to 10-15 copies/μl.
A Ct of 35 corresponds to about 1 copy/μl.
Above Ct 35, it becomes impossible to isolate a complete virus sequence and culture it!
In France and in most countries, Ct levels above 35, even 40, are still used even today!
The French Society of Microbiology (SFM) issued an opinion on September 25, 2020 in which it does not recommend quantitative results, and it recommends to make positive up to a Ct of 37 for a single gene [20]!
With 1 copy/μl of a sample (Ct 35), without cough, without symptoms, one can understand why all these doctors and scientists say that a positive RT-PCR test means nothing, nothing at all in terms of medicine and clinic!
Positive RT-PCR tests, without any mention of Ct or its relation to the presence or absence of symptoms, are used as is by our governments as the exclusive argument to apply and justify their policy of severity, austerity, isolation and aggression of our freedoms, with the impossibility to travel, to meet, to live normally!
There is no medical justification for these decisions, for these governmental choices!
In an article published on the website of the New York Times (NYT) on Saturday, August 29, American experts from Harvard University are surprised that RT-PCR tests as practiced can serve as tests of contagiousness, even more so as evidence of pandemic progression in the case of SARS-CoV-2 infection [21].
According to them, the threshold (Ct) considered results in positive diagnoses in people who do not represent any risk of transmitting the virus!
The binary “yes/no” answer is not enough, according to this epidemiologist from the Harvard University School of Public Health.
“It’s the amount of virus that should dictate the course of action for each patient tested. »
The amount of virus (viral load); but also and above all the clinical state, symptomatic or not of the person!
This calls into question the use of the binary result of this RT-PCR test to determine whether a person is contagious and must follow strict isolation measures.
These questions are being raised by many physicians around the world, not only in the United States but also in France, Belgium (Belgium Health Experts Demand Investigation Of WHO For Faking Coronavirus Pandemic), France, Germany, Italy, the United Kingdom, the United States and the United Kingdom. in Germany, Spain…
According to them: “We are going to put tens of thousands of people in confinement, in isolation, for nothing. » [22]. 22] And inflict suffering, anguish, economic and psychological dramas by the thousands!
Most RT-PCR tests set the Ct at 40, according to the NYT. Some set it at 37.
“Tests with such high thresholds (Ct) may not only detect live virus but also gene fragments, remnants of an old infection that do not represent any particular danger,” the experts said.
A virologist at the University of California admits that an RT-PCR test with a Ct greater than 35 is too sensitive. “A more reasonable threshold would be between 30 and 35,” she adds.
Almost no laboratory specifies the Ct (number of amplification cycles performed) or the number of copies of viral RNA per sample μl.
Here is an example of a laboratory result (approved by Sciensano, the Belgian national reference center) in an RT-PCR negative patient:
No mention of Ct.
In the NYT, experts compiled three datasets with officials from the states of Massachusetts, New York and Nevada that mention them.
Conclusion?
“Up to 90% of the people who tested positive did not carry a virus. »
The Wadworth Center, a New York State laboratory, analyzed the results of its July tests at the request of the NYT: 794 positive tests with a Ct of 40.
“With a Ct threshold of 35, approximately half of these PCR tests would no longer be considered positive,” said the NYT.
“And about 70% would no longer be considered positive with a Ct of 30! “
In Massachusetts, between 85 and 90% of people who tested positive in July with a Ct of 40 would have been considered negative with a Ct of 30, adds the NYT. And yet, all these people had to isolate themselves, with all the dramatic psychological and economic consequences, while they were not sick and probably not contagious at all.
In France, the Centre National de Référence (CNR), the French Society of Microbiology (SFM) continue to push Ct to 37 and recommend to laboratories to use only one gene of the virus as a primer.
I remind you that from Ct 32 onwards, it becomes very difficult to culture the virus or to extract a complete sequence, which shows the completely artificial nature of this positivity of the test, with such high Ct levels, above 30.
Similar results were reported by researchers from the UK Public Health Agency in an article published on August 13 in Eurosurveillance: “The probability of culturing the virus drops to 8% in samples with Ct levels above 35.” [23]
In addition, currently, the National Reference Center in France only evaluates the sensitivity of commercially available reagent kits, not their specificity: serious doubts persist about the possibility of cross-reactivity with viruses other than SARS-CoV-2, such as other benign cold coronaviruses. [20]
It is potentially the same situation in other countries, including Belgium.
Similarly, mutations in the virus may have invalidated certain primers (genes) used to detect SARS-CoV-2: the manufacturers give no guarantees on this, and if the AFP fast-checking journalists tell you otherwise, test their good faith by asking for these guarantees, these proofs.
If they have nothing to hide and if what I say is false, this guarantee will be provided to you and will prove their good faith.
We must demand that the RT-PCR results be returned mentioning the Ct used because beyond Ct 30, a positive RT-PCR test means nothing. We must listen to the scientists and doctors, specialists, virologists who recommend the use of adapted Ct, lower, at 30. An alternative is to obtain the number of copies of viral RNA/μl or /ml sample. [23] We need to go back to the patient, to the person, to his or her clinical condition (presence or absence of symptoms) and from there to judge the appropriateness of testing and the best way to interpret the result.
Until there is a better rationale for PCR screening, with a known and appropriate Ct threshold, an asymptomatic person should not be tested in any way.
Even a symptomatic person should not automatically be tested, as long as they can place themselves in isolation for 7 days.
Let’s stop this debauchery of RT-PCR testing at too high Ct levels and return to clinical, quality medicine.
Once we understand how RT-PCR testing works, it becomes impossible to let the current government routine screening strategy, inexplicably supported by the virologists in the safety councils, continue.
My hope is that, finally, properly informed, more and more people will demand that this strategy be stopped, because it is all of us, enlightened, guided by real benevolence and common sense, who must decide our collective and individual destinies.
No one else should do it for us, especially when we realize that those who decide are no longer reasonable or rational.
Summary of important points :
The RT-PCR test is a laboratory diagnostic technique that is not well suited to clinical medicine.
It is a binary, qualitative diagnostic technique that confirms (positive test) or not (negative test) the presence of an element in the medium being analyzed. In the case of SARS-CoV-2, the element is a fragment of the viral genome, not the virus itself.
In medicine, even in an epidemic or pandemic situation, it is dangerous to place tests, examinations, techniques above clinical evaluation (symptoms, signs). It is the opposite that guarantees quality medicine.
The main limitation (weakness) of the RT-PCR test, in the current pandemic situation, is its extreme sensitivity (false positive) if a suitable threshold of positivity (Ct) is not chosen. Today, experts recommend using a maximum Ct threshold of 30.
This Ct threshold must be informed with the positive RT-PCR result so that the physician knows how to interpret this positive result, especially in an asymptomatic person, in order to avoid unnecessary isolation, quarantine, psychological trauma.
In addition to mentioning the Ct used, laboratories must continue to ensure the specificity of their detection kits for SARS-CoV-2, taking into account its most recent mutations, and must continue to use three genes from the viral genome being studied as primers or, if not, mention it.
Overall Conclusion
Is the obstinacy of governments to use the current disastrous strategy, systematic screening by RT-PCR, due to ignorance?
Is it due to stupidity?
To a kind of cognitive trap trapping their ego?
In any case, we should be able to question them, and if among the readers of this article there are still honest journalists, or naive politicians, or people who have the possibility to question our rulers, then do so, using these clear and scientific arguments.
It is all the more incomprehensible that our rulers have surrounded themselves with some of the most experienced specialists in these matters.
If I have been able to gather this information myself, shared, I remind you, by competent people above all suspicion of conspiracy, such as Hélène Banoun, Pierre Sonigo, Jean-François Toussaint, Christophe De Brouwer, whose intelligence, intellectual honesty and legitimacy cannot be questioned, then the Belgian, French and Quebec scientific advisors, etc., know all this as well.
So?
What’s going on?
Why continue in this distorted direction, obstinately making mistakes?
It is not insignificant to reimpose confinements, curfews, quarantines, reduced social bubbles, to shake up again our shaky economies, to plunge entire families into precariousness, to sow so much fear and anxiety generating a real state of post-traumatic stress worldwide, to reduce access to care for other pathologies that nevertheless reduce life expectancy much more than COVID-19! [24]
Is there intent to harm?
Is there an intention to use the alibi of a pandemic to move humanity towards an outcome it would otherwise never have accepted? In any case, not like that!
Would this hypothesis, which modern censors will hasten to label “conspiracy”, be the most valid explanation for all this?
Indeed, if we draw a straight line from the present events, if they are maintained, we could find ourselves once again confined with hundreds, thousands of human beings forced to remain inactive, which, for the professions of catering, entertainment, sales, fairgrounds, itinerants, canvassers, risks being catastrophic with bankruptcies, unemployment, depression, suicides by the hundreds of thousands. [25-26-27-28]
The impact on education, on our children, on teaching, on medicine with long planned care, operations, treatments to be cancelled, postponed, will be profound and destructive.
“We risk a looming food crisis if action is not taken quickly.” [29].
It is time for everyone to come out of this negative trance, this collective hysteria, because famine, poverty, massive unemployment will kill, mow down many more people than SARS-CoV-2!
Does all this make sense in the face of a disease that is declining, over-diagnosed and misinterpreted by this misuse of overly sensitively calibrated PCR tests?
For many, the continuous wearing of the mask seems to have become a new norm.
Even if it is constantly downplayed by some health professionals and fact-checking journalists, other doctors warn of the harmful consequences, both medical and psychological, of this hygienic obsession which, maintained permanently, is in fact an abnormality!
What a hindrance to social relations, which are the true foundation of a physically and psychologically healthy humanity!
Some dare to find all this normal, or a lesser price to pay in the face of the pandemic of positive PCR tests.
Isolation, distancing, masking of the face, impoverishment of emotional communication, fear of touching and kissing even within families, communities, between relatives…
Spontaneous gestures of daily life hindered and replaced by mechanical and controlled gestures …
Terrified children, kept in permanent fear and guilt…
All this will have a deep, lasting and negative impact on human organisms, in their physical, mental, emotional and representation of the world and society.
This is not normal!
We cannot let our rulers, for whatever reason, organize our collective suicide any longer.
Translated from French by Global Research. Original source: Mondialisation.ca
Dr Pascal Sacré is a physician specialized in critical care, author and renowned public health analyst, Charleroi, Belgium. He is a Research Associate of the entre for Research on Globalization (CRG)
Professionals whose references and comments are the basis of this article in its scientific aspect (especially and mainly on RT-PCR):
1) Hélène Banoun
https://www.researchgate.net/profile/Helene_Banoun
PhD, Pharmacist biologist
Former INSERM Research Officer
Former intern at the Paris Hospitals
2) Pierre Sonigo
Virologist
Research Director INSERM, worked at the Pasteur Institute
Heads the Virus Genetics Laboratory in Cochin, Paris.
Participated in 1985 in the sequencing of the AIDS virus.
3) Christophe De Brouwer
PhD in Public Health Science
Honorary Professor at the School of Public Health at ULB, Belgium
4) Jean-François Toussaint
Doctor, Professor of Physiology at the University of Paris-Descartes
Director of IRMES, Institute for BioMedical Research and Sports Epidemiology
Former member of the High Council of Public Health
Notes (French)
[1] “Une nette augmentation du nombre de cas dans toutes les provinces et toutes les tranches d’âge”, 7sur7 ACTU Belgique, 5-10-2020
[2] Le gouvernement belge renforce des mesures anti-Covid, VRT.be ; 6 octobre 2020.
[3] Non, l’inventeur du test PCR n’a pas dit que sa méthode était inefficace pour détecter les virus, dans Le Monde, 7 octobre 2020
[4] Kary Mullis : « Le test PCR ne permet pas de savoir si vous êtes malade », vidéo accessible sur YouTube, 9 octobre 2020.
[5] https://www.weblyf.com/2020/05/coronavirus-the-truth-about-pcr-test-kit-from-the-inventor-and-other-experts/
[6] « The Truth about PCR Test Kit from the Inventor and Other Experts »
[7] PCR en microbiologie : de l’amplification de l’ADN à l’interprétation du résultat
[8] COVID : La PCR nasale peut-elle mentir ?, Dr Pascal Sacré, AIMSIB, 30 août 2020.
[9] https://www.youtube.com/watch?v=CaAcSJI0oMs&feature=youtu.be, 8 octobre 2020. Évolution génomique des virus ARN à l’Institut Pasteur, environ la moitié des nucléotides sont susceptibles d’avoir muté sur les 30 000 nucléotides de l’ARN viral. « Pour l’instant aucune mutation ou délétion n’a été associée à une perte de sévérité de la maladie sur une grande échelle géographique mais de nombreuses publications devraient bientôt préciser ces points. »
[10] https://www.mediterranee-infection.com/wp-content/uploads/2020/04/FD_Raoult_SARS-CoV-2_EID_Sep2020_vL2.pdf, Article IHU-Méditerranée, Professeur D. Raoult, Dramatic increase in the SARS-CoV-2 mutation rate and low mortality rate during the second epidemic in summer in Marseille, 7 septembre 2020
Conclusions :
Dans l’ensemble, comme l’ont récemment souligné Tomaszewski et al. (7) qui ont décrit pour les génomes viraux disponibles jusqu’en mai 2020 un déplacement mutationnel sur la spike et le complexe de réplication vers des gènes codant pour d’autres protéines non structurelles qui interagissent avec les voies de défense de l’hôte, il semble que le taux de mutation du SARS-CoV-2 s’accélère depuis mai, impliquant principalement des mutations C vers U. L’augmentation du taux de mutation du SRAS-CoV-2 génère des génotypes viraux plus éloignés de la souche Wuhan initiale que ceux observés de mars à avril. Cela semble entraîner des épidémies de durée limitée, du moins pour le premier nouveau génotype que nous avons identifié, et est associé à une gravité globalement moindre à ce stade du développement de cette nouvelle épidémie.
Mutations observed in these seven different viral genotypes are located in most SARS- CoV-2 genes including structural and non-structural genes among which nsp2, nsp3 (predicted phosphoesterase), nsp5 (membrane glycoprotein), nsp12 (RNA-dependent RNA polymerase), S (Spike glycoprotein), ORF3a, E (membrane glycoprotein), M (membrane glycoprotein), ORF8 and N (Nucleocapsid phosphoprotein).
[11] https://www.researchgate.net/profile/Helene_Banoun Evolution of SARS-CoV-2: Review of mutations, role of the host immune system, octobre 2020, mise à jour par Hélène Banoun,
PhD, Pharmacien biologiste, ancien Chargé de Recherches INSERM, ancien Interne des Hôpitaux de Paris.
[12] https://nextstrain.org/, We are incorporating SARS-CoV-2 genomes as soon as they are shared and providing analyses and situation reports. In addition we have developed a number of resources and tools, and are facilitating independent groups to run their own analysis. Please see the main SARS-CoV-2 page for more.
[13] Tutoriel prélèvement nasopharyngé : Un geste technique, essentiel à la fiabilité du test COVID-19
[14] Covid-19 : comment fonctionnent les tests et quelles sont leurs utilités ?
[15] COMMENT FONCTIONNENT LES TESTS DE DÉPISTAGE DU COVID-19 ? 7 avril 2020, Laboratoire de biologie et pharmacologie appliquée (LBPA), Clémence Richetta, maître de conférences au département biologie de l’ENS Paris-Saclay et chercheuse en virologie au LBPA : https://www.youtube.com/watch?v=hNVDHCf8bGA
Independent researcher, PhD 9
Former research fellow at INSERM (French Institute for Health and Medical Research)
[16] Par Pierre Sonigo, virologiste (un des découvreurs du VIH), MD PhD, CSO at Sebia, clinical diagnostics
https://www.linkedin.com/pulse/diagnostic-du-covid19-comprendre-les-tests-pcr-leur-et-pierre-sonigo/?trackingId=pTYxDkpvRzKHWZwCzxSIag%3D%3D
Diagnostic du COVID19 : comprendre les tests PCR, leur interprétation et leurs limites, publié le 16 septembre 2020
La PCR utilise un principe très particulier : la cible du test, un fragment d’ARN viral, est massivement amplifiée afin de permettre sa détection. Au cours de l’analyse, une réaction enzymatique associée à des « cycles » de variation de température permet une série de « réplications » successives de l’acide nucléique cible. Chaque cycle correspond à une multiplication théorique de la cible par 2. On multiplie donc par 2 en un cycle, par 4 en 2 cycles, par 8 en 3 cycles, par 16 en 4 cycles, et ainsi de suite de manière exponentielle. A l’heure actuelle, l’amplification est généralement pratiquée sur 40 cycles, soit une amplification théorique de 2^40, environ mille milliards de fois ! En réalité, la réplication n’est pas efficace à 100%, mais la cible est amplifiée environ un million de fois, ce qui permet de détecter moins d’une dizaine de fragments d’ARN dans le volume analysé.
Lorsque l’acide nucléique viral est détectable après un petit nombre de cycles, cela signifie que la quantité de virus dans l’échantillon de départ est grande. Au contraire, lorsqu’il faut un grand nombre de cycles de réplication pour détecter l’ARN viral, cela signifie que l’échantillon de départ contient une quantité de virus très faible. On parle alors en nombre de cycles, ou Ct, qui signifie « cycle time », pour définir, au moins de façon semi quantitative, la quantité d’ARN présent dans l’échantillon de départ. Ainsi, un petit Ct correspond à un grand nombre de copies, un grand Ct à un petit nombre de copies.
Cette spectaculaire sensibilité n’est pas sans inconvénient et nécessite des précautions particulières. En effet, un échantillon positif amplifié un million de fois contient une très haute concentration de cible et le risque qu’il contamine (carry over) d’autres échantillons est particulièrement élevé. La saturation des laboratoires peut encore accroître ce risque et générer des faux positifs accidentels. Dans ces conditions, il est important que les résultats positifs soient confirmés par un second test, à plus forte raison lorsqu’un test positif présente des conséquences significatives, qu’elles soient médicales, professionnelles ou liées à l’obligation d’isolement.
La deuxième question importante concernant la PCR, une fois encore conséquence de sa spectaculaire sensibilité, est celle de sa signification clinique. Un sujet parfaitement asymptomatique présentant une PCR positive ne peut être qualifié de « malade », comme on le lit dans les médias qui rapportent la progression de l’épidémie ! Peut-on même parler de « cas » ? C’est pourtant le terme utilisé dans les dénombrements officiels. Ne sommes-nous pas en train d’oublier le patient pour se focaliser sur la technologie ? Est-ce une épidémie d’ARN dans des tubes que nous surveillons ou une maladie grave et potentiellement mortelle ?
Des publications récentes soulignent que la dose détectable par PCR est inférieure à la dose infectieuse ou contagieuse : aucun virus infectieux n’a pu être retrouvé chez les patients asymptomatiques présentant des tests PCR positifs avec un Ct élevé. Suite à ces résultats, la question du seuil de Ct qui permet de déclarer un échantillon positif est débattue. Peut-on rendre un résultat négatif chez un sujet asymptomatique dont la positivité apparaît au-delà de 35 cycles ? A défaut, est-il utile de retester ces échantillons ? Comme souvent en matière de diagnostic médical, lorsqu’un seuil de positivité est déterminé, faut-il privilégier la sensibilité ou la spécificité du test ?
De plus, un échantillon confirmé positif d’un point de vue analytique reste un faux positif du point de vue de la clinique, si la personne testée est en parfaite santé, parfois même prêt à affronter une compétition de tennis ou de football professionnels ! La question devient uniquement celle de sa potentielle contagiosité. C’est la question de la transmission éventuelle par des sujets asymptomatiques, qui sans être eux-mêmes en danger, pourraient en représenter un pour les autres.
Par rapport à cette question, il est important de raisonner quantitativement. La virologie, ce n’est pas du tout ou rien. De manière générale, au cours des infections virales aiguës, le risque de contagion et la gravité de l’infection varient en fonction de la quantité de virus présents dans l’organisme et de leur excrétion dans le milieu extérieur. Quelques copies de virus tapis dans les sinus n’ont pas la dangerosité d’un million projetés par la toux. Un sujet asymptomatique produit moins de virus qu’un sujet symptomatique et les sécrète moins vers l’extérieur. La quantité de virus produite et donc le risque de contagion sont corrélés à la gravité des symptômes. Même si elle n’est pas de zéro, le risque de transmission est donc vraisemblablement faible pour un sujet asymptomatique. Malheureusement, répéter sans cesse que la contagion venant d’un sujet parfaitement asymptomatique est possible sans aucune précision sur le niveau de risque pousse à prendre des mesures disproportionnées avec le risque.
De même, la stratégie « dépister-isoler » n’est pas réaliste lorsque le dépistage n’est pas suffisamment fiable et surtout lorsque le virus est déjà largement répandu dans la population. Il est bien trop tard pour appliquer une méthode conçue pour bloquer une épidémie à sa naissance. Comme pour une invasion de coccinelles ou de frelons, on ne peut stopper un virus qui est déjà partout avec une passoire trouée à 25% et bouchée par endroits. L’échec de la stratégie actuelle est plutôt lié à sa conception naïve et inapplicable qu’aux mauvais comportements des citoyens.
Si, comme on l’observe en ce moment, la diffusion virale reprend, faut-il dépister plus massivement ou revoir la stratégie de protection de la population ?
Cette question ne relève pas de la science. Elle dépend des risques acceptables par un individu ou par un groupe. Si on est dans la recherche du risque minimal, proche de zéro, parce que le risque n’a pas été quantifié, ou pour des raisons de responsabilité juridique, on doit prendre les précautions maximales. Si on accepte un risque même faible, on peut reprendre certaines libertés et protéger ceux qui en ont réellement besoin.
Le scientifique doit mesurer la grandeur des risques et ne pas se contenter d’affirmer qu’un événement adverse est « possible ». Mais ce n’est pas son rôle de décider si ces risques peuvent être pris par autrui.
Les tests PCR permettent une détection extrêmement sensible de l’ARN viral. Ils sont indispensables mais ne sont pas la solution ultime et unique qui permettra de contrôler l’épidémie et de gérer efficacement les risques de contagion. Appliquée lorsque le virus est largement disséminé dans la population, la stratégie « dépister isoler » est vouée à l’échec. Du fait de la sensibilité très élevée et des limites de leur spécificité, les tests PCR doivent être pratiqués et interprétés avec précaution, et comme toujours en lien avec le contexte clinique et épidémiologique. N’oublions pas qu’un sujet asymptomatique doit plutôt être considéré comme immunisé que comme malade.
[17] Les tests RT-PCR du Covid-19 se révèlent être de très mauvais tests de contagiosité, Xavier Boisinet, mis à jour le 3/9/2020.
[18] De nombreuses publications partagées des milliers de fois sur les réseaux sociaux en quelques jours affirment que « 90% » des personnes déclarées positives au Covid-19 ont en fait des charges virales trop basses pour être « malades » ou « contagieuses ». C’est faux.
[19] Mise au point du CNR sur la réalisation des prélèvements et la sensibilité des tests RT-PCR pour la détection du SARS-CoV-2, 9 mai 2020
[20] Avis du 25 septembre 2020 de la Société Française de Microbiologie (SFM) relatif à l’interprétation de la valeur de Ct (estimation de la charge virale) obtenue en cas de RT-PCR SARS-CoV-2 positive sur les prélèvements cliniques réalisés à des fins diagnostiques ou de dépistage, 25 septembre 2020
[21] Coronavirus – Les tests PCR inadaptés contre l’épidémie? « Jusqu’à 90% de personnes testées ne seraient pas contagieuses », basé sur une étude d’une équipe de Harvard ( Harvard TH Chan School of Public Health) de Michael Mina, département d’épidémiologie, je vous mets en fichier joint le PDF correspondant, une étude, reprise par le NY Times :
« Pour eux, la limite du test PCR (prélèvement par voie nasale ou salivaire) réside dans la brutalité et la simplicité du résultat qu’il donne. La personne est soit positive, soit négative. Pas plus de renseignement, notamment sur la contagiosité du malade.
Or, les scientifiques d’Harvard soulèvent le problème de la quantité de virus que ce test PCR ne donne pas et qui pourrait, selon eux, permettre de donner des clés supplémentaires pour contrer l’épidémie.
« Les tests standards diagnostiquent un grand nombre de personnes qui peuvent être porteuses de quantités relativement insignifiantes du virus », explique ainsi le Dr. Michael Mina, épidémiologiste à la Harvard TH Chan School of Public Health. »
[22] « Au rythme actuel avec nos tests RT-PCR, nous allons confiner des dizaines de milliers de gens pour rien », alerte le Dr. Yvon Le Flohic, manuel Moragues, 3 septembre 2020.
[23] Tests de diagnostic ultra sensibles, les tests RT-PCR sortent positifs même pour des individus qui portent trop peu de virus pour être encore contagieux. Pour en faire de meilleurs tests de contagiosité, certains appellent à baisser leur seuil de détection. Est-ce une bonne idée ? Quelles sont les limites de cette solution ? Décryptage.Xavier Boinivet, 15 septembre 2020
[24] Jean-Luc Gala (UCL) estime que les futures mesures de la Celeval, tel le lockdown, vont tuer l’économie, provoquer des suicides et déstabiliser l’État. Le Celeval, ou Cellule d’évaluation, est le groupe d’experts qui conseillent le gouvernement belge dans la gestion du COVID.
[25] L’OMS plaide pour éviter à tout prix les confinements : ‘Cela ne rend que les pauvres plus pauvres’
[26] Voici comment la pandémie risque de faire exploser la pauvreté mondiale, une première en 22 ans
[27] ‘Le coronavirus menace 500 millions de personnes de pauvreté’, prévient l’Oxfam. Ce n’est pas le coronavirus, la menace, mais l’attitude de nos gouvernants face au coronavirus !
[28] Le chômage de masse est désormais mondial
[29] ‘Nous risquons une crise alimentaire imminente si des mesures ne sont pas prises rapidement’. Encore une fois, ce n’est pas à cause du coronavirus, mais à cause de notre attitude face à cette crise.
The original source of this article is Global Research Copyright © Dr. Pascal Sacré , Global Research, 2020 **** Please DONATE to HELP support our ongoing battle to expose the COVID-19 FRAUD! PRINCIPIA SCIENTIFIC INTERNATIONAL, legally registered in the UK as a company incorporated for charitable purposes. Head Office: 27 Old Gloucester Street, London WC1N 3AX. Please DONATE TODAY To Help Our Non-Profit Mission To Defend The Scientific Method
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principiascientificinternational--2020-11-10--How Quicycle Is Advancing the Cause of Pure Science

How Quicycle Is Advancing the Cause of Pure Science The Quicycle Society is an organization dedicated to furthering the principles of pure science .
One of its principal goals is to illuminate the unity between quantum , classical and relativistic mechanics .
Standard model physicists have been unable to link them together .
Some have gone so far as to say that quantum mechanics and relativity are mutually exclusive .
Some Quicycle members believe they have found the link between all three branches of mechanics through the properties of photons .
Quicycle was founded with the aims of getting valid @ @ @ @ @ @ @ model reviewers .
It features regular printed articles , but focuses on audio-visual presentations since these are often a better means of communication than written articles .
It is based around the following principles .
• Furthering Pure Science • Science that is analytic , testable , and calculable • Science that is subject to the scientific method • Science that can be used in imagining new materials , devices , and systems • Proving a concept , from thinking it to making it to bringing it into material reality , is considered @ @ @ @ @ @ @ • Enabling thinking which could otherwise not be thought about at all • Elementary particles are not assumed to be axiomatic • Sub-quantum mechanics and particle structures are investigated and elucidated • Excluding the untestable • Many worlds , hypothesized particles , infinities , or unphysical concepts that are not subject to experiment , are not contemplated • Extra dimensions beyond those of the fabric of spacetime are avoided • That which is unobservable is not worth thinking about • Public Peer Review • Peer review should occur in a transparent and public @ @ @ @ @ @ @ demonstrate their understanding of the content and their ability to critique it substantively The essence of the link is that photons have mass , as determined by Einstein and measured many times .
The suggestion is that all individual particles consist of photons of the appropriate energy making two revolutions within their wavelength .
Although that may seem surprising , both the physics and mathematics indicate that rotating photons are more stable than are the linear photons of which they are composed .
This work extends quantum mechanics in a way that is @ @ @ @ @ @ @ particles .
It is their structure that gives rise to their properties .
The expression of both photon and particle wave functions can now be realized via the Williamson equation , summarized in the form 𝒟μΞ𝒢=0 .
( “ d-mu ksi-gee equals zero ” ) .
This is a Clifford-Dirac algebra in which all components ( such as current , field , angular momentum , mass ) can be expressed in their appropriate inter relationships .
( See Video QC0068 on www.Quicycle.com ) .
Physically it expresses the relationship that the sum of @ @ @ @ @ @ @ of least action , in which the energy change for any single event tends to zero , expressed mathematically as ΔE→0 , is also used .
The first consequence revealed by the rotating photon structure is Einstein ’ s special relativity corrections .
In the equation E = mc2 , energy E is the photon travelling in a straight line and mass m is the same photon making two revolutions per wavelength .
That rotating photon structure is automatically subject to the special relativity corrections of mass , length and time as it @ @ @ @ @ @ @ a fourth special relativity correction , which helps to unite quantum properties with special relativity .
( QC0021 ) Quicyclists have also described the structures that the only known stable particles — electrons , protons , ( bound ) neutrons and neutrinos —have under the rotating photon model .
( QC0043 ) Their structure gives their observed properties .
Predictions are made of some new and intriguing ones .
The structure , properties and mass of electron neutrinos is predicted .
A description of the origins of the myriad of elementary particles generated @ @ @ @ @ @ @ is given , and the properties of some of them are described .
( QC0045 ) We go on to show how the neutral neutron can bind positively charged protons together in nuclei .
That shows the nature of the strong force and the rules of nuclear binding .
( QC0060 ) That is sufficient to enable any interested party to determine the structure and many properties of any nucleus of any Z and A .
( QC0078 ) It shows why the 12C nucleus is equilateral triangle shaped , why 4He has @ @ @ @ @ @ @ while its neighbor 6Li has the lowest , the nature of the skin effect , and a lot more .
The calculations are not complicated although they can be time consuming if done manually .
The match between theory and observation is remarkably good .
It turns what is otherwise a complex topic under all other models into a simple exercise that is highly accurate in its predictions .
Knowing the nature of the nuclear interactions , we have gone on to show how the fusion of heavy elements occurs , predicting the @ @ @ @ @ @ @ 3 < Z < 92 ( Fe excluded ) to within a factor of about 3 over more than 7 orders of magnitude .
We then show how treating electrons as particles can explain many of the observed properties of electrons around atoms ( QC0095 ) .
Electron energies in atoms are fixed by the number of protons in the nucleus and the screening effects of other electrons closer to the nucleus .
There is no need to introduce artificial constraints like quantized orbits because of orbital angular momentum or the de Broglie @ @ @ @ @ @ @ automatic consequence of this rotating photon structure of matter .
We also show the nature of electron binding and why it is so important for electrons to pair .
That takes us in continuity from the nuclear and quantum worlds to the classical world without the need to hypothesize any artificial constraints .
From that point on , the classical and special relativity worlds do a good job of explaining most observations .
We have found that photons are also the key to understanding the physics that supports Einstein ’ s gravity .
@ @ @ @ @ @ @ ’ s work , including the approximations he introduced .
Within those approximations we find no error in his calculations .
It is hoped that an understanding of the physics he used and the ability to make the same derivations using simpler mathematics will silence those who wish to criticize his work .
An evaluation of the work of some general relativity specialists shows they seem unable to recognize the physics he used or the approximations he introduced .
All is not what the “ experts ” tell us .
( QC0106 ) @ @ @ @ @ @ @ how photons provide the link between the smallest subatomic particles , nuclear physics , the quantum world of atoms and molecules , the classical worlds of Newton and Maxwell , Einstein ’ s special relativity corrections and gravity .
They are all part of the one continuum in three space dimensions and time , in a universe free of quarks , gluons , gravitons , tachyons , strings and other hypothesized particles .
Other topics covered include the photon-electron model ( QC0007 ) , the Higgs Boson ( QC0089 ) and high temperature @ @ @ @ @ @ @ publish some of this work in standard model journals have not been successful .
Some of the rejection notices have included words to the effect of “ the mathematics is not sufficiently complex !
” , “ we have a theory that says your theory is wrong !
” , and “ it is not standard model so we can ’ t publish it !
” Publishing on www.quicycle.com provides an outlet for our findings .
Not all of the work mentioned above has been published .
The science underpinning these descriptions is @ @ @ @ @ @ @ .
In addition , Quicycle aims to disrupt the manner in which peer review is conducted , bringing the process more transparency and accountability .
An example of our peer review system is given in QV0101 , with a panel discussion on the subject shown in QC0082 .
A selection of the published Quicycle presentations mentioned above is given in the following link : https : //quicycle.com/links-1/ The number after the topic refers to the number of the presentation that gives its details .
Below are a selection of some videos : PRINCIPIA @ @ @ @ @ @ @ UK as a company incorporated for charitable purposes .
Head Office : 27 Old Gloucester Street , London WC1N 3AX .
Please DONATE TODAY To Help Our Non-Profit Mission To Defend The Scientific Method .

How Quicycle Is Advancing the Cause of Pure Science
Written by John G. Williamson, Vivian Robinson & Arnold Benn
The Quicycle Society is an organization dedicated to furthering the principles of pure science. One of its principal goals is to illuminate the unity between quantum, classical and relativistic mechanics. Standard model physicists have been unable to link them together. Some have gone so far as to say that quantum mechanics and relativity are mutually exclusive.
Some Quicycle members believe they have found the link between all three branches of mechanics through the properties of photons.
Methodology
Quicycle was founded with the aims of getting valid information past unsubstantiated objections forwarded by standard model reviewers. It features regular printed articles, but focuses on audio-visual presentations since these are often a better means of communication than written articles. It is based around the following principles.
Furthering Pure Science Science that is analytic, testable, and calculable Science that is subject to the scientific method Science that can be used in imagining new materials, devices, and systems Proving a concept, from thinking it to making it to bringing it into material reality, is considered the most solid scientific proof of all
Enabling thinking which could otherwise not be thought about at all Elementary particles are not assumed to be axiomatic Sub-quantum mechanics and particle structures are investigated and elucidated Discussion forums are arranged where experts exchange ideas
Excluding the untestable Many worlds, hypothesized particles, infinities, or unphysical concepts that are not subject to experiment, are not contemplated Extra dimensions beyond those of the fabric of spacetime are avoided That which is unobservable is not worth thinking about
Public Peer Review Peer review should occur in a transparent and public manner Reviewers should be able to demonstrate their understanding of the content and their ability to critique it substantively
Some Achievements
The essence of the link is that photons have mass, as determined by Einstein and measured many times. The suggestion is that all individual particles consist of photons of the appropriate energy making two revolutions within their wavelength. Although that may seem surprising, both the physics and mathematics indicate that rotating photons are more stable than are the linear photons of which they are composed.
This work extends quantum mechanics in a way that is able to include the sub-structure of subatomic particles. It is their structure that gives rise to their properties. The expression of both photon and particle wave functions can now be realized via the Williamson equation, summarized in the form 𝒟μΞ𝒢=0. (“d-mu ksi-gee equals zero”). This is a Clifford-Dirac algebra in which all components (such as current, field, angular momentum, mass) can be expressed in their appropriate inter relationships. (See Video QC0068 on www.Quicycle.com). Physically it expresses the relationship that the sum of all changes is zero. The principle of least action, in which the energy change for any single event tends to zero, expressed mathematically as ΔE→0, is also used.
The first consequence revealed by the rotating photon structure is Einstein’s special relativity corrections. In the equation E = mc2, energy E is the photon travelling in a straight line and mass m is the same photon making two revolutions per wavelength. That rotating photon structure is automatically subject to the special relativity corrections of mass, length and time as it moves. It also gives rise to a fourth special relativity correction, which helps to unite quantum properties with special relativity. (QC0021)
Quicyclists have also described the structures that the only known stable particles — electrons, protons, (bound) neutrons and neutrinos —have under the rotating photon model. (QC0043) Their structure gives their observed properties. Predictions are made of some new and intriguing ones. The structure, properties and mass of electron neutrinos is predicted. A description of the origins of the myriad of elementary particles generated by cosmic rays and in particle accelerators is given, and the properties of some of them are described. (QC0045)
We go on to show how the neutral neutron can bind positively charged protons together in nuclei. That shows the nature of the strong force and the rules of nuclear binding. (QC0060) That is sufficient to enable any interested party to determine the structure and many properties of any nucleus of any Z and A. (QC0078) It shows why the 12C nucleus is equilateral triangle shaped, why 4He has the highest charge density of any nucleus while its neighbor 6Li has the lowest, the nature of the skin effect, and a lot more. The calculations are not complicated although they can be time consuming if done manually.
The match between theory and observation is remarkably good. It turns what is otherwise a complex topic under all other models into a simple exercise that is highly accurate in its predictions. Knowing the nature of the nuclear interactions, we have gone on to show how the fusion of heavy elements occurs, predicting the observed solar abundances of most elements, 3